Digital Commons Network^™

Parent Borrowing And College Completion, Jennie H. Woo, Stephen Lew

Journal of Student Financial Aid

Parent PLUS loans are available for parents of traditional students, allowing them to borrow up to the complete cost of attendance if they pass a credit check. Having access to more loan funds might increase a student’s chances of obtaining a bachelor’s degree by allowing them to attend a higher quality school, or to spend fewer hours working and perform better academically. Among students who intend to earn a 4-year degree and are eligible for PLUS loans, are those whose parents take out Parent PLUS loans, more likely to earn BA degrees than those who don’t? Using the 2004/09 Beginning …

The Restatements And The Rule Of Law, Kristina Daugirdas

Book Chapters

This chapter explores the promotion of the rule of law. In drafting and publishing Restatements of Foreign Relations Law, both the American Law Institute and the reporters have understood the projects as contributing to the rule of law at the international level, at the domestic level, or both. There are at least three distinct ways that these Restatements might promote the rule of law. First, they might do so by clarifying the content of the law. Second, the Restatements might contribute to the development of new legal rules, specifically to the evolution and consolidation of customary international law. Finally, the …

Milton's Plant Eyes: Minimal Cognition, Similitude, And Sexuality In The Garden, Perry Guevara

English and Creative Writing | Faculty Scholarship

This essay turns to minimal cognition, a theoretical extension of embodied cognition, to argue for plant sentience in John Milton’s Paradise Lost. Milton imagines plants as minimally cognitive beings within an affective ecosystem, where they readily enter into the epic poem’s complex circuits of desire with appetites of their own. Specifically, the essay claims that botanical cognition arises at the convergence of two seventeenth-century philosophical systems: the first, Milton’s materialist monism, and the second, Paracelsian medicine, which avers a plant’s therapeutic effect on a human body part sharing morphological resemblance. The essay concludes that Milton’s eroticization of similitude enables a …

Investigating The Effects Of Brainstem Neuronal Adaptation On Cardiovascular Homeostasis., James H Park, Jonathan Gorky, Babatunde Ogunnaike, Rajanikanth Vadigepalli, James S Schwaber

Articles, Abstracts, and Reports

Central coordination of cardiovascular function is accomplished, in part, by the baroreceptor reflex, a multi-input multi-output physiological control system that regulates the activity of the parasympathetic and sympathetic nervous systems via interactions among multiple brainstem nuclei. Recent single-cell analyses within the brain revealed that individual neurons within and across brain nuclei exhibit distinct transcriptional states contributing to neuronal function. Such transcriptional heterogeneity complicates the task of understanding how neurons within and across brain nuclei organize and function to process multiple inputs and coordinate cardiovascular functions within the larger context of the baroreceptor reflex. However, prior analysis of brainstem neurons revealed …

Inducing Partner Preference In Mice By Chemogenetic Stimulation Of Ca2 Hippocampal Subfield., Adi Cymerblit-Sabba, Adam S Smith, Sarah K Williams Avram, Michelle Stackmann, Austin C Korgan, Maria C Tickerhoof, W Scott Young

Faculty Research 2020

Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can …

Aml Risk Stratification Models Utilizing Eln-2017 Guidelines And Additional Prognostic Factors: A Swog Report., Era L Pogosova-Agadjanyan, Anna Moseley, Megan Othus, Frederick R Appelbaum, Thomas R Chauncey, I-Ming L Chen, Harry P Erba, John E Godwin, Isaac C Jenkins, Min Fang, Mike Huynh, Kenneth J Kopecky, Alan F List, Jasmine Naru, Jerald P Radich, Emily Stevens, Brooke E Willborg, Cheryl L Willman, Brent L Wood, Qing Zhang, Soheil Meshinchi, Derek L Stirewalt

Articles, Abstracts, and Reports

Background: The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal therapies. Despite the identification of many prognostic factors, relatively few have made their way into clinical practice.

