Digital Commons Network^™

Non-Invasive Method For Leptin Supplementation In Zebrafish (Danio Rerio), Regan Mcnamara

Williams Honors College, Honors Research Projects

I tested the hypothesis that recombinant leptin protein can be introduced to zebrafish in vivo through non-invasive soaking in a solution containing the protein. One way to study various molecules’ effects in vivo is through intraperitoneal or intracerebroventricular injections during the embryonic or larval stage, which is invasive, difficult to administer, and can have a high mortality rate. 48 hours post fertilization (hpf) zebrafish were soaked in a His-tagged recombinant leptin protein solution at 10 nM and 100 nM concentrations (produced by Genscript). After soaking, zebrafish larvae were washed extensively to remove all recombinant protein on their exterior before homogenization. …

St. Augustine And St. Thomas Aquinas On The Mind, Body, And Life After Death, Christopher Choma

Williams Honors College, Honors Research Projects

Historical and philosophical investigation of the thoughts of two of philosophy's most innovative Christian thinkers. The thesis primarily deals with the relationship between the mind and the body through the lenses of St. Augustine of Hippo and St. Thomas Aquinas. Thesis also includes theological discussions of life after death, and how one can be certain that the soul survives the corruption of the body.

The Relationship Between Intensity Of Fitness Tracker Usage And Motivation, Rachel Cannata, Abigail C. Daugherty, Madison O. Dirocco, Julianne Green, Pial Dasgupta

Williams Honors College, Honors Research Projects

Many college students engage in unhealthy behaviors which may contribute to diseases. Additionally, some students may lack motivation to rectify these behaviors to improve their long-term health. This study assessed the relationship between intensity of fitness tracker usage and motivation among health professions students at a large, public Midwestern university. This non-experimental, correlational study used convenience sampling and a theoretical framework based on Bandura’s Social Cognitive Theory. Online recruitment announcements were emailed and included links to the consent form and survey. Motivation was measured with Deci and Ryan’s modified self-determination tool. Intensity of tracker usage was measured using a scale …

Enforcing Socioeconomic Rights In Neoliberal India, Rehan Abeyratne

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

This Article challenges the conventional narrative on fundamental rights adjudication in India. The narrative goes like this: The Indian judiciary, led by the Supreme Court, produced several transformational decisions in the 1980s. These decisions, among other things, loosened procedural rules to permit fundamental rights petitions on behalf of poor and marginalized groups and also recognized an array of socioeconomic rights, such as rights to work and shelter. In the 1990s, however, the Court retrenched its fundamental rights jurisdiction. It has since been limited to ensuring good governance and adjudicating within neoliberal economic constraints. The Article calls this narrative into question …

A Critical Assessment Of The Epa’S Air Program At Fifty And A Suggestion For How It Might Do Even Better, E. Donald Elliott

Case Western Reserve Law Review

No abstract provided.

Northeastern Illinois University, Academic Catalog 2020-2021, Northeastern Illinois University

Course Catalogs

No abstract provided.

Heart Work: A Phenomenological Analysis Of School-Embedded Program Facilitators In High-Need South Florida Schools, Takia Bullock

Department of Conflict Resolution Studies Theses and Dissertations

Student misconduct leading to youth violence has been recognized as a major public health problem requiring intervention. To reduce antisocial behaviors, school districts and non-profit organizations promote prosocial behaviors and problem-solving skills. Positive youth development, social emotional learning, positive behavioral intervention support, and conflict resolution programs have been implemented in many school districts; yet problems associated with aggression, poor decision-making, and low student achievement still occur. This Interpretative Phenomenological Analysis study explored the lived experiences of seven school-embedded positive intervention program facilitators implementing programs with conflict management components for at-risk students in high need South Florida schools. Semi-structured interviews were …

Confirmatory Factor Analysis Of The Wisc-Iv With A Trinidad Referred Sample, Cherisse Rambarose

Open Access Dissertations

There has been an extensive amount of research in the intelligence-assessment literature on the structure of the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV; 2003a). Numerous studies show that the test’s general factor structure replicates across normative and referred groups, in the U.S. and globally. Thus far, few studies have been done examining the factor structure of this, and other intelligence tests with Caribbean samples. The current study adds to this body of literature by examining the factor structure of the WISC-IV with a referred sample from Trinidad. This study utilized archival data from a sample accessed through private …

