Digital Commons Network^™

Diagnosis And Management Of Malignant Peripheral Nerve Sheath Tumors: Current Practice And Future Perspectives, Bethany C Prudner, Tyler Ball, Richa Rathore, Angela C Hirbe

2020-Current year OA Pubs

One of the most common malignancies affecting adults with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the malignant peripheral nerve sheath tumor (MPNST), a highly aggressive sarcoma that typically develops from benign plexiform neurofibromas. Approximately 8-13% of individuals with NF1 will develop MPNST during young adulthood. There are few therapeutic options, and the vast majority of people with these cancers will die within 5 years of diagnosis. Despite efforts to understand the pathogenesis of these aggressive tumors, the overall prognosis remains dismal. This manuscript will review the current understanding of the cellular and molecular progression of MPNST, diagnostic …

The Society For Immunotherapy Of Cancer Consensus Statement On Immunotherapy For The Treatment Of Multiple Myeloma, Nina Shah, Ravi Vij, Et Al

2020-Current year OA Pubs

Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents (IMiDs), proteasome inhibitors and monoclonal antibodies. In recent years, immunotherapy for the treatment of MM has advanced rapidly, with the approval of new targeted agents and monoclonal antibodies directed against myeloma cell-surface antigens, as well as maturing data from late stage trials of chimeric antigen receptor CAR T cells. Therapies that engage the immune system to treat myeloma offer significant clinical benefits with durable responses and manageable toxicity profiles, however, the appropriate use of these immunotherapy agents can …

Mechanism Of Ligand Activation Of A Eukaryotic Cyclic Nucleotide-Gated Channel, Xiangdong Zheng, Ziao Fu, Deyuan Su, Yuebin Zhang, Minghui Li, Yaping Pan, Huan Li, Shufang Li, Robert A Grassucci, Zhenning Ren, Zhengshan Hu, Xueming Li, Ming Zhou, Guohui Li, Joachim Frank, Jian Yang

Faculty, Staff and Students Publications

Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We report both closed- and open-state atomic cryo-EM structures of a full-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nanodiscs. These structures, together with computational and functional analyses and a mutant channel structure, reveal a double-barrier hydrophobic gate formed by two S6 amino acids in the central cavity. cGMP binding produces global conformational changes that open the cavity gate located ~52 Å away but do not alter the structure …

Combined Lenvatinib And Pembrolizumab As Salvage Therapy In Advanced Adrenal Cortical Carcinoma, Sara Bedrose, Kevin Charles Miller, Lina Altameemi, Mohamed S Ali, Sameh Nassar, Naveen Garg, Marilyne Daher, Keith D Eaton, Jeffrey Thomas Yorio, Davey B Daniel, Matthew Campbell, Keith C Bible, Mabel Ryder, Ashish V Chintakuntlawar, Mouhammed Amir Habra

Faculty, Staff and Students Publications

BACKGROUND: There is no effective systemic therapy for metastatic adrenal cortical carcinoma (ACC) after failure of platinum-based chemotherapy. The efficacies of single-agent oral multikinase inhibitors (MKIs) or salvage immune checkpoint inhibitors (CPIs) have been very limited. It is unknown whether combining CPIs, such as pembrolizumab (PEM), with other therapies, such as MKIs, could yield higher response rates in ACC, yet this combination has shown promise in other cancers. Herein, we describe the first case series using PEM in combination with the MKI lenvatinib (LEN) in patients with progressive, metastatic ACC.

METHODS: A retrospective case series describing the use of LEN/PEM …

Development And Open Trial Of A Psychosocial Intervention For Young Children With Chronic Tics: The Cbit-Jr Study, Shannon M. Bennett, Matthew R. Capriotti, Christopher C. Bauer, Susanna W. Chang, Alex E. Keller, John T. Walkup, Douglas W. Woods, John Piacentini

