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Tissue-Specific Responses From A Global Developmental Signal: A Detailed Subcellular Analysis Of The 20e And Rab Signaling Pathways Controlling Exocrine Secretion During Drosophila Development, Nichalas Nelson

UNLV Theses, Dissertations, Professional Papers, and Capstones

During metamorphosis, the steroid hormone 20-hydroxecydysone (20E) triggers a plethora of tissue-specific responses in the common fruit fly, Drosophila melanogaster. The salivary glands are exocrine organs that respond to a large pulse of 20E to secrete a massive cargo of stored glycoproteins called glue. Because the glands are amenable to ex vivo-organ culture and powerful genetic manipulations, they are an excellent model for studying the conserved developmental and physiological signaling pathways that regulate the general function of these specialized secretory tissues. Our lab has generated transgenic animals in which the secreted glue molecules are tagged with fluorescent proteins. I have …

A Combined Approach To Evaluating Student Engagement In A Virtual Laboratory Environment, Aster Sigel

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study measured student engagement with galvanic skin response (GSR) using a one group randomized pretest–posttest design in a science, technology, engineering, and mathematics (STEM) learning environment to develop effective intervention strategies for engaging students in STEM learning experiences. Student engagement is a multi-dimensional interrelated construct, consisting of emotional, behavioral, and cognitive components, and varies in different subjects and learning environments. Student engagement in higher education is associated with academic achievement, retention, and graduation. In this study, the emotional, behavioral, and cognitive engagement data of 30 college students were obtained using self-report surveys, observation and physiological data, which was recorded …

Microbe-Mineral Interactions During Exceptional Fossil Preservation, Stromatolite Formation, And Desert Varnish Growth, Michael Strange

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Ediacaran to Cambrian Deep Spring Formation consists of mixed carbonate-siliciclastic strata which contain an increasingly complex and biogeographically important biota. Past investigations of the Deep Spring Formation at Mt. Dunfee, Nevada, explored the highly diverse microbialite reefs consisting of a wide range of stromatolite morphologies which exerted significant control on local sedimentation and topography. Early investigations also documented the biomineralizing metazoan Cloudina (an Ediacaran index fossil). However, recent exploration of the area has resulted in the discovery of several new metazoan fossil communities consisting of a diverse assemblage of Ediacaran soft-tissue tubicolous vermiforms (tube fossils) similar to Cloudina. The …

An Exploration Of The Numeracy Skills Required For Safe, Quality Nursing Practice, Anna Wendel

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to explore the numeracy skills required for safe, quality nursing practice. Using a descriptive mixed methods design, this study answered two research questions: 1) What numeracy skills do nurses perceive as important for providing safe, quality nursing care in the first three years of practice? 2) How do nurses incorporate numeracy skills into daily patient care during the first three years of practice? Early career nurses from a not-for-profit health care organization in the mid-Atlantic region of the United States (n=109) responded to an online survey tool developed by the student investigator that ranked …

Influence Of Curricular Organization On Cognitive Load And Student Performance In Online Learning Environments, Michael Wilder

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to explore the influence of curricular organization on student cognitive load and student performance in online learning environments. The findings of this study contribute to the development of usable instruction design principles for online education.

This research study used the lens of cognitive load theory to examine how online course organization affects student learning. A review of the literature included the elements of cognitive architecture that have been measured in prior studies, various methods in which cognitive load has been measured, and the basic requirements for measurement of cognitive load in instructional research.

A …

Development Of Novel Pectinase And Xylanase Juice Clarification Enzymes Via A Combined Biorefinery And Immobilization Approach, Shady Hassan

Doctoral

Hydrolytic enzymes, such as pectinase and xylanase, maybe harnessed for numerous industrial applications in food industry. Therefore, economic factors such as achievement of optimum yieldsandoverall production costs, in addition to biocatalyst instability,are the main obstacles tothe industrial production and exploitation of a enzymes. For example, microbially-derived enzymes are typically produced in fermenters using expensive growth media, which may account for 30 to 40% of the production cost, and such expense may be compounded further by downstream processing operations.To counter such disadvantages, the major trend in industrial utilization of enzymes in cost-sensitive processes has been to immobilize such biocatalysts on a …

Inflammatory Myopathies: Update On Diagnosis, Pathogenesis And Therapies, And Covid-19-Related Implications., Marinos C. Dalakas