The Effects Of Gspt1 Degradation On Serum Calcium, Parathyroid Hormone, And Fibroblast Growth Factor 23 Concentrations In Human Cereblon Knock-In Mice, Kamran Ghoreishi

Theses and Dissertations

Test article CC-325 is a potent oral cereblon (CRBN) modulator that has shown potent G1 to S phase transition 1 (GSPT1) degradation and anti-tumor activity in pre-clinical models. One of the adverse effects associated with CC-325 was dose dependent hypocalcemia, which was determined to be an on-target toxicity.

To investigate the mechanism of hypocalcemia, we conducted a toxicity study in human cereblon (huCRBN) knock-in (KI) mice with CC-325. The huCRBN KI mice are transgenic mice engineered to express human cereblon that is capable of binding to CRBN and degrading GSPT1. Four groups of mice were treated with vehicle (0 mg/kg), …

School Of Nursing Bs Program - Catalog Entry, Nursing

Program Revisions/Additions

No abstract provided.

School Of Nursing Program Map, Nursing

Program Revisions/Additions

No abstract provided.

School Of Nursing Proposal, Nursing

Program Revisions/Additions

No abstract provided.

Exercise Science Occupational Therapy Bs, Ksr

Program Revisions/Additions

No abstract provided.

Accounting For The Uncertainty Due To Chemicals Below The Detection Limit In Mixture Analysis, Paul M. Hargarten

Theses and Dissertations

Humans are exposed to multiple chemicals every day. Epidemiological studies have shown that chemical mixtures are associated with cancers, allergies, neurodevelopmental disorders, and other adverse health effects. To assess these associations, investigators are increasingly using chemical mixture approaches like weighted quantile sum (WQS) regression. In these studies, the research objectives are to determine whether a mixture of correlated chemicals is associated with an adverse health outcome and to identify the important chemicals. However, as experimental equipment measures each exposure to a chemical-specific detection limit, the exposures are unknown between zero and the detection limit. Indeed, the number of exposures below …

Fate Of White Fringetree Through The Invasion Wave Of Emerald Ash Borer And Its Variation In Resistance To Attack, Emily A. Ellison

Browse all Theses and Dissertations

Ornamental white fringetrees in IL, IN, OH, and PA were reassessed in 2018 as a follow-up study to determine the fate of the white fringetree through the invasion wave of emerald ash borer. Attack rates decline by half from 2015-2018 and only 13% of trees were infested. Health of not reinfested trees in 2018 improved suggesting resilience against EAB attack whereas currently infested trees in 2018 displayed signs of declining health. Trees differed in their resistance to EAB attack and 41 additional ornamental and wild white fringetrees were studied in OH to determine if the anti-herbivory defense chemical, oleuropein, influenced …

Impact Of Passive Range Of Motion Exercises And Stretching In Knee Osteoarthritis Pain During Walking, Dominique Marchelle Ottonello

Browse all Theses and Dissertations

Knee osteoarthritis (KOA), is globally prevalent source of disability for the elderly. This degenerative malady progresses with age and has no cure. It manifests in gait changes and affects overall quality of life. Exercise therapy has been shown to improve knee joint range of motion, stiffness and pain due to KOA. This improvement is due in part to the direct relationship between muscle strength and joint stability. The purpose of this study is to examine how a passive range of motion (ROM) exercises and stretching regimens affect gait-alterations and associated pain from KOA experienced during walking. Nine KOA subjects were …

Adverse Childhood Experiences Among Individuals With Opioid Use Disorder, Megan Creviston

Browse all Theses and Dissertations

The study examines adverse childhood experiences among individual who use illicit opioids, focusing on emotional, physical, and sexual abuse. The study uses data collected from a sample of 357 individuals with opioid use disorder who were recruited in the Dayton area between May 2017 and October 2018. The study builds on the life course and social learning theories to examine the association between childhood experiences and drug use behaviors in later life. The key aims of the study are to: 1) assess the prevalence of adverse childhood experiences in the community-recruited sample of individuals with opioid use disorder; 2) analyze …

