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Out-Patient Neurological Disorders In Tanzania: Experience From A Private Institution In Dar Es Salaam, Philip Adebayo, Omar Aziz, Rose E. Mwakabatika, Mandela Makakala, Mugisha Clement, Shabbir Adamjee, Noureen Mushi, Ahmed Jusabani, Eric Aris

Internal Medicine, East Africa

Background and introduction: Low and middle-income countries (LMIC) have a considerable burden of neurological disorders. Available profile of neurological disorders in our environment is biased towards neurological admissions. There is a paucity of data on out-patient neurological conditions in sub-Saharan Africa.

Objective: To determine the frequency and demographic data of neurological illnesses being managed at the adult out-patient neurology clinic of the Aga Khan Hospital, Dar es Salaam (AKHD).

Materials and methods: The electronic medical records of all cases with neurological diseases who presented to the adult neurology clinic of the AKHD between January 2018, and December 2019 were retrospectively …

Investigating The Metabolic Progression Of Glioblastoma With Hyperpolarized Magnetic Resonance, Travis Salzillo

Dissertations and Theses (Open Access)

Rapid diagnosis and therapeutic monitoring of aggressive diseases such as glioblastoma (GBM) can improve patient survival by providing physicians the time to optimally deliver treatment. This includes early in development, while the tumor is still manageable, or following initial therapy, when alternative treatments should be considered. The main goal of this project was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively capture the dynamic nature of cancer metabolism, in vivo pyruvate-to-lactate conversion with hyperpolarized MRI, …

Detecting Periods Of Eating In Everyday Life By Tracking Wrist Motion — What Is A Meal?, Surya Sharma

All Dissertations

Eating is one of the most basic activities observed in sentient animals, a behavior so natural that humans often eating without giving the activity a second thought. Unfortunately, this often leads to consuming more calories than expended, which can cause weight gain - a leading cause of diseases and death. This proposal describes research in methods to automatically detect periods of eating by tracking wrist motion so that calorie consumption can be tracked. We first briefly discuss how obesity is caused due to an imbalance in calorie intake and expenditure. Calorie consumption and expenditure can be tracked manually using tools …

Embryonic Exposure To The Synthetic-Progesterone Levonorgestrel (Lng) Results In Hyperactive Behavior In Zebrafish (Danio Rerio), Austin D. Fuentes

Theses and Dissertations

Exposure to endocrine-disrupting chemicals has been associated with an increased risk of anxiety-like behavior at various life stages. Levonorgestrel (LNG), a synthetic contraceptive, could potentially alter steroidal regulated brain development based on the findings of this thesis. In-silico measurements were used for comparing LNG, which had been found in surface water, to chemical databases to predict the bioavailability, half-life, and estrogen binding potential. Zebrafish (Danio rerio) for illuminating the effects of LNG exposure during early zebrafish embryonic development, similar to fetal development, on behavior was investigated. Our data suggests exposure in a dose-dependent manner of LNG can potentially …

Effects Of Char On Nitrogen Management In Agricultural Soils Of Semi-Arid Western Nebraska, Dinesh Panday

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Soils in western Nebraska are characterized by low soil organic C due to semi-arid environment in the region and further aggravated by disruption of soil aggregates and rapid C decomposition from intensive tillage, erosion, and frequent droughts. Proper management of soil C may improve soil properties, reduce N losses, and subsequently improve crop yields in this low C soil and low moisture condition. This dissertation focuses on C-rich coal char (henceforth “char”) as a potential strategy to overcome the existing problem of low C in semi-arid region. Char is an industrial by-product, resulting from inefficient coal burning during sugar beet …

Postmenopausal Hormone Therapy And Colorectal Cancer Risk By Molecularly Defined Subtypes And Tumor Location, Julia D. Labadie, Yin Cao, Et Al

Open Access Publications

Background: Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogeneous disease, we evaluated whether the association of HT and CRC differs across etiologically relevant, molecularly defined tumor subtypes and tumor location.

Methods: We pooled data on tumor subtypes (microsatellite instability status, CpG island methylator phenotype status,

Results: Among postmenopausal women, ever HT use was associated with a 38% reduction in overall CRC risk (OR =0.62, 95% CI = 0.56 to 0.69). This association was similar according to microsatellite instability, CpG island methylator phenotype and

Conclusions: We observed a strong inverse association …

Exploring The Relationships Between Mothers' Use Of Food To Soothe, Feeding Type And Mode, Maternal Feeding Style, Infant Behavior, And Infant Weight-Related Outcomes During Early Infancy, Megan K. Hupp

Master's Theses

Rapid infant weight gain (RWG) in the first six months postpartum is a strong predictor for obesity during childhood and adolescence. Although biological factors can influence infant weight gain trajectories, the modifiable factor of parent feeding practices can also have an influence. The use of food to soothe (FTS), or the act of feeding a child when he/she is upset for reasons other than hunger, has been associated with unhealthy eating behaviors and less-favorable weight outcomes in children and older infants. However, limited studies have explored the use of FTS during early infancy before the introduction of solids foods. The …

