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Comparison Of Chemotherapeutic Activities Of Rhodamine-Based Gumbos And Nanogumbos, Nimisha Bhattarai, Mi Chen, Rocío L. Pérez, Sudhir Ravula, Robert Strongin, Karen Mcdonough, Isiah M. Warner

Chemistry Faculty Publications and Presentations

Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties that result from their lipophilic cationic structures. In previous research, we have found that conversion of Rhodamine 6G into nanoGUMBOS, i.e., nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS), led to selective chemotherapeutic toxicity for cancer cells over normal cells. Herein, we investigate the chemotherapeutic activity of GUMBOS derived from four different rhodamine derivatives, two bearing an ester group, i.e., Rhodamine 123 (R123) and SNAFR-5, and two bearing a carboxylic acid group, i.e., rhodamine 110 (R110) and rhodamine B (RB). In this …

Correlation Of Blood Oxidative Stress Parameters To Indoor Radiofrequency Radiation: A Cross Sectional Study In Jordan, Yazan Akkam, Ahmed A. Al-Taani, Salam Ayasreh, Abeer Almutairi, Nosaibah Akkam

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Electromagnetic pollution is a general health concern worldwide, as cell phone towers are ubiquitous and are located adjacent to or on the roof of schools, and hospitals. However, the health risks are still inconclusive. This cross-sectional study evaluated the potential effect of electromagnetic radiation generated from various resources including cell phone towers on blood glutathione S transferase activity (e-GST) and total antioxidant activity of the Jordanian population. Methods: The power density of three districts in the city of Irbid, Jordan was mapped to generate “outside the houses” and “inside the …

Enzymatic In-Situ Transesterification Of Neutral Lipids From Simulated Wastewater Cultured Chlorella Emersonii And Pseudokirchneriella Subcapitata To Sustainably Produce Fatty Acid Methyl Esters, Priyanka Priyanka, Gemma K. Kinsella, Gary Henehan, Barry J. Ryan

Articles

Alternative, more sustainable and environmentally positive, sources of energy are one of the current global challenges. One approach to achieving more sustainable sources of energy is to use waste from one system as a raw material for energy production, following the circular biosystem philosophy. This study successfully adopted this approach whereby microalgae strains Chlorella emersonii and Pseudokirchneriella subcapitata were bioprospected and metabolically engineered in simulated wastewater supplemented with glucose to produce neutral lipids. Using a two-step cultivation approach neutral lipid content was enhanced in Chlorella emersonii and Pseudokirchneriella subcapitata biomass. Via in-situ transesterification, these neutral lipids were subsequently bioconverted to …

College Of Natural Sciences Newsletter, July 2020, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 1. Issue 6

Contents:

Dean’s Update P.1
Awards & Recognition P.2
Interest in Science | Updates P.3
Research Spotlight | Open PRAIRIE P.4
Monthly Photo Series: Books P.5

Temporal And Stoichiometric Patterns Of Algal Stimulation Of Litter-Associated Heterotrophic Microbial Activity, Steven N. Francoeur, Robert K. Neely, Savannah Underwood, Kevin A. Kuehn

Faculty Publications

1. Periphyton communities associated with submerged plant detritus contain interacting autotrophic and heterotrophic microbes, and are sites of extracellular enzymatic activity. The strength and nature of these interactions might be expected to change over time as microbial communities develop on plant litter. Microbial interactions and enzymatic activity can be altered by nutrient availability, suggesting that litter stoichiometry could also affect these phenomena.
2. We grew wetland plants under ambient and nutrient‐enriched conditions to generate plant litter of differing nutrient content. In two experiments, we investigated: (1) the influence of algal photosynthesis on fungal and bacterial production and the activities of four extracellular …

Isolation And Characterization Of Bacteriophages Infecting Enterobacter Cloacae To Reduce Bloater Defect In Cucumber Fermentations, Samantha Thompson

Master of Science in Integrative Biology Theses

Fermented cucumbers are one of the most important fermented vegetables consumed worldwide. During cucumber fermentations, certain undesirable changes may occur. One of such changes is known as bloater defect (hollow cavities in fermented cucumbers), which is primarily caused by gas-producing bacteria including Enterobacter cloacae. Bloater defect lowers product quality and leads to significant economic loss to the pickle industry, and effective preventative methods are needed. Bacteriophages (phages) are highly host-specific bacteria killers. Use of phages to control unwanted bacteria in foods is a promising approach because phages do not change food properties. The goals of this research were to …

