Digital Commons Network^™

Endocrine Significance Of Sars-Cov-2'S Reliance On Ace2, Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis

School of Medicine Faculty Publications

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and …

Catastrophic Cardiac Complications Of Takayasu's Arteritis., Sara Godil Md, Bilal Saqi Md, Kareem Godil Md, Syed Rafay Ali Sabzwari, Yasotha Rajeswaran Md

Department of Medicine

Takayasu's arteritis (TA) causes inflammation and necrosis of vessel walls, leading to aneurysm formation, extensive coronary damage and valvular abnormalities. We review a case of recurrent coronary, aortic and mitral valve involvement in a patient with TA and discuss the various treatment options available for such patients.

Strong But Sidelined: A Call For The Elimination Of The Contact Sport Exception Through The Lens Of Title Vii’S Disparate Treatment Analysis, Katlynn Dee

DePaul Law Review

No abstract provided.

Contribution Of Velocity Congruency And Apparent Stiffness To Interference Of Bimanual Rhythmic-Discrete Movements., Marcelline E. Dechenaud

LSU Master's Theses

Many actions feature rhythmic and discrete movements, individually or in combinations. Rhythmic movements are defined as those having no clearly defined start and end-point, while discrete movements have a definite starting and ending posture. Performing a discrete movement against a base rhythm by the contralateral limb typically speeds up the rhythmic movement -- indicating the presence of bimanual coupling. While bimanual rhythmic/rhythmic interaction has been studied extensively in the field, understanding of the interaction between discrete and rhythmic movements has been less represented. In this thesis, I examined two potential sources of interlimb interference during rhythmic-discrete bimanual actions: 1) velocity …

Solvation Structures And Dynamics Of Small Molecules: Experimental And Computational Studies Using Carbonyl Vibrational Modes As Probe, Xiaoliu Zhang

LSU Doctoral Dissertations

Solutions are ubiquitous in both the global environment and the human body, and play a significant role in scientific research and industrial production. The structures and dynamics of solutions have been studied for centuries. However, conventional experimental methods, whose intrinsic measuring time is on the order of nanoseconds to microseconds, could not detect the fast dynamics taking place in the solution on the timescale of femto- and pico-second. In this dissertation, the ultrafast two-dimensional infrared (2DIR) spectroscopy was applied to characterize the structure and dynamics in three different types of solutions on the sub-picosecond timescale. Linear Fourier transform infrared spectroscopy …

Polymeric Nanoparticles As An Antioxidant Delivery System For Age-Related Eye Disease, Sean M. Swetledge

LSU Doctoral Dissertations

Advantages of polymeric nanoparticles as ocular drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. A review was conducted to serve as a guide to optimizing polymeric nanoparticle delivery systems for ocular drug delivery by discussing the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, …

An Autoethnography Of A Registered Nurse Living With Chronic Undiagnosed Illness, Frances M. Ricker

Nursing ETDs

Abstract

This autoethnographic study examines a registered nurse’s experience living with chronic undiagnosed illness. The number living with undiagnosed illness is unknown and little is understood about living with chronic undiagnosed illness.

This analytic autoethnography (Anderson, 2006) used multiple data sources: my journal, medical history narrative, and artifacts including my handwork, examples of my father’s handwriting, and family photographs. Narrative analysis, thematic analysis, and visual analysis were conducted.

My experience of living with chronic undiagnosed illness was characterized by three themes that reinforced isolation: not knowing, loss, and hidden secret self. Family context evidenced diverse themes of not being believed, …

(S)-2-[(4-Fluoro­Phen­Yl)Formamido]-3-Phenyl­Propanoic Acid, Kathleen Lee, Luke Turner, Cynthia Powell, Eric W. Reinheimer

Chemistry and Biochemistry

No abstract provided.

Consider Palliative Care: A Decision Aid To Improve Palliative Care Knowledge, Meg Schultheiss

Yale School of Medicine Physician Associate Program Theses

Palliative care enhances a patient’s quality of life by managing symptoms and psychosocial needs and facilitating advanced care planning. Engagement with palliative care improves satisfaction with care in patients and the informal caregivers identified by patients. However, palliative care is underutilized because many patients and their informal caregivers have limited knowledge about palliative care. Decision aids effectively educate patients and informal caregivers in a variety of clinical settings. We propose a randomized clinical trial that will test the effectiveness of a decision aid for informal caregivers considering palliative care. Specifically, we will match informal caregivers to a decision aid and …

Bridging The Gap In Primary Care Of Inflammatory Bowel Disease (Ibd) Patients, Deanna Dial

Dissertations

Abstract

Problem. Patients in rural or medically underserved areas (MUAs) with inflammatory bowel disease (IBD) have limited access to primary care preventative services, making them even less likely to obtain preventative care, placing them at even greater risk for adverse health outcomes.

