Digital Commons Network^™

The Ethics Of Dna Testing At The Border, Medha D. Makhlouf

Faculty Scholarly Works

From 2018 to 2020, the U.S. government dramatically expanded DNA surveillance of immigrants. The most recent expansion, finalized in March 2020, effectively requires the collection of DNA from all immigration detainees and storage of their genetic information in the Federal Bureau of Investigation’s (“FBI”) Combined DNA Index System (“CODIS”) database for criminal forensic investigation. This new policy is ethically troubling because it fails to address the potential privacy harms it creates; shifts the application of DNA analysis for criminal investigation from retrospective to prospective assessment of criminality; and disparately impacts racial and ethnic minorities. In this time of extreme immigration …

Structure, Formation, And Biological Interactions Of Supported Lipid Bilayers (Slb) Incorporating Lipopolysaccharide, Palak Sondhi, Dhanbir Lingden, Keith Stine

Chemistry & Biochemistry Faculty Works

Biomimetic membrane systems play a crucial role in the field of biosensor engineering. Over the years, significant progress has been achieved creating artificial membranes by various strategies from vesicle fusion to Langmuir transfer approaches to meet an ever-growing demand for supported lipid bilayers on various substrates such as glass, mica, gold, polymer cushions, and many more. This paper reviews the diversity seen in the preparation of biologically relevant model lipid membranes which includes monolayers and bilayers of phospholipid and other crucial components such as proteins, characterization techniques, changes in the physical properties of the membranes during molecular interactions and the …

Learning To Jump Like Corbin Bleu: The Physics Behind Jump Rope, Caroline Camfield

Mahurin Honors College Capstone Experience/Thesis Projects

This project seeks to determine how engineering can be applied to the sport of jump rope so that athletes may better understand the science behind the sport and apply it to improve their performance in “speed jumping.” This style of jump rope consists of a jumper alternating their feet, with the rope passing under them with each step. Several types of ropes, handles, rope lengths, and widths between a jumper’s handles were tested to determine correlations between each variable and different STEM concept. These findings were then transitioned into a lesson plan so that both the jumpers and coaches could …

Adaptive Tolerance To Sodium Chloride In Daphnia Magna, Brady P. Parlato, Rick Kopp

Kentucky Journal of Undergraduate Scholarship

Salinity levels of some freshwater systems have been altered by humans, posing a threat to aquatic life. We hypothesized that a Daphnia magna population pre-treated with a low concentration of NaCl would develop greater salinity tolerance than an untreated population. Two Daphnia magna cultures with 60 individuals each were established, one started with 1.00 ppt NaCl and increased by 0.20 ppt weekly, and the other with pure spring water. After 4 weeks, 40 neonates from each culture were individually placed in a solution of 2.30 ppt NaCl (separately determined to be the LC₅₀) for 48 hours. Survival was …

Assessing Biomass Fuel Consumption In Kasigau, Kenya As A Predictor Of Hypertension, Conner Hounshell

Mahurin Honors College Capstone Experience/Thesis Projects

Cardiovascular disease is the leading cause of death globally and disproportionately affects low- and middle-income countries, such as Kenya. Hypertension is the leading risk factor for cardiovascular disease and is influenced by a variety of factors such as diet, tobacco use, and genetics. One such factor linked to hypertension is exposure to air pollution, but minimal research exists on the effects of household air pollution. Hypertension that is not related to common Western risk indicators, such as waist-to-hip ratio, body mass indices, and hypercholestorlemia, is prevalent in the community of Kasigau, Kenya, along with the prevalence of risks for household …

Assessing Access To Healthcare For Limited English Proficient Patients, Hannah Bergamini

Mahurin Honors College Capstone Experience/Thesis Projects

Patients with limited English skills often face additional struggles when accessing medical care. These patients, referred to as limited English proficient (LEP) patients, are unable to communicate directly with their physician. This lack of direct communication typically results in unique challenges for the patient and provider. Due to these challenges, LEP patients often have poorer health statuses and experience poorer health outcomes. However, when provided with access to qualified medical interpreters, many of these challenges facing LEP patients can be ameliorated. Therefore, using qualified interpreters is an important component in improving the access to healthcare for LEP patients. To determine …