Lipid Quantification And Cryopreservation Of In Vitro Produced Jersey Cattle Embryos, Katherine A. Rhodes-Long

Master's Theses

Cryopreservation of in vivo derived Jersey bovine embryos have resulted in a 10% lower pregnancy rate compared to other dairy breeds. Poor embryo survival after cryopreservation has been partially attributed to the high lipid content of Jersey embryos. In vitro-produced (IVP) bovine embryos have darker cytoplasm than their in vivo-derived counterparts because of higher lipid accumulation. High lipid accumulation is associated with impaired embryo quality. Forskolin is an adenylate cyclase activator that regulates cAMP levels in cells and has been shown to induce lipolysis in IVP embryos. L-carnitine is required for transport of fatty acids from the intermembrane space of …

Quantifying The Ecological Drivers And Impacts Of Parrotfish Predation On Caribbean Corals Communities, Hannah Sima Rempel

Master's Theses

Parrotfishes (Scarinae) are dominant Caribbean herbivores that play an important role in reducing coral-algae competition by grazing algae; yet some species are also occasional coral predators (corallivores) and thereby can have direct negative impacts on coral growth and survivorship. There is concern that parrotfish corallivory may contribute to substantial long-term declines in targeted coral species, particularly in areas with a high biomass of parrotfishes and low cover of corals. However, the capacity of target coral species to heal from parrotfish predation and the ecological drivers of corallivory are poorly understood.

In Chapter 1, we examined the patterns of coral healing …

Animal Science E-Newsletter, August 2020, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

Child Body Fat And Body Mass Index: Which Determinants Are Most Important?, Marilyn Frenn, Astrida S. Kaugars, Juanita Terrie Garcia, Mauricio Garnier-Villarreal

College of Nursing Faculty Research and Publications

The purpose of this study was to examine child and parent determinants of children’s body fat percentage (BF%) along with their body mass index percentile (BMIp). Children’s BF% and BMIp auger lifelong health risks when elevated, and one in five children are affected. Participants (N = 135) included 62% female children; 50.7% Caucasian, 31.7% Hispanic, and 8.5% African American. Children were aged 9–15 years (2% underweight, 47.9% normal weight, 19.7% overweight, and 24.6% obese). Parent BMI average was 30.67 (1.4% underweight, 20.4% normal weight, 23.9% overweight, 40% obese, and 7% extreme obesity); 77.5% of the participating parents were mothers. …

Effect Of Plant Derived Tannins On Nitrogen And Carbon Cycling In Pasture Soils, Kathryn A. Slebodnik

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pasture-finished beef has become increasingly popular, but nitrogen losses from these pastures are of concern. Legumes containing condensed tannins such as birdsfoot trefoil (Lotus corniculatus) and sainfoin (Onobrychis viciifolia) may serve as environmentally and economically viable alternative forages in pasture finishing systems while reducing soil nitrogen loss. The goal of this project was to understand how tannin type and concentration affects soil nitrogen cycling both in the lab and the field. This thesis: 1) compared the physical, chemical, and biological characteristics of soil samples obtained from grazed grass and tannin and non-tannin containing legume pastures, 2) …

Novel Three-Dimensional Scaffold For Skeletal Muscle Tissue, Matthew H. Clegg

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cells are traditionally grown on a flat, plastic surface that has been optimized for cell attachment. While this is appropriate for growing and maintaining cells, this two-dimensional cell culture model is not an adequate representation of a three-dimensional body. Creating three-dimensional lab models is an important step to model diseases and damage to the skeletal muscle system.

To create this three-dimensional environment, a plastic frame was designed to support silkworm fibers. Skeletal muscle cells were then grown along the silkworm fibers and the growth of these cells in a three-dimensional environment was compared to cells grown on a flat, two-dimensional …

Reusable Light-Activated Antimicrobial Materials Prepared With Food Ingredients, Andrew T. Gagon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Microbial contamination and proliferation in food processing, distribution and storage continues to be a real risk in spite the wide variety of food processing and preservation techniques available. Some of these techniques (such as heat treatments and the use of chemical preservatives) may require substantial amounts of energy and their effects in the general population and the environment may be harmful. This has generated an interest over alternative methods of food preservation. The use of reusable light-activated materials may represent an effective approach. In this study, a polypropylene plastic was modified with either zein, which is found in corn, or …

The Effects Of Different Organic Pastures On Dairy Heifer Growth And Development, Jacob A. Hadfield

