Digital Commons Network^™

Impact Of Need For Cognitive Closure On Framing, Omar Yanouri

McNair Scholars Research Journal

No abstract provided.

Scholarships, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Divalent Cations Mediate Bacterial Tolerance To Carbapenems Via Outer Membrane Stabilization, Richard D. Schargel

McNair Scholars Research Journal

No abstract provided.

Adverse Event Reporting For Cellular Therapy Products: Current Status And Future Directions, Kathy Loper, Michele W. Sugrue, Jay S. Raval, Joseph Yossi Schwartz, Kevin Land, Mickey Koh, Thilo Mengling, Hildegard Greinix, Jörg P. Halter, Christina M Celluzzi, Maysum Chaudhri

Pathology Research and Scholarship

Adverse event (AE) and adverse reaction (AR) reporting are key components of patient safety and surveillance systems. Review and analysis of this data yields opportunities for process improvement, product information and interventions, and can lead to improved patient outcomes and donor safety overall. AE and AR reporting for cellular therapy products is fragmented and not well characterized in a central reference. This review article, authored by experts from various organizations, serves to summarize the current state of reporting and offers opportunities for streamlining and coordination, as well as key reference for professionals in this field.

Evolution Of The Epigenetic Landscape In Childhood B Acute Lymphoblastic Leukemia And Its Role In Drug Resistance, Shella Saint Fleur-Lominy, Nikki A. Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H. Choi, Xiaotu Ma, Jun J. Yang, Stephen Kelly, Elizabeth Raetz, Richard C. Harvey, Cheryl Willman, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown, Kylie M. Getz, Cem Meydan, Christopher E. Mason, Aristotelis Tsirigos, William Carroll

Pathology Research and Scholarship

Although B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children and while highly curable, it remains a leading cause of cancer-related mortality. The outgrowth of tumor subclones carrying mutations in genes responsible for resistance to therapy has led to a Darwinian model of clonal selection. Previous work has indicated that alterations in the epigenome might contribute to clonal selection, yet the extent to which the chromatin state is altered under the selective pressures of therapy is unknown. To address this, we performed chromatin immunoprecipitation, gene expression analysis, and enhanced reduced representation bisulfite sequencing on a cohort of …

2020-December-01-Enjoy Retirement, University Marketing And Communication, East Tennessee State University

ETSU News

Congratulations to the following members of the East Tennessee State University family who retired in December.  Thank you for your service!

Fred J. Alsop III – Professor, Biological Sciences, 48 years

Gary D. Burkette – Professor, Accountancy, 28 years

Mary Elizabeth Cradic – Office Manager, Office of the President, 27 years

Bruce Dalton – Professor, Social Work, 17 years

Joseph G. Disque – Professor, Counseling and Human Services, 26 years

Edward J. Dwyer – Professor, Curriculum and Instruction, 44 years

Brian G. Evanshen – Research Specialist, Environmental Health, 30 years

Richard J. Felts – Boiler Mechanic, Power House Operations, 22 …

2020-December-01-Governors School Applications, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – The Governor’s School for the Scientific Exploration of Tennessee Heritage, offered by the East Tennessee State University Center of Excellence for Appalachian Studies and Services, is now accepting applications for summer 2021. The School will run from May 30-June 25.

Students live on the ETSU campus and earn three hours of college credit. Rising juniors and seniors in Tennessee high schools or home schools are eligible to apply, but applications must be submitted through the school counselor. Interested students should see their school counselor. The deadline for applications is January 15, 2021. More information is available at …

Coordination And Privacy Preservation In Multi-Agent Systems, Huan Gao

All Dissertations

This dissertation considers two key problems in multi-agent systems: coordination (including both synchronization and desynchronization) and privacy preservation.

For coordination in multi-agent systems, we focus on synchronization/desynchronization of distributed pulse-coupled oscillator (PCO) networks and their applications in collective motion coordination. Pulse-coupled oscillators were originally proposed to model synchronization in biological systems such as flashing fireflies and firing neurons. In recent years, with proven scalability, simplicity, accuracy, and robustness, the PCO based synchronization strategy has become a powerful clock synchronization primitive for wireless sensor networks. Driven by these increased applications in biological networks and wireless sensor networks, synchronization of pulse-coupled oscillators …

The Female Face Of Misogyny: A Review Of Decriminalizing Domestic Violence: A Balanced Policy Approach To Intimate Partner Violence By Leigh Goodmark And The Feminist War On Crime: The Unexpected Role Of Women's Liberation In Mass Incarceration By Aya Gruber, Dianne L. Post

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.

