Digital Commons Network^™

An Investigation Of Motivational Dysfunctions In A Rat Model Of Effort-Related Choice Behavior: Behavioral And Neurochemical Evidence For Possible Novel Pharmacological Treatments, Renee A. Rotolo

Doctoral Dissertations

Motivational symptoms such as fatigue, anergia, and amotivation are seen in depression, Parkinson’s disease, schizophrenia, and other disorders. These symptoms are often left untreated by the most frequently prescribed antidepressants, which typically block serotonin transport. Considerable evidence implicates brain dopamine (DA) in the regulation of behavioral activation and effort-related aspects of motivation. Animal studies of effort-based choice are being used to provide formal models of motivational dysfunctions in humans. Drugs that block DA transport (DAT) are able to reverse the effort-related effects of the vesicular monoamine transport inhibitor tetrabenazine, a drug that blocks DA storage and depletes DA. Many of …

Animal Science E-Newsletter, July 2020, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

Chronic Thromboembolic Pulmonary Hypertension, Alyssa Curry

Nursing Student Class Projects (Formerly MSN)

Chronic pulmonary hypertension (CTEPH) is a rare and underdiagnosed complication of unresolved acute pulmonary embolism (PE). A chronic fibrotic thrombus replaces the unresolved emboli in the pulmonary vascular bed causing pre-capillary pulmonary hypertension (Mahmud et al., 2018). Symptoms rang from mild nonspecific such as exercise intolerance and dyspnea. As the disease progresses, symptoms present similarly to right ventricular heart failure (Gopalan et al., 2016). Although the pathophysiology and etiology of CTEPH is still not fully understood, risk factors include increased size of the PE, right ventricular strain, chronic inflammation, and defects in fibrinolysis among others (Fernandes et al., 2016). Treatment …

The Florida Radiation Oncology Resident Experience During Coronavirus Disease 2019: Perspectives And Recommendations., Homan Mohammadi, Alexandra N. De Leo, David Asher, Timothy D. Malouff, Mark R. Waddle, Nicholas B. Figura, Nirav V. Patel, James E. Bates, Akash D. Parekh

All publications

No abstract provided.

A Comparison Between Rectal Dose In Prostate Radiotherapy Patients Treated With Spaceoar Hydrogel Present Versus Patients Treated Without Spaceoar Hydrogel., David Desano

Masters Projects

Introduction: External beam radiation therapy is a common treatment option for prostate cancer patients with localized disease. Radiation-induced side effects associated with the rectum can impact a patient’s ability to complete treatment or affect the quality of life years after radiation treatment. Spaceoar hydrogel has been developed to reduce radiation dose to nearby pelvis structures, and therefore decreasing potential side effects.

Methods: A total of 20 patients who received definitive radiation therapy to the prostate and seminal vesicles were selected and placed into 2 groups (10 spaceoar, 10 non-spaceoar). The individuals’ age ranged from 60 to 79 years old with …

The Concept, Design, Implementation, And Assessment Of Case-Based Learning In An Information Literacy Classroom, Junli Diao

Publications and Research

Case-Based Learning (CBL) is a popular and successful teaching method used for a long time in disciplines such as medicine, business, law, and computer science. In the past decade, there has been a trend to introduce CBL into library instructions as an active teaching approach in the field of library and information science. Although a few studies have been conducted to investigate the advantages of this teaching technique in the library and information science literature, there remains a substantial absence of first-hand instructional experiences and observations from academic librarians who are actively teaching information literacy. This article presents a personal …

Secretion Of Proteins And Antibody Fragments From Transiently Transfected Endothelial Progenitor Cells, Loree Heller, Reynald Thinard, Melanie Chevalier, Sezgi Arpag, Yu Jing, Ruth Greferath, Richard Heller, Claude Nicolau

Bioelectrics Publications

In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood-brain barrier (BBB) breakdown. After intravenous or intra-arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Here, we demonstrate that EPC transfection by electroporation with plasmids encoding the reporter protein GFP or an anti-beta-amyloid antibody fragment (Fab) leads to secretion of each protein. We also demonstrate the secreted anti-beta-amyloid Fab protein functions in beta-amyloid aggregate solubilization.