Department of Neurology Faculty Papers

The inflammatory myopathies constitute a heterogeneous group of acquired myopathies that have in common the presence of endomysial inflammation. Based on steadily evolved clinical, histological and immunopathological features and some autoantibody associations, these disorders can now be classified in five characteristic subsets: Dermatomyositis (DM) Polymyositis (PM), Necrotizing Autoimmune Myositis (NAM), Anti-synthetase syndrome-overlap myositis (Anti-SS-OM), and Inclusion-Body-Myositis (IBM). Each inflammatory myopathy subset has distinct immunopathogenesis, prognosis and response to immunotherapies, necessitating the need to correctly identify each subtype from the outset to avoid disease mimics and proceed to early therapy initiation. The review presents the main clinicopathologic characteristics of each subset …

Bioconversion Of Industrial Hemp Biomass For Bioethanol Production: A Review, Jikai Zhao, Youjie Xu, Weiqun Wang, Jason Griffin, Kraig Roozeboom, Donghai Wang

School of Earth, Environmental, & Marine Sciences Faculty Publications

Industrial hemp (Cannabis sativa L.) with robust drought-resistant features has excellent agronomic and pharmaceutical characteristics. As the federal prohibition on hemp cultivation was lifted, its valorization in various aspects is highly required. This review aims to summarize the potential of hemp biomass for bioethanol production. Chemical compositions of hemp biomass were evaluated as compared with those of corn fiber, corn stover, and sorghum bagasse. Several representative pretreatment technologies used for hemp biomass were summarized in terms of sugar recoveries, lignin removal, and sugar and ethanol yields. This review presents numerous technical barriers attributed to insufficient fermentable sugar and ethanol …

Consensus Parameter: Research Methodologies To Evaluate Neurodevelopmental Effects Of Pubertal Suppression In Transgender Youth., Diane Chen, John F Strang, Victoria D Kolbuck, Stephen M Rosenthal, Kim Wallen, Deborah P Waber, Laurence Steinberg, Cheryl L Sisk, Judith Ross, Tomas Paus, Sven C Mueller, Margaret M Mccarthy, Paul E Micevych, Carol L Martin, Baudewijntje P C Kreukels, Lauren Kenworthy, Megan M Herting, Agneta Herlitz, Ira R J Hebold Haraldsen, Ronald Dahl, Eveline A Crone, Gordon J Chelune, Sarah M Burke, Sheri A Berenbaum, Adriene M Beltz, Julie Bakker, Lise Eliot, Eric Vilain, Gregory L Wallace, Eric E Nelson, Robert Garofalo

Department of Pediatrics Faculty Papers

Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment.

Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were …

Understanding The Professional Experiences Of White Jewish Women In Higher Education: An Intrinsic Case Study Analysis, Janna M. Bernstein

UNLV Theses, Dissertations, Professional Papers, and Capstones

The exploration of female professionals’ experiences within the realm of higher education is steadily increasing, yet researchers have yet to analyze, much less include, Jewish women. Following a qualitative intrinsic case study approach, this study assesses the lived experiences of ten white Jewish women professionals to better understand how they engage in the world of higher education differently than their non-Jewish counterparts. Using racial formation theory and intersectional analysis as theoretical frameworks, the research examined the current and historical literature on Jewish identity, the role of Jews and Jewish women in higher education, and the relevant methodological research. The study …

Validity And Diagnostic Accuracy Of An Adhd Symptom Rating Scale For Identifying Adults With Adhd, Stacy Jean Graves

UNLV Theses, Dissertations, Professional Papers, and Capstones

Specific rating scales of ADHD symptomatology are often included in neuropsychological assessments evaluating adults diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). The Barkley Adult ADHD Rating Scale-IV (BAARS-IV) is a widely used symptom rating scale that includes four questionnaires: self-report current, self-report childhood, other-report current, and other-report childhood. In addition to ADHD symptoms, each of the forms include items that assess functional impact and developmental history of symptomatology. While similar symptom rating scales have been found to have high validity and diagnostic utility in children, it is unclear the extent to which the BAARS-IV shares substantial common variance with other …

Bayesian Variable Selection Methods For Genome-Wide Association Studies With Categorical Phenotypes, Benazir Rowe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Genome-wide association studies (GWAS) attempt to find the associations between genetic markers and studied traits (phenotypes). The problem of GWAS is complex and various methods have been developed to approach it. One of such methods is Bayesian variable selection (BVS). We describe the BVS methods in detail and demonstrate the ability of BVS method Posterior Inference via Model Averaging and Subset Selection (piMASS) to improve the power of detecting phenotype-associated genetic loci, potentially leading to new discoveries from existing data without increasing the sample size.

