Digital Commons Network^™

Pandemic Driven Innovation: Development Of An Alternative Respiratory Pathogen Self-Collection Device, Thang Nguyen

Theses & Dissertations

The SARS-CoV-2 virus outbreak has underscored numerous weak links in our biodefense countermeasures against highly communicable diseases. Many believe it was our lack of an effective testing model that allowed the virus to become a global pandemic within a short period. The gold standard collection method for the SARS-CoV-2 virus involves mechanical debridement of the nasopharyngeal cavity with a stiff swab applicator, which has been known to cause pain and injury to patients, subsequently resulting in low patient acceptance of the procedure. Due to the invasive nature of the nasopharyngeal swab collection method, it may not be conducive to the …

Body Snatching In Philadelphia: A Social And Cultural History, 1762-1883, Timothy R. Dewysockie

Theses and Dissertations

In 18th-century Philadelphia the first medical school in the thirteen British colonies was established. However, cadavers for dissection could only be obtained involuntarily, a posthumous punishment generally reserved for murderers and suicides. Body snatching, the disinterment of corpses for dissection, immediately became a problem because legal sources of "subjects" did not meet demand. Body snatching was resisted in popular representations and the actions of everyday citizens in riots, petitions, and other forms of protest. However, in the late 19th century the requisition of "unclaimed" bodies for dissection - that is, dead "paupers" - became enshrined in Pennsylvania's 1883 Anatomy Act, …

Essays On Rehospitalization Under The Hospital Readmission Reduction Program, Yangyuna Yang

Theses & Dissertations

The Hospital Readmission Reduction Program (HRRP), a part of the Affordable Care Act (ACA), requires the Centers for Medicare and Medicaid Services (CMS) to penalize hospitals with excess readmissions. The following conditions/procedures with high 30-day readmission rates were included in the program: Acute Myocardial Infarction, heart failure, pneumonia, chronic obstructive pulmonary disease, total hip arthroplasty and/or total knee arthroplasty, and coronary artery bypass graft (CABG). More research needs to be done regarding the national impact of the program. In addition, the risk factors of newly targeted CABG needs to be investigated robustly. Lastly, besides evaluating the risk of readmissions before …

Dna Polymerase Ε: Replication Error Prevention And Consequences Of A Cancer-Associated Mutation, Chelsea R. Bulock

Theses & Dissertations

Genome integrity is necessary to prevent mutations and disease. During eukaryotic DNA replication, DNA polymerases ε (Polε) and δ (Polδ) synthesize the leading and lagging strand, respectively. Polε and Polδ also have exonuclease activity that acts in series with post-replicative mismatch repair (MMR) to remove replication errors. Defects in proofreading and MMR lead to an increase in mutations and cause cancer in humans. This dissertation focuses on several unresolved issues involving the relationship between Polε and Polδ in replication error avoidance. First, despite an abundance of data supporting the one-strand-one-polymerase replication fork model, defects in the fidelity of Polε have …

Investigating The Relationship Between Unavoidable, Hospital Acquired Pressure Injury And Mortality: Is Unavoidable, Hospital Acquired Pressure Injury A Signal Of Increased One-Year Mortality Risk?, Eileen Jimenez

Theses & Dissertations

The purpose of this dissertation was to explore the strength of the relationship between unavoidable Hospital Acquired Pressure Injury (HAPI) and increased risk of one-year mortality for patients age 55 and older who were admitted to a hospital from 2015 to 2018. A quantitative, retrospective case-control study was designed to compare demographics, comorbid conditions, pressure injury risk, and living situation of those patients that developed unavoidable HAPI and hospitalized adults with similar physiological burdens that remained injury-free. The one-year mortality for the HAPI group was 27 of 48 (56%), and 26 of 47 patients (55%) for the Control group. The …

Multi-Level Small Area Estimation Based On Calibrated Hierarchical Likelihood Approach Through Bias Correction With Applications To Covid-19 Data, Nirosha Rathnayake