Inactivation Of Hippo And Cjun-N-Terminal Kinase (Jnk) Signaling Mitigate Fus Mediated Neurodegeneration In-Vivo, Ankita Sarkar, Abijeet Singh Mehta, Prajakta Deshpande, Madhuri Kango-Singh, Udai Bhan Pandey, Amit Singh

Biology Faculty Publications

Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which plays a crucial role in regulating different aspects of RNA metabolism. Targeted misexpression of FUS in Drosophila model recapitulates several interesting phenotypes relevant to ALS including cytoplasmic mislocalization, defects at the neuromuscular junction and motor dysfunction. We screened for the genetic modifiers of human FUS-mediated neurodegenerative phenotype using molecularly …

Parenteral Lipids Shape Gut Bile Acid Pools And Microbiota Profiles In The Prevention Of Cholestasis In Preterm Pigs, Lee Call, Tiffany Molina, Barbara Stoll, Greg Guthrie, Shaji Chacko, Jogchum Plat, Jason Robinson, Sen Lin, Caitlin Vonderohe, Mahmoud Mohammad, Dennis Kunichoff, Stephanie Cruz, Patricio Lau, Muralidhar Premkumar, Jon Nielsen, Zhengfeng Fang, Oluyinka Olutoye, Thomas Thymann, Robert Britton, Per Sangild, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL), a multi component lipid emulsion, SMOFlipid (SMOF), a novel emulsion with a modified fatty-acid composition [experimental emulsion (EXP)], or a control enteral diet (ENT) for 22 days. We assayed serum cholestasis markers, measured total bile acid levels in plasma, liver, and gut contents, and analyzed colonic bacterial 16S rRNA gene sequences and metabolomic profiles. Serum cholestasis markers (i.e., bilirubin, bile acids, …

Towards A Safe And Sustainable Industry Of Ship Breaking: International Initiatives And South Asian Response, Ishtiaque Ahmed

Journal of Maritime Law and Commerce

No abstract provided.

St. Norbert College Magazine Spring/Summer 2020, St. Norbert College

St. Norbert College Magazine 2019-2023

The home page of Spring/Summer 2020 St. Norbert College Magazine.

Women And (In)Justice: The Effects Of Employer Implicit Bias And Judicial Discretion On Title Vii Plaintiffs, Kya Rose Coletta

UC Law Business Journal

Current disparate treatment jurisprudence requires a plaintiff to prove that her employer intentionally discriminated based on sex, ignoring the social cognitive view that emphasizes the role of unconscious, unintentional mental processes. Women are unable to reach the top- tiers of the legal profession, like partnership, due to employers’ deeply engrained biases that emerge during assignment distribution and performance evaluations. This Note challenges that dominant approach, arguing that disparate treatment liability should turn on proof of actuation rather than evidence of intentionality. This Note presents a prescriptive discussion of how employers can implement compliance measures to prevent implicit bias in decision-making …

Federal Right To Try Act: Heightened Informed Consent And Price Regulation Measures Will Improve Quality, Autonomy, And Exploitation Issues, Brenda Lin

UC Law Business Journal

This Note will examine the federal Right to Try Act, which was enacted on May 30, 2018. The federal statute followed the passage of Right to Try legislation in thirty-eight states, including California. Much controversy has surrounded “Right to Try” as an alternative to preexisting pathways to investigational drug treatments, such as traditional clinical trials and the FDA-regulated Expanded Access program, also commonly known as “Compassionate Use.”

This Note will examine those criticisms, evaluate the federal Right to Try Act, and propose amendments through the lenses of health care quality, patient autonomy, and long-term scientific innovation. Some controversy stems from …

Gut Microbiomes Of Sympatric Amazonian Wood-Eating Catfishes (Loricariidae) Reflect Host Identity And Little Role In Wood Digestion, Mark Mccauley, Donovan P. German, Nathan K. Lujan, Colin R. Jackson

Faculty and Student Publications

© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. Neotropical wood-eating catfishes (family Loricariidae) can occur in diverse assemblages with multiple genera and species feeding on the same woody detritus. As such, they present an intriguing system in which to examine the influence of host species identity on the vertebrate gut microbiome as well as to determine the potential role of gut bacteria in wood digestion. We characterized the gut microbiome of two co-occurring catfish genera and four species: Panaqolus albomaculatus, Panaqolus gnomus, Panaqolus nocturnus, and Panaque bathyphilus, as well as that of submerged wood …

The Effects Of Recasting On The Cytotoxicity Of Dental Base Metal Casting Alloys, B. Nandish, K. Jayaprakash, Harish Shetty, Sowmya Rao