Effects Of Creatine And Nicotinamide On Experimentally Induced Senescence In Dermal Fibroblasts, Avinash Satyanarayan Mahajan

Browse all Theses and Dissertations

Dermal fibroblasts provide structural support by producing collagen and other structural/support proteins beneath the epidermis. Fibroblasts also produce Insulin-like growth factor-1 (IGF-1), which binds to the IGF-1 receptors (IGF-1Rs) on keratinocytes to activate signaling pathways that regulate cell proliferation and cellular responses to genotoxic stressors like ultraviolet B radiation found in sunlight. Our group has determined that the lack of IGF-1 expression due to fibroblast senescence in the dermis of geriatric individuals is correlated with an increased incidence of skin cancer in geriatric patients. The present studies were designed to test the hypothesis that pro-energetics like creatine monohydrate and nicotinamide …

Non-Invasive Retrieval Of Prefabricated Zirconia Crowns With Er,Cr:Ysgg Laser From Primary And Permanent Teeth, Connor W. Mccall Dds

Theses and Dissertations

Purpose: Compromised tooth structure on permanent and deciduous teeth in the pediatric population is increasingly being restored with tooth-colored prefabricated zirconia crowns. These restorations may need to be removed or replaced with permanent crowns. The purpose of this in vitro study was to explore the use of an Er,Cr:YSGG laser for removal of prefabricated zirconia crowns cemented with RMGI as a non-invasive alternative to rotary instruments.

Methods: Thirteen permanent and 12 primary molars were prepared to dentin and prefabricated zirconia crowns were passively fitted and cemented with two resin modified glass ionomer cements. The irradiation parameters for ErCR:YSGG were 4.5 …

Selenomonas Sputigena: Growth Conditions And Projected Virulence Factors Of An Emerging Oral Pathogen, Kayla A. Keller

Theses and Dissertations

Periodontal diseases are ubiquitous diseases. They can affect people through a chronic infection that happens over a lifetime, but also as an aggressive infection that afflicts the younger population. It not only results in tooth loss and a lower quality of life, but it can also lead to fatal secondary infections like cervical cancer, heart disease, and Alzheimer’s disease. This study looks at Selenomonas sputigena, an emerging oral pathogen, that has been hypothesized to contribute to periodontal disease. It has been linked to fatal septicemia and has been found in increased abundance within the oral biofilm during peak infection. …

The Role Of Law And Policy In Achieving Healthy People’S Disability And Health Goals Around Access To Health Care, Activities Promoting Health And Wellness, Independent Living And Participation, And Collecting Data In The United States, Elizabeth Pendo, Lisa I. Iezzoni

Articles

Ensuring that the almost 60 million Americans with disabilities live as healthy and independent lives as possible is an important goal for our nation. This evidence-based report highlights efforts to better use law and policy to support and protect people with disabilities. Specifically, it examines how existing federal laws and policies could be leveraged by states, communities, and other sectors to reduce barriers to primary and preventive care; reduce barriers to local health and wellness programs; increase access to leisure, social, or community activities (and indirectly, to religious activities) for individuals with disabilities; and generate better disability data needed to …

Using The Rapid Assessment For Adolescent Preventative Services Risk Screening Tool To Identify Depression In Two Omaha High Schools, Annie Ballén, Melanie Menning, Jenenne A. Geske

EMET Projects

No abstract provided.

Exploring Substrate Specificity Of Fructose Transporters En Route To Glut Specific Probes For Biochemical And Biomedical Applications, Vagarshak Vigenovich Begoyan

Dissertations, Master's Theses and Master's Reports

Carbohydrate Transporters (GLUTs) are responsible for the transportation of sugars into the cell and have been of great interest in research for decades. Alterations or mutations that result in overexpression of GLUTs have been linked to a great number of diseases including, obesity, diabetes, and cancer. Differentiation between transporters has been shown to be incredibly difficult due to the highly conserved nature of the transporter structure, and thus specific targeting of transporters has proven a difficult challenge. Additionally, the GLUTs have been shown to high flexibility in their conformations, so it is difficult to determine what can or cannot pass …

Electrospun Nanofiber Scaffolds As A Platform For Breast Cancer Research, Carolynn Que

