Digital Commons Network^™

Genome-Wide Association Mapping And Genomic Prediction Of Anther Extrusion In Cimmyt Hybrid Wheat Breeding Program Via Modeling Pedigree, Genomic Relationship, And Interaction With The Environment, Anil Adhikari, Bhoja Raj Basnet, Jose Crossa, Susanne Dreisigacker, Fatima Camarillo, Pradeep Kumar Bhati, Diego Jarquin, Yann Manes, Amir M.H. Ibrahim

Department of Agronomy and Horticulture: Faculty Publications

Anther extrusion (AE) is the most important male floral trait for hybrid wheat seed production. AE is a complex quantitative trait that is difficult to phenotype reliably in field experiments not only due to high genotype-by-environment effects but also due to the short expression window in the field condition. In this study, we conducted a genome-wide association scan (GWAS) and explored the possibility of applying genomic prediction (GP) for AE in the CIMMYT hybrid wheat breeding program. An elite set of male lines (n = 603) were phenotype for anther count (AC) and anther visual score (VS) across three field …

Structural Determinants Of Flavin Dynamics In A Class B Monooxygenase, Ashley C. Campbell, Reeder Robinson, Didier Mena-Aguilar, Pablo Sobrado, John J. Tanner

Chemistry Faculty Research & Creative Works

The ornithine hydroxylase known as SidA is a class B flavin monooxygenase that catalyzes the first step in the biosynthesis of hydroxamate-containing siderophores in Aspergillus fumigatus. Crystallographic studies of SidA revealed that the FAD undergoes dramatic conformational changes between out and in states during the catalytic cycle. We sought insight into the origins and purpose of flavin motion in class B monooxygenases by probing the function of Met101, a residue that contacts the pyrimidine ring of the in FAD. Steady-state kinetic measurements showed that the mutant variant M101A has a 25-fold lower turnover number. Pre-steady-state kinetic measurements, pH profiles, and …

Job Satisfaction Of Library And Information Science Professionals: An Over View, Anand Y. Kenchakkanavar Dr., Santosh M. Chavan Dr.

Library Philosophy and Practice (e-journal)

The library is a growing organism it requires highly skilled and experienced library and information science (LIS) professionals to fulfill requires of the user and for information management. It is also very essential for the professionals to satisfy their own requirements because only satisfied professionals can give new services to the end user. In this research paper, we explore the different literature related to the job satisfaction of Library and Information Science professionals and highlighted essential information. This study examines that to the Library and Information Science professionals’ literature and practice in the following techniques, this study provides new awareness …

Microbial Dark Matter Coming To Light: Challenges And Opportunities, Jian Yu Jiao, Lan Liu, Zheng Shuang Hua, Bao Zhu Fang, En Min Zhou, Nimaichand Salam, Brian P. Hedlund, Wen Jun Li

Life Sciences Faculty Research

Microbes are the most abundant and diverse cellular life forms on Earth and colonize a wide range of environmental niches. However, more than 99% of bacterial and archaeal species have not been obtained in pure culture [1] and we have only glimpsed the surface of this mysterious microbial world. This is so-called Microbial Dark Matter (MDM): the enormous diversity of yet-uncultivated microbes that microbiologists can only study by using cultivation-independent techniques. Recently, a number of international projects have dramatically increased our understanding of the extent and distribution of microbial diversity, including the Global Catalogue of Microorganisms (GCM), the Genomic Encyclopedia …

Keep Calm Or Get Excited? Examining The Effects Of Different Types Of Positive Affect On Responses To Acute Pain, Amanda M. Acevedo, Kate A. Leger, Brooke N. Jenkins, Sarah D. Pressman

