Digital Commons Network^™

Cross-Cultural Analysis Of Gamer Identity: A Comparison Of The United States And Poland, Małgorzata Ćwil, William T. Howe

Communication Faculty Publications

Who is a gamer? What kind of people are perceived to be gamers? And finally – who perceives themselves as a gamer? In this article the authors attempt to answer these three questions from a multinational perspective.

Background. Games are nowadays one of the most frequently encountered forms of entertainment and constitute an ever-increasing part of many people’s day-to-day lives. With the rising popularity of video games, there is a need to conduct a research concerning gamer identity and to find out who perceives themselves as a gamer. The aim of this study is to compare the results of …

Teacher Perceptions Of Collegial Collaboration In An Academy Structure., Kristy Marie Field

Electronic Theses and Dissertations

Collaboration in is an often researched, many-named concept with a definition which has historically been unclear. What one calls collegiality another may call teacher teaming and yet another may refer to as professional networking. Scholars agree effective teacher collaboration can lead to higher student achievement, teacher efficacy, and teacher retention. However, as elusive as an agreed-upon definition may be an agreed-upon structure that fosters an effective version of this collaboration. When Ford began the Ford Next Generation Learning initiative, they embarked on the path to developing a school model that focused on school and community partnerships to support long-term, transformational …

Mitigating Black Claustrophobia: Space, Trauma, And Healing Modalities In The Postcolonial Narrative., Saleema Mustafa Campbell

Electronic Theses and Dissertations

This dissertation examines the space or spaces of blackness and the black body in the United States. This nation was shaped by the institution of slavery, and its greatest legacy is the trauma that still resonates in social structures and spaces complicating the lived experiences of many. The various responses to these traumas are documented in literary form by authors who serve as cultural witnesses. The narratives featured in this research project, collectively and individually, offer a voice to the traumatic plight of individuals in the U.S. who struggle to contemplate and rectify the traumas of this nation’s past. This …

Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das

Electronic Theses and Dissertations

Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …

Kindergarten Readiness And Grade 1 Mathematics Achievement., Faneshia Mcpherson Jones

Electronic Theses and Dissertations

From 2013-2019, all Kentucky school districts have administered a common screener to each student entering kindergarten. In this study, kindergarten readiness—determined by academic skills/cognitive development, language development, and physical development—was a significant predictor of grade 1 end-of-year mathematics achievement. The model predictions show that kindergarten students who met the readiness benchmark had higher grade 1 end-of-year mathematics scores compared to students who entered kindergarten below the readiness benchmark. The model predictions improved substantially with the inclusion of prior level of achievement as indicated by grade 1 beginning of the year mathematics achievement. However, students with stronger readiness skills demonstrated significantly …

Structural Characterization And Selective Drug Targeting Of Higher-Order Dna G-Quadruplex Systems., Robert Chandos Monsen

Electronic Theses and Dissertations

There is now substantial evidence that guanine-rich regions of DNA form non-B DNA structures known as G-quadruplexes in cells. G-quadruplexes (G4s) are tetraplex DNA structures that form amid four runs of guanines which are stabilized via Hoogsteen hydrogen bonding to form stacked tetrads. DNA G4s have roles in key genomic functions such as regulating gene expression, replication, and telomere homeostasis. Because of their apparent role in disease, G4s are now viewed as important molecular targets for anticancer therapeutics. To date, the structures of many important G4 systems have been solved by NMR or X-ray crystallographic techniques. Small molecules developed to …

The Effects Of Whole Life, Low Dose Cadmium Exposure On High Fat Diet-Induced Nonalcoholic Fatty Liver Disease And The Role Of Zinc., Jamie Lynn Young

Electronic Theses and Dissertations

Nonalcoholic fatty liver disease (NAFLD) is a major global public health concern affecting more than 25% of the world’s population. Although obesity is a major risk factor for NAFLD, it cannot account for many cases, indicating the importance of other factors such as sex and environmental exposures. Cadmium exposure is implicated in the development of NAFLD; however, the influence of early-life, in utero cadmium exposure on the development of diet-induced NAFLD is poorly understood. Therefore, we developed an in vivo, multiple-hit model to study the effect of whole-life, low-dose cadmium exposure on high fat diet (HFD)-induced NAFLD. Additionally, we …

