Digital Commons Network^™

The Influence Of Weather On The Spatial Behavior Of Visitors Within Utah National Parks, Emily Wilkins, Jordan Smith

All Current Publications

Social media has been increasingly used to understand visitor use in parks and protected areas (Wilkins, Wood, & Smith, 2020). When people post photos on social media, these photos often contain information on the location, time, and date the photo was taken; all of this information is stored as metadata. Using geotagged images from Flickr, we explored how summer visitors to Utah’s national parks may vary their locations within the park based on the daily weather. We specifically looked at the elevations visitors went to within the parks, as well as their distances from roads, waterbodies, parking areas, and buildings.

Identification Of Clonal Evolution Pattern And Mutation Event Associated With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Using Next-Generation Sequencing, Cheng Wang

Theses & Dissertations

Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoid malignancy. About 30% of DLBCL cases respond poorly to initial treatment and eventually relapse. For these patients, the current treatment regimen is quite limited, and the prognosis is poor. Gene mutations and genetic alterations play an important role in lymphomagenesis. However, the genetic alterations or gene mutations underlying the disease resistance/relapse in DLBCL are still unknown. The clonal evolution during the process of disease progression is elusive as well. Our goal is to study the genetic alterations in DLBCL, particularly paired diagnostic and relapsed/refractory DLBCL, to better understand the mutation landscape …

Cardioprotective Roles Of Hydrogen Sulfide Donor Treatment In Diabetic Cardiomyopathy, Sumit Kar

Theses & Dissertations

Diabetes mellitus (DM) increases the risk of heart failure 2-4-fold. Intensive glycemic control does not abate this risk in DM patients, suggesting that DM-induced heart failure is beyond hyperglycemia. DM silently induces cardiac muscle disorder termed diabetic cardiomyopathy (DMCM), which progresses to heart failure. The objective of this dissertation is to understand the mechanistic underpinnings of DMCM to develop new solutions to diagnose and treat heart failure in DM.

The heart pumps blood due to the contraction and relaxation of terminally differentiated cardiomyocytes with limited regenerative capacity. The DM environment of hyperglycemia, hyperlipidemia, and inflammation causes cardiomyocyte death and leads …

Glycemic Variability In Patients With Stage Ii-Iii Colon Cancer, Natalie Mandolfo

Theses & Dissertations

Patients with cancer experience metabolic changes such as hypoglycemia, hyperglycemia, and glycemic variability; collectively termed malglycemia. Glycemic variability, defined as fluctuations in glucose, is a marker of metabolic instability. Higher glycemic variability is associated with adverse health outcomes in the general population and in those with diabetes. Little is known about glycemic variability in patients with cancer, especially those with solid tumor malignancies. Glycemic variability is associated with increased infection, shorter periods of remission, and higher mortality in patients with hematological cancer. This body of work describes the concept and measurement of glycemic variability to assess glycemic control in patients …

Pandemic Driven Innovation: Development Of An Alternative Respiratory Pathogen Self-Collection Device, Thang Nguyen

Theses & Dissertations

The SARS-CoV-2 virus outbreak has underscored numerous weak links in our biodefense countermeasures against highly communicable diseases. Many believe it was our lack of an effective testing model that allowed the virus to become a global pandemic within a short period. The gold standard collection method for the SARS-CoV-2 virus involves mechanical debridement of the nasopharyngeal cavity with a stiff swab applicator, which has been known to cause pain and injury to patients, subsequently resulting in low patient acceptance of the procedure. Due to the invasive nature of the nasopharyngeal swab collection method, it may not be conducive to the …

The Cellular Origin And Molecular Drivers Of Claudin-Low Mammary Cancer, Patrick D. Raedler

Theses & Dissertations

Breast cancers of the claudin-low subtype make up a substantial portion of triple-negative breast cancers and have stem cell-like and mesenchymal features. Although it has been recognized for some time that this breast cancer subtype is highly aggressive and difficult to treat, the molecular drivers and cellular origin of claudin-low breast cancer have been poorly defined. The lack of suitable in vivo models has prohibited the study of tumor initiation and progression of this subtype. In this work, we report two novel mouse models that, upon expression of oncogenic RAS in the mammary epithelium, develop highly metastatic triple-negative mammary tumors …

Multistrain Hiv-1 Elimination: A Crispr-Cas9 And Theranostics-Based Approach, Jonathan Herskovitz

Theses & Dissertations

A critical barrier to achieving a functional cure for infection by human immunodeficiency virus type one (HIV-1) rests in the presence of latent proviral DNA integrated in the nuclei of host CD4+ T cells and mononuclear phagocytes. Accordingly, HIV-1-infected patients must adhere to lifelong regimens of antiretroviral therapy (ART) to prevent viral rebound, CD4+ T cell decline, and progression to acquired immunodeficiency syndrome (AIDS). Gene editing using clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 technology stands as one means to inactivate integrated proviral DNA. We devised a mosaic gRNA CRISPR-Cas9 system- TatDE- that targets viral transcriptional regulator genes tat / …

Long-Acting Nanoformulated Antivirals For The Treatment And Prevention Of Hiv-1 And Hbv Infections, Dhruvkumar M. Soni Dr.