Psychology Faculty Research and Publications

The Comprehensive Behavioral Intervention for Tic Disorders (CBIT) has demonstrated efficacy in large randomized controlled trials for children (≥9 yrs), adolescents and adults with Tourette Syndrome and Chronic Tic Disorders. Given the early age of onset for tic disorders, a large portion of affected individuals with chronic tic disorders are less than 9 years of age and appropriate developmental adaptations of behavioral treatment have not yet been tested. The goal of this study was to adapt and evaluate the acceptability and utility of a family-based adaptation of CBIT for children under 9 years of age. Children 5–8 years of age …

A Transdiagnostic Perspective Of Constructs Underlying Obsessive-Compulsive And Related Disorders: An International Delphi Consensus Study, Leonardo F. Fontenelle, Erin Oldenhof, Maria Eduarda Moreira-De-Oliveira, Jonathan S. Abramowitz, Martin M. Antony, Danielle Cath, Adrian Carter, Darin D. Dougherty, Ygor A. Ferrao, Martijn Figee, Ben J. Harrison, Marcelo Hoexter, Jun Soo Kwon, Anne Küelz, Luisa Lazaro, Christine Lochner, Donatella Marazziti, David Mataix-Cols, Dean Mckay, Euripedes C. Miguel, Sharon Morein-Zamir, Steffen Mortiz, Gerald Nestadt, Kieron O'Connor, Stefano Pallanti, Christine Purdon, Scott Rauch, Peggy Richter, Jean-Yves Rotge, Roseli G. Shavitt, Carles Soriano-Mas, Vladan Starcevic, Dan J. Stein, Gail Steketee, Eric A. Storch, Steven Taylor, Odile A. Van Den Heuvel, David Veale, Douglas W. Woods, Antonio Verdejo-Garcia, Murat Yucel

Psychology Faculty Research and Publications

Background:

The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders.

Methods:

Based on a modified Delphi method, 46 experts were recruited …

Reducing Risky Behavior With Habit Reversal: A Review Of Behavioral Strategies To Reduce Habitual Hand-To-Head Behavior, Megan R. Hienicke, Jordan T. Stiede, Raymond G. Miltenberger, Douglas W. Woods

Psychology Faculty Research and Publications

Habit reversal training (HRT) has been a mainstay of behavior analysts' repertoire for nearly the last 50 years. HRT has been effective in treating a host of repetitive behavior problems. In the face of the current coronavirus pandemic, HRT has practical public health importance as a possible intervention for reducing hand-to-head behaviors that increase the risk of viral infection. The current paper provides a brief review of HRT for hand-to-head habits that is designed for a broad audience and concludes with practical suggestions, based on HRT, for reducing face-touching behaviors.

An Immune Response To The Avascular Lens Following Wounding Of The Cornea Involves Ciliary Zonule Fibrils., Jodirae Dedreu, Caitlin J Bowen, Caitlin M Logan, Sonali Pal-Ghosh, Paola Parlanti, Mary Ann Stepp, A Sue Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The lens and central cornea are avascular. It was assumed that the adult lens had no source of immune cells and that the basement membrane capsule surrounding the lens was a barrier to immune cell migration. Yet, microfibril-associated protein-1 (MAGP1)-rich ciliary zonules that originate from the vasculature-rich ciliary body and extend along the surface of the lens capsule, form a potential conduit for immune cells to the lens. In response to cornea debridement wounding, we find increased expression of MAGP1 throughout the central corneal stroma. The immune cells that populate this typically avascular region after wounding closely associate with this …

Biological Flora Of The Tropical And Subtropical Intertidal Zone: Literature Review For Rhizophora Mangle L., Hudson R. Deyoe, Robert I. Lonard, Frank W. Judd, Richard Stalter, Ilka Feller

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Rhizophora mangle L. is a tropical and subtropical mangrove species that occurs as a dominant tree species in the intertidal zone of low-energy shorelines. Rhizophora mangle plays an important role in coastal zones as habitat for a wide range of organisms of intertidal food webs, as a natural barrier to coastal erosion, and as carbon sequestration. A review of mangrove literature has been performed, but a review specifically on red mangroves has not. The approach was to cover a broad range of topics with a focus on topics that have seen significant work since the 1970s. This review includes a …

Astroalign: A Python Module For Astronomical Image Registration, Martin Beroiz, Juan B. Cabral, Bruno Sanchez

Physics & Astronomy Faculty Publications

We present an algorithm implemented in the Astroalign Python module for image registration in astronomy. Our module does not rely on WCS information and instead matches three-point asterisms (triangles) on the images to find the most accurate linear transformation between them. It is especially useful in the context of aligning images prior to stacking or performing difference image analysis. Astroalign can match images of different point-spread functions, seeing, and atmospheric conditions.