Psychology Faculty Articles and Research

Researchers typically assume that all forms of positive affect (PA) are equally beneficial for attenuating the physiological stress response. We tested whether this association is more nuanced by examining the role of arousal level of PA on physiological responses to acute pain. Participants (N = 283, 75.6% female, M_age = 20.6) were randomized to a low, mid, or high arousal (calm, happy, and excited, respectively) induction condition or to a neutral control and then completed an acute pain-inducing cold pressor task. Sympathetic and parasympathetic responses along with self-reported pain and distress were assessed. Results indicated that the calm condition …

An Examination Of Barriers And Determinates Impacting The Healthcare Of Kalamazoo County's Transgender And Non-Binary Young Adult Population, Tyler Signorella

Honors Theses

Historically non-binary and transgender individuals have faced and continue to face a unique set of obstacles and challenges in seeking and receiving general healthcare. Within the US this is well documented on a national level. In this exploratory study we will seek to understand the experience of young adults in Kalamazoo County comparing their perspectives to the already established pool of information. This will be accomplished through surveying emergent adults identifying as either transgender or gender non-binary within Kalamazoo County and then synthesizing this data into an analyzable collective format.

High School Students As Citizen Scientists To Decrease Radon Exposure, Ellen J. Hahn, Craig Wilmhoff, Mary Kay Rayens, Nicholas B. Conley, Emily Morris, Angela Larck, Trista Allen, Susan M. Pinney

Nursing Faculty Publications

Residents in rural Kentucky (KY) and suburban Ohio (OH) expressed concerns about radon exposure and lung cancer. Although 85% of lung cancer cases are caused by tobacco smoke, radon exposure accounts for 10–15% of lung cancer cases. Academic and community members from the University of KY and the University of Cincinnati developed and pilot-tested a family-centered, youth-engaged home radon testing toolkit. The radon toolkit included radon information, and how to test, interpret, and report back findings. We educated youth as citizen scientists and their teachers in human subjects protection and home radon testing using the toolkit in the classroom. Youth …

The Key Glycolytic Enzyme Phosphofructokinase Is Involved In Resistance To Antiplasmodial Glycosides, Gillian M Fisher, Simon A Cobbold, Andrew Jezewski, Emma F Carpenter, Megan Arnold, Annie N Cowell, Erick T Tjhin, Kevin J Saliba, Tina S Skinner-Adams, Marcus C S Lee, Audrey Odom John, Elizabeth A Winzeler, Malcolm J Mcconville, Sally-Ann Poulsen, Katherine T Andrews

Open Access Publications

No abstract provided.

Vessel Trajectory Prediction Using Historical Ais Data, Jagir Laxmichand Charla

Dissertations and Theses

Maritime vessel position coordinates are important information for maritime situational planning and organization. A better estimate of future locations of the maritime vessels, from their current locations, can help maritime authorities to make planned decisions, which can be helpful to avoid traffic congestion and longer waiting times. This thesis develops a method for estimating future locations of the vessels using their current and previous locations and other data.

The motivating scenario for this work is that of determining the future locations of the vessels based on their current location and previous locations for accurate modelling of underwater acoustic noise. As …

Constraints And Affordances Of Online Engagement With Scientific Information—A Literature Review, Friederike Hendriks, Elisabeth Mayweg-Paus, Mark Felton, Kalypso Iordanou, Regina Jucks, Maria Zimmermann

Faculty Research, Scholarly, and Creative Activity

Many urgent problems that societies currently face—from climate change to a global pandemic—require citizens to engage with scientific information as members of democratic societies as well as to solve problems in their personal lives. Most often, to solve their epistemic aims (aims directed at achieving knowledge and understanding) regarding such socio-scientific issues, individuals search for information online, where there exists a multitude of possibly relevant and highly interconnected sources of different perspectives, sometimes providing conflicting information. The paper provides a review of the literature aimed at identifying (a) constraints and affordances that scientific knowledge and the online information environment entail …