Methods: In order to assess and improve the performance of the European LeukemiaNet guidelines, we developed novel prognostic models using the biomarkers from the guidelines, age, performance status and select transcript biomarkers. The models were developed separately for mononuclear cells and viable leukemic blasts from previously untreated acute myeloid leukemia patients (discovery cohort,

Results: Models …

Transcriptional And Immunohistological Assessment Of Immune Infiltration In Pancreatic Cancer., Brady Bernard, Venkatesh Rajamanickam, Christopher Dubay, Brian D. Piening, Emilio Alonso, Zeljka Jutric, Ephraim Tang, Pippa Newell, Paul D Hansen, Terry R Medler, Andrew J Gunderson, Kristina H Young, Carlo Bifulco, Joanna Pucilowska, Marka R Crittenden, Michael J. Gough

Articles, Abstracts, and Reports

Pancreatic adenocarcinoma is characterized by a complex tumor environment with a wide diversity of infiltrating stromal and immune cell types that impact the tumor response to conventional treatments. However, even in this poorly responsive tumor the extent of T cell infiltration as determined by quantitative immunohistology is a candidate prognostic factor for patient outcome. As such, even more comprehensive immunophenotyping of the tumor environment, such as immune cell type deconvolution via inference models based on gene expression profiling, holds significant promise. We hypothesized that RNA-Seq can provide a comprehensive alternative to quantitative immunohistology for immunophenotyping pancreatic cancer. We performed RNA-Seq …

The Impact Of Age On Survival In Cll Patients Receiving Ibrutinib As Initial Therapy., Chaitra Ujjani, Anthony Mato, Brian T Hill, John N Allan, Frederick Lansigan, Ryan Jacobs, Alan Skarbnik, Hande Tuncer, John M Pagel, Danielle Brander, Bruce Cheson, Paul Barr, Lindsey E Roeker, Jeffrey Pu, Nirav N Shah, Andre Goy, Stephen J Schuster, Nicole Lamanna, Alison Sehgal, Constantine S Tam, Mazyar Shadman

Articles, Abstracts, and Reports

Introduction: Recent randomized trials have demonstrated the efficacy of ibrutinib-based therapy in the treatment of patients with CLL. In Alliance A041202, a higher than expected number of unexplained deaths were reported with front-line ibrutinib in a patient population aged at least 65 years compared to ECOG 1912, which included patients up to 70 years of age.

Methods: Therefore, we conducted a retrospective analysis to investigate whether ibrutinib was associated with a greater mortality in older patients outside of a clinical trial setting. This multicenter analysis was performed by investigators at 20 academic and community practices.

Results: Amongst the 391 patients …

Environmental Forensics Of Complexly Contaminated Sites: A Complimentary Fingerprinting Approach, Michael A. Kruge, Azucena Lara-Gonzalo, José Luis Gallego

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The environmental forensics approach is most often applied in petroleum and fuel spill incidents, for which sophisticated chemical fingerprinting procedures have evolved. In cases in which pollutant discharges occur in settings with prior contamination, more care must be taken in source discrimination, requiring further advances in methodology. Additional obstacles can arise if the spill is an atypical industrial discharge. This would necessitate painstaking characterization of unfamiliar substances lying outside of existing regulatory regimes and thus overlooked by mandated analytical protocols (i.e., contaminants of emerging concern). Towards these ends, this paper presents a systematic, multi-faceted GC-MS approach using the saturated, aromatic, …

Characterization Of Coal Particles In The Soil Of A Former Rail Yard And Urban Brownfield: Liberty State Park, Jersey City (Nj), Usa, Diane F. Hagmann, Michael A. Kruge, Nina M. Goodey, Jennifer Adams Krumins

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

From the 1850's until the 1960's, the Central Railroad of New Jersey was among several major railways shipping anthracite and bituminous coal to the New York City area, transferring coal from railcar to barge at its extensive rail yard and port facility in Jersey City. The 490 ha Liberty State Park was developed on the site after the rail yard closed, but a ca. 100 ha brownfield zone within the park remains off limits to visitors pending future remediation. As part of an environmental forensic and industrial archeological investigation of this zone, the present study characterizes anthracite and bituminous coal …

Using Site Visits To Strengthen Collaboration, Victor Piercey, Rebecca Segal, Afroditi Vennie Filippas, Tao Chen, Soloman Kone, Rosalyn Hobson Hargraves, Jack Bookman, John Hearn, Debbie Pike, Kathy S. Williams

