Digital Commons Network^™

Entomology/Beekeeping, 6-9 Years In Project, Dewayne Shoemaker, Scott Stewart, Karen Vail, Jennifer Tsuruda, Jennifer Richards, Kaushalya Amarasekare

Extension Publications

No abstract provided.

Plants That Attract Insect Predators And Parasitoids, Kaushalya Amarasekare

Extension Publications

No abstract provided.

On Mutualism, Models, And Masting: The Effects Of Seed-Dispersing Animals On The Plants They Disperse, Christopher M. Moore, Jacob W. Dittel

Biology

Species interactions are context dependent, in that their direction and magnitude can vary across ecological conditions. For seed dispersal interactions—especially interactions between plants and seed-caching animals—the direction of the interactions is often obscured because of seed mortality inherent in seed handling and the delayed effects of fitness benefits received by plants. It is, therefore, an open question in ecology to understand the ecological contexts

Switching Fractioned R-Chop Cycles To Standard R-Chop Cycles Guided By Endoscopic Ultrasonography In Treating Patients With Primary Gastric Diffuse Large B-Cell Lymphoma, Yizhen Liu, Yumei Liu, Ping Zhao, Qunling Zhang, Xiaojian Liu, Junning Cao, Kai Xue

Biology

Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) is a common subtype of extranodal non-Hodgkin lymphoma (NHL), with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) as the commonly used treatment regimen. However, full cycles of standard R-CHOP present the risk of severe bleeding or perforation, even leading to emergency surgery, especially for those with deep lesions in their first 1–2 cycles of treatment. This study aims to explore the safety and efficacy of fractioned R-CHOP (rituximab d0, 50%dose of CHOP d1 and d5) followed by standard R-CHOP cycles in PG-DLBCL patients guided by endoscopic ultrasonography (EUS).

Biogeography Of American Northwest Hot Spring A/B′-Lineage Synechococcus Populations, Eric D. Becraft, Jason M. Wood, Frederick M. Cohan, David M. Ward

Biology

Previous analyses have shown how diversity among unicellular cyanobacteria inhabiting island-like hot springs is structured relative to physical separation and physiochemical differences among springs, especially at local to regional scales. However, these studies have been limited by the low resolution provided by the molecular markers surveyed. We analyzed large datasets obtained by high-throughput sequencing of a segment of the photosynthesis gene psaA from samples collected in hot springs from geothermal basins in Yellowstone National Park, Montana, and Oregon, all known from previous studies to contain populations of A/B′-lineage Synechococcus. The fraction of identical sequences was greater among springs separated by …

Hiding In Plain Sight: The Globally Distributed Bacterial Candidate Phylum Pauc34f, Michael L. Chen, Eric D. Becraft, Maria Pachladaki, Julia M. Brown, Jessica K. Jarett, Josep M. Gasol, Nikolai V. Ravin, Duane P. Moser, Takuro Nunoura, Gerhard J. Herndl, Tanja Woyke, Ramunas Stepanauskas

Biology

Bacterial candidate phylum PAUC34f was originally discovered in marine sponges and is widely considered to be composed of sponge symbionts. Here, we report 21 single amplified genomes (SAGs) of PAUC34f from a variety of environments, including the dark ocean, lake sediments, and a terrestrial aquifer. The diverse origins of the SAGs and the results of metagenome fragment recruitment suggest that some PAUC34f lineages represent relatively abundant, free-living cells in environments other than sponge microbiomes, including the deep ocean. Both phylogenetic and biogeographic patterns, as well as genome content analyses suggest that PAUC34f associations with hosts evolved independently multiple times, while …

Insights Into The Dynamics Between Viruses And Their Hosts In A Hot Spring Microbial Mat, Jessica K. Jarett, Mária Džunková, Frederik Schulz, Simon Roux, David Paez-Espino, Emiley Eloe-Fadrosh, Sean P. Jungbluth, Natalia Ivanova, John R. Spear, Stephanie A. Carr, Christopher B. Trivedi, Frank Corsetti, Hope A. Johnson, Eric Becraft, Nikos Kyrpides, Ramunas Stepanauskas, Tanja Woyke