Recombinase-Mediated Integration Of A Multigene Cassette In Rice Leads To Stable Expression And Inheritance Of The Stacked Locus, Bhuvan Pathak, Vibha Srivastava

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Efficient methods for multigene transformation are important for developing novel crop varieties. Methods based on random integrations of multiple genes have been successfully used for metabolic engineering in plants. However, efficiency of co-integration and co-expression of the genes could present a bottleneck. Recombinase-mediated integration into the engineered target sites is arguably a more efficient method of targeted integration that leads to the generation of stable transgenic lines at a high rate. This method has the potential to streamline multigene transformation for metabolic engineering and trait stacking in plants. Therefore, empirical testing of transgene(s) stability from the multigene site-specific integration locus …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Nighttime Blood Pressure Interacts With Apoe Genotype To Increase The Risk Of Incident Dementia Of The Alzheimer’S Type In Hispanics, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Ciro Gaona, Carlos A. Chavez, Gustavo E. Calmon, Egle R. Silva, Gabriel A. De Erausquin, Mario Gil, Luis J. Mena, Joseph D. Terwilliger, Humberto Arboleda, Nikolaos Scarmeas, Joseph H. Lee, Gladys E. Maestre

School of Medicine Publications

Background: Dementia of the Alzheimer’s type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics.

Objective: To investigate the association of APOE ɛ4 and BP levels, measures with 24 h ambulatory BP monitoring, with incidence of DAT in an elderly cohort of Hispanics.

Methods:1,320 participants from the Maracaibo Aging Study, free of dementia at the baseline, and with ambulatory BP …

Not The First But The Second, Richard E. Bennett

BYU Studies

Professor James B. Allen, distinguished scholar of Joseph Smith’s First Vision accounts, wrote the following in a 2012 article: “The writing of Mormon history has only begun. As in the case of other institutions and movements, there is still room in Mormonism for fresh historical scholarship. . . . What is needed, simply, is the sympathetic historian who can approach his tradition with scholarship as well as faith and who will make fresh appraisal of the development of the Mormon mind.”1 The purpose of this presentation is to provide such a “fresh appraisal” of Joseph Smith’s 1820 theophany, less perhaps …

Western Michigan University Magazine, Spring/Summer 2020, Western Michigan University

Western Michigan University Magazine (1997-present)

• University News
• Uncharted Waters: Campus community navigates unprecedented shift to distance learning
• Unique Collection: University Libraries acquires David Small and Sarah Stewart archive
• Alumni Profiles
• Product design students envisioning future of mobility with Eaton partnership
• For the birds: Avian adventures at Asylum Lake Preserve
• Student aviation opportunities take off with launch of Aviate partnership
• Community Collaborations
• Renewable energy researchers at WMU receive $9.6 million grant
• Figures of speech: Instructor helps Kalamazoo TV anchor recover his voice
• Taboo topics course uses dialogue to break through barriers
• Classnotes
• In Memoriam

5-Ht Receptor Subtype May Mediate Crh Production In Hypothalamus, Bailey Underwood

Lawrence University Honors Projects

Increased levels of corticotropin releasing hormone (CRH) are associated with anxiety, as are decreased levels of serotonin (5-HT). Do 5-HT levels influence CRH production and anxiety? The ventral hippocampus is associated with anxiety behavior, contains cells expressing 5-HT receptors (including 5HT7R), and extends axons into CRH producing regions of the hypothalamus (Jalewa et al., 2014; Jiminez et al., 2018). Therefore, 5-HT responsive neurons may play a role in the anxiety response and CRH production. To analyze how 5-HT may influence anxiety, 5dpf Danio rerio were examined following application of a 5-HT7R agonist (AS-19) and antagonist (SB-258179). A distance assay was …

Intraspecific And Biogeographical Variation In Foliar Fungal Communities And Pathogen Damage Of Native And Invasive Phragmites Australis, Warwick J. Allen, Aaron E. Devries, Nicholas J. Bologna, Wesley A. Bickford, Kurt P. Kowalski, Laura A. Meyerson, James T. Cronin

Faculty Publications

© 2020 John Wiley & Sons Ltd Aim: Recent research has highlighted that the relationship between species interactions and latitude can differ between native and invasive plant taxa, generating biogeographical heterogeneity in community resistance to plant invasions. In the first study with foliar pathogens, we tested whether co-occurring native and invasive lineages of common reed (Phragmites australis) exhibit non-parallel latitudinal gradients in foliar fungal communities, pathogen susceptibility and damage, and whether these biogeographical patterns can influence the success of invasion. Location: North America. Time period: 2015–2017. Major taxa studied: Perennial grass P. australis. Methods: We surveyed 35 P. australis field …

Dynamic Glucose Disposal Is Driven By Reduced Endogenous Glucose Production In Response To Voluntary Wheel Running: A Stable Isotope Approach, Timothy D. Allerton, Greg M. Kowalski, Hardy Hang, Jacqueline Stephens