Methods. A two-phase retrospective chart review utilizing a convenience sample of patients diagnosed with IBD from a privately-owned gastroenterology office to evaluate the effectiveness of increasing preventative screenings for IBD patients. The first review included 53 patients seen from January to April 2019. A preventative screening

evaluation tool (PSET) was developed based on literature recommendations, including the American …

Diversity In Pre-Nursing Majors And Nursing Program Applicants, Christel Fehr

Dissertations

Problem: The population of the US has become increasingly ethnically diverse. This diversity has not been reflected in the nursing workforce with approximately 70% being Caucasian and 85% being female, resulting in a disparity in healthcare delivery by minorities. The purpose of this project was to perform an analysis of race, ethnicity, and gender diversity in undergraduate nursing applicants at a rural midwestern university.

Method: A retrospective review of nursing applications, enrollment reports, and graduation rates were examined for three academic years.

Results: 326 students (N=326) applied to the nursing program from Fall 2016 through Spring 2019. Of …

Taxonomic Richness And Diversity Of Larval Fish Assemblages In The Oceanic Gulf Of Mexico: Links To Oceanographic Conditions, Corinne R. Meinert, Kimberly Clausen-Sparks, Maëlle Cornic, Tracey Sutton, Jay R. Rooker

Marine & Environmental Sciences Faculty Articles

Biodiversity enhances the productivity and stability of marine ecosystems and provides important ecosystem services. The aim of this study was to characterize larval fish assemblages in pelagic waters of the northern Gulf of Mexico (NGoM) and identify oceanographic conditions associated with areas of increased taxonomic richness (T ) and Shannon diversity (H’). Summer ichthyoplankton surveys were conducted in the NGoM in 2015 and 2016 using neuston net (surface layer; upper 1 m) and oblique bongo net (mixed layer; 0–100 m) tows. Over 17,000 fish larvae were collected over the two-year study, and 99 families of fish larvae were present. Catch …

The Human Dimension Of Nuclear Security: Legacy Of The Nuclear Security Summit, Franca Padoani

International Journal of Nuclear Security

A deeply rooted nuclear security culture and adequate human resources at all levels – involving regulators, the law enforcement agencies, academia, industry - are universally recognized as the foundation of a robust and sustainable nuclear security regime, national and global. International cooperation and networks are fundamental elements in ensuring the development and sustainability of what may be called the “human dimension” of Nuclear Security, and the Nuclear Security Summit (NSS) process has been the cornerstone for their consolidation.

Towards More Realistic Estimates Of Dom Decay In Streams: Incubation Methods, Light, And Non-Additive Effects, Julia E. Kelso, Emma J. Rosi, Michelle A. Baker

Ecology Center Publications

Dissolved organic matter (DOM) is the largest pool of organic matter in aquatic ecosystems and is a primary substrate for microbial respiration in streams. However, understanding the controls on DOM processing by microbes remains limited, and DOM decay rates remain largely unconstrained. Many DOM decay rates are quantified with bioassays in dark bottles, which may underestimate DOM decay in streams because these bioassays do not include a benthic zone and do not account for abiotic factors of DOM loss, such as photodegradation and volatilization. We measured decay of labile and semi-labile DOM over 3 d in experimental streams and bottle …

Baroreflex Sensitivity During Positional Changes In Patients With Traumatic Brain Injury, Norma D. Mcnair

Dissertations

Traumatic brain injury (TBI) affects 1.7 million Americans annually leading to significant morbidity and health care costs. An important cause of morbidity in TBI is secondary brain injury due to abnormal cerebrovascular autoregulation (CA). Standard measures of CA are not amenable to use outside of the intensive care unit (ICU) and patients continue to be at risk for secondary brain injury post- ICU. Baroreflex sensitivity (BRS) is a non-invasive assessment of autonomic tone that may be useful in evaluating CA. Evaluation of BRS and its relation to CA has not been examined in patients with TBI and predictors of CA …

Identifying, Understanding And Combating Complex Inequality: The Fight To Make The Invisible, Visible, Rachel Whitt

Black History at UNM

Dr. Nancy López, professor of sociology at UNM and director of the Institute for the Study of “Race” and Social Justice, explains the role of complex inequality in fueling social unrest. Complex inequality is rooted in decades of disparities towards minorities, particularly Blacks, Latinx, people of color and Native American communities. López outlines how invisible, deeply embedded injustices are common practice in the United States citing research that shows there are compounding challenges facing marginalized communities. These hurdles are multifaceted and cannot be distilled down to single data points. Recognizing the experience of marginality is layered and must be viewed …

A Study On Ecological Distribution Of And Selected Gene Expression In Amblyomma Americanum: An Insight Into The Alpha-Galactose Allergy Caused By Tick Bites, Leah Cuthill

