Digital Commons Network^™

Ampk And Mtor Impose Dualistic Regulation Of Mitophagy And Autophagy In In Vitro Models Of Prostate Cancer, Brianne Richardson

PCOM Biomedical Studies Student Scholarship

Prostate cancer is the abnormal growth and proliferation of previously normal cells of the prostate and has the second highest incidence in men worldwide. Physiologic manipulation of AMP-activated protein kinase (AMPK), a highly conserved enzyme responsible for regulation of energy homeostasis during metabolic stress, is a potential treatment, especially for metastatic, castration-resistant prostate cancers. AMPK is a known inhibitor of the enzyme mTOR, the final enzyme in the PKT/AKT/mTOR pathway responsible for cell growth and proliferation signaling. The hypothesis of this project is that activation of AMPK leads to increased mTOR-dependent mitophagy and subsequent autophagy in prostate cancer cells. The …

Etsu Today - Summer 2020, University Marketing And Communication, East Tennessee State University

ETSU Today [magazine]

At East Tennessee State University, we are accustomed to dealing with hardship. It has been a defining part of our past. When tested by economic crises, wars, and threats to our very existence, our leaders, our faculty and staff, our students, our alumni, and our neighbors have met the challenge. ETSU not only survived, but it prevailed and prospered. It will continue to do so. From the very earliest days, our leaders faced uncertainty. Only eight days after the beginning of classes at East Tennessee State Normal School, our founding President, Sidney Gilbreath, was troubled. Faculty had already been on …

Chevron As Construction, Lawrence B. Solum, Cass R. Sunstein

Cornell Law Review

In 1984, the Supreme Court declared that courts should uphold agency interpretations of ambiguous statutory provisions, so long as those interpretations are reasonable. The Chevron framework, as it is called, is now under serious pressure. Current debates can be both illuminated and softened with reference to an old distinction between interpretation on the one hand and construction on the other. In cases of interpretation, judges (or agencies) must ascertain the meaning of a statutory term. In cases of construction, judges (or agencies) must develop implementing principles or specify a statutory term. Chevron as construction is supported by powerful arguments; it …

Routine Childhood Immunization—Insights For Improving Malaria, Family Planning, And Maternal And Child Health Outcomes In Northwestern Nigeria Through Social And Behavior Change Programming, Breakthrough Research

Reproductive Health

This brief provides rigorous evidence-based insights to implementers and researchers of social and behavior change (SBC) programs that seek to improve community knowledge, attitudes, norms and behaviors for improved health of women and their young children. The brief focuses on key outcomes in routine childhood immunization, including all basic vaccinations needed for a child to be considered fully immunized by their first birthday according to the Nigerian Ministry of Health: BCG, three doses of oral polio vaccine, three doses of DPT vaccine, and one dose of measles vaccine. It also addresses the barriers and facilitators to vaccine uptake. It is …

Evaluating The Utilization Of A Combination Therapy To Improve Self-Efficacy And Glycemic Control In Patients With Type Two Diabetes Mellitus And Low Health Literacy, Crystal Manus Masling

Doctoral Dissertations and Projects

Type 2 diabetes mellitus is a significant health issue, as it requires patients to perform daily self-management activities. One in every three Americans with Type 2 diabetes has limited or low health literacy skills. Limited or low health literacy skills can impact a patient’s overall health outcome; therefore, a critical element for disease management and patient adherence is health literacy. The purpose of this three-month scholarly project was to determine if the utilization of an educational intervention specific to one’s level of health literacy, combined with a short message service reinforcement tool, could improve glycemic control and self-efficacy in Type …

Improving Newborn Outcomes Through Implementation Of Delayed Bathing: An Integrative Review, Tennille Ideen O'Connor

Doctoral Dissertations and Projects

Evidence-based practice is foundational to ensuring patient safety and quality of care. Implementing evidence-based practice is the responsibility of all care providers. The completion of an in-depth integrative review provides a project leader the opportunity to explore the benefits of delayed bathing of the newborn and impact of the practice on newborn outcomes. The goal of this integrative review is to identify the benefits of delayed bathing and ways to implement this practice in the clinical setting. This integrative review seeks to present care providers with the most recent research and guidelines as it relates to the practice of delayed …

Four Health Science Librarians’ Experiences: How They Responded To The Covid-19 Pandemic Crisis, Misa Mi, Yingting Zhang, Lin Wu, Wendy Wu

Library Scholarly Publications

In this article, four health sciences librarians from four academic libraries across the country will share their personal or library experiences in reaching out to faculty and students to meet their needs through their initiatives and continuous efforts using various technologies and tools. Three of the four academic libraries are located in two COVID-19 hard-hit states, Michigan and New Jersey. The article will describe their practice of health sciences librarianship during the unprecedented time and provide examples demonstrating how each of them strives to stay relevant, proactive, and become integral to their institutional efforts in support of students and employees …

Arcadia Magazine, 2020-07

Alumni Magazine

No abstract provided.