Emerging Agents For The Treatment Of Chagas Disease: What Is In The Preclinical And Clinical Development Pipeline?, Nieves Martínez-Peinado, Nuria Cortes-Serra, Irene Losada-Galvan, Julio A. Urbina, Ana Rodríguez, John L. Vandeberg, Maria-Jesus Pinazo, Joaquim Gascon, Julio Alonso-Padilla

School of Medicine Publications

Introduction: Chagas disease treatment relies on the lengthy administration of benznidazole and/or nifurtimox, which have frequent toxicity associated. The disease, caused by the parasite Trypanosoma cruzi, is mostly diagnosed at its chronic phase when life-threatening symptomatology manifest in approximately 30% of those infected. Considering that both available drugs have variable efficacy by then, and there are over 6 million people infected, there is a pressing need to find safer, more efficacious drugs.

Areas covered: We provide an updated view of the path to achieve the aforementioned goal. From state-of-the-art in vitro and in vivo assays based on genetically engineered …

Disparity In Outcomes Of Melanoma Adjuvant Immunotherapy By Demographic Profile, Alexandra Ikeguchi, Michael Machiorlatti, Sara K. Vesely

School of Medicine Publications

Background: Randomized comparisons have demonstrated survival benefit of adjuvant immunotherapy in node-positivemelanoma patients but have limited power to determine if this benefit persists across various demographic factors.

Materials & methods: We assessed the impact of demographic factors on the survival benefit of adjuvant immunotherapy in a database of 38,189 node-positive melanoma patients using the Kaplan–Meier method and Cox proportional hazards models.

Results: All assessed demographic factors other than race significantly impacted survival of node-positive melanoma patients in univariate analysis. In multivariable analysis, only the age group interacted with immunotherapy.

Conclusion: Analysis of this large database of unselected node-positive melanoma patients …

Mini-Logger- A Wearable Inertial Measurement Unit (Imu) For Postural Sway Analysis, Michael Pollind, Rahul Soangra

Physical Therapy Faculty Articles and Research

Postural instability assessment is an important tool in fall risk analysis and for timely intervention of falls to reduce or prevent fall injuries. Traditionally fall risk is measured though postural sway assessment and is collected through forceplates by mapping Center of Pressure (COP) excursions or using motion analysis camera system for marker sway trajectories. However, both of these systems are expensive and lack portability to their usage in clinical environments. In this study, we developed a novel wearable low-cost MEMS inertial sensor and validated its usage for human postural sway assessment in standing posture with eyes open/closed, vibration/no vibration, and …

Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre

School of Medicine Publications

Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics.

Objective: To investigate the association of APOE ɛ4 and BP levels, measures with 24 h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics.

Methods:1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP …

Comprehensive Review On Current Interventions, Diagnostic, And Nanotechnology Perspectives Against Sars-Cov-2, Deepak S. Chauhan, Rajendra Prasad, Rohit Srivastava, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

COVID-19 has dramatically challenged the healthcare system of almost all countries. The authorities are struggling to minimize the mortality along with ameliorating the economy downturn. Unfortunately, till now, there has been no promising medicine or vaccine available. Herein, we deliver a perspective of nanotechnology for increasing the specificity and sensitivity of current interventional platforms towards the urgent need of quickly deployable solutions. This review summarizes the recent involvement of nanotechnology from the development of biosensor to fabrication of multifunctional nanohybrid system practiced for respiratory and deadly viruses, along with the recent interventions and current understanding about SARS-CoV2.