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Raising dairy heifers in a certified organic setting can be difficult for producers. Conventionally, heifers are raised in a confined setting, and fed a total mixed ration (TMR) that is balanced daily to contain all the needed nutrients for developing heifers. Organic producers can use a TMR in their operations, but due to high organic feed costs, many choose to raise their heifers in pasture-based systems. While pasture-based systems may lower costs, heifers on pasture commonly have lower rates of gain, which can be financially burdensome to producers. Grass-legume pastures may help improve rates of gain in heifers on pasture-based …

Influence Of Forage Diversity And Condensed Tannins On Livestock Foraging Behavior, Production And Environmental Impact, Sebastian P. Lagrange

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Eating a combination of forages with different chemistries (i.e., nutrients, beneficial compounds such as tannins) may enhance ruminant nutrition and reduce environmental impacts relative to eating single forages. I explored the influence of offering sheep and cattle all possible combinations of tanniferous (i.e., plants with tannins; birdsfoot trefoil, sainfoin) and non-tanniferous legumes (i.e., plants without tannins; alfalfa) or their monocultures on animal performance, behavior, and methane and nitrogen (N) emissions. Offering choices among these legumes to penned sheep improved intake and diet digestibility relative to feeding monocultures. Mixtures selected by sheep were better digested than mixtures containing equal parts of …

Evaluation Of Enrichment And Identification Media For Isolation Of Common Bovine Salmonella Serotypes, Katie Irene Swanson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Salmonellosis is an important cause of diarrhea in humans and animals, which can lead to death in severe cases. Rapid and efficient detection of Salmonella spp. is essential to limit the spread of disease. Many enrichment procedures have been described for the isolation of Salmonella, and often include variations on Rappaport-Vassiliadis medium, which is recommended by the Food and Drug Administration (FDA). The current procedures vary in incubation temperature, incubation time, and type of media used for identification of Salmonella. This project compared four procedures for enrichment and identification of common bovine Salmonella serotypes. We determined the best …

Response Of Glyphosate-Resistant Alfalfa To Glyphosate Application In The Intermountain West, Logan Chet Loveland

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Glyphosate-resistant (GR) alfalfa (Medicago sativa L.) has been widely adopted in the Intermountain West United States, where alfalfa plays an important role in agriculture. Exceptional tolerance to glyphosate application has been a reported strength of this technology; however, growers have recently reported potential crop injury under certain environmental conditions. The purpose of this study was to document and characterize the injury, identify local conditions that may have contributed to crop injury, and determine best management practices for avoiding injury to GR alfalfa in the Intermountain West. The effects of glyphosate rate and application timing were investigated at 24 sites …

Characterization Of Chinese Hamster Ovary Cell Performance With Pentanoic Acid And N-Acetyl Cysteine Treatment, Joseph Camire

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

To improve the cost of producing protein therapeutics manufacturers can attempt to increase the amount of protein produced per unit volume. Some small fatty-acids have shown the ability to increase protein concentrations in some manufacturing systems. An example system is in the industrially important cell line derived from a Chinese Hamster Ovary (CHO). A drawback of adding these fatty-acids is they can increase the rate of cell death.

A potential way to minimize the cell death rate, caused by adding fatty-acids, is to also add additional anti-oxidants. Through a series of studies, we demonstrate production with different fatty-acids, butanoic acid …

Enhancing The Production And Sustainability Of Pasture-Fed Beef Using Non-Traditional Legume Forages, Andrea I. Bolletta

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Despite the increasing worldwide demand for beef as a protein source, consumers are concerned about the sustainability of ruminant production systems. Their main concerns are animal welfare for feedlot-fed animals, greenhouse gas (GHG) emissions, global warming and worker safety. Traditional feedlot-based beef production systems have been associated with locally greater levels of soil, water and air contamination, as well as the overuse of antibiotics and growth hormones. The use of legume pastures such as cicer milkvetch (CMV) and birdsfoot trefoil (BFT), which fix their own nitrogen (N) and often contain beneficial secondary compounds such as tannins and provide for rapid …

The Effects Of Milk Phospholipids On Functional Properties Of Anhydrous Milk Fat And Oil Structured Gel Systems, Zachary Cooper

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Lecithin is an ingredient commonly used in foods composed of high concentration of phospholipids. Phospholipids are a type of fat that can mix with both water and oil. In the current food industry, most lecithins come from sunflower, egg, and soybean sources. An additional source of phospholipids can be the waste streams from the dairy industry, such as the whey protein and butter making processes, since these contain a high concentration of phospholipids. Dairy phospholipids have been isolated in the past, but their traits as a functional ingredient are still unknown. In addition, most isolated dairy phospholipids still contain protein, …

Interactions Between Water-Stress And Maize Resistance To Spider Mites With Varied Host Specialization, Gunbharpur S. Gill