Theses & Dissertations

Small area estimation (SAE) has been widely used in a variety of applications to draw estimates in geographic domains represented as a metropolitan area, district, county, or state. The direct estimation methods provide accurate estimates when the sample size of study participants within each area unit is sufficiently large, but it might not always be realistic to have large sample sizes of study participants when considering small geographical regions. Meanwhile, high dimensional socio-ecological data exist at the community level, providing an opportunity for model-based estimation by incorporating rich auxiliary information at the individual and area levels. Thus, it is critical …

Cardioprotective Roles Of Hydrogen Sulfide Donor Treatment In Diabetic Cardiomyopathy, Sumit Kar

Theses & Dissertations

Diabetes mellitus (DM) increases the risk of heart failure 2-4-fold. Intensive glycemic control does not abate this risk in DM patients, suggesting that DM-induced heart failure is beyond hyperglycemia. DM silently induces cardiac muscle disorder termed diabetic cardiomyopathy (DMCM), which progresses to heart failure. The objective of this dissertation is to understand the mechanistic underpinnings of DMCM to develop new solutions to diagnose and treat heart failure in DM.

The heart pumps blood due to the contraction and relaxation of terminally differentiated cardiomyocytes with limited regenerative capacity. The DM environment of hyperglycemia, hyperlipidemia, and inflammation causes cardiomyocyte death and leads …

Glycemic Variability In Patients With Stage Ii-Iii Colon Cancer, Natalie Mandolfo

Theses & Dissertations

Patients with cancer experience metabolic changes such as hypoglycemia, hyperglycemia, and glycemic variability; collectively termed malglycemia. Glycemic variability, defined as fluctuations in glucose, is a marker of metabolic instability. Higher glycemic variability is associated with adverse health outcomes in the general population and in those with diabetes. Little is known about glycemic variability in patients with cancer, especially those with solid tumor malignancies. Glycemic variability is associated with increased infection, shorter periods of remission, and higher mortality in patients with hematological cancer. This body of work describes the concept and measurement of glycemic variability to assess glycemic control in patients …

Bayesian Modeling For Longitudinal Count Data: Applications In Biomedical Research, Morshed Alam

Theses & Dissertations

Biomedical count data such as the number of seizures for epilepsy patients, number of new tumors at each visit or the number vomiting after each chemo-radiation for the cancer patients are common. Often these counts are measured longitudinally from patients or within clusters in multi-site trials. The Poisson and negative binomial models may not be adequate when data exhibit over or under-dispersion, respectively. On the contrary, a variety of dispersion conditions in count data can be captured by Conway-Maxwell Poisson (CMP) model.

This doctoral dissertation relegates to developing a statistical methodology to model longitudinal count data distributed as CMP via …

Elucidating The Role Of Ecdysoneless In Mrna Processing, Irfana Saleem

Theses & Dissertations

The mammalian orthologue of the evolutionarily conserved Ecdysoneless (ECD) protein is required for embryogenesis, cell cycle progression and mitigation of ER stress. However, the molecular mechanisms of ECD function in mammalian cells remain unclear. Here, using mass spectrometry analysis of the mammalian ECD interactome, we identified several components of the mRNA export complexes as binding partners of ECD and then characterized the functional interaction of ECD with key mRNA export-related DEAD BOX protein helicase DDX39A and its associated partners. FISH analysis of Poly-A-tailed mRNAs revealed that ECD depletion/deletion blocks the mRNA export from the nucleus to the cytoplasm. We have …

Targeted Therapies In Select Gastrointestinal Cancers And Cancer Cachexia, Scott Mulder