The Nebraska Bird Review, Volume 88 December 2020 Number 4

Nebraska Bird Review

Fall Field Report, August - November 2020, by W. Ross Silcock …13.8

History of the Seward - Branched Oak Christmas Bird Count, 1993-2020, by Joseph Gubanyi …162

Index to Volume 88 … 173

Subscription and Organization Information …187

Fall Field Report, August-November 2020, W. Ross Silcock

Nebraska Bird Review

Two issues were of concern this fall, and both appeared to have consequences or at least similarities in Nebraska. A major die-off in New Mexico made national news: https://www.aba.org/the-data-behind-mysterious-bird-deaths-in-new-mexico/. On Sep 9, 2020, the temperature dropped from 96°F to 40°F in the Albuquerque area, a record low, winds reached 70 mph, and several inches of snow fell, killing large numbers of birds directly. Over the next few days, hundreds more dead birds were picked up. Some have linked this high mortality to birds displaced from the mountains due to fire and unfortunately being caught in the severe weather. While fire …

History Of The Seward-Branched Oak Lake Christmas Bird Count, 1993-2020, Joseph A. Gubanyi

Nebraska Bird Review

The Seward-Branched Oak Lake Christmas Bird Count (Seward-BOL CBC) began in 1993 and has been conducted every year since then except for 2010 for a total of 27 counts. Weather conditions prevented the count on the selected date in 2010 and a backup date could not be set up. The count was started for several reasons. The area west of Lincoln has a diversity of habitats including all or part of four public lakes (Branched Oak, Pawnee, Twin Lakes, and Meadowlark) as well as a diversity of terrestrial habitats on both public and private land. The circle is close to …

Index To Volume 88

Nebraska Bird Review

Index to The Nebraska Bird Review, Volume 88 (2020)

From: Aden, Scott 95

to: Zonotrichia leucophrys gambelii 158 leucophrys 70, 158 oriantha 70

Analyzing Basket Trials Under Multisource Exchangeability Assumptions, Michael J. Kane, Nan Chen, Alexander M. Kaizer, Xun Jiang, H Amy Xia, Brian P. Hobbs

The R Journal

Basket designs are prospective clinical trials that are devised with the hypothesis that the presence of selected molecular features determine a patient’s subsequent response to a particular “targeted” treatment strategy. Basket trials are designed to enroll multiple clinical subpopulations to which it is assumed that the therapy in question offers beneficial efficacy in the presence of the targeted molecular profile. The treatment, however, may not offer acceptable efficacy to all subpopulations enrolled. Moreover, for rare disease settings, such as oncology wherein these trials have become popular, marginal measures of statistical evidence are difficult to interpret for sparsely enrolled subpopulations. Consequently, …

A Fast And Scalable Implementation Method For Competing Risks Data With The R Package Fastcmprsk, Eric S. Kawaguchi, Jenny I. Shen, Gang Li, Marc A. Suchard

The R Journal

Advancements in medical informatics tools and high-throughput biological experimentation make large-scale biomedical data routinely accessible to researchers. Competing risks data are typical in biomedical studies where individuals are at risk to more than one cause (type of event) which can preclude the others from happening. The Fine and Gray (1999) proportional subdistribution hazards model is a popular and well-appreciated model for competing risks data and is currently implemented in a number of statistical software packages. However, current implementations are not computationally scalable for large-scale competing risks data. We have developed an R package, fastcmprsk, that uses a novel forward-backward scan …

Six Years Of Shiny In Research: Collaborative Development Of Web Tools In R, Peter Kasprzak, Lachlan Mitchell, Olena Kravchuk, Andy Timmins

The R Journal

The use of Shiny in research publications is investigated over the six and a half years since the appearance of this popular web application framework for R, which has been utilised in many varied research areas. While it is demonstrated that the complexity of Shiny applications is limited by the background architecture, and real security concerns exist for novice app developers, the collaborative benefits are worth attention from the wider research community. Shiny simplifies the use of complex methodologies for people of different specialities, at the level of proficiency appropriate for the end user. This enables a diverse community of …

Assembling Pharmacometric Datasets In R: The Puzzle Package, Mario González-Sales, Olivier Barrière, Pierre Olivier Tremblay, Guillaume Bonnefois, Julie Desrochers, Fahima Nekka

The R Journal

Pharmacometric analyses are integral components of the drug development process. The core of each pharmacometric analysis is a dataset. The time required to construct a pharmacometrics dataset can sometimes be higher than the effort required for the modeling per se. To simplify the process, the puzzle R package has been developed aimed at simplifying and facilitating the time consuming and error prone task of assembling pharmacometrics datasets.