A Steroid Receptor Coactivator Stimulator (Mcb-613) Attenuates Adverse Remodeling After Myocardial Infarction, Lisa K Mullany, Aarti D Rohira, John P Leach, Jong H Kim, Tanner O Monroe, Andrea R Ortiz, Brittany Stork, M Waleed Gaber, Poonam Sarkar, Andrew G Sikora, Todd K Rosengart, Brian York, Yongcheng Song, Clifford C Dacso, David M Lonard, James F Martin, Bert W O'Malley

Faculty, Staff and Students Publications

Progressive remodeling of the heart, resulting in cardiomyocyte (CM) loss and increased inflammation, fibrosis, and a progressive decrease in cardiac function, are hallmarks of myocardial infarction (MI)-induced heart failure. We show that MCB-613, a potent small molecule stimulator of steroid receptor coactivators (SRCs) attenuates pathological remodeling post-MI. MCB-613 decreases infarct size, apoptosis, hypertrophy, and fibrosis while maintaining significant cardiac function. MCB-613, when given within hours post MI, induces lasting protection from adverse remodeling concomitant with: 1) inhibition of macrophage inflammatory signaling and interleukin 1 (IL-1) signaling, which attenuates the acute inflammatory response, 2) attenuation of fibroblast differentiation, and 3) promotion …

Wildfire Risk Assessment For A Municipal Watershed In Western Oregon, Usa: Methods For Projecting The Impact Of Mid-21st Century Climate Change On Wildfire Hazard, Andy Mcevoy

Dissertations and Theses

In the western United States, climate change is projected to lead to significant changes in regional wildfire regimes. Historically, forests west of the Cascade crest in Oregon and Washington, USA (westside) have been characterized by low-frequency wildfire events, but climate change projections indicate that wildfire could become a more common disturbance, altering ecological processes and impairing ecosystem services like surface water quality and quantity. Wildfire risk assessments based on simulation models have been used in high frequency fire regimes to evaluate contemporary and future risk, but present unique challenges in westside forests because characteristic low annual burn probabilities result in …

Thermal Time Requirements For Leaf Appearance Of Frontier Balansa Clover, D. P. Monks, D. J. Moot

IGC Proceedings (1977-2023)

No abstract provided.

The Effect Of Rapid Paddock Movement On Yearling Steer Weight Gain And Forage Condition In North‐Central Nebraska, Usa, D. G. Mickey Steward

IGC Proceedings (1977-2023)

No abstract provided.

Two Techniques To Measure Herbage Intake Of Grazing Dairy Cows, Mary Mcevoy, M. O'Donovan, Tommy M. Boland, Luc Delaby

IGC Proceedings (1977-2023)

No abstract provided.

The Effect Of Pre‐Grazing Herbage Mass On Milk Production And Of Dairy Cows In Mid‐Lactation, Mary Mcevoy, M. O'Donovan, Tommy M. Boland, Luc Delaby

IGC Proceedings (1977-2023)

No abstract provided.

Stonewalling And Taking A Break Are Not The Same Thing, Emma Todd Carpenter

Family Perspectives

Marriage research has identified stonewalling, or leaving a conversation without any intention of resolving the issue, as unhealthy and damaging. However, experts also identify taking a break, or alleviating pent-up anger by pausing a conversation to be resolved after calming down as beneficial and effective.

The Adaptations Of Immigrant Chinese American Mothers' Parenting With Their Reticent Young Children, Allie Sharp

Family Perspectives

Maternal warmth, or the expression of affection to a child by their mother both physically and emotionally, can play a critical role in encouraging healthy social development among reticent children, meaning children who are less likely to be social with their peers. However, recent research is beginning to recognize that this maternal warmth, which was typically defined as an open expression of affection, may look differently in other cultures. For example, Chinese parenting is generally rooted in Confucian values, which emphasizes group orientation and collectivism, compared to European American societies that typically promote self-expression and individualism. While cultural contexts may …

A Closer Look: Spotlight On Verse Novels, Kristin Mcilhagga

Michigan Reading Journal

No abstract provided.

