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2020

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Effect Of Processing Technology On The Volatile Flavor Components Of Zhijiang Duck, Gong Yao-Qian, Liu Hong-Mei, Luo Feng-Lian, Liu Yan Jul 2020

Effect Of Processing Technology On The Volatile Flavor Components Of Zhijiang Duck, Gong Yao-Qian, Liu Hong-Mei, Luo Feng-Lian, Liu Yan

Food and Machinery

In order to study the effect of processing technology on the volatile flavor components of Zhijiang duck, SPME combined with GC-MS spectrometry was used to detect the types and types of volatile flavor substances in the four stages of raw meat, fried, fried, and sterilized. Relative content. The results showed that the number of volatile flavor components after the four processing stages of raw meat, deep-fried, fried, and sterilized were 44, 19, 39, and 39, respectively. Among them, aldehydes, terpenes, alcohols, and ketones are the main flavor substances, followed by esters, alkanes, and other heterocyclic compounds. Principal component analysis showed …


Nutritive Composition Analysis Of Highland Barley Flour And Optimization Of Processing Parameters For Highland Barley Chips, He Wei Jul 2020

Nutritive Composition Analysis Of Highland Barley Flour And Optimization Of Processing Parameters For Highland Barley Chips, He Wei

Food and Machinery

Nutritional components of highland barley flour were analyzed, including protein, fat, ash, moisture and amino acids. The processing parameters for highland barley chips was studied, including extrusion puffed, pre-drying and roasting. The results showed that, in the highland barley flour, the protein contents of protein, fat, moisture and ash were 10.23 g/100 g, 2.51 g/100 g, 8.41 g/100 g, and 1.86 g/100 g respectively. Highland barley flour contained 17 amino acids, and the contents of total amino acid were 9.471 g/100 g. The optimum preparation of extrusion puffed conditions were determined as follows: barrel temperature of T2 to T6 were …


Study On The Hydrolysis Of Starch And Protein In Tobacco Leaves By Formic Acid For Improving The Quality Of Tobacco, Lin Yun, Luo Si-Wei, Ou-Yang Lu-Si, Chen Sen-Lin, Lai Yan-Hua, Tao Hong, Lin Bao-Min, Jia Li-Shan Jul 2020

Study On The Hydrolysis Of Starch And Protein In Tobacco Leaves By Formic Acid For Improving The Quality Of Tobacco, Lin Yun, Luo Si-Wei, Ou-Yang Lu-Si, Chen Sen-Lin, Lai Yan-Hua, Tao Hong, Lin Bao-Min, Jia Li-Shan

Food and Machinery

In order to solve the problem of poor sensory quality caused by the high content of starch and protein in tobacco leaves, a method for degrading starch and protein without affecting the workability of tobacco leaves was investigated. In this study, formic acid was used as catalyst to spray proper amount on tobacco leaves. The hydrolysis of starch and protein in tobacco leaves catalyzed by formic acid, which played an effective role in regulating and reducing the starch and protein content. When the concentration of formic acid ranged from 5% to 10% at 50 ℃, with the sprinkling rate of …


Recent Advance In Research Of Chitin In The Field Of Food Science, Wang Yun-Tao, Yang Fang, Li Bin, Bai Yan-Hong Jul 2020

Recent Advance In Research Of Chitin In The Field Of Food Science, Wang Yun-Tao, Yang Fang, Li Bin, Bai Yan-Hong

Food and Machinery

This review summarizes the latest research of chitin in food field, including the application of chitin film as food packaging materials, the application of chitin microspheres in immobilization, adsorption and separation of macromolecules, the preparation of nano chitin and its application in emulsification, regulation of food texture, antibacterial function, and health promoting effect, the new method for preparing chitin oligosaccharides.


Nearly One-Third Of Non-Hispanic Black Young Adults In The U.S. Have Hypertension, Adam Pope Jul 2020

Nearly One-Third Of Non-Hispanic Black Young Adults In The U.S. Have Hypertension, Adam Pope

Browse All News

No abstract provided.