Dissertations, Master's Theses and Master's Reports

Tumorigenesis is a complex process involving numerous cellular signaling cascades and environmental factors. Here, we report the fabrication of 3D scaffolds with different morphologies obtained by to study cancer cell proliferation and migration. Using an FDA approved, biocompatible and biodegradable polymer Polycaprolactone (PCL), we electrospun nanofiber scaffolds having mesh, aligned, and honeycomb morphologies. The role of the morphology and cellular preferences to nutrition in cell adhesion and proliferation was assessed using scaffolds obtained by electrospinning PCL with fluorescent fructose-like molecular probes. Cell viability, cell morphology, localized cellular growth as related to scaffold morphology and availability of the fructose-like molecular probes …

2020-2021 Nursing Graduate Msn-Fnp Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2020-2021 Graduate Student Handbook for the Department of Nursing at Morehead State University.

Sustainability, Urban Planning And Development: Sustainable And Self-Reliant Urban Development In Post- Pandemic Nepal, Ambika P. Adhikari, Keshav Bhattarai

Himalayan Research Papers Archive

COVID-19 pandemic is affecting many aspects of the society, economy and the way people live. The pandemic is also disrupting the process of physical planning and development in the cities. It will perhaps permanently change the way planners and policy makers think about the city and plan for its development. The residents and visitors will also find the city to be different from the pre-COVID-19 era. The emerging situation would likely require new ways of moving, working and living in the city, and building the different physical components of the city.

Cities around the world are experiencing varieties of unexpected …

Issues And Perspective On The Covid-19 And Nepal: An Introduction, Ambika P. Adhikari, Basu Sharma

Himalayan Research Papers Archive

Even though Nepal has relatively fewer Covid-19 cases as of 24 September 2020 (about 70,000 cases and more than 450 deaths), the numbers are on the rise. If this trend continues for a while, the likely consequences of the Pandemic would be no less severe than elsewhere. Further, Nepal’s next-door neighbor India is now experiencing a rapid rise in the virus infection rate and virus-related death toll. In fact, as of 24 September, 2020, India is seeing some about six million total Covid-19 cases, and more than 92,000 deaths. As India and Nepal have open borders, and as India is …

A Symbolic Participation Of The Local Community In The Implementation Of A Proper-Based Corporate Social Responsibility (Csr) Program, Yosef Hillarius Timu Pera, Yusup Ridwansyah

Masyarakat: Jurnal Sosiologi

CSR practices continue to grow as a promising alternative development resource, yet still predominantly charitable in nature, preventing them from optimal community empowerment. Therefore, studies and policies at the national and global levels remain in search of the best format to optimize CSR programs’ role in community empowerment. A number of literature show less than optimal active participation and capacity-building of the community if a program is initiated by a directive, top-down approach, providing only a minimal participatory space based on the community’s potentials. Using qualitative method and in-depth interview techniques, this paper finds that the local community participation in …

To Eat Or Not To Eat: Urbanization And The Foraging Behaviors Of Michigan Passerines, Victoria T. Vo

Senior Honors Theses and Projects

Urbanization creates novel problems for wildlife, potentially altering the foraging behavior of passerine birds. Foraging is driven by factors like food preference and food accessibility; the foraging of urban birds may be more innovative due to frequent exposure to unfamiliar items. I hypothesized that high novelty exposure in urban birds would promote faster discovery and longer visits to novel feeders compared to rural conspecifics. Additionally, I hypothesized that birds would prioritize food quality over access regardless of habitat, but when faced with barriers, urban birds would be better at accessing food compared to rural birds because of frequent exposure to …

The Implications Of Gut Health On Mental Health, Cali Curlee

Senior Honors Theses and Projects

The neurotransmitter deficiency hypothesis suggests that neurotransmitter imbalance is the physiologic cause for mental health conditions like depression and anxiety. With up to 90% of serotonin produced in the gut, it is of particular interest whether diet may influence this balance. The current research seeks to identify a connection between one’s intake of microbiome-influencing foods/beverages and mental health status. The hypothesis of the study is that participants who regularly consume greater amounts of pre/probiotic foods will have a decreased prevalence of depression and anxiety, relative to those who rarely consume pre/probiotic foods. Differences in survey data were not statistically significant, …