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Evaluating A Culprit: A Review Of The Biochemical Mechanisms Of Non-Celiac Gluten Intolerance, Callie Cinque

Honors Theses

Non-Celiac Gluten Intolerance (NCGI) has evaded biological and chemical mechanisms since it was first reported in 1978. Celiac Disease, a multi-system immune mediated disorder has long served as the most similar counterpart to NCGI. Less cases of celiac disease are going undiagnosed reflecting an improvement on sensitive and decisive diagnostic tools. However, NCGI has been significantly growing as a diagnosis over the past decade with little match or similarity to the markers found in celiac disease patients. Critical evaluation of NCGI theories, experimentation, and existing hypotheses is necessary. This review seeks to synthesize multiple disciplines of gluten research and enhance …

Annual Report 2019, Tennessee. Department Of Human Services.

Annual Report

No abstract provided.

Why Matter Of Devera Matters: Universal Pre-K, Quality, Oversight, And The Need To Restore Public Values In New York Statutory Interpretation, Natalie Gomez-Velez

City University of New York Law Review

New York City is at the vanguard in introducing free, high-quality universal pre-kindergarten as a strategy to address educational inequity and significant opportunity gaps by improving early school readiness. New York State law authorizing universal pre-kindergarten (“UPK”), accompanied by robust quality standards, paved the way for New York City’s impressive UPK initiative. A separate New York State law authorizes charter schools and limits regulatory oversight of such schools. Matter of DeVera v. Elia, a recent decision by New York State’s highest court, dealt a blow to New York City and State efforts to require a powerful charter entity to abide …

R-Α-Lipoic Acid And 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms In Hepatic Cells, Bo He, Régis Moreau

Department of Nutrition and Health Sciences: Faculty Publications

The constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1) leads to the overproduction of apoB-containing triacylglycerol-rich lipoproteins in HepG2 cells. R-α-lipoic acid (LA) and 4-phenylbutyric acid (PBA) have hypolipidemic function but their mechanisms of action are not well understood. Here, we reported that LA and PBA regulate hepatocellular lipid metabolism via distinct mechanisms. The use of SQ22536, an inhibitor of adenylyl cyclase, revealed cAMP’s involvement in the upregulation of CPT1A expression by LA but not by PBA. LA decreased the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the culture media of hepatic cells and increased …

Perceptions And Beliefs Of African American Men And Women 30 Years And Older About The Health Care System In The United States, Jacqueline Chadwick Mcnair

Walden Dissertations and Doctoral Studies

This qualitative study described perceptions and beliefs of African American men and women ages 30 and over regarding their experiences with the health care system in the United States. The health belief model was the theory that drove this research, and it was grounded in the concept of cultural competency. The study used grounded theory methodology as well as phenomenology to describe the lived experiences of the participants and ethnography to describe the cultural characteristics of African American men and women ages 30 and over as related to their perceptions and beliefs about health care in the United States. The …

Moderators Of Depression And Self-Management In Type 2 Diabetes Patients, Cynthia Elaine Fraser

Walden Dissertations and Doctoral Studies

Although Type 2 diabetes can be reversed or controlled, many individuals choose not to adhere to treatment regimens, nor do they engage in self-management practices. The purpose of this cross-sectional study was to explore self-management among individuals with Type 2 diabetes, examining whether some psychosocial variables have a moderating effect on self-management. The psychosocial variables explored in this research were perception of body image, fear of hypoglycemia, level of family support, and depression. The biopsychosocial model was the theoretical framework. Using the Body Appreciation Scale, Diabetes Self-Management Questionnaire, The Family Relationship Scale, Hypoglycemic Fear Survey (HFS-II), and the Beck Depression …

Why Does The Importance Of Education For Health Differ Across The United States?, Blakelee R. Kemp, Jennifer Karas Montez

Department of Sociology: Faculty Publications

The positive association between educational attainment and adult health (“the gradient”) is stronger in some areas of the United States than in others. Explanations for the geographic pattern have not been rigorously investigated. Grounded in a contextual and life-course perspective, the aim of this study is to assess childhood circumstances (e.g., childhood health, compulsory schooling laws) and adult circumstances (e.g., wealth, lifestyles, economic policies) as potential explanations. Using data on U.S.-born adults aged 50 to 59 years at baseline (n = 13,095) and followed for up to 16 years across the 1998 to 2014 waves of the Health and Retirement …