Infant Temperament And Cardiac Physiology As Predictors Of Infant Locomotion, Mequeil Howard

Mahurin Honors College Capstone Experience/Thesis Projects

Infant locomotion is a major milestone that occurs during the first year of an infant’s life, and the onset of crawling is associated with various developmental changes. Previous work has focused on changes in infant temperament, specifically anger, during the onset of crawling. Other work has focused on changes in infant cardiac physiology in association with temperament development. Little research has examined both temperament and cardiac physiology (e.g., respiratory sinus arrythmia, RSA) as predictors of infant locomotion. Examining both factors in the same study could further explain variability in infant motor development. The current longitudinal study examined infant temperament (anger, …

Impact Of Geographic Location And Social Determinants Of Health On Lung Cancer Incidence And Mortality Rates, Katherine Ashley

Mahurin Honors College Capstone Experience/Thesis Projects

This paper studies the effect of geographic location and socioeconomic status, specifically level of education and income, on rates of incidence and mortality of lung and bronchus cancer. While some prior studies have focused on socioeconomic status’ and global geographic location’s impact on these rates, few have focused on the impact in Appalachian Kentucky and non-Appalachian Kentucky. In this paper, level of education and income are controlled for using four variables: median household income, percentage of persons in poverty, percentage of high school graduates or higher who are at least 25, and percentage of persons with a bachelor’s degree or …

Landscape Genetics Of Salamander Populations At Mammoth Cave National Park, Jackson Resser

Mahurin Honors College Capstone Experience/Thesis Projects

Habitat connectivity affects the distribution of genetic diversity among populations by influencing the movements of individuals and the resulting pattern of gene flow across landscapes. It has become evident that amphibians are experiencing a period of worldwide population declines brought about by environmental change. An understanding of the effects of habitat structure on landscape connectivity is important for developing effective amphibian conservation strategies. The purpose of this study is to investigate the effect of landscape characteristics on gene flow and population structure of the marbled salamander (Ambystoma opacum) in Mammoth Cave National Park, Kentucky, USA. Salamander larvae were …

Rodent Seed Preference Trials Of Ecologically Important Plants In Kentucky, Katelyn Thomason

Mahurin Honors College Capstone Experience/Thesis Projects

Seed predation is an important ecological process that can affect the success of individual plants and plant populations as a whole. However, seed preferences of herbivores have received little detailed attention in comparison to seedling predation studies (Hulme, 1994). In this project I researched how rodents, specifically their seed preferences, affect the recruitment and survival of ecologically important native plants in Western Kentucky. I used traps to catch Peromyscus leucopus (white-footed mice). Once caught, each mouse was placed in a trial arena with seeds from Silphium perfoliatum (cup plant), Baptisia australis (blue false indigo), Silphium lanciniatum (compass plant), and the …

The Role Of Mitochondrial Pyruvate Carrier 1 (Mpc1) In Heart Failure And Its Implications For Cardiac Recovery, Obadiah Issachar Kirk

Mahurin Honors College Capstone Experience/Thesis Projects

Heart failure (HF) is a complex syndrome with high mortality rates around the world. HF also has diverse etiology as many things contribute such as hypertension, obesity, coronary artery disease, inflammation, and cardiac arrhythmias. Studies have shown that unloading of a failing heart with a left ventricular assist device (LVAD) can lead to cardiac recovery in a subpopulation of individuals with advanced HF. RNA-sequencing and protein expression analysis of myocardial tissue from HF patients who underwent the LVAD implant and heart transplant indicated that subpopulation of HF patients who responded to LVAD unloading had significantly lower levels of mitochondrial pyruvate …