Publications and Research

The SUMMIT-P project is a multi-institutional endeavor to leverage interdisciplinary collaboration in order to improve the teaching of undergraduate mathematics courses in the first two years of college. One goal of this work is to establish collaborative communities among the institutions involved. As part of the project, institutions visit one another on site visits that are structured according to a common protocol. The site visits have been valuable to the project. Participating institutions report the exchange of actionable ideas and feedback; members of the grant leadership team have used the site visits to direct the overall project, and evaluators have …

Fishbowl Discussions: Promoting Collaboration Between Mathematics And Partner Disciplines, Stella K. Hofrenning, Rosalyn Hobson Hargraves, Tao Chen, Afroditi Vennie Filippas, Rhonda Fitzgerald, John Hearn, Lori J. Kayes, Joan Kunz, Rebecca Segal

Publications and Research

A National Consortium for Synergistic Undergraduate Mathematics via Multi-institutional Interdisciplinary Teaching Partnerships project (SUMMIT-P) is a collaboration of institutions focused on revising first- and second-year mathematics courses with the help of partner disciplines with prerequisite mathematics courses. This paper describes the fishbowl discussion technique used by the consortium members to encourage interdisciplinary conversation. Vignettes describing the results of conversations that occurred at several consortium member institutions are provided by the co-authors.

Image And Storytelling New Approaches To Hispanic Cinema And Literature, Gina Herrmann, Isabel Jaén Portillo

World Languages and Literatures Faculty Publications and Presentations

This special issue of Periphērica, Image and Storytelling: New Approaches to Hispanic Cinema and Literature, features leading research by scholars of Hispanic cultures at the crossroads of literature, film, mind, and society. The collection showcases cutting-edge fields and themes including cognitive studies, affect studies, embodiment, and empathy, as well as new perspectives on adaptation, film typology, film teaching, gender, and genre. The research presented in this special issue underscores the excitement produced by crossing disciplinary boundaries in the study of verbal and visual narratives, moving beyond prevalent transnational approaches that do not sufficiently address key factors in the creation and …

Comparison Of Calcium Hydroxide Extrusion With Syringe Vs Spiral Filler Delivery: A Pilot Study, Gordon San Lai

Orthodontics and Endodontics Theses

Introduction: The aim of this study was to evaluate the frequency and amount of Ca(OH)2 extrusion in relation to the intracanal delivery technique, apical foramen size, and depth of placement. Methods: Standardized training blocks with j-shaped canals were used (n=64); half of the simulated canals were shaped to apical size #35(.06 taper) and the remaining 32 to #45(.06). The frequency and extent of Ca(OH)2 extrusion were measured relative to apical taper, the depth of insertion, and whether syringe or spiral filler was used. Blocks were immersed in pH-sensitive gel and observed for color change. The visible extent of extrusion, indicated …

Assessing The Potential Of Implementing Blockchain In Supply Chains Using Agent-Based Simulation And Deep Learning, Mohammad Obeidat

Electronic Theses and Dissertations, 2020-2023

In this decade, with the rise of data science accompanying the growth of e-commerce, many technologies have been developed. An example of these technologies is Blockchain, which has appeared to overcome security problems potentially. This research assesses Blockchain's implementation in supply chains through a methodology that uses deep learning and agent-based simulation. A case study was utilized to observe and validate research developments. The unique method predicts intrusions by using deep learning, and agent-based modeling reproduces artificial but convincing agents (e.g., customers, companies, hackers, and cyber pirates) in a computer-generated market. Trust and other relationships are systematically captured to represent …

Your Face Is A Commodity, Fiercely Contract Accordingly: Regulating The Capitalization Of Facial Recognition Technology Through Contract Law, Y. Amy Chen

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Prior Tonsillectomy Is Associated With An Increased Risk Of Esophageal Adenocarcinoma., Katherine S Garman, Teminioluwa A Ajayi, Harold J Boutte, Shih-Ting Chiu, Richard J Von Furstenberg, Benjamin R Lloyd, Cecelia Zhang, Mark W Onaitis, Shein-Chung Chow, Shannon J Mccall