On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng

Electronic Theses and Dissertations

This dissertation focused on the ways that social beliefs about sex/gender and sexuality manifest in biology classrooms. Especially for health science students, classes include topics like sex, sexuality, sexual behaviors, or sex determination that forms the foundation of their understanding of human forms and behaviors. If the information they receive does not include the LGBTQIA+ community, their education will fail to adequately prepare them for the reality of healthcare practice where they will be expected to treat all patients with dignity and respect. There are three chapters in this dissertation. In chapter one, I asked what beliefs about and conceptions …

Development And Applications Of Condensed Phase Cavity Ring-Down Spectroscopy For Studies Of Electrochemical And Interfacial., Shadi Ahmad Alnaanah

Electronic Theses and Dissertations

This dissertation reports the development of ultra-sensitive platforms based on the laser cavity ring-down spectroscopic (CRDS) technique to enable optical and spectroelectrochemical investigations in the condensed phase of matter at challenging scenarios. Firstly, an electrically-active solid/liquid interface for the evanescent-wave cavity ring-down spectroscopy (EW-CRDS) was developed to specroelectrochemically investigate redox events. By coating the interface of total internal reflection of the EW-CRDS platform with a high quality optically transparent and electrically conductive indium tin oxide thin film (ITO), we demonstrated that sufficiently long ring-down times can be achieved to allow for spectroelectrochemical investigations of redox species at solid/liquid interfaces at …

In Need Of A Hero? The Creation And Use Of The Legend Of General George S. Patton, Jr., Nathan Curtis Jones

Electronic Theses and Dissertations

During WWII, General George Patton became the hero Americans needed through the creation of a self-crafted brand and with help from journalists. After Patton’s death, opportunists forwarded a legend narrative that developed into a collective memory that morphed over time to meet contemporary challenges. Stakeholders of that collective memory commemorated and memorialized the dead hero for monetary and political gain, to promote patriotism, make military doctrinal changes, and even promote peace. Today, this collective memory has potential for the U.S. Army as it transforms civilians into soldiers and officers. This study contributes to history and memory studies by linking representations …

Predicting Dental Student's Performance On National Board Dental Examination (Nbde) Part I: Exploring Demographic Factors, Dental Admission Test (Dat) Factors, Pre-Program Academic Factors, And Dental Program Academic Performance., Wei-Shao Lin

Electronic Theses and Dissertations

Dental students need to successfully challenge a national licensure examination to be able to practice dentistry. Dental educators currently have difficulty in identifying candidates who are at risk of failing this examination. This non-experimental quantitative study examined existing dental student data from the 2017, 2018, and 2019 graduating classes, using a retrospective and correlational approach to identify possible markers for at risk students. Demographic factors, dental admission test (DAT) factors, pre-program academic factors, dental program academic performance, and National Board Dental Examination (NBDE) Part I performance. A series of independent t-tests and One-Way analysis of variances (ANOVAs) were used to …

External Homophobia And Outness In Gay Men., Thomas Charles Isaak Jr

Electronic Theses and Dissertations

Prior studies regarding outness among gay men have often focused on internalized homophobia as a barrier to coming out for gay men, while less emphasis has been placed on external homophobia. Drawing upon social construction theory and Connell’s hierarchy of masculinity, I utilize data from the 2010 Social Justice Sexuality Project to complete an ordinary least square regression to examine the impact of external homophobia on the level of outness among the 987 gay men in this study. In this study, I find that gay men who were exposed to external homophobia reported decreased levels of outness. Further, I find …

The Impact Of Adenotonsillectomy On Monosymptomatic Primary Nocturnal Enuresis In Children With Obstructive Sleep Apnea Syndrome, Rim Ghanem, Mazen A. Ghanem, Manal A. Safan, Ahmed M. Ghanem

Dentistry

No abstract provided.

