Digital Commons Network^™

Blood Eosinophil Counts In Clinical Trials For Chronic Obstructive Pulmonary Disease, Dave Singh, Mona Bafadhel, Christopher E. Brightling, Frank C. Sciurba, Jeffrey L. Curtis, Fernando J. Martinez, Cara B. Pasquale, Debora D. Merrill, Norbert Metzdorf, Stefano Petruzzelli, Ruth Tal-Singer, Christopher Compton, Stephen I. Rennard, Ubaldo J. Martin

Journal Articles: Pulmonary & Critical Care Med

No abstract provided.

Heme Metabolism Genes Downregulated In Copd Cachexia, Ava C. Wilson, Preeti L. Kumar, Sool Lee, Margaret M. Parker, Itika Arora, Jarrett D. Morrow, Emiel F.M. Wouters, Richard Casaburi, Stephen I. Rennard, David A. Lomas, Alvar Agusti, Ruth Tal-Singer, Mark T. Dransfield, J. Michael Wells, Surya P. Bhatt, George Washko, Victor J. Thannickal, Hemant K. Tiwari, Craig P. Hersh, Peter J. Castaldi, Edwin K. Silverman, Merry-Lynn N. Mcdonald

Journal Articles: Pulmonary & Critical Care Med

INTRODUCTION: Cachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes. Our goal was to identify differential gene expression signatures associated with COPD cachexia in current and former smokers.

METHODS: We analyzed whole-blood gene expression data from participants with COPD in a discovery cohort (COPDGene, N = 400) and assessed replication (ECLIPSE, N = 114). To approximate the consensus definition using available criteria, cachexia was defined as weight-loss > 5% in the past 12 months or low body mass index (BMI) (<  20 kg/m

RESULTS: The prevalence of …

What Is The Trade-Off: Are New Trade Deals Worth The Changes To Pharmaceutical Patents?, Kaitlyn Carter

Marquette Intellectual Property Law Review

None.

Gene Patents, Drug Prices, And Scientific Research: Unexpected Effects Of Recently Proposed Patent Eligibility Legislation, Charles Duan

Marquette Intellectual Property Law Review

Recently, Congress has considered legislation to amend § 101, a section of the Patent Act that the Supreme Court has held to prohibit patenting of laws of nature, natural phenomena, and abstract ideas. This draft legislation would expand the realm of patent-eligible subject matter, overturning the Court’s precedents along the way. The draft legislation, and movement to change this doctrine of patent law, made substantial headway with a subcommittee of the Senate holding numerous roundtables and hearings on the subject.

This article considers some less-discussed consequences of that draft leg- islative proposal. The legislation likely opens the door to patenting …

American Privacy Law At The Dawn Of A New Decade (And The Ccpa And Covid-19): Overview And Practitioner Critique, Kimberly Dempsey Booher, Martin B. Robins

Marquette Intellectual Property Law Review

No abstract provided.

Machine Learning-Based Automated Phenotyping Of Inflammatory Nocifensive Behavior In Mice., Janine M Wotton, Emma Peterson, Laura C. Anderson, Stephen A Murray, Robert E Braun, Elissa J Chesler, Jacqueline K White, Vivek Kumar

Faculty Research 2020

The discovery and development of new and potentially nonaddictive pain therapeutics requires rapid, yet clinically relevant assays of nociception in preclinical models. A reliable and scalable automated scoring system for nocifensive behavior of mice in the formalin assay would dramatically lower the time and labor costs associated with experiments and reduce experimental variability. Here, we present a method that exploits machine learning techniques for video recordings that consists of three components: key point detection, per frame feature extraction using these key points, and classification of behavior using the GentleBoost algorithm. This approach to automation is flexible as different model classifiers …

Agonist-Specific Desensitization Of Pge2-Stimulated Camp Signaling Due To Upregulated Phosphodiesterase Expression In Human Lung Fibroblasts, Francisco J. Nunez, Nancy Schulte, David M. Fogel, Joel Michalski, Stephen I. Rennard, Raymond B. Penn, Myron L. Toews, Rennolds S. Ostrom