Theses & Dissertations

While antiretroviral therapy (ART) has revolutionized treatment and prevention of human immunodeficiency virus type one (HIV-1) infection, regimen adherence, viral mutations, drug toxicities, stigma and pill fatigue are limitations. These have led to the development of long acting (LA) ART. These include, but are not limited to, implantable devices, new chemical entities, prodrug modifications and nanoformulations. To these ends, this thesis focues on the transformation of nucleoside reverse transcriptase inhibitors (NRTIs) into LA parenterals, While elusive, data from our laboratories demonstrated that modifications to the PROdrug and nucleoTide technology (ProTide) enables improvements in drug apparent half-life and tissue and cell …

Targeted Therapies In Select Gastrointestinal Cancers And Cancer Cachexia, Scott Mulder

Theses & Dissertations

Hepatocellular carcinomas exhibit metabolic alterations to support their proliferative and biosynthetic needs. We identified that elevated expression of the mitochondrial oxidative carboxylase, malic enzyme 2 (ME2), correlates with poorer hepatocellular carcinoma patient survival. Hepatocellular carcinoma patient tumors with high ME2 expression exhibit transcriptomic alterations indicative of PI3K/AKT/mTOR and c-Myc signaling as well as elevated central carbon, fatty acid, and redox metabolism pathways. Depletion of ME2 in the hepatocellular carcinoma cell line PLC or in the livers of mice treated with diethylnitrosamine to chemically induce hepatocellular carcinomas, results in impaired proliferation and reduced tumor formation. Additionally, the loss of …

The Development Of Psychological And Educational Measurement In China, Houcan Zhang, Fang Luo

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

No abstract provided.

An Intellectual History Of Parametric Item Response Theory Models In The Twentieth Century, David Thissen, Lynne Steinberg

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

No abstract provided.

De-“Constructing” Test Validation, Stephen G. Sireci

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

No abstract provided.

Introduction To The Inaugural Issue Of Cejeme, Li Cai, Tao Xin

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

No abstract provided.

Booklet: United Way Of Northeast Florida Strategic Plan, United Way Of Northeast Florida

Florida Blue Archives Printed Materials

No abstract provided.

Solution Of The Beer Problem For Prohibition Trade, Standard Vacuum Machine Company

Dayton Liederkranz-Turner Ephemera

This flyer details information on the process pioneered by the Standard Vacuum Machine Company. The flyer is a sales pitch for their method of removing the alcohol from beer, and how it can best suit the company during prohibition times.

Influence Of Some Climatic Elements On Radon Concentration In Saeva Dupka Cave, Bulgaria, Peter Nojarov, Petar Stefanov, Karel Turek

International Journal of Speleology

This study reveals the influence of some climatic elements on radon concentration in Saeva Dupka Cave, Bulgaria. The research is based mainly on statistical methods. Radon concentration in the cave is determined by two main mechanisms. The first one is through penetration of radon from soil and rocks around the cave (present all year round, but has leading role during the warm half of the year). The second one is through thermodynamic exchange of air between inside of the cave and outside atmosphere (cold half of the year). Climatic factors that affect radon concentration in the cave are temperatures (air, …

Disciplinary Measures And Job Performance Of Library Staff In Academic Libraries In Imo State., Adaora Udo-Anyanwu, Linda Ijeoma Uwandu, Doris Chinyere Obiano

Library Philosophy and Practice (e-journal)

Abstract

The paper examined disciplinary measures and job performance of library staff in academic libraries in Imo State. It was guided by five objectives of the study. The survey research design was adopted for the study. The population of the study is thirty (34) Heads of Departments in the five academic libraries studied. The instrument for data collection was an online questionnaire rated using the four-point scale. Out of the 34 copies of instrument sent, 28 were returned showing 82% return rate. Data generated from the study were analyzed using mean (x) scores. Findings of the study revealed that; indiscipline …

Highly Cited Articles Of Desidoc Journal Of Library And Information Technology Indexed In Google Scholar:An Informetric Analysis, Renjith V R, Mini Devi B

Library Philosophy and Practice (e-journal)

The impact of scientific articles in respective subject fields are reflected by its citation counts in citation databases. Google Scholar (GS), a freely accessible database of scholarly papers along with their citations data, has an extensive coverage of Library and Information Science (LIS) literature. It is the only availableglobal database for the citation analysis of Indian LIS journals.The purpose of this study is an attempt to analyzethe publication age, citation density, most prolific authors and most occurred terms in the titles of highly cited articles of the journal“DESIDOC Journal of Library and Information Technology (DJLIT)”based on Google Scholar data.Harzing’s Publish …