Influence Of Blood Contamination On The Bond Strength And Biointeractivity Of Biodentine Used As Root-End Filling, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To evaluate the influence of blood contamination on the bond strength and apatite forming ability of Biodentine used as root-end filling material. Methodology: Eighty (n = 80) extracted single-rooted, sound human maxillary anterior teeth were prepared and obturated. Then, the roots were resected, retrograde cavities were prepared and Biodentine was inserted as the root-end filling material. Teeth were then randomly divided into 2 equal groups (n = 40) according to the setting environment of Biodentine i.e., group A where setting took place in human blood and group B where setting took place in deionized water (control group). Teeth were …

Exploring The Niche Of Rickettsia Montanensis (Rickettsiales: Rickettsiaceae) Infection Of The American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches, Catherine A. Lippi, Holly Gaff, Alexis L. White, Heidi K. St. John, Allen L. Richards, Sadie J. Ryan

Biological Sciences Faculty Publications

The American dog tick, Dermacentor variabilis (Say) (Acari: Ixodidae), is a vector for several human diseasecausing pathogens such as tularemia, Rocky Mountain spotted fever, and the understudied spotted fever group rickettsiae (SFGR) infection caused by Rickettsia montanensis. It is important for public health planning and intervention to understand the distribution of this tick and pathogen encounter risk. Risk is often described in terms of vector distribution, but greatest risk may be concentrated where more vectors are positive for a given pathogen. When assessing species distributions, the choice of modeling framework and spatial layers used to make predictions are important. …

Fine-Scale Patterns Of Genetic Structure In The Host Plant Chamaecrista Fasciculata (Fabaceae) And Its Nodulating Rhizobia Symbionts, Mahboubeh Hosseinalizadeh Nobarinezhad, Lisa A. Wallace

Biological Sciences Faculty Publications

In natural plant populations, a fine-scale spatial genetic structure (SGS) can result from limited gene flow, selection pressures or spatial autocorrelation. However, limited gene flow is considered the predominant determinant in the establishment of SGS. With limited dispersal ability of bacterial cells in soil and host influence on their variety and abundance, spatial autocorrelation of bacterial communities associated with plants is expected. For this study, we collected genetic data from legume host plants, Chamaecrista fasciculata, their Bradyrhizobium symbionts and rhizosphere free-living bacteria at a small spatial scale to evaluate the extent to which symbiotic partners will have similar SGS …

Introduction To Neutrosophic Genetics, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Neutrosophic Genetics is the study of genetics using neutrosophic logic, set, probability, statistics, measure and other neutrosophic tools and procedures. In this paper, based on the Neutrosophic Theory of Evolution (that includes degrees of Evolution, Neutrality (or Indeterminacy), and Involution) – as extension of Darwin’s Theory of Evolution, we show the applicability of neutrosophy in genetics, and we present within the frame of neutrosophic genetics the following concepts: neutrosophic mutation, neutrosophic speciation, and neutrosophic coevolution.

Relationship Between Personal Distress And Aggression Is Moderated By Nucleus Accumbens Volume, Yuan Ta Poh

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Studies into the relationship between empathy and aggression has found that the effect is weak (Vachon et al., 2014). This weak relationship is observed through aspects of empathy interacting with aspects of aggression in different ways depending on the types of empathy and aggression being measured. The present study utilized neuroimaging approach to examine the relationship among empathy, aggression and nucleus accumbens (NAc) volume. Forty nine college students underwent magnetic resonance imaging scans and completed the Interpersonal Reactivity Index as well as the Reactive-Proactive Questionnaire. Using FreeSurfer, bilateral NAc volumes were obtained for statistical analysis. Hierarchal regression analyses were utilized …

The Influence Of Proximal And Distal Familial Factors On Preschool Children's Inhibitory Control And Social Emotional Skills, Amy Encinger

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Children in the United States experience higher rates of poverty than any other age group, including elderly adults and the poverty rate of young children (0-5 years) is considerably higher than that of older children (Proctor et al., 2016). There is an extensive body of research examining familial socioeconomic status (SES) and the influence on the skills and behaviors of young children; however, common key indicators of family SES may not fully depict the ways in which children living in poverty/low-income homes are influenced by economic disadvantage. The focus of the current study is to explore the ways in which …

