Digital Commons Network^™

A Patient-Specific Infrared Imaging Technique For Adjunctive Breast Cancer Screening: A Clinical And Simulation - Based Approach, Alyssa Owens

Theses

Breast cancer is currently the most prevalent form of cancer in women with over 266,000 new diagnoses every year. The various methods used for breast cancer screening range in accuracy and cost, however there is no easily reproducible, reliable, low-cost screening method currently available for detecting cancer in breasts, especially with dense tissue. Steady-state Infrared Imaging (IRI) is unaffected by tissue density and has the potential to detect tumors in the breast by measuring and capturing the thermal profile on the breast surface induced by increased blood perfusion and metabolic activity in a rapidly growing malignant tumor. The current work …

Repression Of Tick Microrna-133 Induces Organic Anion Transporting Polypeptide Expression Critical For Anaplasma Phagocytophilumsurvival In The Vector And Transmission To The Vertebrate Host, Ellango Ramasamy, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

The microRNAs (miRNAs) are important regulators of gene expression. In this study, we provide evidence for the first time to show that rickettsial pathogen Anaplasma phagocytophilum infection results in the down-regulation of tick microRNA-133 (miR-133), to induce Ixodes scapularis organic anion transporting polypeptide (isoatp4056) gene expression critical for this bacterial survival in the vector and for its transmission to the vertebrate host. Transfection studies with recombinant constructs containing transcriptional fusions confirmed binding of miR-133 to isoatp4056 mRNA. Treatment with miR-133 inhibitor resulted in increased bacterial burden and isoatp4056 expression in ticks and tick cells. In contrast, treatment with …

Rna-Gps Predicts High-Resolution Rna Subcellular Localization And Highlights The Role Of Splicing, Kevin E Wu, Kevin R Parker, Furqan M Fazal, Howard Y Chang, James Zou

Faculty, Staff and Students Publications

Subcellular localization is essential to RNA biogenesis, processing, and function across the gene expression life cycle. However, the specific nucleotide sequence motifs that direct RNA localization are incompletely understood. Fortunately, new sequencing technologies have provided transcriptome-wide atlases of RNA localization, creating an opportunity to leverage computational modeling. Here we present RNA-GPS, a new machine learning model that uses nucleotide-level features to predict RNA localization across eight different subcellular locations-the first to provide such a wide range of predictions. RNA-GPS's design enables high-throughput sequence ablation and feature importance analyses to probe the sequence motifs that drive localization prediction. We find localization …

Mechanism Of Ligand Activation Of A Eukaryotic Cyclic Nucleotide-Gated Channel, Xiangdong Zheng, Ziao Fu, Deyuan Su, Yuebin Zhang, Minghui Li, Yaping Pan, Huan Li, Shufang Li, Robert A Grassucci, Zhenning Ren, Zhengshan Hu, Xueming Li, Ming Zhou, Guohui Li, Joachim Frank, Jian Yang

Faculty, Staff and Students Publications

Cyclic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The molecular conformational changes underpinning ligand activation are largely undefined. We report both closed- and open-state atomic cryo-EM structures of a full-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lipid nanodiscs. These structures, together with computational and functional analyses and a mutant channel structure, reveal a double-barrier hydrophobic gate formed by two S6 amino acids in the central cavity. cGMP binding produces global conformational changes that open the cavity gate located ~52 Å away but do not alter the structure …

Biological Flora Of The Tropical And Subtropical Intertidal Zone: Literature Review For Rhizophora Mangle L., Hudson R. Deyoe, Robert I. Lonard, Frank W. Judd, Richard Stalter, Ilka Feller

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Rhizophora mangle L. is a tropical and subtropical mangrove species that occurs as a dominant tree species in the intertidal zone of low-energy shorelines. Rhizophora mangle plays an important role in coastal zones as habitat for a wide range of organisms of intertidal food webs, as a natural barrier to coastal erosion, and as carbon sequestration. A review of mangrove literature has been performed, but a review specifically on red mangroves has not. The approach was to cover a broad range of topics with a focus on topics that have seen significant work since the 1970s. This review includes a …