Rna-Gps Predicts High-Resolution Rna Subcellular Localization And Highlights The Role Of Splicing, Kevin E Wu, Kevin R Parker, Furqan M Fazal, Howard Y Chang, James Zou

Faculty, Staff and Students Publications

Subcellular localization is essential to RNA biogenesis, processing, and function across the gene expression life cycle. However, the specific nucleotide sequence motifs that direct RNA localization are incompletely understood. Fortunately, new sequencing technologies have provided transcriptome-wide atlases of RNA localization, creating an opportunity to leverage computational modeling. Here we present RNA-GPS, a new machine learning model that uses nucleotide-level features to predict RNA localization across eight different subcellular locations-the first to provide such a wide range of predictions. RNA-GPS's design enables high-throughput sequence ablation and feature importance analyses to probe the sequence motifs that drive localization prediction. We find localization …

Association Analysis Of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci With 20,871 Lung Cancer Cases And 15,971 Controls, Yuzhuo Wang, Olga Y Gorlova, Ivan P Gorlov, Meng Zhu, Juncheng Dai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E Goodman, Stig E Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heunz-Erich Wichmann, Heike Bickeboller, David C Christiani, Gad Rennert, Susanne M Arnold, Paul Brennan, John K Field, Sanjay Shete, Loïc Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil E Caporaso, Penella J Woll, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Victoria L Stevens, Hongxia Ma, Guangfu Jin, Zhibin Hu, Christopher I Amos, Hongbing Shen

Faculty, Staff and Students Publications

BACKGROUND: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated.

METHODS: We selected expression-related single-nucleotide polymorphisms (eSNP) and nonsynonymous variants of lung CDGs, and tested their associations with lung cancer risk in two large-scale genome-wide association studies (20,871 cases and 15,971 controls of European descent). Conditional and joint association analysis was performed to identify independent risk variants. The associations of independent risk variants with somatic alterations in lung CDGs or recurrently altered pathways were investigated using data …

Which Vegetation Sampling Approach Is More Efficient For A Rangeland Inventory?, Gh. Ghanbarian, M. Mesdaghi, H. Barani, M. Azimmohseni

IGC Proceedings (1977-2023)

No abstract provided.

Presentation Of Diversity, Life Forms And Chorology Of Plant Species In Rangelands Of Jahrom, Gh. Ghanbarian, E. Jafari, A. Hatami, M. Tayebi Khorrami

IGC Proceedings (1977-2023)

No abstract provided.

Analysis Of C‐Banding And Karyotype Of Chromosome Of Two Galega Species, Hongwen Gao, Xinyu Zhang, Zan Wang

IGC Proceedings (1977-2023)

No abstract provided.

Obstacles Of Determining Compensation In Grassland Ecological Values, Zhiyi Gai, Xiufang Gao

IGC Proceedings (1977-2023)

No abstract provided.

Application Of Analytical Hierarchy Process (Ahp) In Priority Classification Of Utilization Measurement Methods In Agropyrun Trichophrum Stands In Upland Grasslands Of Iran, Fazel Amiri

IGC Proceedings (1977-2023)

No abstract provided.

Method For Using Soya Grain Juice In Production Of Pasta Products, Sanaev Ermat, Tursunkhodjaev Po'lat, Ayhodjaeva Nodira, Umarov Orif

CHEMISTRY AND CHEMICAL ENGINEERING

Considering the protein need for human nutrition, the use of protein-rich grains plays an important role in the production of pasta. The study used soy protein as one of the protein sources, which serves as an effective source of energy in the physical and mental activities of humans. In the form of nutritious juice from soybeans, a protein concentration of 4.67% was obtained, and the resulting soy juice, rich in proteins, was used as an unconventional raw material for the production of pasta. Concentrations and methods were identified that made it possible to achieve technological and economic efficiency.