Theses & Dissertations

Hepatocellular carcinomas exhibit metabolic alterations to support their proliferative and biosynthetic needs. We identified that elevated expression of the mitochondrial oxidative carboxylase, malic enzyme 2 (ME2), correlates with poorer hepatocellular carcinoma patient survival. Hepatocellular carcinoma patient tumors with high ME2 expression exhibit transcriptomic alterations indicative of PI3K/AKT/mTOR and c-Myc signaling as well as elevated central carbon, fatty acid, and redox metabolism pathways. Depletion of ME2 in the hepatocellular carcinoma cell line PLC or in the livers of mice treated with diethylnitrosamine to chemically induce hepatocellular carcinomas, results in impaired proliferation and reduced tumor formation. Additionally, the loss of …

Theatre Arts Integration For Deeper Learning In The English-As-A-Foreign-Language Classroom, Andrew Zutell

LSU New Orleans Theses and Dissertations

This quasi-experimental case study examines the impact of theatre arts integration in an English-as-a foreign language (EFL) course in a competency-based international high school. Aiming to engage students in a process of deeper learning through drama, this study focuses on the domain of speaking and oral communicative competence. Although widely recognized as one of the most important college-and-career-readiness skills, oral communication is often overshadowed by high-stakes testing priorities such as reading and writing. In particular, many Chinese students of English struggle to achieve confident oral fluency despite years of study. This research was designed to investigate whether theatre arts integration …

Investigating Language Variation And Change In Appalachian Dialects: The Case Of The Perfective Done, Julia Horton, Anna Muraco

Honors Thesis

The perfective done (“She done tended the garden”) is an often-overlooked grammatical feature specific to relatively few dialects of American English, most prominently seen in Appalachian dialects. While the perfective done has been described in detail by linguists since the 1970s, and there has been a demonstrated decline in the frequency of use of the perfective done among Appalachian dialect speakers in the past fifty years, there is very little existing scholarship that investigates an empirical basis for the claim that this long-term variation in the use of done can be considered a true language change-in-progress. The present research reviews …

See You Next Year, University Of Dayton

News Releases

University of Dayton offices will be closed for a Christmas break from Dec. 19 through Jan. 3. Public safety and facilities staff will be on duty for necessary campus operations, but academic and administrative offices, Roesch Library and RecPlex will be closed. For emergencies on campus, please contact UD public safety at 937-229-2121.

Foreword: Implementing Adaptive Learning At Scale, Karen Vignare

Current Issues in Emerging eLearning

What follows is the second of now two Specials Issues of the CIEE journal to have been produced and guest edited by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU). Both special issues feature important research resulting from university initiatives to launch, implement and scale up the use of adaptive courseware and the strategies of adaptive learning. The Personalized Learning Consortium has been working with institutions for more than five years to improve student success in high enrollment undergraduate courses. Using a combination of active learning and adaptive courseware, many universities are reporting higher …

A Transformative Approach To Incorporating Adaptive Courseware: Strategic Implementation, Backward Design And Research-Based Teaching Practices, Tonya A. Buchan, Stanley Kruse, Jennifer Todd, Lee Tyson

Current Issues in Emerging eLearning

In July 2016, Colorado State University (CSU) joined seven other land-grant institutions in the Accelerating Adoption of Adaptive Courseware grant sponsored by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU). A primary objective of the grant was to scale the adoption of adaptive courseware in general education courses at each of the grant institutions. CSU targeted high-enrollment, general education courses and took a three-pronged, transformative approach to the integration of adaptive courseware. Specifically, CSU divided the courseware integration into three components: 1) strategic implementation of courseware, 2) backward course design, and 3) incorporation of …

Adaptive Analytics: It’S About Time, Charles Dziuban, Colm Howlin, Patsy Moskal, Tammy Muhs, Connie Johnson, Rachel Griffin, Carissa Hamilton

Current Issues in Emerging eLearning

This article describes a cooperative research partnership among a large public university, a for-profit private institution and their common adaptive learning platform provider. The focus of this work explored adaptive analytics that uses data the investigators describe as metaphorical “digital learning dust” produced by the platform as a matter of course. The information configured itself into acquired knowledge, growth, baseline status and engagement. Two complimentary models evolved. The first, in the public university, captured end-of-course data for predicting success. The second approach, in the private university, formed the basis of a dynamic real-time data analytic algorithm. In both cases the …