Working Together: Women And Men On The Amish Family Farm In 1930s Lancaster County, Pennsylvania, Katherine Jellison, Steven Reschly

Journal of Amish and Plain Anabaptist Studies

Old Order Amish men did not own gasoline tractors or other large power farm implements to amplify their manhood, and Amish women did not own mechanical household appliances to symbolize their feminine role as housekeepers. Rejecting the notion of mechanized, capital-intensive agriculture in favor of traditional, labor-intensive family farming, the Old Order Amish of Lancaster County, Pennsylvania, practiced a system of labor that necessarily required the crossing of strict gender-role boundaries. Although men primarily identified as farmers and women as homemakers, agricultural success among the Amish necessitated a significant degree of cooperation and mutual labor. In the words of one …

Anthropology In Florida, Rhea M. Smith

Florida Historical Quarterly

Any attempt to investigate the origin and customs of the aborigines of Florida through reliance on written materials is almost immediately frustrated by the paucity of such material and the scantiness of data available. Even an attempt to summarize the work done by field investigators leads to the baffling task of trying to reconcile conflicting theories, a condition that arises from the fact that the conclusions reached as to the origin, antiquity, and life of the early peoples of Florida are so indefinite. Yet there are few regions in the United States more abundantly supplied with mounds that call for …

Using An Idiographic Approach To Clients With Health Anxiety, Scott Peters, Christine D. Gonzalez-Wong

Journal of Counseling Research and Practice

Worries about one’s health, while ubiquitous, can for some become quite distressing. Health anxiety occurs when one becomes focused on symptoms and fears they may become ill or die. This often overtakes their life due to continued worry. They often spend an inordinate amount of time and effort to seek answers. Other aspects of their life are placed in the periphery or abandoned. Traditional approaches are aimed at symptom relief. While effective for some, others continue to struggle. A more novel approach that aims to look at the client both holistically and individualistically can address much more than symptom amelioration.

Interleukin-17-Induced Neutrophil Extracellular Traps Mediate Resistance To Checkpoint Blockade In Pancreatic Cancer, Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, Michelle Zoltan, Nivedita Arora, Seyda Baydogan, William Horne, Jared Burks, Hanwen Xu, Perwez Hussain, Huamin Wang, Sonal Gupta, Anirban Maitra, Jennifer M. Bailey, Seyed J. Moghaddam, Sulagna Banerjee, Ismet Sahin, Pratip Bhattacharya

Faculty Publications

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive PDAC is undetermined. We hypothesized that IL17 triggers and sustains PDAC immunosuppression. We inhibited IL17/IL17RA signaling using pharmacological and genetic strategies alongside mass cytometry and multiplex immunofluorescence techniques. We uncovered that IL17 recruits neutrophils, triggers neutrophil extracellular traps (NETs), and excludes cytotoxic CD8 T cells from tumors. Additionally, IL17 blockade increases immune checkpoint blockade (PD-1, CTLA4) sensitivity. Inhibition of neutrophils or Padi4-dependent NETosis phenocopies IL17 neutralization. NMR spectroscopy revealed changes in …

Implementation Of The University Of Louisville Covid-19 Biorepository: Experiences From The Center Of Excellence In Infectious Diseases (Cerid), Dawn Balcom, Leslie A Wolf, Subathra Marimuthu, William Johnson, Danial Malik, Chet Dhakal, Pavani Nathala, Mohammed Abbas, Sahaj Hardeep Singh, Basel Haddad, Rafik Elbeblawy, Fnu Deepti, Ahmed Ali, Evelyn Exposito Gonzalez, Ruth Carrico

The University of Louisville Journal of Respiratory Infections

The limited availability of biological samples from patients testing positive for SARS-CoV-2 for future research was quickly identified at the onset of the COVID-19 pandemic. In response to this need, a COVID-19 biobank was initiated by the University of Louisville Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID). The COVID-19 biobank contains waste samples obtained from patients hospitalized with COVID-19 in any of the nine Louisville, Kentucky, area hospitals during the timeframe of April 13 to September 20, 2020. The COVID-19 biobank stores approximately 1,623 waste samples with 2,127 aliquots for distribution. All samples are …