Puzzle consist of a series of functions written in R. These functions create, from tabulated files, datasets that are compatible with the formatting requirements of the gold standard non-linear mixed effects modeling …

The Biglasso Package: A Memory- And Computation-Efficient Solver For Lasso Model Fitting With Big Data In R, Yaohui Zeng, Patrick Breheny

The R Journal

Penalized regression models such as the lasso have been extensively applied to analyzing high-dimensional data sets. However, due to memory limitations, existing R packages like glmnet and ncvreg are not capable of fitting lasso-type models for ultrahigh-dimensional, multi-gigabyte data sets that are increasingly seen in many areas such as genetics, genomics, biomedical imaging, and high-frequency finance. In this research, we implement an R package called biglasso that tackles this challenge. biglasso utilizes memory-mapped files to store the massive data on the disk, only reading data into memory when necessary during model fitting, and is thus able to handle out-of-core computation …

The Prairie Naturalist, Vol. 52, Issue 2, December 2020

The Prairie Naturalist

Comparing Native Bee Communities on Reconstructed and Remnant Prairie in Missouri • Joseph LaRose, Elisabeth B. Webb, and Deborah Finke

Patterns and Potential Causes of Changing Winter Bird Distributions in South Dakota • David L. Swanson, Reza Goljani Amipkhiz, and Mark D. Dixon

Greater prairie-chickens and sharp-tailed grouse have similarly high nest survival in the Nebraska Sandhills • Larkin A. Powell, Walter H. Schacht, Julia P. Ewalt, and Katie R. McCollum

Captive Ring-necked Pheasant Response to Very High Experimental Doses of Lead • Travis J. Runia and Alex J. Solem

Trends in a Greater Prairie Chicken Population Established by Translocation …

Rngforgpd: An R Package For Generation Of Univariate And Multivariate Generalized Poisson Data, Hesen Li, Hakan Demirtas, Ruizhe Chen

The R Journal

This article describes the R package RNGforGPD, which is designed for the generation of univariate and multivariate generalized Poisson data. Some illustrative examples are given, the utility and functionality of the package are demonstrated; and its performance is assessed via simulations that are devised around both artificial and real data.

Tulip: A Toolbox For Linear Discriminant Analysis With Penalties, Yuqing Pan, Qing Mai, Xin Zhang

The R Journal

Linear discriminant analysis (LDA) is a powerful tool in building classifiers with easy computation and interpretation. Recent advancements in science technology have led to the popularity of datasets with high dimensions, high orders and complicated structure. Such datasetes motivate the generalization of LDA in various research directions. The R package TULIP integrates several popular high-dimensional LDA-based methods and provides a comprehensive and user-friendly toolbox for linear, semi-parametric and tensor-variate classification. Functions are included for model fitting, cross validation and prediction. In addition, motivated by datasets with diverse sources of predictors, we further include functions for covariate adjustment. Our package is …

News From The Bioconductor Project, Bioconductor Core Team

The R Journal

Bioconductor provides tools for the analysis and comprehension of high-throughput genomic data. Bioconductor 3.12 was released on 28 October, 2020. It is compatible with R 4.0.3 and consists of 1974 software packages, 398 experiment data packages, 968 up-to-date annotation packages, and 28 workflows. Books are a new addition, built regularly from source and therefore fully reproducible; an example is the community-developed Orchestrating Single-Cell Analysis with Bioconductor.

A Unified Algorithm For The Non-Convex Penalized Estimation: The Ncpen Package, Dongshin Kim, Sangin Lee, Sunghoon Kwon

The R Journal

Various R packages have been developed for the non-convex penalized estimation but they can only be applied to the smoothly clipped absolute deviation (SCAD) or minimax concave penalty (MCP). We develop an R package, entitled ncpen, for the non-convex penalized estimation in order to make data analysts to experience other non-convex penalties. The package ncpen implements a unified algorithm based on the convex concave procedure and modified local quadratic approximation algorithm, which can be applied to a broader range of non-convex penalties, including the SCAD and MCP as special examples. Many user-friendly functionalities such as generalized information criteria, cross-validation …

Farmtest: An R Package For Factor-Adjusted Robust Multiple Testing, Koushiki Bose, Jianqing Fan, Yuan Ke, Xiaoou Pan, Wen-Xin Zhou