Identifying Essential Viral Genes Through Genomic Engineering, Amber Carroll

Mahurin Honors College Capstone Experience/Thesis Projects

Bacteria developed resistance to penicillin a mere four years after the groundbreaking antibiotic was first mass produced (Casadevall, 2010). Since then, the development of antibiotic-resistant bacteria has steadily risen, causing millions of difficult to treat infections annually. The challenge is to identify ways to combat these menacing microbes. Bacteriophages are viruses that infect bacteria and can potentially be used to eliminate deadly antibiotic-resistant bacteria. The number of sequenced bacteriophage genomes has increased tremendously over the past 10 years, but little is known about the function of most bacteriophage genes. The purpose of this study was to expand our understanding of …

Achroma Virus: A Gateway To Explore Virology Concepts, Allyssa Richardson

Undergraduate Review

The Achroma virus is a virtual virus invented as a part of the virtual virus project in BIOL 450/Virology during the Fall of 2018. Viruses are tiny, abundant, and diverse packets of genetic material enclosed in a protein capsid. Viruses can infect many different types of life, from plants and animals to bacteria. In order to propagate, viruses need to infect a host cell, and hijack a living cell’s machinery to build more of themselves. Some viruses destroy the host cell in order to release the newly synthesized viruses, a process known as lysis. Lysis is particularly damaging when the …

Whitepaper: Understanding Land-Atmosphere Interactions Through Tower-Based Flux And Continuous Atmospheric Boundary Layer Measurements, Manuel Helbig, Tobias Gerken, E Beamesderfer, D D. Baldocchi, T Banerjee, S C. Biraud, N A. Brunsell, S P. Butterworth, W S. Chan, A R. Desai, J D. Fuentes, D Y. Hollinger, N Klijun, M Mauder, K A. Novick, J M. Perkins, C Rey-Sanchez, R L. Scott, B Seyednasrollah, P C. Stoy, R C. Sullivan, J Vilà-Guerau De Arellano, S Wharton, C Yi, A D. Richardson

Libraries

Executive summary

● Target audience: AmeriFlux community, AmeriFlux Science Steering Committee & Department of Energy (DOE) program managers [ARM/ASR (atmosphere), TES (surface), and SBR (subsurface)]

● Problem statement: The atmospheric boundary layer mediates the exchange of energy and matter between the land surface and the free troposphere integrating a range of physical, chemical, and biological processes. However, continuous atmospheric boundary layer observations at AmeriFlux sites are still scarce. How can adding measurements of the atmospheric boundary layer enhance the scientific value of the AmeriFlux network?

● Research opportunities: We highlight four key opportunities to integrate tower-based flux measurements with continuous, …

Ototoxicity Of Cisplatin, Pyriplatin, And Phenathriplatin In The Auditory Hybridoma Cell Line, Hei-Oc1, Alexandra Johnston

Mahurin Honors College Capstone Experience/Thesis Projects

Cisplatin is an anti-cancer drug which is effective against several cancers, but also causes harmful side-effects, including ototoxicity and hearing loss. While cisplatin is a bifunctional compound that forms coordinate covalent bonds with both strands of DNA, recently investigated monofunctional platinum(II) compounds bind to only one DNA strand, and may activate different cell-death mechanisms. As several monofunctional platinum(II) compounds have anti-cancer properties, but could target different cell-death pathways, they could potentially have different and reduced side-effects. In this study, the HEI-OC1 auditory hybridoma cell line was used to investigate the ototoxicity of cisplatin and two monofunctional platinum(II) compounds, phenanthriplatin and …

Mathematical Modeling Of Diabetic Foot Ulcers Using Optimal Design And Mixed-Modeling Techniques, Michael Belcher

Mahurin Honors College Capstone Experience/Thesis Projects

A mathematical model for the healing response of diabetic foot ulcers was developed using averaged data (Krishna et al., 2015). The model contains four major factors in the healing of wounds using four separate differential equations with 12 parameters. The four differential equations describe the interactions between matrix metalloproteinases (MMP-1), tissue inhibitors of matrix metalloproteinases (TIMP-1), the extracellular matrix (ECM) of the skin, and the fibroblasts, which produce these proteins. Recently, our research group obtained the individual patient data that comprised the averaged data. The research group has since taken several approaches to analyze the model with the individual …