Considering The Impact Of Social Support And Student Perceptions Of Life Stress, Pearl Joanna Winckler

Doctoral Dissertations and Projects

Leaving the family home to attend university may be one of the rites of passage into adulthood, and independence for many high school graduates, yet the journey that ensues may be one of self-discovery, excitement, and delectation. Indeed, the college experience is as much about preparing for life event stressors mentally and emotionally as it is about intellectual attainment. The purpose of this study was to determine whether college student’s reported social support is correlated with perceived life stress. The Undergraduate Stress Questionnaire USQ, which is an 83-item checklist was used to measure perceived life stress. Many students may wrestle …

Evaluation Of Early Biomarkers Of Renal Dysfunction In Diabetic Patients, Shrouq F. Al-Hazmi, Aliaa A. Alamoudi, Basmah M. Eldakhakhny, Sarah K. Binmahfooz, Amani M. Alhozali

Saudi Medical Journal

Objectives: To evaluate 2 renal tubular enzymes; urinary neutrophil gelatinase-associated lipocalin (uNGAL), and urinary N-acetyl-beta-D-glucosaminidase (uNAG), and serum Cystatin C as candidate biomarkers for early diagnosis of early stage of diabetic nephropathy (DB) in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional study was carried out at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia during the period between May 2017 and May 2018 and was conducted on 86 patients with T2DM. Patients were classified according to their albumin/creatinine ratio (ACR) into 3 groups; a normal albuminuria group with ACR <30 mg/g creatinine, a moderately increased albuminuria group with ACR: 30-299 mg/g creatinine, and a severely increased albuminuria group with ACR ≥300 mg/g. Healthy adults were recruited as a control group. Urine uNGAL, uNAG, and serum Cystatin C were measured in all patients. Results: Compared with healthy control, diabetic patients with normal albuminuria excreted significantly higher levels of uNGAL ( p <0.001). In addition, significantly elevated uNGAL, uNAG and cystatin C levels were observed in moderately increased albuminuria and severely increased albuminuria groups when compared to the control and normoalbuminuric groups ( p <0.001). urinary neutrophil gelatinase-associated lipocalin, urinary N-acetyl-beta-D-glucosaminidase and Cystatin C showed a positive correlation with fasting blood glucose (FBG), HbA1c, duration of diabetes, urea, creatinine, and ACR. Conclusion: Our results indicated that uNGAL could be a sensitive biomarker for early renal dysfunction in diabetic patients while uNAG and serum Cystatin C might have prognostic value.

Use Of Ultrasound Guidance In Central Venous Catheter Placement By Emergency Physicians In Saudi Arabia, Mohammed A. Malabarey, Khaled N. Alrajhi

Saudi Medical Journal

Objectives: To determine the ultrasound guidance for central venous catheter (USG-CVC) placement rate of emergency physicians (EPs) in Kingdom of Saudi Arabia. Methods: A cross-sectional survey study regarding the respondents’ demographic profiles, formal and informal training in USG-CVC placement, experiences, and attitudes towards the procedure was emailed to all EPs registered with the Saudi Commission for Health Specialties (SCFHS) between October and December 2018. Results: In total, 234/350 SCFHS-registered EPs completed the survey; the response rate was 66.9%. Most respondents (70.5%) were board-certified in emergency medicine (EM). Ninety percent indicated that US device for CVC placement assistance was available. Most …

Leeds Sleep Evaluation Questionnaire In Jordanian University Students: A Psychometric Investigation Using Comparative Confirmatory Factor Analysis, Unaise A. Hameed, Muhammed D. Al-Jarrah, Md Dilshad Manzar, Chithira Nair, Abdulrhman Albougami, Bader A. Alrasheadi, Majumi M. Noohu, Mohammed Salahuddin