Open Access archive

Aim and Objectives: In dentistry, base metal casting alloys are extensively used for the fabrication of inlays, onlays, crowns, bridges, partial dentures, etc. During the casting of these alloys, excess amount of material used than needed will be collected as sprue buttons at the end, which is either added to the fresh alloy during casting and reused or disposed of. Materials and Methods: The aim of the present in vitro experimental study was to investigate the effect of the complete recasting of four commercially available cobalt-chromium (Co-Cr) and nickel-chromium (Ni-Cr) base metal casting alloys on their cytotoxicity. During the study, …

Evaluation Of Vascular Endothelial Growth Factor - A Release From Platelet-Rich Fibrin, Platelet-Rich Fibrin Matrix, And Dental Pulp At Different Time Intervals, Shruthi Nagaraja, Sylvia Mathew, Anil Abraham, Poornima Ramesh

Open Access archive

Background: Lack of collateral blood supply and the low compliance environment of pulp makes its healing, a challenge. Vascular endothelial growth factor (VEGF) is a primary angiogenic growth factor. Knowledge of dose and time-dependent expression of VEGF from platelet concentrates, namely platelet-rich fibrin (PRF) and PRF matrix (PRFM), along with vital pulp can aid in developing strategies to improve the outcome of vital pulp therapy and regenerative procedures. Hence, the aim of this study was to compare VEGF kinetics of PRF, PRFM, and dental pulp. Materials and Methods: The PRF, PRFM, and vital dental pulp were placed in culture media …

Clinical And Therapeutic Implications Of Sex Steroid Hormone Receptor Status In Urothelial Bladder Cancer, H. Krishna Moorthy, G. G.Laxman Prabhu, P. Venugopal

Open Access archive

Studies on the clinical profile of urothelial bladder cancer (UBC) have shown significant gender differences, namely, higher occurrence in males (male-to-female ratio of 3.5:1) and an advanced stage of disease at the time of diagnosis with rapid progression of the disease after initial diagnosis seen more commonly in females. The relationship between gender and UBC is complex and probably influenced by biological and epidemiological factors. Potential contributory factors such as sex steroid hormone pathway, gender difference in environmental carcinogen exposure, metabolic enzyme activity, and disparities in the intensity of diagnostic evaluation could probably explain the demographic trends in UBC. This …

Solid Dosage Forms: A Detailed Research On Non-Conforming Product Quality, G. Katta Hemanth, U. Ravindra Shenoy, Girish Thunga, Sudeep Kumar Agrawal

Open Access archive

Introduction: Any defects in pharmaceutical products lead to minor, major, or critical deviation and if such a product is released, it also leads to product recalls and legal actions. In such cases, the concern is about patient’s safety rather than the company’s economy and fame. This study aimed to investigate the various quality defects which have occurred in marketed tablets. Materials and Methods: The investigation was carried out which involved identification of defects, categorizing the type, root causes, suggesting remedial measures and documenting the clinical significance of defective dosage forms of tablets. Dosage forms included were film-coated tablets, uncoated tablets, …

Novel Validated Uv Spectroscopic Method For Routine Analysis Of Decitabine Drug Substance, Ankit Awasthi, H. M. Dheeraj, Muddukrishna Badamane Sathyanarayana

Open Access archive

Objectives: In the proposed study, a basic, novel, protected economic, delicate and cost-effective UV-Spectrophotometric technique for the analysis of Decitabine which is antineoplastic drug. Methods: The created method was approved according to ICH rules. The decitabine indicated maximum absorption at 221 nm. This strategy can successfully apply for estimation of Decitabine in active pharmaceutical ingredient (API) form for routine examination with UV identification at 221 nm. A Shimadzu UV-Visible spectrophotometer 1800 with 1 cm quartz cells and Acetonitrile (ACN) as diluent was utilized in this technique. Results: The Developed technique obeyed Beer's-Lambert's law in the conc. of 5.0-15.0 ug/ml, having …

Synthesis, Antioxidant And Anticancer Activity Of New Quinoline-[1, 2, 4]-Triazole Hybrids, Hemant Hegde, Santosh L. Gaonkar, Naveen P. Badiger, Nitinkumar S. Shetty

Open Access archive

A set of quinoline coupled triazole derivatives was synthesized using substituted quinoline hydrazide and isothiocyanate derivatives. The structures of the synthesized molecules were confirmed using spectral techniques like FTIR,1H &13C NMR spectroscopy. Novel triazole thione derivatives were subjected to anticancer and antioxidant activity. The studies revealed the moderate anticancer activity of the molecules but have shown potent antioxidant activity.