Intergenerational Trauma, Ruqia Abdirahman

Counselor Education Capstones

The following literature review will explore cumulative research on intergenerational trauma. Although, many communities have encountered massive traumas the research has mainly focused on Canadians First Nations people and Holocaust survivors. The effects of trauma can be multifaceted, impacting an individual’s psychological and emotional well-being across generations. Furthermore, this paper will discuss the impact of intergenerational trauma among various communities, ways trauma transmission occurs, and review of the Intergenerational Trauma Treatment Model.

Optimization Of Electron Beam-Deposited Silver Nanoparticles On Zinc Oxide For Maximally Surface Enhanced Raman Spectroscopy, Andrew L. Cook, Christopher P. Haycook, Andrea K. Locke, Richard R. Mu, Todd D. Giorgio

TIGER Institute Faculty Research

Surface enhanced Raman spectroscopy enables robust, rapid analysis on highly dilute samples. To be useful, the technique needs sensing substrates that will enhance intrinsically weak Raman signals of trace analytes. In particular, three-dimensional substrates such as zinc oxide nanowires decorated with electron-beam deposited silver nanoparticles are easily fabricated and serve the dual need of structural stability and detection sensitivity. However, little has been done to optimize electron beam-deposited silver nanoparticles for maximal surface enhancement in the unique dielectric environment of the zinc oxide substrate. Herein, fabrication and anneal parameters of electron beam-deposited silver nanoparticles were examined for the purpose of …

New York Times Quotes Zoccola On How Teens Use Downtime, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Effect Of Concentrate Supplementation On Milk Production And Cow Traffic In Early And Late Lactation In A Pasture-Based Automatic Milking System, John Shortall, Cathriona Foley, Roy D. Sleator, Bernadette O'Brien

Department of Biological Sciences Publications

The objective of this experiment was to establish the effect of low-concentrate (LC) and high-concentrate (HC) supplementation in the early and late periods of lactation on milk production and cow traffic in a pasture-based automatic milking (AM) system. In total, 40 cows (10 primiparous and 30 multiparous) were randomly assigned to one of the two treatments. The experimental periods for the early and late lactation trials extended from 23 February to 12 April 2015 and 31 August to 18 October 2015, respectively (49 days in each trial period). The early lactation supplement levels were 2.3 and 4.4 kg/cow per day …

Intercultural Communication, Shannon Ahrndt

Open Educational Resources Collection

Intercultural Communication examines culture as a variable in interpersonal and collective communication. It explores the opportunities and problems arising from similarities and differences in communication patterns, processes, and codes among various cultural groups. It explores cultural universals, social categorization, stereotyping and discrimination, with a focus on topics including race, ethnicity, social class, religion, gender and sexuality as they relate to communication.

Minor revisions made January 2024, uploaded 7/26/2024.

Nek1 Phosphorylation Of Yap Promotes Its Stabilization And Transcriptional Output, Md Imtiaz Khalil, Ishita Ghosh, Vibha Singh, Jing Chen, Haining Zhu, Arrigo De Benedetti

Molecular and Cellular Biochemistry Faculty Publications

Most prostate cancer (PCa) deaths result from progressive failure in standard androgen deprivation therapy (ADT), leading to metastatic castration-resistant PCa (mCRPC); however, the mechanism and key players leading to this are not fully understood. While studying the role of tousled-like kinase 1 (TLK1) and never in mitosis gene A (NIMA)-related kinase 1 (NEK1) in a DNA damage response (DDR)-mediated cell cycle arrest in LNCaP cells treated with bicalutamide, we uncovered that overexpression of wt-NEK1 resulted in a rapid conversion to androgen-independent (AI) growth, analogous to what has been observed when YAP1 is overexpressed. We now report that overexpression of wt-NEK1 …