Posttraumatic Stress Disorder Rates Among Children In Foster Versus Family Kinship Care, Rashanda Allen

Walden Dissertations and Doctoral Studies

Children in foster care represent a highly traumatized population. However, trauma researchers studying this population have focused primarily on maltreatment rather than the full spectrum of posttraumatic stress disorder (PTSD) attributes and symptoms for children living in nonkinship foster homes versus kinship foster homes. The purpose of this study was to address this gap in the literature, as well as examine the benefits and limitations of children placed in kinship and nonkinship foster homes. Attachment theory was the theoretical framework. The research questions centered on the prevalence of specific types of posttraumatic stress symptoms for a sample of children living …

Experience Of Academic Motivation Among Disadvantaged High School Graduates, Jamaal Anthony Thomas

Walden Dissertations and Doctoral Studies

Impoverished students face obstacles that influence academic achievement and motivation. These young people are disadvantaged by their circumstances and are at risk for missing opportunities that could prepare them for meaningful careers and improved quality of life. The purpose of this qualitative study was to gain a deeper understanding of academic motivation in academic scholarship students who attended disadvantaged schools. Social identity theory provided the theoretical framework for a narrative analysis of the experience of academic motivation, academic achievement, and social identity. Five female and 4 male college students were interviewed. The thematic analysis revealed 4 themes: motivated by overcoming …

Lifestyle Factors And Social Determinants As Predictors Of Weight/Body Mass Index, Uthman Alhaji Baba

Walden Dissertations and Doctoral Studies

Obesity is a major public health concern that includes the risk of developing cardiovascular disease and premature death in adults. Previous studies have established the relationship between gender, educational level, household income and respondents’ weight but additional research is needed to factor the nature of education in relation to gender differences, diet, and other important behavioral mediators such as social determinants. The purpose of this quantitative cross-sectional study is to determine the extent to which frequency of physical activity, household income, social determinants of health (money for balanced meals, finances at the end of month, and poor mental health), respondent …

Effects Of Short-Term Intensive Insulin Therapy In Type 2 Diabetes Mellitus Management, Ernest Mwathi

Walden Dissertations and Doctoral Studies

Diabetes is a chronic illness affecting millions of individuals in the United States and is the seventh leading cause of death. Most of the Type 2 Diabetes Mellitus (T2DM) patients manage their illness with non-insulin therapies resulting in inadequate glycemic control but there are times when they experience inadequate glycemic control and require short-term intensive insulin therapy (SIIT). Despite proven effectiveness of SIIT, there is a lack of research focusing on the effectiveness of clinical practice where providers revert their clients to non-insulin therapy after SIIT. The focus of this quality improvement (QI) project was to evaluate pre/post data and …

Exploring A Pathway Out Of Poverty Using The Welfare System, Cadarrall A. Eddings

Walden Dissertations and Doctoral Studies

Individuals dependent on Temporary Assistance for Needy Families (TANF) encounter

multiple contributors that impede economic empowerment and a pathway out of poverty

that leads to self '€“ sufficiency. Previous research has not been fully clarified as to why

TANF has not been successful in moving recipients out of dependency and into lasting

economic success. The purpose of this phenomenological qualitative study was to

conduct a comparative analysis between two administrations, namely the Obama and

Trump administrations, concerning welfare policies. The human capital theory provided

the theoretical framework for the study. This study explored the lived experiences of

TANF recipients related …

Clinical Profile Of Alzheimer’S Patients: A Multihospital Based Study Done In India, Nitin Joseph, Sarthak Sharma, Madhur Khullar, Sreemanth Ched