Assessment Of Grain Safety In Developing Nations, Jose R. Mendoza

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Grains are the most widely consumed foods worldwide, with maize (Zea mays) being frequently consumed in developing countries where it feeds approximately 900 million people under the poverty line of 2 USD per day. While grain handling practices are acceptable in most developed nations, many developing nations still face challenges such as inadequate field management, drying, and storage. Faulty grain handling along with unavoidably humid climates result in recurrent fungal growth and spoilage, which compromises both the end-quality and safety of the harvest. This becomes particularly problematic where there is little awareness about health risks associated with poor …

Population Demographics, Distribution, And Environmental History Of Asian Carp In A Great Plains River, Jake Werner

School of Natural Resources: Dissertations, Theses, and Student Research

Silver Carp Hypophthalmichthys molitrix, Bighead Carp H. nobilis, and Black Carp Mylopharyngodon piceus, collectively known as Asian carp, are a group of invasive fishes in the U.S.A. that have garnered much attention over the last couple decades. Most research devoted to this group of fishes has been focused in the Mississippi River basin with little investigation in the Missouri River drainage, particularly in tributary systems. The Kansas River is a major tributary to the Missouri River that has multiple anthropogenic barriers creating varying levels of connectivity within the Kansas River itself, and with the Missouri River. Information …

The Application And Development Of Metabolomics Methodologies For The Profiling Of Food And Cellular Toxicity, Jade Woods

Department of Chemistry: Dissertations, Theses, and Student Research

Metabolomics is a rapidly growing field of study. Its growth reflects advancements in technology and an improved understanding of the impact of the environment on metabolism. As a result, metabolomics is now commonly employed to investigate and characterize human and plant metabolism. The first chapter of this thesis provides an introduction to metabolomics and an overview of the protocols for sample preparation, data collection and statistical analysis. The second thesis chapter describes in explicit detail the step-by-step process of extracting and analyzing metabolites collected from mammalian cells, specifically brain tissue with a focus on Parkinson’s disease. The chapter highlights important …

Controlling And Synchronizing Combined Effect Of Chaos Generated In Generalized Lotka-Volterra Three Species Biological Model Using Active Control Design, Taqseer Khan, Harindri Chaudhary

Applications and Applied Mathematics: An International Journal (AAM)

In this work, we study hybrid projective combination synchronization scheme among identical chaotic generalized Lotka-Volterra three species biological systems using active control design. We consider here generalized Lotka-Volterra system containing two predators and one prey population existing in nature. An active control design is investigated which is essentially based on Lyapunov stability theory. The considered technique derives the global asymptotic stability using hybrid projective combination synchronization technique. In addition, the presented simulation outcomes and graphical results illustrate the validation of our proposed scheme. Prominently, both the analytical and computational results agree excellently. Comparisons versus others strategies exhibiting our proposed technique …

The Lattice Of Intuitionistic Fuzzy Topologies Generated By Intuitionistic Fuzzy Relations, Soheyb Milles

Applications and Applied Mathematics: An International Journal (AAM)

We generalize the notion of fuzzy topology generated by fuzzy relation given by Mishra and Srivastava to the setting of intuitionistic fuzzy sets. Some fundamental properties and necessary examples are given. More specifically, we provide the lattice structure to a family of intuitionistic fuzzy topologies generated by intuitionistic fuzzy relations. To that end, we study necessary structural characteristics such as distributivity, modularity and complementary of this lattice.