Electronic Theses & Dissertations

Ticks transmit a wide variety of pathogens including viruses, bacteria, protozoa, and helminthes to vertebrates. Their life cycle depends on blood meals from various hosts as well as on environmental conditions such as the temperature and habitat type. A newly recognized allergic disease has been identified and is characterized by a delayed reaction following the consumption of some mammalian meats. The allergy often results in life threatening reactions such as anaphylaxis, hives, and breathing problems 3-6 hours after the consumption of mammalian meat. Not everyone develops the allergy when they are bitten by a lone star tick, and the cause …

Inhibition Of Hdac1/2 Along With Trap1 Causes Synthetic Lethality In Glioblastoma Model Systems, Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

The heterogeneity of glioblastomas, the most common primary malignant brain tumor, remains a significant challenge for the treatment of these devastating tumors. Therefore, novel combination treatments are warranted. Here, we showed that the combined inhibition of TRAP1 by gamitrinib and histone deacetylases (HDAC1/HDAC2) through romidepsin or panobinostat caused synergistic growth reduction of established and patient-derived xenograft (PDX) glioblastoma cells. This was accompanied by enhanced cell death with features of apoptosis and activation of caspases. The combination treatment modulated the levels of pro- and anti-apoptotic Bcl-2 family members, including BIM and Noxa, Mcl-1, Bcl-2 and Bcl-xL. Silencing of Noxa, BAK and …

Deep Learning Predictive Modeling With Data Challenges (Small, Big, Or Imbalanced), Renhao Liu

USF Tampa Graduate Theses and Dissertations

In the real world, data used to build machine learning models always has different sizes and characteristics. These size and characteristic features, including small datasets, big datasets, imbalanced datasets, often lead to different challenges when training machine learning models. Models trained on a small number of observations tend to overfit the training data and produce inaccurate results. When it comes to big data, efficiently learning from "huge" size data in a short time becomes important. With an imbalanced dataset, learning is usually biased towards the majority class in the data and appropriate measurements are needed to check model performance.

As …

Enhancement Of Fast Scan Cyclic Voltammetry Detection Of Dopamine With Tryptophanmodified Electrodes, Sarah E. Davis, Andrew L. Korich, Eric S. Ramsson

Peer Reviewed Articles

Fast scan cyclic voltammetry (FSCV) allows for real -time analysis of phasic neurotransmitter levels. Tryptophan (TRP) is an aromatic amino acid responsible for facilitating electron transfer kinetics in oxidoreductase enzymes. Previous work with TRP-modified electrodes showed increased sensitivity for cyclic voltammetry detection of dopamine (DA) when used with slower scan rates (0.05 V/s). Here, we outline an in vitro proof of concept for TRP-modified electrodes in FSCV detection of DA, and decreased sensitivity for ascorbic acid (AA). TRP-modified electrodes had a limit of detection (LOD) for DA of 2.480 ± 0.343 nM compared to 8.348 ± 0.405 nM for an …

Eusectra: European Nuclear Security Training Centre Providing Hands-On Training And Education In Nuclear Security And Safeguards, Willem Janssens, Veronique Berthou, Abbas Kamel, Jean Galy, Klaus Luetzenkirchen, Klaus Mayer, Stefan Nonneman

International Journal of Nuclear Security

The European Nuclear Security Training Centre (EUSECTRA) inaugurated under this global name about 10 years ago and operated by the European Commission Joint Research Centre (JRC), located both on the Karlsruhe (Germany) and Ispra (Italy) sites, includes a large variety of capacity building and professional development activities which span from the hands-on training for nuclear security and safeguards actors (e.g. respectively border guards or customs and nuclear inspectors) to educational efforts in both nuclear security and safeguards. Whereas the first ones, which gave rise to the new name, focus mainly on detection, on-site assistance, crime-scene management, technical reach-back and nuclear …

What Do Children Need From Playwork In The Time Of Covid-19? A Reflection On Playwork Practice In A Pandemic., Freya H. Howard

International Journal of Playwork Practice

This article explores the child’s need for play especially at the time of the coronavirus (COVID-19) pandemic in terms of the child’s welfare and rights, playfulness and their wellbeing. It reflects on previously learnt lessons with regards to virus outbreaks and the production of activity packs as a means of playwork in the pandemic context.