Journal Articles: Pulmonary & Critical Care Med

Pulmonary fibrosis is characterized by fibroblasts persisting in an activated form, producing excessive fibrous material that destroys alveolar structure. The second messenger molecule cyclic 3',5'-adenosine monophosphate (cAMP) has antifibrotic properties, and prostaglandin E2 (PGE2) can stimulate cAMP production through prostaglandin E (EP)2 and EP4 receptors. Although EP receptors are attractive therapeutic targets, the effects of long-term exposure to PGE2 have not been characterized. To determine the effects of long-term exposure of lung fibroblasts to PGE2, human fetal lung (HFL)-1 cells were treated for 24 h with 100 nM PGE2 or other cAMP-elevating agents. cAMP levels stimulated by acute exposure to …

Molecular Biology, North Carolina Agricultural And Technical State University

Open Educational Resources Syllabus Review

This course examines the molecular events in cell function using molecular genetics, cell biology, and fundamental biochemistry; using both prokaryotic and eukaryotic systems. The laboratory will emphasize fundamental techniques used in molecular biology.

Environmental And Occupational Toxicology, North Carolina Agricultural And Technical State University

Open Educational Resources Syllabus Review

Environmental health is associated with recognizing, assessing, understanding and controlling the impacts of people in their environment and the impacts of the environment on the public health. The science of environmental health spans a wide range of topics, requiring the use of multidisciplinary approaches to study the impact of environmental factors on human health. Toxicology, a major component of environmental health, can be broadly defined as the science that explores how drugs and chemicals adversely affect human health. Student enrolled in this course will learn the basic principles of toxicology as they apply to human health. Topics will include activation …

Myrf Represses Nodal Signaling Via Furin During Left-Right Patterning And Gastrulation, Sarah Amalraj

Yale Medicine Thesis Digital Library

Congenital heart disease (CHD) is the most common major birth defect in children, affecting nearly 3% of children and is the leading cause of infant mortality. Heterotaxy (Htx) is a disorder of left-right (LR) patterning, in which organs, including the heart, are mispatterned relative to the LR axis. Htx is associated with severe forms of CHD, but its genetic causes remain largely undefined. Exome sequencing studies of large patient cohorts have recently revealed hundreds of CHD/Htx candidate disease genes, which now need to be validated in experimental systems for causality in order to better understand the causes and biological mechanisms …

The Importance Of Understanding Trophic Transfer In Top Marine Predators Due To An Increase In Plastic Production, Annika M. Markovich

Scientific Communication News

No abstract provided.

St. Vincent’S College, Sacred Heart University Student Guide 2020-2021 Edition, Sacred Heart University

Handbooks & Factbooks

The Student Guide is the official student handbook and provides essential St. Vincent’s College policies and procedures for academic progression and graduation. This guide is intended to supplement the University Catalog and provide information specific to our programs. All students are expected to review and abide by the current Student Guide.

Covid-19 Mutual Aid, Anti-Authoritarian Activism, And The Law, Michael Haber

Faculty Scholarship

No abstract provided.

Dying For Equal Protection, Teri Dobbins Baxter

Scholarly Works

When health policy experts noticed that health outcomes for African Americans were consistently worse than those of their White counterparts, many in the health care community assumed that the poor outcomes could be blamed on poverty and lifestyle choices. Subsequent research told a different story. Studies repeatedly showed that neither money, nor marriage, nor educational achievement protect African American men, women, or children from poor health. Instead, the disparities were more likely explained by racism. Specifically, multiple studies have shown that experiencing racism has been linked to increased infant and maternal mortality rates, elevated stress levels, and an increased risk …

A Qualitative Study Of Non-Relational Foster Families Experiences Navigating The Education System, Emma Grace Topf

Electronic Theses and Dissertations

This qualitative study used a phenomenological approach to capture the lived experience of non-relational foster families navigating the Colorado public education system. While most research on children in foster care looks at all sub-populations of foster care combined, this is the first known study to focus solely on non-relational foster families navigating the education system. I explored non-relational foster parents experience navigating the education system for the school-age children in their care through a semi-structured two-interview approach. Four levels of data analysis were completed (descriptive coding, emergent coding of themes, a priori coding of research questions, and a priori coding …

Sensitivity Of Radical Sam Enzyme Mftc To Molecular Oxygen, Vishnu Govindarajan

Electronic Theses and Dissertations

MftC is a radical S-adenosyl L-methionine (SAM) enzyme that catalyzes the first step in the production of mycofactocin. It is a ribosomally synthesized post-translationally modified (RiPP) redox cofactor shown to be essential for the survival of bacteria in the Mycobacterium genus in the presence of cholesterol as a carbon source and for the sequestration of ethanol. MftC catalyzes the C – terminal decarboxylation of tyrosine and the subsequent cross-linking of tyrosine to the penultimate valine on the precursor peptide MftA. The product formed out of the reaction is processed into mycofactocin in downstream processes. The bacteria in the Mycobacterium tuberculosis …