Policing The Wombs Of The World's Women: The Mexico City Policy, Samantha Lalisan

Indiana Law Journal

This Comment argues that the Policy should be repealed because it undermines

firmly held First Amendment values and would be considered unconstitutional if

applied to domestic nongovernmental organizations (DNGOs). It proceeds in four

parts. Part I describes the inception of the Policy and contextualizes it among other

antiabortion policies that resulted as a backlash to the U.S. Supreme Court’s

landmark decision in Roe v. Wade. Part II explains the Policy’s actual effect on

FNGOs, particularly focusing on organizations based in Nepal and Peru, and argues

that the Policy undermines democratic processes abroad and fails to achieve its stated

objective: reducing …

Sac Newsletter 2020, South Asia Center

Newsletters from the South Asia Center

No abstract provided.

Digital Mapping Of Togo’S Soil Fertility: Savannah Region, Aminou Saibou

International Programs

A soil assessment was carried out in the savannah region of Togo in 2018, aiming at drawing the digital map of Togo’s soil fertility and making fertilizer recommendations. Soil samples were taken from geo-referenced GPS points and were analyzed for parameters such as water pH, Organic matter, available phosphorus and exchangeable potassium. Thematic maps have been drawn using an ArcGIS package. The results showed that the soils of the Savannah region in Togo are mainly (84%) not very acidic (pH = 5.5 to 6.5), overall poor to very poor (84%) in organic matter (<2% OM), essentially poor to very poor (86%) in available phosphorus (<15 mg/kg of soil) and mostly very poor (87%) in exchangeable potassium (<90 mg / kg of soil). These results allowed the agricultural research institute of Togo to make fertilizer use recommendations and to develop, in partnership with Morocco, a digital platform (fertitogo.tg ) for decision making in crop fertilization.

Chevron As Construction, Lawrence B. Solum, Cass R. Sunstein

Faculty Scholarship

In 1984, the Supreme Court declared that courts should uphold agency interpretations of ambiguous statutory provisions, so long as those interpretations are reasonable. The Chevron framework, as it is called, is now under serious pressure. Current debates can be both illuminated and softened with reference to an old distinction between interpretation on the one hand and construction on the other. In cases of interpretation, judges (or agencies) must ascertain the meaning of a statutory term. In cases of construction, judges (or agencies) must develop implementing principles or specify a statutory term. In cases that involve statutory construction, the argument on …

Early Childhood Education In Ethiopia: A Case Study With Implications For Ethiopian Immigrants, Fadila Adam

School of Education and Leadership Student Capstone Theses and Dissertations

The research study analyzed early childhood education in Ethiopia. The objective of this study was to find out about early childhood education in Ethiopia in order to effectively support Ethiopian families in St. Paul, Minnesota. The following are the research guiding questions: 1) What are the early childhood teaching methodologies being used in the Ethiopian education system? 2) What are the teachers’ qualifications in Ethiopian early childhood education? 3) What are teachers’ perceptions of early childhood education in Ethiopia? Studies from the Center on the Developing Child found that learning in early childhood sets the foundation for future learning and …

Sdsu Beef Day 2020 Complete Proceedings, Department Of Animal Science

SDSU Beef Day 2020 Summary Publication

This is the complete proceedings of the South Dakota State University, Department of Animal Science Beef Day 2020. The proceedings contain research presented on the following topics:
Cow/Calf
SDSU Extension
Feedlot
Meat and Human Nutrition
Reproduction

Women’S Participation And Globalization, Madeline R. Buerle

Student Publications

What effect does women’s participation in national legislatures have on the levels of globalization, specifically economic and social globalization? I contend that women’s participation in national legislatures will have differing effects on economic and social globalization. I expect that higher levels of women’s participation in national legislatures will have a negative effect on levels of economic globalization and a positive effect on levels of social globalization. I demonstrate the plausibility of these relationships through an analysis of 194 countries between the years 1990 and 2017. Interestingly, my findings suggest that women’s participation in national legislatures has a positive and statistically …

Mitochondrial Contributions To Disuse Atrophy: Let’S Talk About Sex, Megan Rosa-Caldwell

Graduate Theses and Dissertations

Skeletal muscle atrophy is a hallmark of many pathologies and is associated with disease prognosis, quality of life, and mortality. Specifically, lack of contractile activity of the muscle can result in disuse-associated atrophy. Disuse-induced atrophy is a common phenomenon in intensive care unit (ICU) patients and significantly impacts patient prognosis and ability to transition of out of intensive care. However, effective therapeutics to mitigate disuse-associated atrophy do not exist, clearly demonstrating the scientific and clinical need to further understand mechanisms contributing to disuse atrophy. In particular, a significant portion of the scientific literature has utilized male models, yet there is …