Saudi Medical Journal

Objectives: To analyze the fit of different competing factor models (a one-factor model, 3 2-factor models, and 2 4-factor models) of the Leeds sleep evaluation questionnaire (LSEQ) in the data from a Jordanian student population. Methods: A cross-sectional study was conducted on university students, with 2 sleep-related tools - the LSEQ and the sleep hygiene index (SHI). The students (n=166) at Jordan University of Science and Technology, Irbid, Jordan participated in this study from January-April, 2019. A total of 12 LSEQ models (6 models with all 10-items, and 6 models with one item deleted) were evaluated by using confirmatory factor …

Association Of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (Covid-19), Pierre Francois Laterre, Bruno François, Christine Collienne, Philippe Hantson, Robin Jeannet, Kenneth E. Remy, Richard S. Hotchkiss

Open Access Publications

No abstract provided.

The Endosymbiont Wolbachia Rebounds Following Antibiotic Treatment, Emma L. Gunderson, Young-Jun Choi, Makedonka Mitreva, Et Al.

Open Access Publications

Antibiotic treatment has emerged as a promising strategy to sterilize and kill filarial nematodes due to their dependence on their endosymbiotic bacteria, Wolbachia. Several studies have shown that novel and FDA-approved antibiotics are efficacious at depleting the filarial nematodes of their endosymbiont, thus reducing female fecundity. However, it remains unclear if antibiotics can permanently deplete Wolbachia and cause sterility for the lifespan of the adult worms. Concerns about resistance arising from mass drug administration necessitate a careful exploration of potential Wolbachia recrudescence. In the present study, we investigated the long-term effects of the FDA-approved antibiotic, rifampicin, in the Brugia pahangi …

Climate Toolkit: A Resource Manual For Science And Action - Version 2.0, Frank Granshaw

PDXOpen: Open Educational Resources

The Climate Toolkit is a resource manual designed to help the reader navigate the complex and perplexing issue of climate change by providing tools and strategies to explore the underlying science. As such it contains a collection of activities that make use of readily available on-line resources developed by research groups and public agencies. These include web-based climate models, climate data archives, interactive atlases, policy papers, and “solution” catalogs. Unlike a standard textbook, it is designed to help readers do their own climate research and devise their own perspective rather than providing them with a script to assimilate and repeat. …

Random Packing Material In Disinfection Contactors: Effects On Final Drinking Water Quality, Jessica L. Baker, Susan K. De Long, Subhas K. Venayagamoorthy

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This study investigates the concern about biofilm growth on random packing material (RPM) used to enhance the hydraulic disinfection efficiency of a chlorine contactor. The inflow, outflow, and RPM were monitored for heterotrophic bacteria (via heterotrophic plate counts) and Pseudomonas aeruginosa as indicators of bacteriological water quality and the presence of biofilm. The results of this study show that there was no substantial biofilm growth in a lab-scale chlorine contactor and no substantial increase in bacterial counts for the bulk outflow over a 10-week period. Thus, the potential for excessive biofilm growth should not be considered a barrier concerning the …

Customer Experience In Tourism: A Review Of Definitions, Components, And Measurements, Maksim Godovykh, Asli D. A. Tasci

Faculty Scholarship and Creative Works

Considered as a more competitive advantage than price, product, or quality, the concept of experience has received increasing attention in different disciplines. However, the pathway for handling experience has not been clearly set forth due to divergent conceptualizations and insufficient measures of customer experience. This study critically analyzes empirical and conceptual literature on experience, provides a holistic definition of experience, proposes an experience model with four main components (emotional, cognitive, sensorial, and conative), and suggests using a combination of several measures to capture the totality of tourism experience at pre-visit, onsite, and post-visit stages. These suggestions provide important implications for …

Meeting Report Of The Third Annual Tri-Service Microbiome Consortium Symposium, J Philip Karl, Robyn A. Barbato, Laurel A. Doherty, Aarti Gautam, Sarah M. Glaven, Robert J. Kokoska, Dagmar Leary, Rebecca Mickol, Matthew A. Perisin, Andrew J. Hoisington, Edward J. Van Opstal, Vanessa Varaljay, Nancy Kelley-Loughnane, Camilla A. Mauzy, Michael S. Goodson, Jason W. Soares