Aspen Next Generation: Conversations From Southern Colorado And Northern New Mexico, Dan Binkley, Bill Romme Jul 2020

Aspen Next Generation: Conversations From Southern Colorado And Northern New Mexico, Dan Binkley, Bill Romme

Aspen Bibliography

Aspen trees and forests are especially important in the Rocky Mountains. Aspens add beauty to landscapes, foster high diversity and productivity of understory plants, provide for the habitat needs of many species of animals, and moderate fire behavior. There is a perception that aspen trees and stands are not regenerating well in southern Colorado and northern New Mexico; cohorts of trees younger than a few decades are scarce, at least in some areas. The next generation of aspen in the southern Rockies will be influenced by land use decisions, including harvesting, fire policy and management, and browsing by livestock and …


Interactions Between The Physical And Social Environments With Adverse Pregnancy Events Related To Placental Disorders—A Scoping Review, Yolisa Prudence Dube, Newton Nyapwere, Laura A. Magee, Marianne Vidler, Sophie E. Moore, Benjamin Barratt, Rachel Craik, Peter Von Dadelszen, Prestige Tatenda Makanga, Marleen Temmerman, Angela Koech, Patricia Okiro, Geoffrey Omuse, Sikolia Wanyonyi Jul 2020

Interactions Between The Physical And Social Environments With Adverse Pregnancy Events Related To Placental Disorders—A Scoping Review, Yolisa Prudence Dube, Newton Nyapwere, Laura A. Magee, Marianne Vidler, Sophie E. Moore, Benjamin Barratt, Rachel Craik, Peter Von Dadelszen, Prestige Tatenda Makanga, Marleen Temmerman, Angela Koech, Patricia Okiro, Geoffrey Omuse, Sikolia Wanyonyi

Obstetrics and Gynaecology, East Africa

Background: Due to different social and physical environments across Africa, understanding how these environments differ in interacting with placental disorders will play an important role in developing effective interventions.

Methods: A scoping review was conducted, to identify current knowledge on interactions between the physical and social environment and the incidence of placental disease in Africa.

Results: Heavy metals were said to be harmful when environmental concentrations are beyond critical limits. Education level, maternal age, attendance of antenatal care and parity were the most investigated social determinants.

Conclusions: More evidence is needed to determine the relationships between the environment and placental …


2020-July-28-Positive Eating Program Pioneers New Ways To Help Children Via Telehealth.Pdf, University Marketing And Communication, East Tennessee State University Jul 2020

2020-July-28-Positive Eating Program Pioneers New Ways To Help Children Via Telehealth.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (July 28, 2020) – As the health care community began transitioning to telehealth services for many types of appointments during the COVID-19 crisis, Dr. Teresa Boggs was uncertain how well telehealth would work for the Positive Eating Program at East Tennessee State University.

ETSU’s Positive Eating Program is designed for children with behavioral and sensory-based feeding challenges. It is housed at The Language Center at Nave, located in Elizabethton and managed by ETSU’s Department of Audiology and Speech-Language Pathology.

Prior to COVID-19, parents or guardians brought their children (typically ages 1-7) to the clinic setting, where supervised graduate …


Individual Learning Phenotypes Drive Collective Behavior, Chelsea N. Cook, Natalie J. Lemanski, Thiago Mosqueiro, Cahit Ozturk, Jürgen Gadau, Noa Pinter-Wollman, Brian H. Smith Jul 2020

Individual Learning Phenotypes Drive Collective Behavior, Chelsea N. Cook, Natalie J. Lemanski, Thiago Mosqueiro, Cahit Ozturk, Jürgen Gadau, Noa Pinter-Wollman, Brian H. Smith

Biological Sciences Faculty Research and Publications

Individual differences in learning can influence how animals respond to and communicate about their environment, which may nonlinearly shape how a social group accomplishes a collective task. There are few empirical examples of how differences in collective dynamics emerge from variation among individuals in cognition. Here, we use a naturally variable and heritable learning behavior called latent inhibition (LI) to show that interactions among individuals that differ in this cognitive ability drive collective foraging behavior in honey bee colonies. We artificially selected two distinct phenotypes: high-LI bees that ignore previously familiar stimuli in favor of novel ones and low-LI bees …


Methods And Compositions For Diagnosis And Management Of Diabetes And Metabolic Syndrome, Niketa A. Patel Jul 2020

Methods And Compositions For Diagnosis And Management Of Diabetes And Metabolic Syndrome, Niketa A. Patel

USF Patents

Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long-coding RNAs in a sample from a subject.