Biology

Our current knowledge of host–virus interactions in biofilms is limited to computational predictions based on laboratory experiments with a small number of cultured bacteria. However, natural biofilms are diverse and chiefly composed of uncultured bacteria and archaea with no viral infection patterns and lifestyle predictions described to date. Herein, we predict the first DNA sequence-based host–virus interactions in a natural biofilm. Using single-cell genomics and metagenomics applied to a hot spring mat of the Cone Pool in Mono County, California, we provide insights into virus–host range, lifestyle and distribution across different mat layers. Thirty-four out of 130 single cells contained …

Camelid Fleece And The Hidden Histories Of Colors In The Andes, Penelope Dransart

Textile Society of America: Symposium Proceedings

This article explores the significance of natural fleece colors that are often hidden by dyeing processes. The earliest domesticated alpacas and llamas probably resembled vicuñas and guanacos, their wild counterparts. By 3000 years ago, differences were beginning to emerge in the coats of alpacas and llamas. Dyers, spinners, and weavers learned to exploit these variations to complement and extend the range of possibilities offered through the use of dyed yarns. The evidence from the Siguas and Nasca cultural traditions considered here is both direct and indirect, taking into account textile remains and the depiction of camelids on ceramics. It indicates …

Evaluating Gene Drive Approaches For Public Benefit, Michael R. Santos

United States Public Health Resources

Gene drive approaches—those which bias inheritance of a genetic element in a population of sexually reproducing organisms—have the potential to provide important public benefits. The spread of selected genetic elements in wild populations of organisms may help address certain challenges, such as transmission of vector-borne human and animal diseases and biodiversity loss due to invasive animals. Adapting various naturally occurring gene drive mechanisms to these aims is a long-standing research area, and recent advances in genetics have made engineering gene drive systems significantly more technically feasible. Gene drive approaches would act through changes in natural environments, thus robust methods to …

Adaptive In Vivo Device For Theranostics Of Inflammation: Real-Time Monitoring Of Interferon-Γ And Aspirin, Chaomin Cao, Ronghua Jin, Hui Wei, Zhongning Liu, Shengnan Ni, Guo Jun Liu, Howard A. Young, Xin Chen, Guozhen Liu

United States Public Health Resources

Cytokines mediate and control immune and inflammatory responses. Complex interactions exist among cytokines, inflammation, and the innate and adaptive immune responses in maintaining homeostasis, health, and well-being. On-demand, local delivery of anti-inflammatory drugs to target tissues provides an approach for more effective drug dosing while reducing the adverse effects of systemic drug delivery. This work demonstrates a proof-of-concept theranostic approach for inflammation based on analyte-kissing induced signaling, whereby a drug (in this report, aspirin) can be released upon the detection of a target level of a proinflammatory cytokine (i.e., interferon-γ (IFN-γ)) in real time. The structure-switching aptamer-based biosensor described here …

2020 Focused Updates To The Asthma Management Guidelines: Clinician's Guide

United States Natonal Institutes of Health: Materials

This Clinician’s Guide summarizes the 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention group.

2020 Focused Updates To The Asthma Management Guidelines: At-A-Glance Guide

United States Natonal Institutes of Health: Materials

This At-A-Glance Guide describes a treatment management approach based on recommendations from the 2020 Focused Updates to the Asthma Management Guidelines.

Advancing Heart, Lung, Blood, And Sleep Research (January 2020)

United States Natonal Institutes of Health: Materials

Advancing Heart, Lung, Blood, and Sleep Research is a brochure that highlights major NHLBI programs, partnership activities, as well as recent advances in science.

Annual Report 2019 - 2020, Houston Academy Of Medicine - Texas Medical Center Library

Annual Reports: 1943 - Present

This file contains the Annual Report for the library from 2019-2020.

Goat Management In Drought, An Peischel

Extension Publications

No abstract provided.

Insect Predators-Multicolored Asian Lady Beetle, Kaushalya Amarasekare

Extension Publications

No abstract provided.