Student Perceptions Of The Effectiveness Of Adaptive Courseware For Learning, Patricia O'Sullivan, Christina Forgette, Stephen Monroe, M. Tyler England

Current Issues in Emerging eLearning

Despite the increasing research on the effectiveness of adaptive learning courseware by vendors and academic institutions, there are few published, peer-reviewed studies on adaptive courseware that address the student experience and student perception of this teaching and learning tool. Over the course of two academic years, 2017/2018 and 2018/2019, researchers at the University of Mississippi conducted 16 course-based student focus groups and gathered data from 4 end-of-semester surveys to understand how students are experiencing adaptive courseware and whether or not they find it adds value to their education. Our study found that, although students generally find courseware to be helpful …

Current Issues In Emerging Elearning, Volume 7, Issue 1: Aplu Special Issue On Implementing Adaptive Learning At Scale

Current Issues in Emerging eLearning

The second of two Specials Issues of the CIEE journal to have been produced and guest edited by the Personalized Learning Consortium (PLC) of the Association of Public and Land-grant Universities (APLU), featuring important research resulting from university initiatives to launch, implement and scale up the use of adaptive courseware and the strategies of adaptive learning.

The Long-Haul: Buddhist Educational Strategies To Strengthen Students’ Resilience For Lifelong Personal Transformation And Positive Community Change, Namdrol Miranda Adams, Kevin Kecskes

Public Administration Faculty Publications and Presentations

For decades, community engagement scholars have built a robust body of knowledge that explores multiple facets of the higher education community engagement domain. More recently, scholars and practitioners from mainly Christian affiliated faith-based institutions have begun to investigate the complex inner world of community-engaged students’ meaning-making and spiritual development. While most of this fascinating cross-domain effort has been primarily based on “Western” influenced Judeo-Christian traditions, this study explores service-learning/community engagement themes, approaches, rationale, and strategies from an “Eastern” perspective based on the rich tradition of Tibetan Buddhism. This case study research focuses on curricular approaches, influences, and impacts of Buddhist …

The Electronic Hardware Music Subculture In Portland, Oregon, James Andrew Hickey

Dissertations and Theses

Music is relatively understudied as a geographic phenomenon, but recently there has been a shift in academic literature to understand the social, cultural and economic factors that determine music and its development in specific places. The purpose of this study is to examine the Electronic Hardware Music Subculture (EHMS) in Portland, why it thrives, and how it is linked to the local cultural economy. To do this, I used semi-structured, long form interviews with key members of the EHMS. These interviews, and my own observations, gave insight into what factors affect the success of members of the EHMS, and how …

Adaptive Courseware Implementation: Investigating Alignment, Course Redesign, And The Student Experience, Patricia O'Sullivan, Janelle De Carrico Voegele, Tonya Buchan, Raiza Dottin, Kari Goin Kono, Misty Hamideh, Wendy S. Howard, Jennifer Todd, Stanley Kruse, Johannes De Gruyter, Kevin Berg

Curriculum and Instruction Faculty Publications and Presentations

In this paper, four institutions share student and faculty feedback on the implementation of adaptive courseware through a common case study: biology for undergraduate non-majors. Additionally, each institution has provided a second case study of their choice. Together, researchers at Colorado State University in Fort Collins, CO, Portland State University in Portland, OR, University of Central Florida in Orlando, FL, and the University of Mississippi in Oxford, MS consider student perception of the benefits to the implementation of adaptive courseware, and how the deliberate alignment between adaptive courseware and course organization and structure impacts student experience. This paper highlights the …

Series Editors' Preface To Ssl 46.2, Patrick Scott, Tony Jarrells

Studies in Scottish Literature

Introduction to special issue on Allan Ramsay; comment on cover illustration from the William Aikman-George White mezzotint portrait of Ramsay.