The Effects Of Excess Dietary Sulfur Using Supplemental Sodium Sulfate On Beef Steer, Heifer, And Progeny Productive And Physiological Responses, Jamie Hawley

Graduate Theses and Dissertations

For studies 1 through 3, 20 steers of predominantly Angus breeding, were stratified by body weight (279 ± 13.2 kg), assigned randomly to 6 paddocks, and fed a low S ground corn and soybean meal supplement that did not contain any byproduct feeds (0.31% total dietary S; LS) or LS supplement with an additional 0.25% S provided from sodium sulfate (Na2SO4; 0.58% total dietary S; HS) for a 114-d growing phase. Steers were moved to feedlot (373 ± 0.2 kg), remained on prior dietary S treatments, and fed corn and soybean meal diets (0.19 and 0.42% total dietary S; LS …

Consumer Food Socialization In The School And Home, Ashley Deutsch Cermin

Graduate Theses and Dissertations

Consumer socialization literature has focused on individual socialization agents and their isolated effects. However, as John (1999) pointed out, children do not grow up in a social vacuum. Instead, the multitude of agents socializing children find their narratives interacting and their effects continually shaped and co-created. To understand how school-age children learn about food, I interrogate the complexity of socialization in three essays.

In the first essay, I take an ethnographic approach to investigate the interactive effect peers and adults, namely service workers, have on children’s food socialization in a public-school lunchroom. By combining a Loseke’s (2007) layered narrative model …

Elucidating Collagen Degradation Synergy Between Col G And Col H From Hathewaya (Clostridium) Histolytica And Identifying Novel Structural Features In Hpt And Rec Domains From Vars Histidine Kinase In V. Alginolyticus, Perry Caviness

Graduate Theses and Dissertations

In this research the mechanisms by which Hathewaya (Clostridia) histolytica collagenases are secreted and work together to degrade collagens are investigated. While H. histolytica collagenases Col G and Col H have similar multi-domain structures the difference in number of and orientation of the domains hint that the two target different regions in collagen. Study small angle x-ray scattering (SAXS) was used to give a low-resolution envelope of full-length Col G and Col H and Col G/Col H non-catalytic domains bound to a collagen-like peptide (mini-collagen). SAXS derived envelopes along with structural information was used to tease out the mechanisms by …

Effects Of Supplementing Crystalline L-Valine And L-Isoleucine And A Novel Threonine Biomass In Reduced Crude Protein Diets Fed To Broilers, Derrell Trevor Lee

Graduate Theses and Dissertations

Poultry nutritionists continue to identify methods to lower feed price without compromising broiler growth performance, processing yields, or animal well-being. A common approach is to reduce dietary crude protein (CP), the second most expensive component in a broiler diet. Subsequently, reducing CP will reduce the inclusion levels of intact protein sources (e.g., soybean meal [SBM]), which can be accomplished by supplementing individual amino acids (AA). This methodology not only reduces diet cost, pending if feed-grade AA are more economical, but can contribute to improving broiler health and environmental sustainability. Therefore, two experiments were conducted to evaluate individual feed-grade AA in …

The Emotional Toil Of Paying For College: Lower Socioeconomic Status White Women’S College Experiences, 1880-1920, Heidi A. Jaeckle

Graduate Theses and Dissertations

Typically historical inquiries in higher education have been centered on privileged individuals from wealthier backgrounds who had the opportunity of attending primarily prestigious institutions. The experiences of college women from lower to middle class socioeconomic backgrounds have been for the most part ignored. This dissertation explores how socioeconomic backgrounds shaped the experiences of college women from the late nineteenth century to the early twentieth century, focusing on lower class students. With no universal financial aid program, the majority of these women were from families who could afford to pay tuition. Women from lower socioeconomic backgrounds did attend college, but their …

Phenotypic Switching Of Bacterial Cells In Extreme Environments, Sudip Nepal

Graduate Theses and Dissertations

A large number of terrestrial microbial lives thrive in extremes of environmental conditions, including extremes of pressure, temperature, salinity, pH, and a combination of them. For example, all the marine biomass thrive at high hydrostatic pressure depending on depth. The temperature in the ocean can be very high near the hydrothermal vents and salinity and pH depends on the composition of salt in the surrounding areas. On the surface, hot springs, lakes and geysers provide high temperature conditions, while many places are permafrost regions with subzero temperatures. There is an emerging body of work on the viability, genomics, and metagenomics …

Distillers Dried Grains With Solubles: Determination Of Metabolizable Energy Values Using Regression-Based Assays And Their Correlation With Chemical Composition, Kenia Mitre