Faculty Publications

© 2020 the American Physiological Society. Dynamic glucose disposal is driven by reduced endogenous glucose production in response to voluntary wheel running: A stable isotope approach. Am J Physiol Endocrinol Metab 319: E2-E10, 2020. First published April 28, 2020; doi:10.1152/ajpendo.00450.2019.-To resolve both the systems level and molecular mechanisms responsible for exerciseinduced improvements in glucose tolerance, we sought to test the effect of voluntary wheel running exercise on postprandial glucose dynamics. We utilized a stable isotope-labeled oral glucose tolerance test (SI-OGTT) incorporating complementary deuterium glucose tracers at a 1:1 ratio (2-2H-glucose and 6-6 2H-glucose; 2g/kg lean body mass) to distinguish between …

Toward Standard Interpreter Education Program Admission Criteria, Marc Holmes

International Journal of Interpreter Education

In the United States,signed language interpreter education programs (IEPs) must strike a balance between attracting a sufficient number of students and admitting only high-quality applicants who possess foundational language skills,can graduate in a timely manner and acquire professional credentials expediently. The Commission on Collegiate Interpreter Education (2014) asserts that all students entering U.S. IEPs should have strong language skills in both American Sign Language(ASL)and English before beginning to acquire interpreting skills. One way to measure a student’s readiness to enter a program of instruction is through the use of admission criteria. I examined online documents and surveyed52 baccalaureate-granting IEPs in …

Undergraduate And Graduate Course Descriptions, 2020 Summer, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Spring 2020.

High Diversity Of Testate Amoebae (Amoebozoa, Arcellinida) Detected By Hts Analyses In A New England Fen Using Newly Designed Taxon-Specific Primers, Alistaire Ruggiero, Jean David Grattepanche, Agnes K.M. Weiner, Laura A. Katz

Biological Sciences: Faculty Publications

Testate (shell-building) amoebae, such as the Arcellinida (Amoebozoa), are useful bioindicators for climate change. Though past work has relied on morphological analyses to characterize Arcellinida diversity, genetic analyses revealed the presence of multiple cryptic species underlying morphospecies. Here, we design and deploy Arcellinida-specific primers for the SSU-rDNA gene to assess the community composition on the molecular level in a pilot study of two samplings from a New England fen: (1) 36-cm horizontal transects and vertical cores; and (2) 26-m horizontal transects fractioned into four size classes (2–10, 10–35, 35–100, and 100–300 μm). Analyses of these data show the following: (1) …

Global Resting-State Functional Connectivity Of Neural Oscillations In Tinnitus With And Without Hearing Loss, Carly Demopoulos, Xuan Duong, Leighton B. Hinkley, Kamalini G. Ranasinghe, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Jennifer Henderson-Sabes, Anne Findlay, Caroline Racine-Belkoura, Steven W. Cheung, Srikantan S. Nagarajan

All Faculty Scholarship

This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus …

Using The Technology Acceptance Model To Analyze K–12 Students’ Behavioral Intention To Use Augmented Reality In Learning, Lei Ping, Yan Liu

Teaching and Learning Faculty Research

Augmented reality (AR) has gained popularity in K-12 education in the past decades; researchers and educators generally agree that AR is a useful pedagogical tool in teaching because it is grounded on efficient teaching and learning models such as constructivist learning, situated learning, and inquiry-based learning. Research on AR in the K-12 context tends to focus on its impact on learning processes and outcomes. However, it is essential to understand K-12 students’ behavioral intentions of use for AR—their perceptions of usefulness, ease of use, and enjoyment—so that teachers can better design and integrate AR-based learning into their courses. Guided by …

The Response Of Synechococcus Sp. Pcc 7002 To Micro-/Nano Polyethylene Particles - Investigation Of A Key Anthropogenic Stressor, Mary C. Machado, Gina V. Vimbela, Tania T. Silva-Oliveira, Arijit Bose, Anubhav Tripathi

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Microplastics or plastic particles less than 5 mm in size are a ubiquitous and damaging pol- lutant in the marine environment. However, the interactions between these plastic particles and marine microorganisms are just starting to be understood. The objective of this study was to measure the responses of a characteristic marine organism (Synechococcus sp. PCC 7002) to an anthropogenic stressor (polyethelene nanoparticles and microparticles) using molecular techniques. This investigation showed that polyethylene microparticles and nanoparticles have genetic, enzymatic and morphological effects on Synechococcus sp. PCC 7002. An RT-PCR analysis showed increases in the expression of esterase and hydro- lase genes …

The Importance Of Trauma-Informed Practices In Schools, Heather French

Master's Theses & Capstone Projects

Students who have been exposed to trauma may face social/emotional, behavioral, or cognitive developmental delays, poor health, problems in school, and mental health issues. These effects may last into adulthood. The intent of a trauma-informed school approach is to break the cycle of trauma by identifying trauma in students, providing support and interventions to help students cope and heal, and helping prevent future trauma. In order to meet these standards, schools need to collaborate with families and mental health professionals. Teachers need the proper training in trauma recognition to be able to provide an environment for all students to feel …

Louisiana Agriculture Summer, 2020, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Southeast- Summer 2020, Lsu Agcenter

Horticulture Hints

No abstract provided.