Measuring What Matters: Insights On The Value Of Whole Child Development, Porticus, Australian Council For Educational Research, Pina Tarricone, Yung Nietschke, Kylie Hillman Jul 2020

Measuring What Matters: Insights On The Value Of Whole Child Development, Porticus, Australian Council For Educational Research, Pina Tarricone, Yung Nietschke, Kylie Hillman

Monitoring Learning

This policy analysis report captures how cities and countries value, define, and measure Whole Child Development (WCD) - and equivalent - both broadly and in the context of reaching those in extreme adversity. The WCD conceptual framework of this study refers to 11 key themes: values, life skills, social and emotional learning, spirituality, academic knowledge, student engagement, adult support, community, academically challenging learning, safe environments, and health. The report provides insights into the challenges experienced in embedding WCD in education systems and offers evidence around the growing recognition and momentum globally around WCD and holistic learning. One of the key …


Alveolar Bone And Airway Changes In Different Maxillary Expansion Treatments: A 3d Cone-Beam Tomography Study, Dennis Wang Jul 2020

Alveolar Bone And Airway Changes In Different Maxillary Expansion Treatments: A 3d Cone-Beam Tomography Study, Dennis Wang

Master's Theses

Objectives: To evaluate the long-term effects on the airway and bone in patients that have undergone BA, TA and control with 3D cone beam computed tomography (CBCT) analysis. Materials and Methods: 180 CBCTs were analyzed for 60 patients at pretreatment (T1), post expansion (T2), and post-treatment (T3). Patients were divided into three groups, bone anchored expansion (BA), tooth anchored expansion (TA) and a control group. For the airway portion of the study, the nasal cavity, nasopharyngeal, oropharyngeal and laryngopharyngeal, and total airway volumes were measured. Total airway area, minimal cross-sectional area, maxillary intermolar, external maxillary and palatal widths were also …


Impact Of 12-Weeks Of Nordic Pole Walking On Arterial Stiffness In Sedentary Overweight And Obese Adults, Arbër N. Shehu Jul 2020

Impact Of 12-Weeks Of Nordic Pole Walking On Arterial Stiffness In Sedentary Overweight And Obese Adults, Arbër N. Shehu

Masters Theses, 2020-current

Arterial stiffness (AS) is an independent predictor for cardiovascular disease morbidity and mortality. Regular aerobic exercise is considered to improve AS. Nordic walking provides important health benefits, however, the effect of this walking method as treatment for AS remains unclear. We conducted a randomized controlled study to examine the effect of a 12-week supervised group walking intervention (controlled pace, ~3000 steps/day, 30 minutes/day, 5 times/week), with (NW) and without (SW) Nordic poles, on AS in sedentary overweight and obese adults. Fourteen individuals were randomly assigned to NW (n=7; median age 54.0 years; body mass index (BMI)=31.3 kg/m2) or …


The Effects Of Exercise On The Fasting Ketone Production Curve: A Randomized Crossover Study, Landon S. Deru Jul 2020

The Effects Of Exercise On The Fasting Ketone Production Curve: A Randomized Crossover Study, Landon S. Deru

Theses and Dissertations

Elevated ketone production and utilization results in a host of health benefits. The aim of this study was to assess the rate of ketone production during a prolonged fast and to evaluate how an initial bout of exercise influences this production. Mood and hunger, along with plasma insulin and glucagon, were also assessed. In this crossover study, 20 adult subjects (11 Male, 9 Female) completed two 36-hour fasts, with one protocol requiring the subject to complete an intense treadmill exercise session at the beginning of the fast. Ketone levels were assessed via blood ketone meter and recorded every two hours. …


Fasting Diets: Are They Safe, Healthy, And Effective?, Carrie Durward, Keshele Stevens Jul 2020

Fasting Diets: Are They Safe, Healthy, And Effective?, Carrie Durward, Keshele Stevens

All Current Publications

Diets are commonly prescribed to induce weight loss and reduce the risk of many diseases. Because a standard daily calorie restriction diet is often hard to maintain, other diet alternatives such as fasting diets were created. Fasting diets have been found to be effective, though they may not be any more effective than typical diets. Before beginning a fasting diet, it is best to seek professional medical advice to assess individual risks and circumstances. This fact sheet helps readers learn more about the safety, health, and effectiveness of fasting diets.


Added Sugars: What You Need To Know, Carrie Durward, Keshele Stevens Jul 2020

Added Sugars: What You Need To Know, Carrie Durward, Keshele Stevens

All Current Publications

Added sugar has become a hot topic among health professionals and in the media. Based on the best available evidence, health professionals recommend that less than 10% of daily calories come from added sugar (U.S. Department of Health and Human Services [HHS] & U.S. Department of Agriculture [USDA], 2015c) in order to maintain a balanced diet with all the important nutrients. In this fact sheet, we will address why and how to limit added sugar in your diet, what it is, and where to find it.