Faculty Publications

The Tri-Service Microbiome Consortium (TSMC) was founded to enhance collaboration, coordination, and communication of microbiome research among U.S. Department of Defense (DoD) organizations and to facilitate resource, material and information sharing among consortium members. The 2019 annual symposium was held 22–24 October 2019 at Wright-Patterson Air Force Base in Dayton, OH. Presentations and discussions centered on microbiome-related topics within five broad thematic areas: 1) human microbiomes; 2) transitioning products into Warfighter solutions; 3) environmental microbiomes; 4) engineering microbiomes; and 5) microbiome simulation and characterization. Collectively, the symposium provided an update on the scope of current DoD microbiome research efforts, highlighted …

Sepsis Screening Education, Brittany R. Horn

Doctor of Nursing Practice Scholarly Project

Sepsis is a significant burden to the healthcare field with 1.7 million Americans annually diagnosed with this condition. Earlier diagnosis and treatment are the most effective ways of reducing morbidity and mortality related to sepsis. The current sepsis screening tool in place at Stormont-Vail Hospital, in Topeka, Kansas, is the systemic inflammatory response (SIRS) criteria; however, this screening tool has proven to be less effective than other screening tools available. The screening tools proven more effective than the SIRS criteria, are the quick sequential organ failure assessment (qSOFA) and the sequential organ failure assessment (SOFA). For this project, nursing staff …

Phosphodiesterase Isoforms And Camp Compartments In The Development Of New Therapies For Obstructive Pulmonary Diseases, Martina Schmidt, Isabella Cattani-Cavalieri, Francisco J. Nuñez, Rennolds S. Ostrom

Pharmacy Faculty Articles and Research

The second messenger molecule 3′5′-cyclic adenosine monophosphate (cAMP) imparts several beneficial effects in lung diseases such as asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). While cAMP is bronchodilatory in asthma and COPD, it also displays anti-fibrotic properties that limit fibrosis. Phosphodiesterases (PDEs) metabolize cAMP and thus regulate cAMP signaling. While some existing therapies inhibit PDEs, there are only broad family specific inhibitors. The understanding of cAMP signaling compartments, some centered around lipid rafts/caveolae, has led to interest in defining how specific PDE isoforms maintain these signaling microdomains. The possible altered expression of PDEs, and thus abnormal …

Mini-Logger- A Wearable Inertial Measurement Unit (Imu) For Postural Sway Analysis, Michael Pollind, Rahul Soangra

Physical Therapy Faculty Articles and Research

Postural instability assessment is an important tool in fall risk analysis and for timely intervention of falls to reduce or prevent fall injuries. Traditionally fall risk is measured though postural sway assessment and is collected through forceplates by mapping Center of Pressure (COP) excursions or using motion analysis camera system for marker sway trajectories. However, both of these systems are expensive and lack portability to their usage in clinical environments. In this study, we developed a novel wearable low-cost MEMS inertial sensor and validated its usage for human postural sway assessment in standing posture with eyes open/closed, vibration/no vibration, and …

The Schools, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Student Life, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Core-Designated Courses, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Majors And Minors, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Course Descriptions, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Academic Regulations, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Emirati Women’S Knowledge About The Menopause And Menopausal Hormone Therapy, Linda Smail, Ghufran A. Jassim, Khawla I. Sharaf

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The aim of this study was to investigate the knowledge of Emirati women aged 30–64 about menopause, menopausal hormone therapy (MHT), and their associated health risks, and additionally, to determine the relationships between Emirati women’s knowledge about menopause and their sociodemographic and reproductive characteristics. A community-based cross-sectional study was conducted of 497 Emirati women visiting five primary healthcare centers in Dubai. Data were collected using a questionnaire composed of sociodemographic and reproductive characteristics, menopause knowledge scale (MKS), and menopause symptoms knowledge and MHT practice. The mean menopause symptoms knowledge percentage was …