Articles, Abstracts, and Reports

BACKGROUND: Esophageal cancer is a deadly cancer with 5-year survival

METHODS: Cases included 452 esophagectomy cases, including 396 with EAC and 56 who underwent esophagectomy for Barrett's esophagus (BE) with high grade dysplasia (HGD). 1,102 thoracic surgery patients with surgical indications other than dysplastic BE or esophageal cancer represented the controls for our analysis. The association of tonsillectomy and HGD/EAC were primarily evaluated by using univariate tests and then verified by logistic regression analysis. Baseline demographics, medical history, and thoracic surgery controls were compared by using χ2 tests or 95% CIs. Significant risk factors were considered as covariates in the …

Biohackathon 2015: Semantics Of Data For Life Sciences And Reproducible Research., Rutger A Vos, Toshiaki Katayama, Hiroyuki Mishima, Shin Kawano, Shuichi Kawashima, Jin-Dong Kim, Yuki Moriya, Toshiaki Tokimatsu, Atsuko Yamaguchi, Yasunori Yamamoto, Hongyan Wu, Peter Amstutz, Erick Antezana, Nobuyuki P Aoki, Kazuharu Arakawa, Jerven T Bolleman, Evan Bolton, Raoul J P Bonnal, Hidemasa Bono, Kees Burger, Hirokazu Chiba, Kevin B Cohen, Eric W Deutsch, Jesualdo T Fernández-Breis, Gang Fu, Takatomo Fujisawa, Atsushi Fukushima, Alexander García, Naohisa Goto, Tudor Groza, Colin Hercus, Robert Hoehndorf, Kotone Itaya, Nick Juty, Takeshi Kawashima, Jee-Hyub Kim, Akira R Kinjo, Masaaki Kotera, Kouji Kozaki, Sadahiro Kumagai, Tatsuya Kushida, Thomas Lütteke, Masaaki Matsubara, Joe Miyamoto, Attayeb Mohsen, Hiroshi Mori, Yuki Naito, Takeru Nakazato, Jeremy Nguyen-Xuan, Kozo Nishida, Naoki Nishida, Hiroyo Nishide, Soichi Ogishima, Tazro Ohta, Shujiro Okuda, Benedict Paten, Jean-Luc Perret, Philip Prathipati, Pjotr Prins, Núria Queralt-Rosinach, Daisuke Shinmachi, Shinya Suzuki, Tsuyosi Tabata, Terue Takatsuki, Kieron Taylor, Mark Thompson, Ikuo Uchiyama, Bruno Vieira, Chih-Hsuan Wei, Mark Wilkinson, Issaku Yamada, Ryota Yamanaka, Kazutoshi Yoshitake, Akiyasu C Yoshizawa, Michel Dumontier, Kenjiro Kosaki, Toshihisa Takagi

Articles, Abstracts, and Reports

We report on the activities of the 2015 edition of the BioHackathon, an annual event that brings together researchers and developers from around the world to develop tools and technologies that promote the reusability of biological data. We discuss issues surrounding the representation, publication, integration, mining and reuse of biological data and metadata across a wide range of biomedical data types of relevance for the life sciences, including chemistry, genotypes and phenotypes, orthology and phylogeny, proteomics, genomics, glycomics, and metabolomics. We describe our progress to address ongoing challenges to the reusability and reproducibility of research results, and identify outstanding issues …

Tardigrade Abundance In Relation To Urbanisation And Highly Anthropogenic Substrates, Thomas Mccarthy, Javier Delbarco-Trillo

Faculty Publications – Biological Sciences

Animals colonising urban environments are exposed to a series of novel stressors and ecological challenges, which can result in adaptations to alternative urban niches. Tardigrades are cosmopolitan invertebrates present in all types of ecosystems, including urban environments; and they can survive under extreme conditions, including periods of desiccation, thus allowing them to colonise novel harsh habitats. Tardigrades are thus a promising model to investigate the challenges and opportunities encountered by urban colonisers. Our aims were 1, to determine if tardigrade abundance in natural substrates (moss, lichen and leaf litter) differs between rural and urban sites and 2, to assess if …

Exogenous Flupirtine As Potential Treatment For Cln3 Disease, Katia Maalouf, Joelle Makoukji, Sara Saab, Nadine J. Makhoul, Angelica V. Carmona, Nihar Kinarivala, Noël Ghanem, Paul C. Trippier, Rose-Mary Boustany