Salt Driven Interactions Between Salsola Inermis And Pistacia Lent, Oz Barazani, Avi Golan-Goldhirsh Jul 2020

Salt Driven Interactions Between Salsola Inermis And Pistacia Lent, Oz Barazani, Avi Golan-Goldhirsh

IGC Proceedings (1977-2023)

No abstract provided.


Nitrogen Cycling In Intensively Grazed Pastures And Practices To Reduce Whole‐Farm Nitrogen Losses, Sterwart F. Ledgard, J. Luo Jul 2020

Nitrogen Cycling In Intensively Grazed Pastures And Practices To Reduce Whole‐Farm Nitrogen Losses, Sterwart F. Ledgard, J. Luo

IGC Proceedings (1977-2023)

No abstract provided.


Shifting Rangeland Mineral Resource Limitations: Ecological Responses To Atmospheric Nitrogen Deposition, Heather L. Throop Jul 2020

Shifting Rangeland Mineral Resource Limitations: Ecological Responses To Atmospheric Nitrogen Deposition, Heather L. Throop

IGC Proceedings (1977-2023)

No abstract provided.


Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats, K.-N. Chen, W.-H. Peng, C.-W. Hou, C.-Y. Chen, H.-H. Chen, C.-H. Kuo, M. Korivi Jul 2020

Codonopsis Javanica Root Extracts Attenuate Hyperinsulinemia And Lipid Peroxidation In Fructose-Fed Insulin Resistant Rats, K.-N. Chen, W.-H. Peng, C.-W. Hou, C.-Y. Chen, H.-H. Chen, C.-H. Kuo, M. Korivi

Journal of Food and Drug Analysis

From ancient times, Dǎngshēn (Codonopsis javanica) has been used in Chinese traditional medicine. In this study we investigated the anti-hyperinsulinemia and antioxidant properties of C. javanica root extracts in a rat model of insulin resistance (IR), induced by chronic fructose feeding. Twenty-four Sprague–Dawley rats were randomized into control, fructose-treated (10%, w/v), and fructose then C. javanica (Fru + Cod)-treated groups. After 8 weeks fructose feeding, increased fasting serum insulin levels (2.6 ± 0.45 μg/L) and insulin area under the curve confirmed the IR (p < 0.001). However, C. javanica treatment to fructose-fed rats significantly attenuated the hyperinsulinemia with correspondingly improved glucose tolerance. Weight gain in Fru + Cod group was comparably (p < 0.01) lower than in the fructose-fed group. Furthermore, IR-induced increased hepatic lipid peroxidation, as demonstrated by elevated malondialdehyde levels, were significantly (p < 0.001) alleviated by C. javanica treatment. These findings reveal that chronic fructose intake may facilitate IR and oxidative damage, which could be eradicated by improved antioxidant status. Accordingly, we found that C. javanica treatment significantly improved the antioxidant enzyme activities, including superoxide dismutase, glutathione peroxidase and glutathione reductase in the liver. These findings that fructose-induced hyperinsulinemia and associated oxidative stress could be attenuated by C. javanica root extracts. © 2013


Effect Of Harvest Time On Saponins In Yam (Dioscorea Pseudojaponica Yamamoto), J.-T. Lin, S.-L. Chen, S.-C. Liu, D.-J. Yang Jul 2020

Effect Of Harvest Time On Saponins In Yam (Dioscorea Pseudojaponica Yamamoto), J.-T. Lin, S.-L. Chen, S.-C. Liu, D.-J. Yang

Journal of Food and Drug Analysis

Steroidal saponins including furostanol and spirostanol glycosides are the important bioactive compounds in yams. In the study, the content of individual saponin in varied organs of yam (Dioscorea pseudojaponica Yamamoto) harvested from November to March of the next year (the harvest season) were determined. Results showed that total saponin levels in yam organs (except rhizophor) harvested at various time were in the order: January > December > February > November > March. Saponin contents in rhizophor gathered in December were higher than those obtained in January. The highest total amounts of saponins among various organs were in the order: tuber cortex (619.79 μg/g dw) …


Shared Spaces, Separate Lives: Community Formation In The California Citrus Industry During The Great Depression, David Shanta Jul 2020

Shared Spaces, Separate Lives: Community Formation In The California Citrus Industry During The Great Depression, David Shanta