Graduate Theses and Dissertations

The inherent variability and lack of standardization of in vivo assays to determine the metabolizable energy (ME) of DDGS has led to inconsistent values and limited its potential to use in broiler diets. Therefore, two experiments were conducted to characterize the content of nitrogen-corrected ME (MEn) in 11 DDGS sources obtained from various ethanol plants using a regression-based broiler assay and to attempt to develop equations to predict MEn based on its chemical composition. In experiment 1, the objectives were to determine the influence of inclusion level and feed intake on the resulting ME and MEn values of a single …

The Impact Of Dietary Egg Intake On Metabolic Health In Food Insecure Households, Sam Walker

Graduate Theses and Dissertations

Food Insecurity (FI) is defined as a condition in which individuals lack access to adequate food due to limited financial resources. FI is estimated to impact 12% of households in United States. Adults and children who experience FI are an increased risk for developing metabolic disease such as type 2 diabetes, obesity, hypertension, and cardiovascular disease. The negative health outcomes associated with FI are multi-factorial, however, many of them may be caused by limited nutritional intake and poor diet quality. Efforts to better understand the obstacles food insecure populations face is critical in order to improve nutrient intake and minimize …

Heat And Mass Transfer In Parboiled Rice During Heating With 915 Mhz Microwave Energy And Impacts On Milled Rice Properties, Deandrae L.W. Smith

Graduate Theses and Dissertations

Microwave (MW) heating offers an energy-efficient, fast method to dry high moisture content (MC) parboiled rice to safe storage MC. However, there is limited research that describes the fundamentals of heat and mass transport in rice kernels exposed to MW energy at 915 MHz, the most promising heating frequency for industrialized processing. This information is vital to explain the implications of MW technology on dried rice quality. The overall objective of this study was to develop a microwave heating technology that can sufficiently dry high MC parboiled rough rice kernels in one pass using a 915-MHz industrial microwave system. An …

Nutritional Strategies For Feeding Broiler Breeders On Hen And Progeny Performance, Antonio Beitia

Graduate Theses and Dissertations

Over the last 60 plus years, broiler breeders have been under an incredible amount of genetic pressure. This genetic pressure comes from the continually increasing consumer demand for poultry products. The objective of this dissertation is to understand the effects of different nutritional and management practices on broiler breeder’s performance. The first series of experiments investigate the impact of broilerization on hen and early progeny performance. Broilerization is a process only used by genetic companies. The results from these experiments showed the adverse effects of broilerization on chick quality and hen performance. Follow up trials were performed to determine the …

Polycystic Ovarian Syndrome: Causes, Complications, And Treatments, Toni Tornberg

Biomedical Sciences Undergraduate Research

Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder prevalent in 6-10% of reproductive age women. The purpose of this review paper is to describe both genetic and environmental causes and symptoms of PCOS. Additionally, to summarize the complications women face with a PCOS diagnosis and present treatment and management options. The information forming this paper was compiled from various online heath journals. The results show that both clinical and biochemical examinations are used for the diagnosis of PCOS while the exact cause is unknown. Genetics and environmental factors, specifically the intrauterine environment, are discussed as causes. Management and treatment options …

Principal Wellness: Principals’ Managing Their Wellbeing, Leah Richardson

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Principals continue to search for the formula with the power to strengthen their leadership skills that will have an impact on achievement. Principals addressing their wellbeing is a strategy that can benefit the effectiveness of the use of their leadership skills. The purpose of this study was to describe principal wellness through the literature on the topic and to provide strategies for principals to manage their wellness. The review of the research and literature addressed principal wellness and included topics such as: principals working in isolation, developing healthier habits to minimize adverse health impacts on principals, engaging and modeling self-care, …

Metabolic Benefits Of Plant-Based N-3 Polyunsaturated Fatty Acids On Brown Thermogenesis, Kyung Ho Park

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

There are two essential fatty acids for humans, a-linolenic acid (ALA) and linoleic acid (LA), which should be taken from foods to maintain health. Once incorporated into cells, ALA and LA, which are omega-3 poly unsaturated fatty acid (n-3 PUFA) and n-6 PUFA respectively, undergo elongation and desaturation to generate longer and more unsaturated fatty acids influencing inflammation and immunological responses. Numerous studies showed a dietary reduction of n-6/n-3 PUFA ratio improves cardiovascular health, inflammation, and insulin resistance. Fish oil, the main resource for n-3 PUFA, is shown to increase these health benefits. In our lab, we investigated the efficacy …

2020 - 2021 University Catalog, Loma Linda University

University Catalog (2005 - present)

This is a one-year CATALOG, effective beginning Summer Quarter 2020.

Volume 110, Number 1, July 2020