Heat And Mass Transfer In Micropolar Model For Blood Flow Through A Stenotic Tapered Artery, Moses S. Dada, Funmilola Alamu-Awoniran

Applications and Applied Mathematics: An International Journal (AAM)

Heat and mass transfer in blood flow through a tapered artery with mild stenosis is examined. The blood is considered to be an incompressible, micropolar fluid flowing through a vessel with nonsymmetric axial and symmetric radial axes. The geometry of the model takes into account the shape parameter, tapered angle and height of the stenosis.The variation in the shape parameter is used to describe the changes in the axial shape of the stenosis in the artery. The governing equations for the model, comprising the continuity, momentum, energy, and mass transfer equations are transformed and simplified under the assumption of mild …

Stability Of Modified Host-Parasitoid Model With Allee Effect, Özlem A. Gümüs, A. G. Maria Selvam, R. Janagaraj

Applications and Applied Mathematics: An International Journal (AAM)

This paper deals with a host-parasitoid model subject to Allee effect and its dynamical behavior. Steady state points of the proposed host-parasitoid model are computed. Stability properties are analyzed with eigen values of Jacobian matrix which are determined at the steady states. Theoretical findings are supported by numerical illustrations and enhanced by pictorial representations such as bifurcation diagrams, phase portraits and local amplifications for different parameter values. Existence of chaotic behavior in the system is established via bifurcation and sensitivity analysis of the system at the initial conditions. Various phase portraits are simulated for a better understanding of the qualitative …

Estimating The Age And Mechanism Of Boulder Transport Related With Extreme Waves Using Lichenometry, Maria A. Oliveira, Esteve Llop, César Andrade, Cristina Branquinho, Ronald Goble, Sónia Queiroz, Maria C. Freitas, Pedro Pinho

Department of Earth and Atmospheric Sciences: Faculty Publications

Tsunamis and storms cause considerable coastal flooding, numerous fatalities, destruction of structures, and erosion. The characterization of energy and frequency associated with each wave contribute to the risk assessment in coastal regions. Coastal boulder deposits represent a physical proof of extreme inundation and allow us to study the effects of marine floods further back in time than instrumental and historical records. Age estimation of these deposits is challenging due to lack of materials (such as sand, shells, corals, or organic matter) that retain information about the passage of time. Lichenometry, a simple age estimation method, which is cost effective, quick …

Using Expanded Natural Killer Cells As Therapy For Invasive Aspergillosis, Win Mar Soe, Joan Hui Juan Lim, David L. Williams, Jessamine Geraldine Goh, Zhaohong Tan, Qi Hui Sam, Sanjay H. Chotirmall, Nur A’Tikah Binte Mohamed Ali, Soo Chin Lee, Ju Ee Seet, Sharada Ravikumar, Louis Yi Ann Chai

ETSU Faculty Works

Invasive aspergillosis (IA) is a major opportunistic fungal infection in patients with haematological malignancies. Morbidity and mortality rates are high despite anti-fungal treatment, as the compromised status of immune system prevents the host from responding optimally to conventional therapy. This raises the consideration for immunotherapy as an adjunctive treatment. In this study, we evaluated the utility of expanded human NK cells as treatment against Aspergillus fumigatus infection in vitro and in vivo. The NK cells were expanded and activated by K562 cells genetically modified to express 4-1BB ligand and membrane-bound interleukin-15 (K562-41BBL-mbIL-15) as feeders. The efficacy of these cells was …

Special Issue: Plant Synthetic Biology, Dhirendra Kumar

ETSU Faculty Works

No abstract provided.

Telomeric Injury By Kml001 In Human T Cells Induces Mitochondrial Dysfunction Through P53-Pgc-1Α Pathway, Madison Schank, Juan Zhao, Ling Wang, Zhengke Li, Dechao Cao, Lam Nhat Nguyen, Xindi Dang, Sushant Khanal, Lam Ngoc Thao Nguyen, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zeyuan Lu, Jinyu Zhang, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Telomere erosion and mitochondrial dysfunction are prominent features of aging cells with progressive declines of cellular functions. Whether telomere injury induces mitochondrial dysfunction in human T lymphocytes, the major component of adaptive host immunity against infection and malignancy, remains unclear. We have recently shown that disruption of telomere integrity by KML001, a telomere-targeting drug, induces T cell senescence and apoptosis via the telomeric DNA damage response (DDR). In this study, we used KML001 to further investigate the role and mechanism of telomere injury in mitochondrial dysregulation in aging T cells. We demonstrate that targeting telomeres by KML001 induces mitochondrial dysfunction, …