History in the Making

The California citrus industry was the engine for the economic and cultural development of twentieth century Southern California. Studies have also focused on citrus as specialty crop agriculture. Its labor usage pattern required the economic, social, and political powerlessness of its workers. Growers and workers shared the spaces of the citrus groves and packinghouses, but otherwise led largely separate lives, delineated by class and race. Community formation during the Great Depression is examined from each perspective – dominant Anglo grower society and workers of Mexican descent. Benedict Anderson’s Imagined Communities: Reflections on the Origin and Spread of Nationalism provides a …


Development Of The Life After Sports Transition (Last) Online Course For Collegiate Student-Athletes: Pretest-Posttest Study, Michael Stellefson, Trevor Bopp, Michael Odio, Min Qi Wang, Linxi Zhang Jul 2020

Development Of The Life After Sports Transition (Last) Online Course For Collegiate Student-Athletes: Pretest-Posttest Study, Michael Stellefson, Trevor Bopp, Michael Odio, Min Qi Wang, Linxi Zhang

Journal of Athlete Development and Experience

Transitioning into athletic retirement can have negative impacts on college student-athletes’ psychological, social, emotional, and physical well-being, yet few educational programs exist to help augment college student-athlete preparation for embracing life after sports. The objective of this study was to develop and evaluate a new Life After Sports Transition (LAST) online course for college student athletes. A single group pretest-post-test study evaluated effects of the LAST course among a convenience sample of college student-athletes (n=10) attending a NCAA Division I university. Paired sample t-tests examined changes in athletic identity, psychological well-being, hope, and self-reflection/insight. Propensity score matching …


Impact Of Ramadan Fasting On Biochemical And Exercise Parameters Among Patients Undergoing Exercise-Based Cardiac Rehabilitation, Hazem Khorshid, Adel Shabana, Osama Rifaie, Yasser Abdellatif Jul 2020

Impact Of Ramadan Fasting On Biochemical And Exercise Parameters Among Patients Undergoing Exercise-Based Cardiac Rehabilitation, Hazem Khorshid, Adel Shabana, Osama Rifaie, Yasser Abdellatif

Journal of the Saudi Heart Association

Background: Ramadan fasting is an important worship activity for Muslims. It is not known if fasting could have deleterious effect on cardiac patients joining cardiac rehabilitation (CR) program, especially during summer season.

Aim: To assess the effect of Ramadan fasting on biochemical and exercise parameters among patients undergoing 12- week exercise-based CR program. Patients and methods: 53 patients joining CR program in university hospital were included in the study. The patients were divided into two groups according to their Ramadan fasting status. Fasting group included 32 patients, while nonfasting group included 21 patients. All patients underwent supervised exercise-based CR during …


Interprofessional Collaboration For Oral Health Education And Screening Of Children With Special Health Care Needs, Lamia Habib Jul 2020

Interprofessional Collaboration For Oral Health Education And Screening Of Children With Special Health Care Needs, Lamia Habib

Master's Theses

In 2016, National Survey of Children’s Health conducted by the U.S. Department (HRSA MCHB) identified 18.8% of children aged 0-17 years old with Special Health Care Needs (CSHCN). Of these children, 83.4% are not receiving adequate healthcare. It has been well established that oral health is an integral part of the child’s general health. Medical primary care physicians may play an important role in improving oral health outcomes through oral screening, referral, oral health education and promotion. CSHCN may be at an increased risk for oral health problems throughout their life which may negatively impact their quality of life and …


A 2-Hour Diabetes Self-Management Education Program For Patients With Low Socioeconomic Status Improves Short-Term Glycemic Control, Michael G. Jakoby Iv, Melissa Schleder, Vickie Luff, Cynthia Yergler, Albert Botchway, Cheryl Burns Jul 2020

A 2-Hour Diabetes Self-Management Education Program For Patients With Low Socioeconomic Status Improves Short-Term Glycemic Control, Michael G. Jakoby Iv, Melissa Schleder, Vickie Luff, Cynthia Yergler, Albert Botchway, Cheryl Burns

Journal of Patient-Centered Research and Reviews

Diabetes self-management education (DSME) improves glycemic control, but patients with low socioeconomic status face institutional and personal barriers to receiving DSME. A retrospective single cohort study of a 2-hour group DSME program prioritizing accessibility and completion of a tightly focused curriculum was performed to determine if glycemic control improved and whether a longer, more comprehensive, prospective evaluation of the program is indicated. All patients who participated in the program from September 2017 to December 2018 were included in the analysis. The primary study endpoint was change in hemoglobin A1c (HbA1c) from baseline. A total of 58 out of 94 patients …