Comparison Of Chemotherapeutic Activities Of Rhodamine-Based Gumbos And Nanogumbos, Nimisha Bhattarai, Mi Chen, Rocío L. Pérez, Sudhir Ravula, Robert M. Strongin, Karen Mcdonough, Isiah M. Warner

Faculty Publications

© 2020 by the authors. Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties that result from their lipophilic cationic structures. In previous research, we have found that conversion of Rhodamine 6G into nanoGUMBOS, i.e., nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS), led to selective chemotherapeutic toxicity for cancer cells over normal cells. Herein, we investigate the chemotherapeutic activity of GUMBOS derived from four different rhodamine derivatives, two bearing an ester group, i.e., Rhodamine 123 (R123) and SNAFR-5, and two bearing a carboxylic acid group, i.e., rhodamine 110 (R110) and …

Sixty-First Supplement To The American Ornithological Society's Check-List Of North American Birds, R. Terry Chesser, Shawn M. Billerman, Kevin J. Burns, Carla Cicero, Jon L. Dunn, Andrew W. Kratter, Irby J. Lovette, Nicholas A. Mason, Pamela C. Rasmussen, J. V. Remsen, Douglas F. Stotz, Kevin Winker

Faculty Publications

No abstract provided.

Frequent Fire Slows Microbial Decomposition Of Newly Deposited Fine Fuels In A Pyrophilic Ecosystem, Jacob R. Hopkins, Jean M. Huffman, William J. Platt, Benjamin A. Sikes

Faculty Publications

© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Frequent fires maintain nearly 50% of terrestrial ecosystems, and drive ecosystem changes that govern future fires. Since fires are dependent on available plant or fine fuels, ecosystem processes that alter fine fuel loads like microbial decomposition are particularly important and could modify future fires. We hypothesized that variation in short-term fire history would influence fuel dynamics in such ecosystems. We predicted that frequent fires within a short-time period would slow microbial decomposition of new fine fuels. We expected that fire effects would differ based on dominant substrates and that fire history …

Mitochondrial Genomes And Thousands Of Ultraconserved Elements Resolve The Taxonomy And Historical Biogeography Of The Euphonia And Chlorophonia Finches (Passeriformes: Fringillidae), Tyler S. Imfeld, F. Keith Barker, Robb T. Brumfield

Faculty Publications

© 2020 American Ornithological Society. Relationships of the Neotropical finches in the genera Euphonia and Chlorophonia (Fringillidae: Euphoniinae) have been clarified by recent molecular studies, but species-level relationships within this group have not been thoroughly addressed. In this study, we sampled specimens representing every recognized species of these genera, in addition to 2 outgroup taxa, and used target enrichment to sequence thousands of ultraconserved element (UCE) loci, as well as mitochondrial DNA reconstructed from off-target reads, from each specimen to infer these relationships. We constructed both concatenation and coalescent-based estimates of phylogeny from this dataset using matrices of varying levels …

Effects Of Hurricane Harvey On The Trophic Status Of Juvenile Sport Fishes (Cynoscion Nebulosus, Sciaenops Ocellatus) In An Estuarine Nursery, Philip Matich, Kaya B. Moore, Jeffrey D. Plumlee

Faculty Publications

Understanding the implications of environmental disturbance is of growing importance as climate change and extreme weather events increasingly threaten estuaries and other coastal ecosystems. Among species at risk in estuarine habitats, sport fishes are of particular interest to conservation and management agencies, because of their ecological and economic value. Here, we evaluate the effects of Hurricane Harvey on the abundance, diet, and body condition of age-0 red drum (Sciaenops ocellatus) and spotted seatrout (Cynoscion nebulosus) in Powderhorn Lake, a nearshore estuary in Texas, USA. Catch data from seines indicated that the abundances of age-0 red drum and spotted seatrout were …

Intermittent Fasting And Metabolic Health: From Religious Fast To Time-Restricted Feeding, Kristin K. Hoddy, Kara L. Marlatt, Hatice Çetinkaya, Eric Ravussin

Clinical Research Faculty Publications

Over the past 10 to 15 years, intermittent fasting has emerged as an unconventional approach to reduce body weight and improve metabolic health beyond simple calorie restriction. In this review, we summarize findings related to Ramadan and Sunnah fasting. We then discuss the role of caloric restriction not only as an intervention for weight control, but importantly, as a strategy for healthy aging and longevity. Finally, we review the four most common intermittent fasting (IF) strategies used to date for weight management and to improve cardiometabolic health. Weight loss is common after IF but does not appear to be different …