A Learner Centered Approach Of Teaching And Learning In Pharmacology: A Questionnaire Based Analysis Of Student Cognizance And Experiences, Rashmi Raghava Rao, Preethi Jnaneshwara Shenoy, Sheetal Dinakar Ullal, Ashwin Kamath

Open Access archive

Background: Innovative and flexible educational methods like Problem Based Learning (PBL) and integrated teaching practices were integrated into the Pharmacology course in a manner that they complement the didactic lectures or, completely replace the lecture classes with the aim to optimize the educational atmosphere for a better learner experience. Aim: The present study is an attempt to gather feedback on newer teaching learning methods and audiovisual aids employed during the didactic lectures and small group teaching sessions newly introduced into the curriculum. Methods: The study is a cross sectional questionnaire-based analysis. The questionnaires were distributed to the second-year medical students …

Guidelines For Various Laboratory Sections In View Of Covid-19: Recommendations From The Indian Association Of Pathologists And Microbiologists, Vatsala Misra, Ranjan Agrawal, Harendra Kumar, Asaranti Kar

Open Access archive

Declared as a pandemic by WHO on March 11, 2020, COVID-19 has brought about a dramatic change in the working of different laboratories across the country. Diagnostic laboratories testing different types of samples play a vital role in the treatment management. Irrespective of their size, each laboratory has to follow strict biosafety guidelines. Different sections of the laboratory receive samples that are variably infectious. Each sample needs to undergo a proper and well-designed processing system so that the personnel involved are not infected and also their close contacts. It takes a huge effort so as to limit the risk of …

The Plausible Role Of Deep Cervical Fascia And Its Continuum In Chronic Craniofacial And Cervicobrachial Pain: A Case Report, Prabu Raja G, Shifra Fernandes, Antony Marie Cruz, Anupama Prabhu

Open Access archive

Background: The painful conditions of the Upper quarter region (UQR) such as chronic Craniofacial Pain (CFP) and Cervicobrachial Pain (CBP) usually occur with a plethora of symptoms. Although biological and psychosocial factors are attributed to such conditions, the involvement of the Deep Cervical Fascia (DCF) is ambiguous and needs further exploration. Objective: We reported a case of CFP and CBP with an intent to showcase the possible involvement of impaired DCF in such presentations and to explore the short-term effect of Fascia directed approach (Fascial Manipulation). Methods: This is a report of a 25-year-old female college student with chronic head, …

Pediatric Dosage Forms-Challenges And Recent Developments: A Critical Review, Amol Dattatreya Galande, Naveen Ahuja Khurana, Srinivas Mutalik

Open Access archive

Pediatric population is a diverse group comprising of different subgroups. The use of unlicensed and off-label medicines for treating children is widespread due to the non-availability of suitable dosage forms for this age group. Although the physiological differences related to the diverse age group remain an important consideration, various other challenges such as insufficient background information on drug molecule, excipient safety, taste-masking issues, technology requirements, low profitability, limitations in conduct of clinical trials, and lack of regulatory clarity are also important factors adversely affecting pediatric dosage form development. These factors are discussed in this review. Liquids are the most preferred …

Quantitative Proteomics Of Urinary Bladder Cancer Cell Lines Identify Uap1 As A Potential Therapeutic Target, Vinuth N. Puttamallesh, Barnali Deb, Kirti Gondkar, Ankit Jain

Open Access archive

Bladder carcinoma (BC) incidence and mortality rates are increasing worldwide. The development of novel therapeutic strategies is required to improve clinical management of this cancer. Aberrant protein expression may lead to cancer initiation and progression. Therefore, the identification of these potential protein targets and limiting their expression levels would provide alternative treatment options. In this study, we utilized a liquid-chromatography tandem mass spectrometry-based global proteomics approach to identify differentially expressed proteins in bladder cancer cell lines. A total of 3913 proteins were identified in this study, of which 479 proteins were overexpressed and 141 proteins were downregulated in 4 out …

Fracture Resistance Of Teeth Obturated With Two Different Types Of Mineral Trioxide Aggregate Cements, Nidambur Vasudev Ballal, Sheetal Rao, Junsang Yoo, Kishore Ginjupalli