Do Adults Utilizing Intermittent Fasting Improve Lipids More Than Those Following A Restricted-Calorie Diet? A Clin-Iq, Mitchell A. Sanford, Tracy S. Sanford, K. F. Campbell, Dustin Davis, Tammy Tandberg, L. N. Eagle Road Jul 2020

Do Adults Utilizing Intermittent Fasting Improve Lipids More Than Those Following A Restricted-Calorie Diet? A Clin-Iq, Mitchell A. Sanford, Tracy S. Sanford, K. F. Campbell, Dustin Davis, Tammy Tandberg, L. N. Eagle Road

Journal of Patient-Centered Research and Reviews

With approximately 95 million Americans diagnosed with high cholesterol, and many searching for a nonmedicinal treatment, intermittent fasting as a method to improve health has become increasingly popular in the lay public. We conducted a clinical inquiry to determine whether intermittent fasting is superior to a low-calorie diet in improving lipids, searching the Cochrane, EBSCOhost, Embase, MEDLINE, and Scopus databases using the terms intermittent fasting, lipids, and calorie-restricted diet. Studies that included surgical weight loss or medicine-assisted weight loss were excluded. We identified 6 published studies, 5 of which were randomized controlled trials. In reviewing the selected studies, …


The Mexican Cognitive Aging Ancillary Study (Mex-Cog): Study Design And Methods, Silvia Mejia-Arango, Rene Nevarez, Alejandra Michaels-Obregon, Belem Trejo-Valdivia, Laura Rosario Mendoza-Alvarado, Ana Luisa Sosa-Ortiz, Adrian Martinez-Ruiz, Rebeca Wong Jul 2020

The Mexican Cognitive Aging Ancillary Study (Mex-Cog): Study Design And Methods, Silvia Mejia-Arango, Rene Nevarez, Alejandra Michaels-Obregon, Belem Trejo-Valdivia, Laura Rosario Mendoza-Alvarado, Ana Luisa Sosa-Ortiz, Adrian Martinez-Ruiz, Rebeca Wong

School of Medicine Publications

Objective: Describe the protocol sample and instruments of the Cognitive Aging Ancillary Study in Mexico (Mex-Cog). The study performs an in-depth cognitive assessment in a subsample of older adults of the ongoing Mexican Health and Aging Study (MHAS). The Mex-Cog is part of the Harmonized Cognitive Assessment Protocol (HCAP) design to facilitate cross-national comparisons of the prevalence and trends of dementia in aging populations around the world, funded by the National Institute on Aging (NIA).

Methods: The study protocol consists of a cognitive assessment instrument for the target subject and an informant questionnaire. All cognitive measures were selected and adapted …


Effect Of Zinc Treatment On Clinical Outcomes In Patients With Liver Cirrhosis: A Systematic Review And Meta-Analysis, Huey K. Tan, Adam Streeter, Matthew E. Cramp, Ashwin D. Dhanda Jul 2020

Effect Of Zinc Treatment On Clinical Outcomes In Patients With Liver Cirrhosis: A Systematic Review And Meta-Analysis, Huey K. Tan, Adam Streeter, Matthew E. Cramp, Ashwin D. Dhanda

Peninsula Medical School

BACKGROUND Zinc is an essential trace element integral to many cellular and immune functions. Zinc deficiency is highly prevalent in patients with cirrhosis and related to disease severity. AIM To evaluate whether zinc supplementation improves clinical outcomes (disease severity and mortality) in patients with cirrhosis. METHODS This prospectively registered systematic review (PROSPERO reference: CRD42018118219) included all studies in Medline, Embase or Cochrane database with inclusion criteria of adult human studies, comparing zinc supplementation of at least 28 d with standard care or placebo in patients with cirrhosis. Mortality and clinical severity score data were extracted. Random effects meta-analyses compared mortality …


Oxidative Stress In Alcohol-Related Liver Disease, Huey K. Tan, Euan Yates, Kristen Lilly, Ashwin D. Dhanda Jul 2020

Oxidative Stress In Alcohol-Related Liver Disease, Huey K. Tan, Euan Yates, Kristen Lilly, Ashwin D. Dhanda

Peninsula Medical School

Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs. Heavy alcohol misuse leads to alcohol-related liver disease, which is responsible for a significant proportion of alcohol-attributable deaths globally. Other than reducing alcohol consumption, there are currently no effective treatments for alcohol-related liver disease. Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants. It plays important roles in several aspects of alcohol-related liver disease pathogenesis. Here, we review how chronic alcohol use results in oxidative stress through increased metabolism via …