Quantification Of Dynamic Epithelial Sheet Architecture In Botryllus Schlosseri Using 2-D & 3-D Image Analysis, Roopa Madhu

Electronic Theses and Dissertations

Epithelial tubules form critical structures in various body tissues; how- ever, since they are difficult to access experimentally, their architecture and dynamics are not well understood. Here we examine the dynamic remodeling of epithelial tubes in vivo using a novel and uniquely accessible model system: the extracorporeal vasculature of Botryllus schlosseri (sea squirt). In Botryllus, massive retraction of blood vessels can be triggered without loss of barrier function, through (i) disrupting collagen crosslinking in the basement membrane using β-aminopropionitrile (BAPN); or (ii) disrupting the integrin pathway through inhibition of focal adhesion kinase (FAK). We performed stereographic projections of 3-dimensional …

Resource Map Of Expenditures For Tennessee Children, Annual Report To The Legislature, April 2020, Tennessee Commission On Children And Youth

Resource Mapping Reports

This report compiles the federal and state expenditures for services across all departments and agencies for Tennessee children from the previous fiscal year.

Covid-19 Personal Protective Equipment Sterilization System, Uwe Reischl

Public and Population Health Faculty Publications and Presentations

A portable system based on a non-destructive sterilization method was developed that consists of a chamber producing ozone concentration levels reported in the scientific literature to deactivate 99.9% of all microorganisms. The system includes a small cordless 30mg/h ozone generator placed inside a 20L enclosed chamber. Personal protective equipment is loaded into the chamber and automatically exposed to an ozone concentration up to 18 ppm for 30 minutes. PPE is then removed and ventilated in open air to allow residual ozone to degrade to oxygen. The paper describes the design and performance characteristics of this technology.

Winter 2020 Som Alumni Connections, New York Medical College

School of Medicine

• NYMC Students Support Their Brethren in Healthcare on the Front Line and Behind the Scenes
• School of Medicine Class of 2020 Celebrates Match Day Virtually
• Dr. Mark Hasten, Philanthropist, Businessman and Touro College Chairman, Dies at 92
• GHHS Celebrates Solidarity for Compassionate Care Week
• Paul T. Diamond, M.D., Is Named the Catherine and Vladislav P. Hinterbuchner Professor and Chair of Rehabilitation Medicine
• Conference Addresses Current Topics in Pediatric Hematology and Oncology
• Department of Surgery Hosts Sixteenth Annual Louis R.M. Del Guercio, M.D., Distinguished Visiting Professorship and Research Day
• Twenty-Fourth Annual Medical Student Research Forum Boasts Record Number of Participants
• Accessibility …

Epipelagic Ocean Waters, Kate E. Watermeyer, Ryan R. Rykaczewski, Imants G. Priede, Tracey Sutton, David A. Keith

Marine & Environmental Sciences Faculty Books and Book Chapters

No abstract provided.

Ms Environmental Biology Capstone Project, Alex Stacy

Regis University Student Publications (comprehensive collection)

Chapter 1 - Literature Review: A More General World Under Climate Change

Chapter 2 - Grant Proposal: Determining the Effectiveness of an Unmanned Aerial Vehicle (UAV) Versus Traditional Ground Surveys to Map the Distribution of Bell’s Twinpod (Physaria bellii) in Boulder County

Chapter 3 - Journal Manuscript: Macroinvertebrate Assemblages Indicate Declining Ecosystem Diversity for In-Stream Restoration Sites at Deer Creek, CO

Chapter 4: Stakeholder Analysis: Pebble Mine Proposal: A Stakeholder Tale of Two Industries

Eklf Mediated Regulation Of Cytokinesis, Erythroid Enucleation, And Megakaryopoiesis During Terminal Differentiation And Congenital Dyserythropoietic Anemia, Maria Habean