Morphological Correlates Of Auditory Sensitivity In The Inner Ear Of Two Species Of Invasive Carp, Tyler Patty

Mahurin Honors College Capstone Experience/Thesis Projects

Silver (Hypopthalmichthys molitrix) and bighead (H. nobilis) carp, are invasive species that have negative impacts upon ecosystems. H. molitrix is known to jump completely out of the water in response to broadband sounds, however, this is not observed in H. nobilis. Preliminary experiments reveal that sounds can be used to modify the behavior of carps. Thus, understanding the hearing abilities of these species is important in order to design appropriate acoustical deterrents. Fish heads were preserved in 4% paraformaldehyde and the inner ears dissected and photographed under a light microscope in order to describe the …

Ms Environmental Biology Capstone Project, Bradley Hamilton

Regis University Student Publications (comprehensive collection)

• Chapter 1 - Literature Review: Hunting as a Management Tool for the Invasive Eurasian-Collared Dove (Streptopelia decaocto)
• Chapter 2 - Grant Proposal: Impacts of the Invasive Eurasian-Collared Dove (Streptopelia decaocto) on the Mourning Dove (Zenaida macroura) in Northeastern Colorado
• Chapter 3 - Journal Manuscript: High Elevations and Cold Temperatures Influence American Pika (Ochotona princeps) Distributions in the White River National Forest
• Chapter 4: Resolving Refugee-Elephant Conflict in Bangladesh via Education and Rebuilding

Use And Partitioning Of Riparian Corridors By Mammalian Carnivores In Rio Mora National Wildlife Refuge, Armando Toral Becker

Regis University Student Publications (comprehensive collection)

Land conversion across the Southwestern U.S. for agricultural and livestock use and prolonged drought conditions cascade to reduce ecosystem function, including habitat provision for wildlife. Arroyo restoration efforts aim to improve wildlife habitat by decreasing soil erosion and enhancing water retention. These hydrologic and geomorphic changes increase the likelihood that wildlife use restored corridors by increasing riparian vegetation cover. Rio Mora National Wildlife Refuge (RMNWR) has restored several arroyos by installing a system of one-rock dams throughout the refuge, but the extent to which mammals prefer restored over unrestored riparian corridors and how habitat structure influences mammalian use and density …

Immunologic Analysis Of Non-Small Cell Lung Cancer In People Living With Hiv, Ramsey Yusuf

Yale Medicine Thesis Digital Library

Among people living with HIV (PLWH), non-small cell lung cancer (NSCLC) has emerged as the most common non-AIDS defining cancer and a leading cause of death. PLWH with NSCLC are diagnosed at younger ages and demonstrate worse outcomes compared to the general population. Global immune dysregulation in the setting of HIV infection may account for these disparities, however little is known about the immunobiology of HIV-associated NSCLC. The goal of this study was to investigate the clinical and pathology of NSCLC in PLWH. This retrospective cohort study examined HIV-associated and uninfected NSCLC cases within Yale-New Haven Hospital between 2000-2016. Medical …

Temporal Systematics The Colonization Of Rapa Nui (Easter Island) And The Conceptualization Of Time, Carl P. Lipo, Terry L. Hunt, Robert J. Dinapoli

Anthropology Faculty Scholarship

No abstract provided.

2020 Spring Commencement, Tennessee State University

TSU Commencements 2013-2024 — Dr. Glenda Baskin Glover, President

No abstract provided.

Editor's Commentary: On The Mutual Adjustment Of Pressure And Velocity Distributions In Certain Simple Current Systems, C.-G. Rossby

Journal of Marine Research

These are the original geostrophic adjustment papers. Rossby starts out by asking what,if anything, limits the ability for a flow to be in geostrophic balance (to precisely follow pressure contours on a rotating planet). This topic is now a classroom standard, but we often forget how insightful the original articles are...