Hurricane Disturbance Stimulated Nitrification And Altered Ammonia Oxidizer Community Structure In Lake Okeechobee And St. Lucie Estuary (Florida), Justyna J. Hampel, Mark J. Mccarthy, Sanni L. Aalto, Silvia E. Newell

Faculty Publications

© Copyright © 2020 Hampel, McCarthy, Aalto and Newell. Nitrification is an important biological link between oxidized and reduced forms of nitrogen (N). The efficiency of nitrification plays a key role in mitigating excess N in eutrophic systems, including those with cyanobacterial harmful algal blooms (cyanoHABs), since it can be closely coupled with denitrification and removal of excess N. Recent work suggests that competition for ammonium (NH₄⁺) between ammonia oxidizers and cyanoHABs can help determine microbial community structure. Nitrification rates and ammonia-oxidizing archaeal (AOA) and bacterial (AOB) community composition and gene abundances were quantified in Lake Okeechobee …

Racial And Ethnic Comparison Of Ecological Risk Factors And Youth Outcomes: A Test Of The Desensitization Hypothesis, Dexter R. Voisin

Faculty Scholarship

Minority youth, because of structural, ecological, and societal inequalities, are at heightened risk of reporting depression and experiencing negative sanctions associated with delinquency. Sociological theories suggest that greater exposure to ecological risk factors at the peer, family, school and community levels are associated with elevated rates of youth depression and delinquency. Desensitization theory posits that repeated exposures to ongoing stressors result in a numbing of psychological and behavioral responses. Thus, it remains unclear whether racial/ethnic differences exist with regards to how contextual stressors correlate with depression and delinquency. Using a sample of 616 Black, 687 Latinx, and 1,318 White youth, …

Plant And Soil Responses To Sediment Deposition And Nutrient Enrichment In Healthy, Deteriorating, And Newly Created Coastal Marshes In Barataria Basin, Louisiana: Implications For Mississippi River Sediment Diversions, Gina N. Groseclose

LSU Master's Theses

To offset wetland loss in the Mississippi River Delta, sediment diversions that will re-introduce river water and sediment into wetlands are being planned for the lower Mississippi River. River diversions will also deliver high nutrient loads, which may reduce belowground plant productivity, reducing inputs of organic matter important for marsh accretion to keep pace with sea-level rise. However, belowground productivity responses to the combinatory effects of sediment and nutrients are unknown. To test the hypotheses that nutrient enrichment and sediment deposition interact to influence vegetation structure, belowground plant productivity and decomposition, and surface accretion, a field experiment was implemented in …

An Ethnography Of Wash Infrastructures And Governance In Sulphur Springs, Florida, Mathews Jackon Wakhungu

USF Tampa Graduate Theses and Dissertations

This dissertation describes the forces that shape the perceptions and practices in Water, Sanitation, and Hygiene (WaSH) services in the community of Sulphur Springs, Tampa, Florida. It also explores how these forces, perceptions, and practices produce adverse experiences and inequalities in water, sewer, drainage, and laundry services. This ethnographic study combines participant observation, ethnographic interviewing, freelisting, oral history, and GIS to uncover the context, experiences, and perceptions about WaSH in Sulphur Springs. The study finds that the present conditions and perceptions about WaSH are embedded into the historical contexts—especially racial segregation, the construction of the interstate, and multiple economic downturns …

Highest Award For Service, Dave Larsen

Materials from the University of Dayton Magazine Website

UD EMS earned the 2020 Collegiate EMS Community Engagement Program of the Year award.

Dissecting Dystrophin's Roles, Subcellular Organization, And Functional Network In Drosophila Oogenesis, Mina Amini Moghaddam

Theses and Dissertations

Mutations in the giant actin-membrane linker protein Dystrophin (Dys) are the cause of Duchenne Muscular Dystrophy (DMD). In the Drosophila model system, the highly conserved Dys protein is not required for viability but is required for proper wing and ovarian development. Dys mutations produce two visible phenotypes: posterior crossveins are detached from the longitudinal veins, and in oogenesis the developing eggs fail to elongate properly. This provides an opportunity to explore the less-understood cellular and developmental roles of Dys and gain a new insight into how tissues adopt their correct shapes.

Animals from worms to flies to humans express multiple …

Extensive Morphological Variability In Asexually Produced Planktic Foraminifera, Catherine V. Davis, Caitlin M. Livsey, Hannah M. Palmer, Pincelli M. Hull, Ellen Thomas, Tessa M. Hill, Claudia R. Benitez-Nelson

Faculty Publications

Marine protists are integral to the structure and function of pelagic ecosystems and marine carbon cycling, with rhizarian biomass alone accounting for more than half of all mesozooplankton in the oligotrophic oceans. Yet, understanding how their environment shapes diversity within species and across taxa is limited by a paucity of observations of heritability and life history. Here, we present observations of asexual reproduction, morphologic plasticity, and ontogeny in the planktic foraminifer in laboratory culture. Our results demonstrate that planktic foraminifera reproduce both sexually and asexually and demonstrate extensive phenotypic plasticity in response to nonheritable factors. These two processes fundamentally explain …

Transfer Mentor Spotlight, Kassidy Taylor

UNH Today Archive

No abstract provided.