Undergraduate Research Posters 2020

Terminal differentiation in erythroid cells culminates in enucleation, a type of cytokinesis, where the nucleus is expelled from the cell. Improper cytokinesis and enucleation is due to a mutation in Erythroid Krüppel-like Factor (EKLF), an erythroid transcription factor, leading to Congenital Dyserythropoeitic Anemia IV (CDA’s) whose pathway remains to be understood. If EKLF is knocked out of mouse erythroid cells, the cells exhibit a failure in cytokinesis and enucleation with more megakaryocyte production. EKLF does have a role in allowing megakaryocyte erythroid cells to enter into erythropoiesis if the megakaryopoiesis genes are suppressed. Although, it is unknown if EKLF suppress …

Effects Of The Dysregulation Of Pancr Regarding The Pitx2 Gene In The Eye, Mohamed Najjar

Undergraduate Research Posters 2020

The PITX2 adjacent noncoding RNA (PANCR) is an intergenic long noncoding RNA adjacent to the PITX2 gene. The PITX2 gene functions as a regulator for bilateral symmetry during development. PANCR is only expressed in the left atrium of the heart and in the eye in humans. PANCR has been studied with its effects in atrial fibrillation in the heart, but very little is known about its expression in the human eye. This project hypothesizes that the dysregulation of PANCR, which causes mutations in the PITX2 gene, will cause deformities to the human eye, similar to those of Axenfeld-Rieger Syndrome, a …

Nsu Translational Research And Economic Development Fy 2020 Annual Report, Nova Southeastern University

Annual Reports

No abstract provided.

The Inim Summer 2020, Nova Southeastern University

INIM Newsletters

No abstract provided.

Oral Probiotic Supplementation As An Adjunct To Non-Surgical Therapy In Peri-Implantitis Lesions: A Pilot Study, Po-Ning Polly Huang

Student Theses, Dissertations and Capstones

Introduction: During the last decade, the results of several clinical studies suggested that oral probiotics may potentially improve oral health. The first study examining the effects of probiotics on oral health demonstrated that almost every patient with gingivitis, periodontitis or pregnancy gingivitis, had significant improvements in measurable periodontal indices when they were treated with a locally administered culture supernatant of a Lactobacillus acidophilus strain. This finding sparked several other studies to further examine the potential for treating oral diseases, such as, combating halitosis, oral candidiasis, and dental caries with probiotics. Of our interest, Fernandez et al. and Hollstrom et al. …

Implications Of A Multicomponent Sleep Program After Brain Injury: A Mixed Methods Study, Brandi M. Fulwider

Occupational Therapy Program Student Theses, Dissertations and Capstones

Decreased sleep can negatively affect mental and physical health and can significantly disrupt participation in daily occupations and leisure interests. Even though sleep is an area of occupation, there is limited evidence on the effectiveness of occupational therapy interventions for sleep. The purpose of this embedded mixed methods research study was to identify how disruptions in sleep affected daily occupational performance and to understand the effectiveness of occupational therapy- directed non-pharmacological sleep interventions for three participants in a community re-entry program for brain injury. This study utilized a single-subject research design during a 4- to 5-week multicomponent sleep program using …

Transitioning From Individualized Pediatric Dental Care Of Children With Autism Spectrum Disorder At The Mailman Segal Dental Clinic To Traditional Dental Settings, Toni-Marie Small

Student Theses, Dissertations and Capstones

Background: Children with special healthcare needs (SHCN) such as Autism Spectrum Disorder (ASD) usually develop strong bonds with their pediatric dental care provider. However, as they mature, transitioning to other services or providers is necessary. Low rates of successful transition of children with SHCN have gained national attention especially since their lifelong conditions require continuous care. It is important to facilitate a smooth transition among providers; dental care providers specifically. These transitions are imperative to prevent these children from losing access to dental care as they mature. This pilot study seeks to describe the proportion of children with ASD seen …

Dental Visual Support Schedule App For Behavior Management Of Pediatric Dental Patients With Autism: Pilot Study, Ana Lina Gonzalez Caceres

Student Theses, Dissertations and Capstones

Background: Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental disorder in the U.S (about 1 in 54 children). Treating children with ASD in the dental office can be challenging due to their impairments in social interactions, communication and aversive behavior. Visual Support Schedules are visual aids or picture cues that have been beneficial for the behavior management of patients with ASD. There are limited studies regarding effective behavior management techniques that could help those patients have a better experience at the dentist. Methods: A Visual Support Schedule App was used for behavior management compared to Tell Show DO (TSD) on …