Suffolk University Alumni Magazine, Fall 2020, Suffolk University

Suffolk University Magazine

No abstract provided.

Helicobacter Pylori Infection And Its Importance In The Development Of Idiopathic Thrombocytopenic Purpura, Zilola Khashimova

Physician Assistant Studies | Faculty Scholarship

Helicobacter Pylori (HP) infection has been associated with chronic inflammation of the stomach and may also be associated with Idiopathic thrombocytopenic purpura (ITP). A literature review was conducted on the reported research of HP infection associated with ITP.

Chicken, Virginia Bell

Nelle (literary magazine)

pp. 67-79

Visionary Politics And Methods In Feminist Disability Studies, Jess Waggoner, Ashley Mog

Journal of Feminist Scholarship

In this introduction we explore the genealogies and methodologies of feminist disability studies (FDS). A feminist methodology is politically situated with a focus on the material conditions and social and cultural structures that marginalized people bear, experience, and resist. Methods, and the theories that underpin and create those methodological tools, can open or foreclose possibilities for praxis. Considering theory and method as mutually informative intellectual projects, we ask, how can our methods influence political investments that open up visionary possibilities and plans? How can we take a coalitional approach to disability politics as a method that is informed by collaboration, …

Finding Tender Roots: Affiliation, Disability, And Racial Melancholia In Monique Truong’S Bitter In The Mouth, Amanda Ong

Journal of Feminist Scholarship

Early on in Bitter in the Mouth, we learn that the protagonist, Linda Linh-Dao Nguyen Hammerick, has auditory-gustatory synesthesia—that is, nearly every word she hears evokes a specific taste. Hammerick, for example, tastes like Dr. Pepper and Linda tastes like mint. There are many articles that analyze Linda’s synesthesia but few articles approach the text through the lens of disability studies. In this article, I employ feminist disability studies and diaspora studies to argue that Linda's identity as a disabled transracial adoptee allow her to seek out additional forms of affiliation and kinship. By constructing an alternative family tree …

The Impact Of Covid-19 On Radiation Oncology Treatments, Lauren Fink

Medical Imaging Senior Posters

When the COVID-19 pandemic began, hospitals became overwhelmed. There was a lack of personal protective equipment (PPE) and a lack of capacity within emergency departments, which caused a panic amongst medical facilities. Facilities were forced to prioritize patients and cancel appointments that were not urgent. Many doctors’ appointments were switched to tele-visits to limit exposure to the virus and to allow priority to COVID-19 patients. Not only were diagnostic testing and treatments postponed or canceled, but news was published that those who were immunosuppressed need to take extra precautions because the risk of fatality is greater for those with preexisting …

2020 Intersession Catalog, Illinois Mathematics And Science Academy

Intersession Catalogs

No abstract provided.

Incorporating Cardiac Substructures Into Radiation Therapy For Improved Cardiac Sparing, Eric Daniel Morris

Wayne State University Dissertations

Growing evidence suggests that radiation therapy (RT) doses to the heart and cardiac substructures (CS) are strongly linked to cardiac toxicities, though only the heart is considered clinically. This work aimed to utilize the superior soft-tissue contrast of magnetic resonance (MR) to segment CS, quantify uncertainties in their position, assess their effect on treatment planning and an MR-guided environment.

Automatic substructure segmentation of 12 CS was completed using a novel hybrid MR/computed tomography (CT) atlas method and was improved upon using a 3-dimensional neural network (U-Net) from deep learning. Intra-fraction motion due to respiration was then quantified. The inter-fraction setup …

Age Differences In Hippocampal Glutamate Modulation During Associative Learning And Memory: A Proton Functional Magnetic Resonance Spectroscopy (1h Fmrs) Study, Chaitali Anand