Open Access archive

Objective: Endodontically obturated teeth have lower fracture resistance depending on the obturating material and technique. The purpose of this study was therefore to evaluate the influence of ProRoot MTA (Dentsply Sirona, Tulsa Division) and OrthoMTA III (BioMTA, Daejeon, Korea) as an obturating material on the fracture resistance of endodontically treated teeth. Material and Methods: Thirty extracted human maxillary central incisors were decoronated and instrumented using Protaper instruments (size F5). Irrigation was performed with 2.5% sodium hypochlorite between each instrument change followed by 7% maleic acid for one minute. Finally, canals were flushed with 5 ml of PBS solution for one …

Nasal Conveyance Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Strains Among Dental Professionals With Varying Levels Of Clinical Exposure: A Comparative Study, Nandita Subba Rao, Prajna Pramod Nayak, K. V.V. Prasad

Open Access archive

Objective: Any control program for MRSA requires identifying the whole hospital reservoir. The likelihood of conveyance of MRSA may be higher in dental settings. Hence, the aim was to compare the nasal conveyance MRSA among dental professionals with varying levels of clinical exposure in a tertiary dental hospital in South India. Methods: A total of 81 volunteers were stratified based on the number of years of clinical exposure. The nasal swabs were subjected to catalase and coagulase tests as well as antibiotic susceptibility test. Chi- Square test was done to compare the different types of organisms isolated from dental professionals …

The Influence Of Human Disturbance On Wildlife Use Of A Highway In South Texas, Thomas J. Yamashita

Theses and Dissertations

Roads can greatly impact wildlife. Wildlife vehicle collisions contribute to population declines while disturbance from human activity may prevent wildlife from using areas around roads. The construction of mitigation structures may lessen these effects through fine scale modification of animal use of roadside areas. In this thesis, how the construction of wildlife mitigation structures impacted the fine scale distribution of wildlife on State Highway 100 in Cameron County, Texas was examined. Spatial and temporal scale may also influence these relationships. The relationship between human activity and wildlife activity around the highway was explored and how the distribution of wildlife road …

C1q/Tnf-Related Protein 5 Contributes To Diabetic Vascular Endothelium Dysfunction Through Promoting Nox-1 Signaling., Jing Liu, Zhijun Meng, Lu Gan, Rui Guo, Jia Gao, Caihong Liu, Di Zhu, Demin Liu, Ling Zhang, Zhen Zhang, Dina Xie, Xiangying Jiao, Wayne Bond Lau, Bernard L. Lopez, Theodore A. Christopher, Xin-Liang Ma, Jimin Cao, Yajing Wang

Department of Emergency Medicine Faculty Papers

OBJECTIVE: Dysregulated adipokine profiles contribute to the pathogenesis of diabetic cardiovascular complications. Endothelial cell (EC) dysfunction, a common pathological alteration in cardiovascular disorders, is exaggerated in diabetes. However, it is unclear whether and how dysregulated adipokines may contribute to diabetic EC dysfunction.

METHODS AND RESULTS: Serum C1q/TNF-Related Protein 5 (CTRP5) were determined in control/diabetes patients, and control/diabetic mice (high-fat diet, HFD). We observed for the first time that serum total CTRP5 was increased, high molecular weight (HMW) form was decreased, but the globular form (gCTRP5) was significantly increased in diabetic patients. These pathological alterations were reproduced in diabetic mice. To …

Technology Attributes, Organizational Learning Attributes, Service Attributes, And Electronic Health Record Implementation Success, Anuradha Rangarajan

All-Inclusive List of Electronic Theses and Dissertations

Electronic Health Record (EHR) is a technology innovation which has the potential to offer valuable benefits to the healthcare industry such as improved quality of patient care and safety, optimization of healthcare workflow processes and availability of electronic data for clinical research. The implementation success of EHR is therefore significant to the healthcare industry in the United States and around the world. Prior studies in research literature have considered the impact of technology attributes, organizational learning attributes, and service attributes on information technology implementations in various other domains based on theories such as Theory of Reasoned Action (TRA), Theory of …

Retaining Moroccan Millennials To The Workplace, Omaima Hajjami

All-Inclusive List of Electronic Theses and Dissertations

The focus of this present study is to understand the factors that influence Moroccan millennial employees to stay at or to leave their organizations. To reach this purpose, the study followed a qualitative phenomenological research design, using interviews as a data collection type. Interviews were conducted with ten Moroccan millennials who have worked or still work in a private organization based in Casablanca, the economic capital of Morocco. Findings of this study discovered five factors that influenced Moroccan millennials to stay, including links with co-workers, good leadership style, responsibilities and tasks, training opportunities, and career advancement. Additionally, five factors were …