The Association Between Operation Time And Post-Operative Pain In Endoscopic Sinonasal Surgery. Short Title: Operative Time And Post-Op Pain After Ess, Yossawee Wangworawut, Peter H. Hwang

Asian Medical Journal and Alternative Medicine

Background: United States is now in the midst of opioid crisis. To reduced perioperative opioid usage, is mean to reduce post-operative pain. This study try to find the association between operative time and post-operative pain in patient who received endoscopic sinonasal surgery. We also aim to study other factors that may play a role in post-operative pain.

Method: We performed a retrospective review of 624 patients, who have sinonasal disease and received endoscopic surgery from the same surgeon, in a tertiary care rhinology clinic from 2015 – 2018. Demographic data, diagnosis, duration of disease, Lund-Mackay CT score, operation, operation time, …

Mitochondrial Contributions To Disuse Atrophy: Let’S Talk About Sex, Megan Rosa-Caldwell

Graduate Theses and Dissertations

Skeletal muscle atrophy is a hallmark of many pathologies and is associated with disease prognosis, quality of life, and mortality. Specifically, lack of contractile activity of the muscle can result in disuse-associated atrophy. Disuse-induced atrophy is a common phenomenon in intensive care unit (ICU) patients and significantly impacts patient prognosis and ability to transition of out of intensive care. However, effective therapeutics to mitigate disuse-associated atrophy do not exist, clearly demonstrating the scientific and clinical need to further understand mechanisms contributing to disuse atrophy. In particular, a significant portion of the scientific literature has utilized male models, yet there is …

Distress Tolerance In Relation To Treatment Persistence, Engagement, And Improvement In An Exposure-Based Treatment For Sexually Abused Incarcerated Women, Ilana S. Berman

Graduate Theses and Dissertations

Incarcerated populations are disproportionately affected by traumatic experiences and symptoms of posttraumatic stress disorder (PTSD). Many effective treatments for PTSD utilize exposure-based techniques which require engaging with emotionally distressing content. However, individuals with PTSD and low distress tolerance (DT) are more likely than those with PTSD and higher DT to engage in avoidant coping behaviors and have relatively high treatment attrition rates in general. This study explored relations between DT and treatment persistence, engagement, and improvement in incarcerated women (N = 85) enrolled in an 8-week exposure-based sexual assault recovery group at a minimum-security prison. I hypothesized lower baseline levels …

Visualizing Interdisciplinary Collaborations Within Exercise Science: A Pilot Study, Elizabeth Bjornsen

Graduate Theses and Dissertations

Exercise science is a growing field with sub-disciplines exploring various aspects of physical activity. Diverse perspectives allow the field to answer complex research questions, but little is known about the collaborative nature of exercise science today. Research practices have implications on undergraduate curriculum, likely incorporating experiential knowledge into course subject matter and providing diverse experiences for students entering the workforce. Therefore, the purpose of the pilot study is to visualize and quantify interdisciplinary collaborations within exercise science. Journal citation analysis and an adaptation of social networking theory were utilized to examine collaborative practices of exercise science faculty at the University …

Phenotypic Plasticity Of Japanese Medaka Gill In Response To Changing Salinities, Laura V. Ellis

Graduate Theses and Dissertations

Japanese medaka (Oryzais latipes) are euryhaline fish, meaning they are capable of surviving in a variety of salinities from fresh water to seawater. The ability to maintain an internal osmotic concentration stems from the phenotypic plasticity of the osmoregulatory organs, the gill, kidney, intestine, and integument. The gill is the main site of osmotic and ionic regulation in fish due to the three-dimensional structure, the direct contact with the outside environment, and the composition of the gill cells. Fish gills are multifunctional as they regulate water movement, acid/base exchange, nitrogenous waste excretion, and ion fluctuations. In freshwater environments, fish are …