We present several ways to improve and extend the applicability of piMASS for GWAS. The …

Effects Of Wildfire On Plant And Insect Pollinator Communities In The Mojave Desert, Nha Trang Vivian Sam

UNLV Theses, Dissertations, Professional Papers, and Capstones

The changing fire regime of landscapes across the Mojave Desert has prompted considerable research on its effects on plant community recovery, but it has not been widely studied what effects wildfire may have on native pollinators and the vital ecosystem services they provide. Ecological changes from increased wildfire severity from invasive exotic annual grasses will likely continue influencing pollinator habitats and floral resources. Understanding the effects that wildfires have on pollinators is valuable to make decisions as to whether active management and restoration activities are required to conserve ecologically vital pollinator functions. The intention of this thesis was to examine …

Sakit Ng Loob, Sakit Ng Labas: Pagtutumbas Sa Mga Neolohismong Umusbong Sa Kontemporanidad Ng Covid-19 Tungo Sa Pag-Unawa Ng Kasaysayan Ng Ketong Sa Patolohiyang Pilipino, Axle Christien Tugano

Katipunan

Layunin ng artikulong ito na itampok ang umaalingawngaw na isyu patungkol sa pandemyang dulot ng COVID-19 sa Pilipinas. Sa pagsasapantaha, tila bagang itinatrato ng mga kontemporanyong Pilipino ang paglaganap nito bilang isang bago at kaunaunahang sakit na naranasan ng ating lipunan. Sinasalamin lamang nito ang hindi lipos na pag-aaral patungkol sa patolohiyang Pilipino. Kaya’t may tendensiya na balahuin o hindi seryosohin ng balanang Pilipino ang kinahaharap na pandemya dahil bukod sa kulang ang mga kaalaman ukol dito, posibleng hindi na napipiho ang naging hamon at tugon ng ating lipunan sa mga nagdaang sakit (na mas malala pa nga sa COVID-19). …

De/Mitolohisasyon Ng Aswang: Isang Pagbasa(G) Sa Mito Bilang Sakit Ng Lipunan, Chloe V. Cabodil, Jaco B. Tango

Katipunan

1986 nang magsimula ang tambalang Lore Reyes at Peque Gallaga sa pagpapalabas ng mga kuwentong bayan at katatakutan sa pelikula. Tumabo sa takilya ang mga idinerehe nilang installments ng Shake Rattle and Roll (1990-1992); Aswang (1992); Hiwaga sa Balete Drive (1988) at marami pang iba. Tinatangka ng papel na ito na isalang sa pagsusuri ang pelikulang Sa Piling ng mga Aswang (1999) nina Reyes at Gallaga. Babalangkasin ng mga mananaliksik ang agapayan ng mga katangian ng aswang sa pagitan ng imahen nito batay sa katutubong paniniwala at imahen nito sa pelikula at sa kung paanong mayroong intertekstuwalidad ng kasaysayan, lipunan, …

Brain Substrates Explain Differences In The Adoption And Degree Of Financial Digitalization, Santiago Carbo-Valverde, Juan A. Lacomba-Arias, Francisco M. Lagos-García, Francisco Rodriguez-Fernandez, Juan Verdejo-Román

All Works

© 2020, The Author(s). This study analyzes neural responses connected to trust and risk to explain financial digitalization decisions. It shows that brain responses distinctively inform differences in the adoption of digital financial channels that are not shown by any other sociodemographic or behavioral indicators. From a methodological standpoint, the study explores if usage patterns of digital financial channels and instruments are associated with psychological and biological indicators; it uses functional magnetic resonance imaging (fMRI) to investigate whether financial digitalization decisions are linked to the evoked brain response to the safety associated with video images of financial transactions through digitalized …

Implications Of Taxon-Level Variation In Climate Change Response For Interpreting Plankton Lifeform Biodiversity Indicators, Jacob Bedford, David G. Johns, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

Abstract Indicators based on broad functional characteristics, which group plankton taxa into “lifeforms”, summarize changes across a high number of taxa in a way that reflects changes in community functioning and are used to inform policy assessments. Key questions remain, however, as to what extent plankton taxa within these lifeforms share responses to environmental change. Addressing this knowledge gap can provide additional information on the influence of environmental drivers, including climate change, on plankton communities. Here, we use a multi-decadal plankton time series to examine the extent to which taxa within lifeforms share responses to sea surface temperature (SST) change. …