Open Access archive

Objectives. To find out the risk factors, clinical features, co-morbid conditions and management practices among AD patients. Materials and methods. This study was conducted at three major tertiary care hospitals in Mangalore city of south India. Medical records of confirmed cases of AD over the recent 10 years were analyzed. A semi-structured proforma was used for data collection. Outcomes. Mean age of the 55 AD patients was 81.1±7.6 years. The mean age at diagnosis was 75.95±7.95 years. The age at the onset of AD in 14 (25.5%) patients was from 76 to 80 years. Early onset AD (≤ 65 years) …

Association Of Clinical Parameters, Oral Hygiene, And Dietary Practices With Active Caries Lesions Among Children With Early Childhood Caries, Shailaja Datta, Baranya S. Suprabha, Ramya Shenoy, Arathi Rao

Open Access archive

Aim: To find whether there is an association of clinical parameters, dental attendance pattern, oral hygiene, and dietary practices with the presence of active caries lesions among children with early childhood caries (ECC). Materials and methods: In this cross-sectional study, 171 children of 3–5 years of age with at least one decayed/filled tooth surface were examined. The presence or absence of visible plaque and decayed, missing, or filled-surface (dmfs) score were recorded. Each tooth surface was scored as per International Caries Detection and Assessment System (ICDAS) II criteria followed by supplemental lesion activity assessment (LAA) criteria, which was used to …

The Burden Of Unintentional Drowning: Global, Regional And National Estimates Of Mortality From The Global Burden Of Disease 2017 Study, Richard Charles Franklin, Amy E. Peden, Erin B. Hamilton, Catherine Bisignano

Open Access archive

Background: Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive causes of injury-related mortality in the Global Burden of Disease (GBD) study. This study's objective is to describe unintentional drowning using GBD estimates from 1990 to 2017. Methods: Unintentional drowning from GBD 2017 was estimated for cause-specific mortality and years of life lost (YLLs), age, sex, country, region, Socio-demographic Index (SDI) quintile, and trends from 1990 to 2017. GBD 2017 used standard GBD methods for estimating mortality …

Comparative Validity Of Microalbuminuria Versus Clinical Mortality Scores To Predict Pediatric Intensive Care Unit Outcomes, Shifa Nismath, Suchetha S. Rao, B. S. Baliga, Vaman Kulkarni

Open Access archive

Background: Predicting the prognosis of patients admitted to the pediatric intensive care unit (PICU) is very important in determining further management and resource allocation. The prognostication of critically ill children can be challenging; hence, accurate methods for predicting outcomes are needed. Purpose: To evaluate the role of microalbuminuria at admission as a prognostic marker in comparison to standard Pediatric Risk of Mortality (PRISM) and Pediatric Logistic Organ Dysfunction (PELOD) mortality scores in children admitted to the PICU. Methods: This cross-sectional study was conducted from January 2015 to October 2016. Eighty-four patients aged 1 month to 18 years admitted to the …

Candidal Carriage In Saliva And Subgingival Plaque Among Smokers And Non-Smokers With Chronic Periodontitis-A Cross-Sectional Study, Gayathri Santhana Krishnan, Dilip Naik, Ashita Uppoor, Sangeeta Nayak

Open Access archive

Background and Objectives. Studies of gum or periodontal disease have focused mainly on bacterial pathogens. However, information related to fungal species in the saliva and subgingival mileu is particularly lacking in smokers with periodontitis. This cross-sectional study compared the prevalence of various Candida species in saliva and subgingival plaque samples of smokers and non-smokers with periodontal disease. Methodology. Study subjects were recruited into three group-Group 1: Smokers with chronic periodontitis (N = 30), Group 2: Non-smokers with chronic periodontitis (N = 30) and Group 3: Healthy controls (N = 30). Clinical parameters recorded included plaque index (PI), gingival index (GI), …

Principles, Applications, And Biosafety Of Plant Genome Editing Using Crispr-Cas9, Kaoutar El-Mounadi, María Luisa Morales-Floriano, Hernan Garcia-Ruiz

Department of Plant Pathology: Faculty Publications

The terms genome engineering, genome editing, and gene editing, refer to modifications (insertions, deletions, substitutions) in the genome of a living organism. The most widely used approach to genome editing nowadays is based on Clustered Regularly Interspaced Short Palindromic Repeats and associated protein 9 (CRISPR-Cas9). In prokaryotes, CRISPR-Cas9 is an adaptive immune system that naturally protects cells from DNA virus infections. CRISPR-Cas9 has been modified to create a versatile genome editing technology that has a wide diversity of applications in medicine, agriculture, and basic studies of gene functions. CRISPR-Cas9 has been used in a growing number of monocot and dicot …

The Role Of European Starlings (Sturnus Vulgaris) In The Dissemination Of Multidrug- Resistant Escherichia Coli Among Concentrated Animal Feeding Operations, Jeffrey C. Chandler, Jennifer E. Anders, Nicolas A. Blouin, James C. Carlson, Jeffrey T. Lejeune, Lawrence D. Goodridge, Baolin Wang, Leslie A. Day, Anna M. Mangan, Dustin A. Reid, Shannon M. Coleman, Matthew W. Hopken, Bledar Bisha

United States Department of Agriculture Wildlife Services: Staff Publications

Antimicrobial use in livestock production is a driver for the development and proliferation of antimicrobial resistance (AMR). Wildlife interactions with livestock, acquiring associated AMR bacteria and genes, and wildlife’s subsequent dispersal across the landscape are hypothesized to play an important role in the ecology of AMR. Here, we examined priority AMR phenotypes and genotypes of Escherichia coli isolated from the gastrointestinal tracts of european starlings (Sturnus vulgaris) found on concentrated animal feeding operations (CAFOs). European starlings may be present in high numbers on cAfos (>100,000 birds), interact with urban environments, and can migrate distances exceeding 1,500 km in North …

Test-Retest Reliability Of Binaural Interaction Component (Bic) Using Speech And Non-Speech Evoked Abr, Kaushlendra Kumar, M. S. Divyashree, Ritik Roushan, Manita Thomas

Open Access archive

Background and Objective: Binaural hearing serves as an advantage in daily communication by facilitating better localization of sounds and perception of speech in the presence of noise. BIC of ABR has been used to understand the binaural representation of different stimuli, such as transient clicks, and complex signals, such as speech. The present study aimed to investigate the test-retest reliability of the binaural interaction component for click and speech evoked ABR. Methods: 30 individuals with normal hearing served as participants for the present study. ABR for click and speech stimuli (/da/) were recorded from these participants in monaural and binaural …

Optical Biopsy And Optical Pathology: Affordable Health Care Under Low-Resource Settings, Swathi Rao, Reena John, Ajeetkumar Patil, V. K. Unnikrishnan

Open Access archive

In this paper the potential of optical spectroscopy based techniques for regular screening and early diagnosis of “Killer” diseases (various types of cancers, cardiovascular diseases, etc.) is discussed with focus on routine use under low-resource settings. A brief account of work carried out in our laboratory to design, assemble and optimize Laser Induced Fluorescence (LIF) based optical devices for routine screening, early diagnosis and discrimination of premalignant/malignant conditions in oral and other cancers is presented. An ultra-sensitive protein profiling system based on highly efficient High Performance Liquid Chromatograpy-Ultrasensitive Laser Induced Fluorescence (HPLC-LIF) detection, and its extensive use in monitoring various …

Assessment Of Knowledge Of Use Of Electronic Cigarette And Its Harmful Effects Among Young Adults, Vidushi Gupta, Madhu Sharma, Natarajan Srikant, Nidhi Manaktala

Open Access archive

Background - The practice of young adults smoking e-cigarette may have been adopted as a way of smoking cessation or just to follow a trend. Most people still remain unaware of the detrimental effects of e-cigarette. This study was carried out to assess the prevalence of the habit of smoking e-cigarette and the awareness of its harmful effects among adults aged 18.23 years. Methods - A questionnaire adopted from a study conducted in Italy was used in the study following due permission. After taking their consent, participants were requested to fill the survey irrespective of their smoking status. Results - …

Estimating Global Injuries Morbidity And Mortality: Methods And Data Used In The Global Burden Of Disease 2017 Study, Spencer L. James, Chris D. Castle, Zachary V. Dingels, Jack T. Fox

Open Access archive

Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality …

Evaluation Of Plaque Removal Efficacy Of Dental Floss With/Without Chlorhexidine Gel Coating In Patients With Gingivitis-A Clinical And Microbological Study, Monika Pal, Santhosh Kumar, Padmaja A. Shenoy, T. A.K. Chaitanya

Open Access archive

BACKGROUND: Chlorhexidine has shown anti-plaque and antimicrobial effects when used as a mouthwash and appears to be effective when used as a topical antiseptic agent. AIM: The present study aimed to compare the efficacy of chlorhexidine gel coated dental floss with that of uncoated dental floss. METHODS: This parallel, single-blinded, randomized controlled clinical trial Included 30 patients with moderate to severe gingivitis. The total population was randomly divided into three groups, with ten patients in each group. Group A received dental floss with 1% chlorhexidine gel, and Group B received only dental floss, while in Group C no dental floss …

Immune Control Of Animal Growth In Homeostasis And Nutritional Stress In Drosophila, Preethi P, Ajay Tomar, Sukanya Madhwal, Tina Mukherjee

Open Access archive

A large body of research implicates the brain and fat body (liver equivalent) as central players in coordinating growth and nutritional homeostasis in multicellular animals. In this regard, an underlying connection between immune cells and growth is also evident, although mechanistic understanding of this cross-talk is scarce. Here, we explore the importance of innate immune cells in animal growth during homeostasis and in conditions of nutrient stress. We report that Drosophila larvae lacking blood cells eclose as small adults and show signs of insulin insensitivity. Moreover, when exposed to dietary stress of a high-sucrose diet (HSD), these animals are further …

Genomic-Based Identification Of Environmental And Clinical Listeria Monocytogenes Strains Associated With An Abortion Outbreak In Beef Heifers, Katherine J. Whitman, James L. Bono, Michael L. Clawson, John D. Loy, Joseph M. Bosilevac, Terrance M. Arthur, Jeff D. Ondrak

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: In a beef cattle facility an outbreak of abortions occurred over a 36-day period and included samples from two aborted (non-viable) fetuses and 21 post-abortion clinical cases. There are numerous etiologies, including clinical listeriosis. At the species level, Listeria monocytogenes is ubiquitous in cattle production environments, including soil, feed, and occasionally water sources, and is a common enteric resident of cattle and other mammals. There are four genetically distinct lineages of L. monocytogenes (I-IV), with most lineage III and IV isolates obtained from ruminants. Definitive diagnosis of L. monocytogenes as a causative agent in disease outbreaks relies upon case …

Introduction: Global Health And Human Rights, Lawrence O. Gostin, Benjamin Mason Meier

Georgetown Law Faculty Publications and Other Works

This introduction highlights the foundational importance of human rights for global health and provides an academic framework for this book by laying out the role of human rights under international law as a basis for public health. Part I seeks to define the evolving conceptualization of health, examining both the shifting focus from medicine to public health and the shifting response from international health to global health. Framing global health as a human rights imperative, Part II examines the establishment of human rights under international law, the implementation of these rights in public policy, and the development of rights for …

Silicone Wristbands As Passive Samplers In Honey Bee Hives, Emma J. Bullock '19, Alexis M. Schafsnitz '17, Chloe H. Wang '17, Robert L. Broadrup, Helen K. White

Chemistry Faculty Scholarship

No abstract provided.

Borderplex Business Barometer, Volume 4, Number 1, Thomas M. Fullerton Jr., Steven L. Fullerton, Ana Gutierrez Zubiate, Ignacio Santana

Border Region Modeling Project

No abstract provided.

The Role Of A Principal In Creating A School Climate In Which New American Students Thrive: An Ethnographic Case Study Of A Midwest Magnet School, Attia Noor

Theses and Dissertations

This ethnographic case study used the lens of multiculturalism to examine the role of a school principal in creating a climate in which New American students can thrive. Three discrete data gathering methods were utilized in this study including policy documents obtained from the school district website and the school, a two week period of in-school observations, and interviews of the principal and school staff members selected through purposive sampling. A focus group interview of parents was also used for data collection. Data were analyzed by using a constant comparative method to explore the meanings educators had attached to their …