Journal Articles: Pharmaceutical Sciences

CLN3 disease is a fatal neurodegenerative disorder affecting children. Hallmarks include brain atrophy, accelerated neuronal apoptosis, and ceramide elevation. Treatment regimens are supportive, highlighting the importance of novel, disease-modifying drugs. Flupirtine and its new allyl carbamate derivative (compound 6) confer neuroprotective effects in CLN3-deficient cells. This study lays the groundwork for investigating beneficial effects in Cln3^Δex7/8 mice. WT/Cln3^Δex7/8 mice received flupirtine/compound 6/vehicle for 14 weeks. Short-term effect of flupirtine or compound 6 was tested using a battery of behavioral testing. For flupirtine, gene expression profiles, astrogliosis, and neuronal cell counts were determined. Flupirtine improved neurobehavioral parameters in …

2020-2021 Nsu Undergraduate Student Catalog, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.

2020 Bachelor's Degree Exit Survey, Southwestern Oklahoma State University

Assessment Center Reports

Exit Surveys produced by the SWOSU Assessment Center.

The Fallacy Of The Intermediate Scrutiny Analysis, Desiree Palomares

Denver Law Review Forum

No abstract provided.

Geological And Environmental Sciences - 2020, Dept. Of Geological And Environmental Sciences

Geological and Environmental Sciences News

• From the Department Chair

• Faculty Updates

• MGS Updates

• MGRRE Updates

• Alumni Notes

• In Remembrance: Dr. Dick Passero

• 2019-2020 Faculty, Staff and Student Accolades

Designing Law To Enable Adaptive Governance Of Modern Wicked Problems, Barbara Cosens

Articles

In the twenty-first century, our planet is facing a period of rapid and fundamental change resulting from human domination so extensive it is expected to be visible in the geologic record. The accelerating rate of change compounds the global social-ecological challenges already deemed "wicked" due to conflicting goals and scientific uncertainty. Understanding how connected natural and human systems respond to change is essential to understanding the governance required to navigate these modern wicked problems. This Article views change through the lens of complexity and resilience theories to inform the challenges of governance in a world dominated by such massive and …

Festschrift In Honor Of University Of Idaho Distinguished Professor Emeritus Dale Goble, Barbara Cosens

Articles

No abstract provided.

Timing And Duration Of Folate Restriction Differentially Impacts Colon Carcinogenesis., Ali M. Fardous

Wayne State University Dissertations

Colorectal cancer (CRC) constitutes a major burden on the healthcare system as the second most commonly diagnosed cancer in the developed world. Dietary folate is considered an important modulator of colorectal cancer. Folate restriction has been implicated in increasing CRC incidence by disrupting nucleotide synthesis, Impacting DNA methylation and inducing genetic instability. Our research shows that the timing and duration of dietary folate restriction can differentially impact Colorectal cancer initiation. Acclimating mice to folate restriction for 8 weeks results in a reduced number of preneoplastic lesions compared to mice placed of folate restriction for 1 week prior to initiating the …

Determinants Of Successful Diabetes Self-Management Behaviors Among Women Of Arab Descent With Type 2 Diabetes, Mona R. Alanzi

Wayne State University Dissertations

ABSTRACT

Type 2 Diabetes (T2D) continues to be an escalating public health problem that contributes to increased morbidity and mortality worldwide (American Diabetes Association, 2017b). According to the National Diabetes Statistics Report (2017), approximately 30.3 million (9.4%) Americans have T2D. It accounted for 252,806 deaths in 2015 in the United States. Although the complications of T2D is a major threat to the health of women of Arab descent, there is lack of information about the health practices and diabetes self-management behaviors of this population. The purpose of this dissertation is to examine the impact of diabetes knowledge, social/family support, acculturation, …

Language Acquisition And Development, Esther Ramirez

Graduate Student Independent Studies

This Integrated Masters Project focuses on first language development in developing children, and how variant it can be, especially in the early years of child growth.

On The Cover: Artist’S Statement For A Glimpse Of Motherhood

The Graduate Review

No abstract provided.