Water, Fish, And Fire: Interdisciplinary Research On Ecosystem Services And Climate Adaptation, Liana Prudencio

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Ecosystem services, or benefits from the environment, are plentiful and vary from place to place. Human activities and climate change have impacted these services in every region of the world. This dissertation explores multiple ecosystem services, from water quality improvement to provisioning of fish and habitat, in multiple and international contexts. The first chapter synthesizes the literature on stormwater management and ecosystem services, finding that research at this intersection has provided many parcel-level studies and frameworks for implementing green infrastructure. The second chapter extends the stormwater management literature by quantifying the impacts of green infrastructure on water quantity and quality …

Effects Of Wi-Fi-Enabled Smart Irrigation Controllers On Water Use And Plant Health Of Residential Landscapes In The Intermountain West, Shane R. Evans

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Residential and commercial landscapes provide home and business owners with several benefits. These benefits range from improved air quality and flood control to the reduction of noise and breakdown of organic chemicals. However, these landscapes are routinely overwatered which can lead to plant disease, nutrient pollution, and large amounts of water being wasted. Utah State University, in conjunction with the Center for Water Efficient Landscaping (CWEL), the Utah Division of Natural Resources and Weber Basin Water Conservancy District, conducted an experiment to determine if Wi-Fi-enabled smart irrigation controllers conserve water as compared to average residential irrigation amounts and manually programmed …

Novel Polymorphisms Of Zrsr2 And Gpm6b Gene Homologs And Their Use In Sex Identification Of Bovine And Porcine Species, Evan K. Peterson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Accurate and cost-effective PCR based sex identification is important in animal production because it gives producers the ability to determine the sex of embryos prior to transfer, saving time and money. The most efficient PCR sex identification assays work by using a single primer pair to amplify a specific target region located on the Y-chromosome and a second, separate target region on the X-chromosome.

This thesis reports the design of two novel assays. The first assay was designed to target the Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 (ZRSR2) gene found on the X-chromosome and its Y-chromosome …

Examination And Empirical Forecast Of Wheat Yield In Northwest India Based On Climate And Socio-Economic Factors, Avik Mukherjee

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study summarizes the findings of research organized in two parts. The first part includes the impact of climate and socio-economic factors that affected wheat yield in northwest India during the 2000s. The second part focused on the forecast of average wheat yield for the two highest wheat producing states Punjab and Haryana.

Initial study focused on the impact of climate factors on wheat yield in northwest India. It has been found that above normal temperature coupled with water shortage i.e. irregular irrigation and low soil moisture contributed to the prolonged yield reduction during 2002-2010.

Next, we reviewed the socio-economic …

Utilizing Earth's Microbiology To Develop The Framework For A Manufactured Martian Nitrogen Cycle, Kyle Valgardson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

History has shown us that space travel is a complicated activity not to be taken lightly. Extended missions such as those that would accompany a manned mission to Mars are guaranteed to have increased complexity and require creative solutions to problems we likely take for granted. One such issue is how to supply the necessary amount of nitrogen to the astronauts to keep them alive. Nitrogen is an essential component to life on Earth as most biological molecules, such as protein and DNA, contain a significant amount of it. Most organisms have to get it from what they eat, but …

Nicotine And Alcohol Interactions, Charles C. J. Frye

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Charles C.J. Frye, a graduate student in the Behavior Analysis program at Utah State University, completed this dissertation as part of the requirements of the degree of Doctor of Philosophy in Psychology.

Alcohol and Nicotine are the two most commonly abused drugs in the United States, often used at the same time. The goal of the dissertation was to more fully understand how exposure to one drug alters motivation for the other. In Chapter I, we investigated how exposure to nicotine affects relapse for alcohol in rats. Nicotine did not affect relapse for alcohol, possibly due to the method of …

Environmental Controls On Didymosphenia Geminata Bloom Formation, Lindsay Capito

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Climate change is causing rapid glacial recession and earlier snowmelt, which alter the physical and chemical properties of rivers. As a result, organisms at the base of the food web are responding in unforeseen ways. We use the nuisance algae D. geminata (Didymo) as a case study for how climate induced shifts in the timing of glacial and snowmelt runoff are affecting river ecosystems. We evaluated how shifts in the timing of nutrient concentrations and light availability affect nuisance blooms of Didymo in three complementary ways. These are, field studies across streams in various stages of glacial recession, weekly measurements …