Relation Between Variations In The Intensity Of The Zonal Circulation Of The Atmosphere And The Displacements Of The Semi-Permanent Centers Of Action, C.-G. Rossby

Journal of Marine Research

This paper attempts to interpret, from a single point of view, several at first sight independent phenomena brought into focus through the synoptic investigations carried on at the Massachusetts Institute of Technology during the last few years. Since this interpretation is very largely based on a consideration of the changes in vorticity which must occur in vertical air columns which are displaced from one latitude to another and since such vorticity changes play a fundamental role also in Ekman’s general ocean current theory (Ekman 1932), the results would appear to be of enough interest to physical oceanographers to warrrant their …

Editor's Commentary: On The Oxidation Of Organic Matter In Marine Sediments By Bacteria, Robert C. Aller, Margaret Hotchkiss

Journal of Marine Research

Selman Waksman is best known for his work on natural antibiotics, for which he originated the term and received a Nobel Prize. However, he and co-workers also extensively investigated soil microbes and their interactions with biogeochemical processes and elemental cycling...

Import, Export, And Recycling Of Dissolved Nutrients In The Ogeechee River Estuary (Georgia, Usa), William B. Savidge, Kathryn R. Doyle, Brock Woodson

Journal of Marine Research

We constructed an empirical mass balance model of nutrient fluxes in the Ogeechee River estuary (Georgia, USA) from eight surveys of seasonal estuarine nutrient concentrations during 2015 and 2016. The model results indicated a net removal of dissolved phosphorus and a net production of dissolved nitrogen (N) within the estuary over an annual cycle. During summer and autumn low flow periods, much of the dissolved N discharged to the ocean seems to be recycled into the estuary in the form of phytoplankton biomass. As a result, the outwelled N is not new nitrogen fueling coastal production but is nitrogen trapped …

Classic Article: Steady Flow In A Frictionless Homogenous Ocean, N. P. Fofonoff

Journal of Marine Research

A mathematical model is developed to study the free (frictionless) steady horizontal flow which can occur in a homogeneous ocean of constant depth. The flow satisfies the dynamic constraint that the vertical component of absolute vorticity is constant along a streamline. The conclusion is reached that in an enclosed ocean a free steady circulation cannot have any slow broad eastward currents. The eastward currents must occur as narrow streams of high velocity and high relative vorticity. Intensified currents are present along the eastern and western coasts. The theory which is developed for the homogeneous ocean of constant depth can be …

Classic Article: Effect Of Coriolis Force On Edge Waves (I) Investigation Of The Normal Modes, Robert O. Reid

Journal of Marine Research

Essentially two classes of free edge waves can exist on a sloping continental shelf in the presence of Coriolis force. For small longshore wave length, fundamental waves of the first class behave like Stokes edge waves. However, for great wave lengths (of several hundred kilometers or more) the characteristics of the first class are significantly altered. In the northern hemisphere the phase speed for waves moving to the right (facing shore from the sea) exceeds the speed for waves which move to the left. Also, the group velocity for a given edge wave mode has a finite upper limit. Waves …

Graduate Medical Education Annual Report 2019-2020, Children's Mercy Hospital

GME Annual Reports

Annual report of the Children's Mercy Hospital Graduate Medical Education department, including pediatric residency, internal medicine/pediatrics residency, fellowship programs, medical students, continuing medical education, and library services.

Writing For Academic Journals In The Business Domain, Deirdre Mcquillan

Books/Book Chapters

Welcome to the first in a series of peer learning handbooks developed by PhD and MPhil research students to help assist their peers along the academic writing journey.

The first of this series of handbooks deals with academic writing for researchers within the business domain. Although approaches to clear writing such as scrutinizing every word and sentence for meaning and purpose and learning to listen to feedback are common features of excellent writing across all disciplines, there are also differences between writing within different domains. Even within the business domain there may be differences in writing approaches between economists for …