Intrahistiocytic Storage Of Clofazimine Crystals In A Cat, Nathan D. Helgert, Debra L. Miller, Jacqueline C. Whittemore, Mee-Ja M. Sula

Faculty & Staff Research and Creative Activity

A 13-year-old castrated male Maine coon cat with a 5-year history of atypical mycobacteriosis was euthanized and submitted for necropsy. The cat had been kept in clinical remission since diagnosis using a combination of the antimycobacterial drug clofazimine and additional multimodal antimicrobial therapy. Grossly, tissues were diffusely discolored red-brown to yellow. Histologically, the myocardial interstitum was expanded by numerous, often multinucleated cells, which were distended by uniformly shaped acicular cytoplasmic spaces. These cells were immunopositive for CD18 and immunonegative for desmin, suggesting a histiocytic rather than muscular origin. Macrophages in other tissues contained similar acicular spaces. Ultrastructurally, the spaces were …

Medical School Watercooler Newsletter - December 17, 2020, Lindsey Lyle

Watercooler Newsletter

This is the December 17, 2020 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA scientist named council member of international society
• Student’s poster on vaccinations wins infographic competition
• Faculty needed for the USA College of Medicine Primary Care Pathway Program
• Medical student studies metastatic breast cancer treatment data to improve therapeutic options
• Research aims to improve outlook for Black women with endometrial cancer
• Townsley set to retire at the end of 2020

The Minutes Of The Marshall University Board Of Governors Meeting, December 17, 2020, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Fostering Children’S Academic Development Through Movement-Based Learning Environments, Hannah Martin

Graduate Teacher Education

Abstract

This study investigated how play and movement affect young children’s learning in order to provide educators with teaching strategies that are effective and developmentally appropriate in supporting the whole child. Academics, standardized testing, and school readiness have been buzzwords in education since No Child Left Behind was enacted in 2001. The term “school readiness” has been interpreted to indicate worksheets, memorization, and direct instruction to increase academic scores on standardized tests (Klein, 2015). The Common Core Standards for reading have dramatically increased in recent decades, including the expectation that children leaving kindergarten be comprehensive emergent readers (Carlsson-Paige, Bywater-McLaughlin, & …

Character Education In Prekindergarten, Lori Clark

Graduate Teacher Education

The outcomes of teaching character education in pre-kindergarten (PK) classrooms were researched for this paper. Challenging behaviors have become commonplace in PK classrooms; Edge, Rose, Honeycutt, McKelvey, Swindle, Courson, and Forsman (2018) reported more than 40% of early educators surveyed had suspended at least one child during the previous year. With changes in family structure, the rise in violent acts, and other ethical issues in society it has become necessary for schools to teach values that will help lead children to academic success and keep children in classrooms (Heidari, Nowrozi, & Ahmadpoor, 2016). Research was analyzed to report the effectiveness …

Healthcare Workers Hospitalized With Covid-19: Outcomes From The Burden Of Covid-19 Study At The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, T'Shura S. Ali, Maria Hill, Lucia B. Puga Sanchez, Catherine M. Bryan, Dawn Balcom, Stephen P. Furmanek, Amr Aboelnasr, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

Introduction: On March 6, 2020, the current ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as COVID-19, reached the commonwealth of Kentucky. Within days, the first cases of infection and hospitalization were identified among healthcare workers (HCW) in Kentucky, other states in the U.S., and around the world. There is little information available regarding the impact of COVID-19 on the HCW population within this area. The objective of this study was to describe the baseline characteristics of hospitalized HCWs infected with COVID-19.

Methods: Data collection was performed as part of a retrospective study of patients hospitalized …

Cultural Identity Formation: A Personal Narrative, Jose Carbajal

Faculty Publications

This paper provides an autoethnography of personal experiences and perceptions of being a minoritized individual. This is the story of a professional social worker learning to adapt to social norms and expectations of self. I discuss the struggles I experienced as an adolescent and as a young adult attending college. This narrative highlights the intersection of faith and social work at moments in my professional development. It is at this intersection that this social worker learns to live a holistic life without feeling discriminated against or ashamed of his identity. I begin to actualize a reality with imperfect beings who …

Vol.48 N.22 December 17th 2020, Voice Media Ventures

Black Voice News

No abstract provided.

2020-12-17_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Expanding The Boundaries Of Food Policy: The Turn To Equity In New York City, Nevin Cohen, Rositsa Ilieva

Publications and Research

Policymakers acknowledge that the food system is multidimensional and that social determinants affect diet-related health outcomes, yet cities have emphasized programs and policies narrowly connected to food access and nutritional health. Over the past fifteen years, the boundaries of food governance have expanded to include a wider range of issues and domains not previously considered within the purview of food policy, like labor, housing, and education policies. This paper illustrates the processes by which this shift occurs by presenting the case of New York City, which has broadened its food governance to a larger set of issues, requiring cross-sectoral initiatives …

2020-12-17_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2020-12-17_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …