Digital Commons Network^™

Safety And Pharmacokinetics Of Naringenin: A Randomized, Controlled, Single-Ascending-Dose Clinical Trial, Candida J. Rebello, Robbie A. Beyl, Juan J.L. Lertora, Frank L. Greenway, Eric Ravussin, David M. Ribnicky, Alexander Poulev, Brandon J. Kennedy, Hector F. Castro, Shawn R. Campagna, Ann A. Coulter, Leanne M. Redman

Clinical Research Faculty Publications

Aims: To evaluate the safety and pharmacokinetics of naringenin in healthy adults consuming whole-orange (Citrus sinensis) extract. Methods and methods: In a single-ascending-dose randomized crossover trial, 18 adults ingested doses of 150 mg (NAR150), 300 mg (NAR300), 600 mg (NAR600) and 900 mg (NAR900) naringenin or placebo. Each dose or placebo was followed by a wash-out period of at least 1 week. Blood safety markers were evaluated pre-dose and 24 hours post-dose. Adverse events (AEs) were recorded. Serum naringenin concentrations were measured before and over 24 hours following ingestion of placebo, NAR150 and NAR600. Four- and 24-hour serum measurements were …

Boundaries And Infomediaries: A Qualitative Study Of The Information Practices Of Community Health Workers, Robert M. Shapiro Ii

Theses and Dissertations--Communication

Despite successful efforts to treat and manage diseases, public health officials have recently begun a campaign to refocus efforts toward initiatives to alleviate the pressures that are often referred to as social determinants of health. In eastern Kentucky, and in other geographical regions labeled as health professional shortage areas or medically underserved areas, issues stemming from social determinants are compounded with health care systems that are often lacking the human resources to meet basic medical needs. One strategy has been to utilize volunteers and paraprofessionals such as community health workers to lessen the burden on the primary care and hospital …

Encouraging Healthy Eating Among Older Adults Using The Transtheoretical Model: An Evaluation Of A Pilot Intervention, Lauren Brinkman Roberson

Theses and Dissertations--Communication

Older adults, defined as those age 60 and above, are at an increased risk for many health-related complications that are directly related to nutrition (Centers for Disease Control and Prevention, 2015). This study highlights the lack of nutrition education material developed for older adults in Kentucky. Such material has great potential to influence the health of older adults (Chernoff, 2001). This study evaluated an intervention developed, by means of formative research, to teach older adults nutrition basics. Both direct and indirect measures related to stages of change for healthy eating behaviors were collected six weeks pre-intervention and then immediately post-intervention. …

Analysis Of Information Value Chains For Gout Self-Care Management, Maranda Russell

Theses and Dissertations--Communication

This value chain analysis study sought to identify information needed by gout patients to successfully manage their disease, leading to a model for information extraction from patient health records. A scoping review was conducted to identify the types of information needed by gout patients. The findings of each included study were divided and analyzed according to the stages of the care delivery value chain. The results of the review were then used to create a gout information value chain as criteria for annotating the information deemed important for gout patients contained in publicly available patient education materials according to the …

Publicly Charged: A Critical Examination Of Immigrant Public Benefit Restrictions, Cori Alonso-Yoder

Scholarly Articles in Law Reviews & Journals

Since the early days of the Trump Administration, reports of the President’s controversial and dramatic immigration policies have dominated the news. Yet, despite the intensity of this coverage, an immigration policy with far broader implications for millions of immigrants and their U.S.- citizen family members has dodged the same media glare. By expanding the definition of who constitutes a “public charge” under immigration law, the Administration has begun a process to restrict legal immigration and chill the use of welfare benefits around the country. The doctrine of public charge exclusion developed from colonial times and has reemerged in Trump Administration …

Dietary Fish Oil Supplement Induces Age-Specific Contractile And Proteomic Responses In Muscles Of Male Rats, David W. Russ, Kalina Dimova, Emily Morris, Marguerite Pacheco, Sean M. Garvey, Stylianos P. Scordilis

Biological Sciences: Faculty Publications

Background: Dietary fish oil (DFO) has been identified as a micronutrient supplement with the potential to improve musculoskeletal health in old age. Few data are available for effects of DFO on muscle contractility, despite the significant negative impact of muscle weakness on age-related health outcomes. Accordingly, the effects of a DFO intervention on the contractile function and proteomic profile of adult and aged in an animal model of aging were investigated.

Methods: This preliminary study evaluated 14 adult (8 months) and 12 aged (22 months) male, Sprague-Dawley rats consuming a DFO-supplemented diet or a control diet for 8 weeks (7 …

Evaluating Appropriateness And Diagnostic Stewardship Opportunities Of Multiplex Polymerase Chain Reaction Gastrointestinal Testing Within A Hospital System, Melissa O'Neal, Hanna Murray, Sangita Dash, Majdi N. Al-Hasan, Julie Ann Justo, P Brandon Bookstaver

Faculty Publications

Objective: This single-center, retrospective, observational cohort study evaluates the appropriateness of the BioFire® FilmArray® Gastrointestinal (GI) multiplex PCR panel testing at a community-teaching hospital. Methods: All adult, hospitalized patients at Prisma Health Richland Hospital with a documented GI multiplex PCR panel from 1 April 2015 through 28 February 2018 were included in the analysis. Inappropriate use of the GI panel was defined as a test obtained without documented diarrhea, greater than 2 days of hospitalization, redundant use with other diagnostic tests (e.g. PCR), or laxative use in the preceding 48 h. Antibiotic use and host variables were compared between groups …

Interleukin 1Β And Prostaglandin E2 Affect Expression Of Dna Methylating And Demethylating Enzymes In Human Gingival Fibroblasts, Sara Seutter, Jacquay Winfield, Alexis Esbitt, Samantha Snyder, Anastasia Magner, Kristine Kim, Craig Carcuffe, Jeremy Schmoyer, Payvand Kamrani, Jason Mercando, Seyed M Shamseddin, Kevan Green, Ruth C. Borghaei

PCOM Scholarly Works

Periodontitis is a common chronic inflammatory condition that results in increased levels of inflammatory cytokines and inflammatory mediators. In addition to oral disease and tooth loss, it also causes low-grade systemic inflammation that contributes to development of systemic conditions including cardiovascular disease, pre-term birth, diabetes and cancer. Chronic inflammation is associated with epigenetic change, and it has been suggested that such changes can alter cell phenotypes in ways that contribute to both ongoing inflammation and development of associated pathologies. Here we show that exposure of human gingival fibroblasts to IL-1β increases expression of maintenance methyltransferase DNMT1 but decreases expression of …

ผลของโปรแกรมการเสริมสร้างพลังอำนาจของมารดาต่อการรับรู้ความสามารถ และปริมาณน้ำนมที่บีบเก็บได้ของมารดา ในการให้นมบุตรที่คลอดก่อนกำหนด, ไฉไล ผาเงิน, ทศา ชัยวรรณวรรต, ธนันต์พร ตรีบุตรดี, ณัฐธิราภรณ์ พูลเพิ่ม, กมลธิดา เหล่าบุตรสา

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาผลของโปรแกรมการเสริมสร้างพลังอำนาจของมารดาต่อการรับรู้ความสามารถ และปริมาณน้ำนมที่บีบเก็บได้ ของมารดาในการให้นมบุตรที่คลอดก่อนกำหนด

แบบแผนการวิจัย: การวิจัยกึ่งทดลอง

วิธีดำเนินการวิจัย: กลุ่มตัวอย่าง คือ มารดาที่คลอดทารกก่อนกำหนด จำนวน 30 คน เครื่องมือที่ใช้ในการวิจัย คือ โปรแกรมการเสริมสร้างพลังอำนาจในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด ตึกเด็ก 1-2 โรงพยาบาลสรรพสิทธิประสงค์ จังหวัดอุบลราชธานี แบบสอบถามการรับรู้ความสามารถในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด แบบสอบถามพลังอำนาจในการให้นมแม่ มีค่าสัมประสิทธิ์แอลฟาครอนบาคเท่ากับ .92 และ .92 วิเคราะห์ข้อมูล ค่าร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และสถิติ Pair t-test ที่ระดับนัยสำคัญทางสถิติ .05

ผลการวิจัย: หลังได้รับโปรแกรมการเสริมสร้างพลังอำนาจในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด พบว่า การรับรู้ความสามารถในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด และความสามารถในการบีบเก็บน้ำนมได้สูงกว่าก่อนได้รับโปรแกรมเสริมสร้างพลังอำนาจ อย่างมีนัยสำคัญที่ระดับ .05

สรุป: โปรแกรมเสริมสร้างพลังอำนาจในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด ตึกเด็ก 1-2 โรงพยาบาลสรรพประสิทธิประสงค์ จังหวัดอุบลราชธานี เพิ่มการรับรู้ความสามารถในการให้นมแม่ในมารดาที่มีทารกคลอดก่อนกำหนด และความสามารถในการบีบเก็บน้ำนมสูงขึ้นได้

The Plight Of An Indian Woman: Role Of Gender And Caste In Determining Land Owning Capacity In India, Grishma Bhattarai

Undergraduate Honors Theses

In India, gender gap in the ownership and control of property significantly contributes to the gender gap in all other aspects of a woman’s life including her physical and emotional well-being, economic autonomy, social status, and her empowerment. Studying property and land rights is a good stepping stone in understanding the paradigm of gender equality in India. In terms of land property in an agrarian country like India, it is particularly ironic given that agriculture is a woman’s occupation, however, land occupation is still tipped in the male population’s favor. Caste subjugates this disparity further. Despite progressive acts and rights …

Relationship Between Obesity-Induced Metabolic Abnormalities And Nutrient Intake: Sex Differences In Japanese University Students, Mayumi Yamamoto, Mausam Mehta, Akihiro Nishio, Ryo Horita, Ricardo Izurieta

Global Health Faculty Publications

Background: Preventive measures and interventions for obesity in young adults are urgently needed. However, evidence-based guidelines for interventional programs in this generation have not been established worldwide because of limited access to data on this group. To establish effective methods of obesity prevention in young adults, we analyzed the relationship between nutrient intake and obesity-related metabolic factors in each body mass index (BMI) group among Japanese university students. Methods: A cross-sectional analysis was performed using annual health checkup data, which is conducted mandatory for all students according to the School Health and Safety Act in Japan, from Gifu University’s incoming …

Prediction Of Chronic Disease-Related Inpatient Prolonged Length Of Stay Using Machine Learning Algorithms, Hasan Symum, José Zayas-Castro

Industrial and Management Systems Engineering Faculty Publications

Objectives: The study aimed to develop and compare predictive models based on supervised machine learning algorithms for predicting the prolonged length of stay (LOS) of hospitalized patients diagnosed with five different chronic conditions. Methods: An administrative claim dataset (2008–2012) of a regional network of nine hospitals in the Tampa Bay area, Florida, USA, was used to develop the prediction models. Features were extracted from the dataset using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes. Five learning algorithms, namely, decision tree C5.0, linear support vector machine (LSVM), k-nearest neighbors, random forest, and multi-layered artificial neural networks, were …

Farm To Food Desert: A Look At How The Agriculture And Nutrition Act Of 2018 Affects Food Insecurity And Access To Fresh Fruits And Vegetables, Lexington Souers

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Asbury Theological Seminary Academic Catalog : 2020-2021, Asbury Theological Seminary

Academic Catalogs

No abstract provided.

Serum 25-Hydroxyvitamin D Levels In Children With Mild And Severe Atopic Asthma, Rhoda Ndinda Masaku

Master of Medicine in Paediatrics and Child Health

Background: Asthma is a chronic respiratory illness affecting an estimated 334 million people worldwide, including 14% of the total pediatric population. It results in significant morbidity, and therefore the etiologies and risk factors associated with asthma are of great interest. Serum 25- hydroxyvitamin D (25(OH)D) has substantial immunomodulatory effects on the innate immune system. It reduces the probability of viral respiratory infections and asthma exacerbations by potentiating the anti-inflammatory action of corticosteroids. Objectives: This study was conducted to determine if there was a difference in serum 25-hydroxyvitamin D levels between children with mild and severe atopic asthma and explored the …

Louisiana Agriculture Winter, 2020, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, P Sandifer, L Knapp, M Lichtveld, R Manley, P Sandifer, R Caffey, D Cochran, T Collier, K Ebi, L Engel, J Farrington, M Finucane, C Hale, D Halpern, E Harville, L Hart, Y Hswen, B Kirkpatrick, B Mcewen, G Morris, R Orbach, L Palinkas, M Partyka, D Porter, G Prather, T Rowles, G Scott, T Seeman, H Solo-Gabriele, E Svendsen, T Tincher, J Trtanj, A H. Walker, R Yehuda

Faculty Publications

The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human health consequences of future disasters requires establishment of a comprehensive, sustained community health observing system, similar to the extensive and well-established environmental observing systems. We propose a system that combines six levels of health data domains, beginning with three existing, national surveys …

Small Molecule Inhibitors Of The Bfrb-Bfd Interaction Decrease Pseudomonas Aeruginosa Fitness And Potentiate Fluoroquinolone Activity, Achala N.D.Punchi Hewage, Huili Yao, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Scott Lovell, Richard A. Bunce, Kate Eshelman, Sahishna M. Phaniraj, Molly M. Lee, Blake R. Peterson, Kevin P. Battaile, Allen B. Reitz, Mario Rivera

Faculty Publications

© 2019 American Chemical Society. All rights reserved. The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- A nd 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively …

Improving Health Behaviors Through Community Engagement: Challenge For A Healthier Louisiana, Stephanie T. Broyles, Elizabeth A. Gollub, Allison Tohme, Peter T. Katzmarzyk

Faculty Publications

There is increasing recognition that community-based approaches may have merit in improving physical activity and healthy eating behaviors. The “Challenge for a Healthier Louisiana” program supported twelve projects that addressed the root causes of obesity through integrated community-level changes. Partnerships provided community-based obesity prevention by promoting healthier eating and/or physical activity through enhanced infrastructure, policy changes, and programming. To evaluate whether the program resulted in changes in healthy eating and/or physical activity among adults, surveys were conducted pre- and postintervention among participants. Participants who were exposed to physical activity programs were more likely to adopt the consumption of fruits (odds …

Assessing Salvinia Molesta Impact On Environmental Conditions In An Urban Lake: Case Study Of Lago Las Curias, Puerto Rico, Charles F. Wahl, Rodrigo Diaz, Jorge Ortiz-Zayas

Faculty Publications

Giant salvinia (Salvinia molesta Mitchell, Salviniaceae) is a free-floating fern native to Brazil that alters natural processes in aquatic ecosystems, causing ecological problems for water resource managers. Due to its ease of dispersal through fragmentation and rapid growth, giant salvinia can quickly become problematic, requiring persistent management efforts. If left unmanaged, giant salvinia creates a thick mat of vegetation, which limits sunlight penetration, reducing aquatic macrophytes, lowering dissolved oxygen and stressing aquatic organisms. Giant salvinia was first reported in Lago Las Curias, Cupey, San Juan, Puerto Rico, USA, in 2016 and covered the entire 19 ha waterbody in 2018. In …

Diverging Landscape Impacts On Macronutrient Status Despite Overlapping Diets In Managed (Apis Mellifera) And Native (Melissodes Desponsa) Bees, Christina L. Mogren, Mariá Soledad Benítez, Kevin Mccarter, Frédéric Boyer, Jonathan G. Lundgren

Faculty Publications

Declining pollinator populations worldwide are attributed to multiple stressors, including the loss of quality forage. Habitat management in agricultural areas often targets honey bees (Apis mellifera L.) specifically, with the assumption that native bees will benefit from an 'umbrella species' strategy. We tested this theory using a conservation physiology approach to compare the effects of landscape composition and floral dietary composition on the physiological status of honey bees and Melissodes desponsa in eastern South Dakota, USA. The total glycogen, lipid and protein concentrations were quantified from field collected bees. Next-generation sequencing of the trnL chloroplast gene from bee guts was …

The Association Between Selected Molecular Biomarkers And Ambulatory Blood Pressure Patterns In African Chronic Kidney Disease And Hypertensive Patients Compared With Normotensive Controls: Protocol For A Longitudinal Study, Abiodun Moshood Adeoye, Oladimeji Adebayo, Busayo Abiola, Bamidele Iwalokun, Bamidele Tayo, Fadi Charchar, Akinlolu Ojo, Richard Cooper

Faculty Publications

Background: Chronic kidney disease (CKD) is a burgeoning epidemic in sub-Saharan Africa. Abnormal blood pressure variations are prevalent in CKD and potentiate the risk of cardiovascular morbidity and mortality. Certain genetic variants (angiotensin II receptor type 1 1166 A>C and angiotensin-converting enzyme insertion and deletion polymorphisms) and biomarkers such as interleukin-6, tumor necrosis factor, soluble (s) E-selectin, homocysteine, and highly sensitive C-reactive protein have been shown to affect blood pressure variability among non-African CKD, hypertensive. and nonhypertensive CKD population. However, the contributions of the pattern, genetic, and environmental determinants of ambulatory blood pressure in African CKD have not been …

Lsu General Catalog 2020-2021, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

Marine Wild-Capture Fisheries After Nuclear War, K.J.N. Scherrer, C.S. Harrison, R.F. Heneghan, E. Galbraith, C.G. Bardeen, J. Coupe, J. Jägermeyr, N.S. Lovenduski, A. Luna, A. Robock, J. Stevens, S. Stevenson, O.B. Toon, L. Xia

Faculty Publications

No abstract provided.

A Perspective On The Transition To Plant-Based Diets: A Diet Change May Attenuate Climate Change, But Can It Also Attenuate Obesity And Chronic Disease Risk, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup

Clinical Research Faculty Publications

Current dietary guidelines advocate more plant-based, sustainable diets on the basis of scientific evidence about diet-health relations but also to address environmental concerns. Here, we critically review the effects of plant-based diets on the prevalence of obesity and other health outcomes. Plant-based diets per se have limited efficacy for the prevention and treatment of obesity, but most have beneficial effects in terms of chronic disease risk. However, with the considerable possibilities of translating plant-based diets into various types of dietary patterns, our analysis suggests that potential adverse health effects should also be considered in relation to vulnerable groups of the …

The Environmental Foodprint Of Obesity, Faidon Magkos, Inge Tetens, Susanne Gjedsted Bügel, Claus Felby, Simon Rønnow Schacht, James O. Hill, Eric Ravussin, Arne Astrup

Clinical Research Faculty Publications

Emissions of greenhouse gases (GHG) are linked to global warming and adverse climate changes. Meeting the needs of the increasing number of people on the planet presents a challenge for reducing total GHG burden. A further challenge may be the size of the average person on the planet and the increasing number of people with excess body weight. We used data on GHG emissions from various sources and estimated that obesity is associated with ~20% greater GHG emissions compared with the normal-weight state. On a global scale, obesity contributes to an extra GHG emissions of ~49 megatons per year of …

One-Year Postpartum Anthropometric Outcomes In Mothers And Children In The Life-Moms Lifestyle Intervention Clinical Trials, Suzanne Phelan, Rebecca G. Clifton, Debra Haire-Joshu, Leanne M. Redman, Linda Van Horn, Mary Evans, Kaumudi Joshipura, Kimberly A. Couch, S. Sonia Arteaga, Alison G. Cahill, Kimberly L. Drews, Paul W. Franks, Dympna Gallagher, Jami L. Josefson, Samuel Klein, William C. Knowler, Corby K. Martin, Alan M. Peaceman, Elizabeth A. Thom, Rena R. Wing, Susan Z. Yanovski, Xavier Pi-Sunyer

Clinical Research Faculty Publications

Background/objectives: Excess gestational weight gain (GWG) is a risk factor for maternal postpartum weight retention and excessive neonatal adiposity, especially in women with overweight or obesity. Whether lifestyle interventions to reduce excess GWG also reduce 12-month maternal postpartum weight retention and infant weight-for-length z score is unknown. Randomized controlled trials from the LIFE-Moms consortium investigated lifestyle interventions that began in pregnancy and tested whether there was benefit through 12 months on maternal postpartum weight retention (i.e., the difference in weight from early pregnancy to 12 months) and infant-weight-for-length z scores. Subjects/methods: In LIFE-Moms, women (N = 1150; 14.1 weeks gestation …

A Snack Formulated With Ingredients To Slow Carbohydrate Digestion And Absorption Reduces The Glycemic Response In Humans: A Randomized Controlled Trial, Candida J. Rebello, William D. Johnson, Yang Pan, Sandra Larrivee, Dachuan Zhang, Mark Nisbet, Jodee Johnson, Yi Fang Chu, Frank L. Greenway

Clinical Research Faculty Publications

This study compared the effect of a snack with ingredients to slow carbohydrate digestion (Test-snack) on postprandial blood glucose and insulin concentrations and subjective appetite ratings. We hypothesized that Test-snack would lower glucose and insulin responses and reduce appetite compared with a Control-snack. Overweight or obese subjects (n = 17) completed a randomized crossover study. Glucose, insulin, and appetite ratings were measured before consuming each snack or white bread (Bread) and over a period of 4 h. Subjects received Test-snack, Control-snack, or Bread in random order at least a week apart. The a priori primary outcome was the glucose response, …

The Love Of Aerial Practice: Art, Embodiment, Phronesis, Maria Kosma, Nick Erickson

Faculty Publications

Background of study: Given the importance of movement and low exercise adherence among young adults, it is imperative to understand reasons for the love of movement. Objective: The purpose of this phronetic, qualitative study was to examine if the values of aerial practice encompassed elements of embodiment, techne (art), and phronesis (practical wisdom). Method: Participants were 13 undergraduate college students in an aerial practice class. Individual-based interview topics included exercise behavior and the values and meaning of aerial practice. Results: All participants were active regardless of aerial practice classification (e.g., beginners vs advanced). Beyond aerial practice, other exercises included dancing, …

Gamified E-Health Solution To Promote Postnatal Care In Morocco, Lamyae Sardi, Ali Idri, Taoufik Rachad, Leanne Redman, Hassan Alami

Clinical Research Faculty Publications

The postnatal period is a critical phase in both the lives of the mothers and the newborns. Due to all the inherent changes that occur during this period, quality care is crucial during this period to enhance the wellbeing of the mothers and the newborns. In Morocco, the neglection of postnatal care services are often associated to poor communication, financial difficulties and cultural barriers. Mobile technology constitutes therefore a promising approach to bridge this gap and promote postnatal care. In order to improve the effectiveness of mobile technology, gamification has become a powerful feature to boost motivation and induce fun …