Introduction: Allan Ramsay's Future, Murray Pittock, Craig Lamont

Studies in Scottish Literature

Presents an overview of the new AHRC-funded edition of the Collected Works of Allan Ramsay, and of related recent scholarly and community activity in relation to Ramsay's public recognition and heritage, both in the Pentlands area south of Edinburgh, near Penicuik and Carlops, and more broadly in Scottish literary history, specifically in relation to the origins of Scottish Romanticism.

Allan Ramsay: Romanticism And Reception, Murray Pittock

Studies in Scottish Literature

Provides a review and interpretation of Allan Ramsay's career and reputation, and of scholarly and critical response to his work, exploring "the foundational nature of his contribution to the language of Scottish literature," reaching a wider audience, for Scots, his dominant role in the history of Scottish song, and the pivotal role of his writing, especially his ballad-opera The Gentle Shepherd, in the formation of Scottish romanticism, and of the wider romantic movement.

'Some Few Miles From Edinburgh': Commemorating The Scenes Of The Gentle Shepherd In Ramsay Country, Craig Lamont

Studies in Scottish Literature

Traces the history of Ramsay commemoration, from the obelisk at Penicuik with an inscription from 1759 onwards, and successive attempts to identify actual settings for scenes and incidents in his ballad opera The Gentle Shepherd, in illustrations (notably by David Allan for the Foulis edition of 1788), other editions and memoirs, and competing contributions by the ministers of rival parishes to the Statistical Account of Scotland, giving particular attention to the roles in the "battle over Ramsay country" of two local landowners, Alexander Fraser Tytler (Lord Woodhouselee) and Robert Brown of Newhall; providing maps and illustrations to clarify …

'Compylit In Latin': Allan Ramsay And Scoto-Latinity In The Eighteenth Century, Ralph Mclean

Studies in Scottish Literature

Discusses the importance and pervasiveness of Latin, including original Latin verse, in early 18th century Scotland, among Jacobites and in Ramsay's Edinburgh circle, with attention to the work of Archibald Pitcairne, Thomas Ruddiman, and later Robert Fergusson; examines Ramsay's own Scots translations of Horace and his use of the Horatian tradition, and looks also at translations from Ramsay into Latin by Alexander Fraser Tytler; and concludes that Ramsay's Scots poetry "helped to maintain" a Scottish link "to the classical past, by presenting the works of classical authors to new and growing audiences in Scotland in a language which was accessible …

'Some Pastoral Improvement' In The Gentle Shepherd: Mediation, Remediation, And Minority, Steve Newman

Studies in Scottish Literature

This essay shows how in The Gentle Shepherd Allan Ramsay engages in the complex work of "pastoral improvement" on an individual and national scale and foresees--to a point--how his work will be received in the decades and even centuries to come. After situating his work within the uprising of the Galloway Levellers, pastoral, and the early work of agricultural improvement, I consider how the concept of improvement shapes the reception of his work in the Linley-Tickell production of the 1780s--including a surprising appearance from the Shakespearean forger, William Henry Ireland--and the key role The Gentle Shepherd plays in "The Young …

Methodising Scots: The Cases Of Allan Ramsay & Thomas Ruddiman, Jeremy J. Smith

Studies in Scottish Literature

Examines the linguistic issues facing editors of two 18th century Scottish editors, Allan Ramsay and Thomas Ruddiman, in modifying or standardizing the language in earlier Scottish poetic manuscripts, arguing that "the editorial process is not—and never has been—“neutral” or “objective” but is rather a hermeneutic act constrained by contemporary conditions of publication and intended audience," and that Ramsay and Ruddiman, like modern editors, were "constrained in quite delicate ways by their historical setting."

Contributors To Ssl 46.2

Studies in Scottish Literature

Brief biographical notes on contributors