The R Journal

We provide a publicly available library FarmTest in the R programming system. This library implements a factor-adjusted robust multiple testing principle proposed by Fan et al. (2019) for large-scale simultaneous inference on mean effects. We use a multi-factor model to explicitly capture the dependence among a large pool of variables. Three types of factors are considered: observable, latent, and a mixture of observable and latent factors. The non-factor case, which corresponds to standard multiple mean testing under weak dependence, is also included. The library implements a series of adaptive Huber methods integrated with fast data-driven tuning schemes to estimate model …

Frames Of Error: Three Behavioral Approaches To Reducing Stigma Towards People With Disabilities, Rocco Giovanni Catrone

Dissertations

What makes a person disabled is a much-debated topic with some focusing on the individuals impairments (putting the onus of disability on the individual) while others focus on how the environment (both architectural and social) exacerbates an individual’s impairments and creates the conceptualization of disability (putting the onus of disability on society). No matter how a person with a disability (PWD) is categorized, they are met with healthcare, education, and work disparities that are perpetuated both unintentionally and intentionally. This paper examines the various ways disability and subsequently stigma arises from a variety of viewpoints both within and outside the …

Offshore Wind Energy And Benthic Habitat Changes Lessons From Block Island Wind Farm, Zoë L. Hutchison, Monique Lafrance Bartley, Steven Degraer, Paul English, Anwar Khan, Julia Livermore, Bob Rumes, John W. King

Graduate School of Oceanography Faculty Publications

The Block Island Wind Farm (BIWF), situated offshore of Block Island, Rhode Island, is the first commercial offshore wind farm (OWF) in the United States. We briefly review pre-siting studies, which provide contextual information about the benthic habitats and fish in the Block Island Sound area before the BIWF jacket foundations were installed in 2015. We focus on benthic monitoring that took place within the BIWF. This monitoring allowed for assessments of spatiotemporal changes in sediment grain size, organic enrichment, and macrofauna, as well as the colonization of the jacket structures, up to four years post-installation. The greatest benthic modifications …

Nutrition At Tipu: A Comparative Analysis Of Juvenile Health In Maya Populations, Sydnie A. Bianchi

Master's Theses

The site of Tipu in west central Belize provided a foothold for Spanish missionaries in the 17^th century. The effects of contact on adults among the 550 burials recovered in the cemetery there have been well studied, but the children have received less attention. Therefore, this study examined juvenile health through four markers: Linear Enamel Hypoplasia (LEH), a non-specific marker of health disruptions; Porotic Hyperostosis (PH), an indicator of anemia; and Periostitis, an indicator of infection. Some 131 individuals were evaluated using criteria developed by Steckel, Sciulli, and Rose (2002). The results were compared to Late Classic Copán (Storey, …

Oregon, Eric L. Martin

Texas A&M Journal of Property Law

Even though no oil and only a small quantity of natural gas is produced in Oregon, the Oregon Legislature enacted bans in 2019 on hydraulic fracturing until 2025 and on using Oregon’s territorial sea for oil and gas activities. Beyond that legislation, though, legal developments in Oregon this year concerning the oil and gas industry focused on downstream issues.

Investigation Of Clinoptilolite Zeolite As A Candidate System For Study By Positron Annihilation, Edward Perez

Physics Theses - Archive

This thesis reports on the characterization of a clinoptilolite zeolite (〖Na〗_3 [〖Al〗_3 〖Si〗_15 O_36 ]12H_2 O) using Energy-dispersive X-ray spectroscopy (EDX/EDS) for chemical analysis, low energy Secondary Electron (SE) analysis for three-dimensional imaging and topography, and Transmission Electron Microscopy (TEM) for two-dimensional imaging at the nanometer level. The goal of this work was to provide additional information that can aid in the interpretation of the data obtained using positron beam based spectroscopies. The measurements were performed using the Hitachi S-3000N Variable Pressure Scanning Electron Microscope (SEM) integrated with a NORAN 7 EDS/EBSD system, the Hitachi S-4800 II Field Emission Scanning …

The Pain In The Pleasure: Electrophysiological Analysis Of The Tail Region Of The Ventral Tegmental Area (Tvta), Akshay Parchure

Psychology Dissertations - Archive

The mesolimbic (midbrain) reward system is well documented to be involved with the analgesic effects of opioids, which involves the ventral tegmental area (VTA) causing release of dopamine (DA). The dopamine neurons from the ventral tegmental area (VTA) directly innervate the nucleus accumbens (NAc) and the prefrontal cortex via D1 DA Receptors. GABAergic inhibition of VTA DA system occurs regularly, but in 1990s Johnson and North showed the administration of opioids led to hyperpolarization of GABA interneurons in the VTA removing this inhibition, further leading to the “disinhibition model”. However, more recent studies have defined a new structure heavily influencing …