Physical And Chemical Characteristics Of Supramolecular Complexes Of Glycirrizinic Acid With Phytohormones, Djuraev Tulqin, Esanov Rakhmatillo, Gafurov Makhmudjon, Kushiev Khabibjon

CHEMISTRY AND CHEMICAL ENGINEERING

The process of formation of supramolecular complexes of glycyrrhizinic acid with some phytohormones (indolylacetic acid, indolylbutyric acid, α-naphthyl acetic acid and kinetin) were studied with the aim of creation the plant growth stimulator. The complexes structure was studied using IR and UV spectroscopy methods. The prepared compounds described by some physicochemical parameters. The stability constants and stoichiometric composition of complexes were determined in an aqueous solution at pH of 7,2 using UV spectrometry method. In result, all complexes have composition as 1:1 ratio, except the kinetin complex which has 2:1 ratio. The stability constants were equal: KGA:IAA=1,86±1×104; KGA:IBA=2,51±1×103; KGA:NAA =2,70±1×103 …

Synthesis And Research Of New Heterometal Complexes Cо(Ii), Ni(Ii), Cu(Ii) And Mn(Ii) Based On V(V) And 5-(4-Pyridyl)-1,3,4-Oxadiazole-2(3h)-Thione Lubricants, Pirimova Mehribon, Kadirova Shakhnoza, Rakhmonоva Dilnoza, Ziyayev Abduhakim

CHEMISTRY AND CHEMICAL ENGINEERING

The oxadiazole derivatives complex compounds with metals are biologically active substances. The aim of the study was to study the interaction of the chlorides of Co (II), Ni (II), Cu (II) and Mn (II) with 5-(4-pyridyl)-1,3,4-oxadiazole-2(3H)–thione, ammonium vanadate. Competitive coordination of donor centers, electronic and geometric structures of the ligand molecule were studied on the basis of the quantum-chemical software package Gaussian09 LanL2DZ. It was shown that 5-(4-pyridyl)-1,3,4-oxadiazole-2(3H)-thione ligand is partially coordinated through a localized nitrogen or sulfur atoms at formation of the complex. А procedure was developed for the synthesis of new mixed-metal complexes. The composition and structure of …

Visualization Of Brown Fat Using X-Ray Dark Field Imaging, Troy D. Jacobs

LSU Master's Theses

Introduction: Obesity has become a major societal issue. Many researchers are looking for ways to combat this growing epidemic. Brown adipose tissue (BAT) might be a way to help individuals overcome the challenges associated with weight loss and maintenance of weight loss, but a better understanding of BAT and how to control and utilize it is needed. BAT differs from white adipose tissue (WAT) in that BAT is rich with mitochondria and therefore is metabolically active. BAT is a source of non-shivering thermogenesis and can be activated both by cold exposure and pharmacologically. Current methods of assessing BAT activity are …

Assessing Breastfeeding Knowledge, Attitudes And Intention Among Adult Female Undergraduate And Graduate Students, Kritee Niroula

LSU Master's Theses

This study measured the breastfeeding knowledge, attitude and intention of adult female students of Louisiana State University. Participants (n=1039; mean age 20.12 ± 3.122 years) were recruited to complete the questionnaire. Racial/ethnic representation was White (76.1%), African American (14.3%), Asian (5.5%), American Indian/ Alaska Native or Native Hawaiian/ Pacific Islander (0.8%) and Multi-racial (3.3%). The questionnaire was used to deliver a set of knowledge, attitude and intention items. Participants were evaluated based on their scores in each section. The questionnaire was pilot tested among five students for comprehensibility and understandability and necessary changes were made according to their suggestions. The …

Assessment Of Important Environmental Factors Affecting Agropyron Trichophrum Establishment By Using An Ordination Method, Fazel Amiri, M. R. Chaichi, T. Tabatabai

IGC Proceedings (1977-2023)

No abstract provided.

Inter‐Annual Dynamics Of Grassland Yields And Assessment Of Herbage Supply In The Headwater Region Of Three Rivers Over 18 Years, Jiangwen Fan, Junbang Wang, Zhouqi Chen, Huaping Zhong, Quanqin Shao, Jiyuan Liu, Wenyan Zhang

IGC Proceedings (1977-2023)

No abstract provided.

Dynamics Of Leymus Chinensis And Hierochloe Glabrain Grassland Plantings Within The Songnen Plains Of China, Guangzhi Fan, Yunfei Yang

IGC Proceedings (1977-2023)

No abstract provided.