The Moderating Role Of Psychological Inflexibility In The Relationship Between Minority Stress, Substance Misuse, And Suicidality In Lgb+ Adolescents, Sean N. Weeks

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Adolescence is a difficult time, especially for those who do not identify as heterosexual (e.g., gay, lesbian, bisexual, asexual, pansexual; LGB+). Increased rates of substance abuse and suicidality are well documented outcomes that tend to be worse in the LGB+ adolescent community than in mainstream groups. Minority stress, the effect of unique stressors experienced by those in the LGB+ community explained by external and societal influences, has been accepted within the research community as a theory used to explain the health disparities seen in this group. This study proposed a possible further explanation, in addition to minority stress, that helps …

Racial And Ethnic Differences In Adverse Childhood Experiences And Health Outcomes In Adulthood, Sallie Mack

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Adverse childhood experiences (ACEs) have been linked to many negative physical and mental health disorders in adulthood. Many individuals in the United States have ACEs, and rates are higher among people of color. Less is known about how to prevent these physical and mental health disorders and symptoms for individuals with ACEs. Five different factors may help in intervening on the negative effects of ACEs. These include: mental wellness, healthy relationships, physical activity, sleep and nutrition (Burke Harris, 2018). This study investigated how these factors influence health in adulthood for individuals with ACEs. The current researcher used data from the …

Habitat, Diet, And Foraging Ecology Of Willow Flycatcher In Sierra Nevada Meadows, Scott E. Dietrich

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The last stronghold of the California Willow Flycatcher (Empidonax traillii) population, which exists in the Sierra Nevada, continues to decline, necessitating a clearer understanding of how meadows provide habitat for the species. To gain this understanding, we assessed vegetation type, saturation levels, and invertebrate species at 51 different sites within four meadows located in the Little Truckee River drainage. 17 of these sites were occupied by nesting Willow Flycatcher during the time of the study, 17 sites had been occupied by nesting Willow Flycatcher in annual surveys between 1997 and 2010 but are no longer used, and 17 …

Applied Species Delimitation In Microbial Taxa And Plants, Austin C. Koontz

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Species are a fundamental concept in biology, and many subdisciplines in biology utilize species in aspects of theory and in the communication of results. Given the centrality of species in biological science, it can seem surprising that there is no universal definition amongst biologists of what, strictly speaking, a species is. In fact, there are, by some estimates, over 20 different "species concepts", and this lack of a consensus is termed "the species problem". This problem has theoretical underpinnings, but has become more relevant as advances in sequencing technologies over the past two decades have allowed researchers to probe the …

Assessing The Effects Of Cold Storage Regimes Of North American Bombus Queens: Long Live The Humble Queen, Thuy - Tien Thai Lindsay

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Bumble bees (Bombus) provide critical pollination services for wild plants and crops. They are generalist pollinators, and do not depend on one singular floral type. Native bumble bees are adapted to pollinating many native plants, such as blueberries, squash, and tomatoes. A critical component of bumble bee pollination in the greenhouse tomato industry is the domestication of commercially bred colonies. However, the domestication of Bombus is pretty early in its development, and not all aspects of the bumble bee life cycle is fully understood. This thesis addresses one of the major obstacles in domestication, which is successful mimicking …

Fate Of Pharmaceuticals And Personal Care Products In Duckweed And Waste Activated Sludge Under Aerobic And Anaerobic Solids Stabilization Conditions, Kwame Tweneboah Duodu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Twelve commonly used pharmaceuticals and personal care products (PPCPs)(acetaminophen, β-Estradiol, caffeine, carbamazepine, DEET, estrone, gemfibrozil, triclosan, TCEP, sulfamethoxazole, progesterone, fluoxetine) were investigated to determine their fate in biosolids. These compounds were selected due to their wide usage, and varying properties, that makes them representative of many other PPCPs.

Commonly used PPCPs (caffeine commonly found in tea, coffee, chocolate and soda, the pain reliever acetaminophen, and the pesticide DEET) were detected in high amounts in the influent of the Hyrum WWTP and Wellsville sewage lagoons. Although conventional WWTPs are not designed to remove PPCPs from wastewater, some PPCPs, such as acetaminophen, …