Wayne State University Dissertations

Episodic and associative memory decline is one of the earliest cognitive impairments in normal aging and among the defining cognitive features of Alzheimer’s disease (AD). Since, age-related cognitive decline gradually devolves into AD, with neuropathology preceding cognitive changes by many years, the identification of biomarkers of early disease progression is crucial. Reduction in glutamate, the main excitatory neurotransmitter involved in associative memory, in key brain regions such as the hippocampus, has been theorized as one of the cellular mechanisms underlying cognitive decline in aging and AD. A few neuroimaging studies that demonstrated a link between older adults’ weaker cognitive performance …

Development Of Specific Natural Bacterial Beta-Glucuronidase Inhibitors For Reducing Irinotecan-Associated Diarrhea, Fei Yang

Wayne State University Dissertations

Irinotecan is a derived compound from the plant alkaloid camptothecin (CPT). It specifically inhibits eukaryotic DNA enzyme topoisomerase I. Irinotecan was approved by the FDA as the second-line therapy for metastatic colon or rectal cancer in 1996. However, one of its leading side effects is diarrhea. It has been reported that up to 88% of treated patients were suffering from diarrhea and 31% of cases with grade 3 or 4 diarrhea. Irinotecan is metabolized into SN-38G in the liver, then SN-38G is excreted to the intestinal tract and deconjugated back to SN-38 by bacterial β-glucuronidase. The free SN-38 in the …

Computational Analysis Of Oxidative Stress In Endothelial Dysfunction: Insights On The Role Of Tetrahydrobiopterin, Ascorbate And Glutathione, Sheetal Kedar Panday

Wayne State University Dissertations

Oxidative stress and endothelial dysfunction are reported in the cardiovascular and neurovascular diseases. Oxidative stress is caused due to an increase in the generation of reactive oxygen (ROS) and nitrogen species (RNS) and incapacity of antioxidant systems to eliminate ROS and RNS. Endothelial dysfunction is characterized by a reduction in nitric oxide (NO) bioavailability. NO is constitutively produced by enzyme endothelial nitric oxide synthase (eNOS). A reduction in tetrahydrobiopterin (BH4), which is an essential cofactor of eNOS, can lead to eNOS uncoupling. There is complex interplay between the ROS/RNS and antioxidant system underlying pathophysiologies of vascular diseases, however our quantitative …

The Arts Of Urgency: Textile Practices And Truth-Telling, Catherine Dormor

Textile Society of America: Symposium Proceedings

To think of the arts of urgency is to think about tactics for making public realities and ‘truths’. It is to ask how art and artists can express horror, suffering, collective and individual trauma with intelligence, rigour, truthfulness, integrity and ethics? In this paper I explore the role of textile as a set of practices deployed as acts of resistance, focusing on the work of Chinese artist Lin Tianmiao and the US artist collective behind the Pussyhat Project (Jayna Zweimann, Krista Suh and Kat Doyle). Both deploy a tactics of spatiality and collaborative action to produce discourse around female disempowerment …

Ashfall Fossil Beds: From Waterhole To Rhino Barn, Sandy Mosel

University of Nebraska State Museum: Programs Information

Twelve million years ago a volcanic super-eruption in what is now southwestern Idaho created an enormous ashfall that blanketed the Great Plains with several inches of volcanic ash, devastating the local wildlife. Evidence of this geologic event lies within the hills of the Niobrara River Valley in northeast Nebraska, at a place aptly named the Ashfall Fossil Beds State Historical Park. Located near the tiny village of Royal, the Ashfall Park has been developed around a waterhole where animals succumbed after breathing in the volcanic dust. Buried deeply by windblown volcanic ash in the weeks following the eruption, the skeletons …

Advances In Targeted Therapy For Acute Myeloid Leukemia., Jifeng Yu, Peter Y Z Jiang, Hao Sun, Xia Zhang, Zhongxing Jiang, Yingmei Li, Yongping Song

Articles, Abstracts, and Reports

Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has been the standard of care for more than half of a century. Although much progress has been made toward improving treatment related mortality rate in the past few decades, long term overall survival has stagnated. Exciting developments of gene mutation-targeted therapeutic agents are now changing the landscape in AML treatment. New agents offer more clinical options for patients and also confer a more promising outcome. Since Midostaurin, a FLT3 inhibitor, was first approved by US FDA in 2017 …