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Spider mites are well-documented pests of many agricultural crops including cereals such as maize. In hot and dry conditions, when crop plants are under water-stress, spider mite populations can rapidly increase within weeks and can cause severe yield losses. One approach to manage pests, such as spider mites, is through the development and selection of plants that can resist pests. Screening of maize lines has provided evidence of spider mite resistance; however, it is unclear how plant water-stress may affect the ability of maize to sustain spider mite resistance. In addition, it is important to understand how plants respond to …

Exploring The Connection Between Acid Exposure And Virulence In Listeria Monocytogenes, Minghao Li

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Listeria monocytogenes is a gram-positive food-borne pathogen that is widely dispersed in the environment and can cause listeriosis with high fatality rates when consumed in contaminated food products. They are capable of growing over a wide range condition. Listeria is also able to tolerate adverse conditions which allows the bacterium to survive in unfavorable environments. The ubiquitous nature of L. monocytogenes makes it difficult to eliminate from food systems. One major problem in the food industry is the survival of L. monocytogenes under sublethal low pH-environment since organic acids are widely used as food decontaminants. Prior research has suggested that …

Protecting Crops From Abiotic Stress: Copper Oxide Nanoparticle Effects On Wheat And A Beneficial Rhizobacterium, Matthew Potter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nanoparticles (NPs) are defined as particles less than 100 nm in at least one dimension. CuO NPs have possible applications in agriculture as micronutrient sources, pesticides, and enhancers of crop stress tolerance. Here, three aspects of CuO NP agricultural applications are studied: 1) the potential of CuO NPs to prevent wheat lodging-when crops irreversibly fall over; 2) CuO NP-induced drought tolerance in wheat seedlings; and 3) the effects of CuO NPs on outer membrane vesicle (OMV) production by Pseudomonas chlororaphis O6 (PcO6), a plant-health promoting bacterium.

Wheat grown 7 d exposed to CuO NPs in the growth matrix …

Impacts Of Tourism On The Ecophysiology Of The Endangered Northern Bahamian Rock Iguana (Cyclura Cychlura), Alison C. Webb

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Increased interest in ecotourism over recent years has led to more direct human-animal interactions and a striking concomitant increase in the provisioning of non-natural food, that may have unintended consequences for the wildlife involved. The critically endangered Northern Bahamian Rock Iguana provides a valuable model to address the potential impact of food provisioning on health as there are populations that represent a graded variation in human presence, with sites experiencing high, low, or no tourism. To assess the potential impacts of tourism on iguana physiology I first reviewed the relevant literature on iguana physiology and then performed three investigations focusing …

Trisiloxane Surfactant Adjuvants In Pollen, Autumn Slade

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Chemicals are often added to agricultural pesticide mixes to help increase the efficiency of the field spray solution, and one of the main groups of chemicals used for this purpose are trisiloxane surfactants (TSSs). Normally TSSs are considered non-toxic, but recent studies have shown TSSs to have negative impacts on organisms like honey bees. Though TSSs have recently been found in environmental sources like water, pollen, and beeswax, little is known about how TSSs behave in the environment or affects active ingredients, like pesticides.

To help determine the environmental prevalence and fate of TSSs, several studies were performed. Pollen was …

Effect Of Long Pasteurization Run Times On Bacterial Numbers In Milk, Brynli Tattersall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This project was funded by the Western Dairy Center to understand how long a milk pasteurizer can be operated before increases in bacterial numbers are observed in the pasteurized milk. While pasteurization kills pathogenic bacteria there are some non-pathogenic bacteria that can survive and have the ability to become attached to the surfaces in the cooling sections of the pasteurizer. Some bacteria can also produce spores that survive pasteurization even if the bacterial cells are killed. Temperatures in the cooling section remain in a range suitable for growth of these heat-tolerant bacteria and can allow germination of bacterial spores. While …

Characterization Of Protein And Fat In Dairy Feeds And Implications On Digestibility And Milk Composition, Kassidy Kate Buse

Department of Animal Science: Dissertations, Theses, and Student Research

A variety of feedstuffs are used to comprise dairy rations, each with their own nutritional contributions. In order to best utilize these feedstuffs to maximize production, characterization of their chemical composition is needed. Through the use of both in vitro and in situ methods, not only can the composition of the feed be determined, but also its digestibility. Also, because of the important role they play in human health, omega 3 fatty acids have received increasing attention. Most individuals consuming Western diets do not meet the recommended requirement for omega 3 fatty acids, and one way to improve that is …

Influence Of Strategic Supplementation And Genetic Potential For Milk Yield On Forage Digestibility, Amino Acid Utilization, And Livestock Production, Tasha M. King

Department of Animal Science: Dissertations, Theses, and Student Research

When consuming low-quality forages or at times when nutrient demands are high, ruminants may be unable to meet these requirements resulting in a state of negative energy balance. With feed costs contributing a large portion of production costs, providing dietary nutrients to maintain energy balance must be done so strategically. Additionally, producers must ensure consistent reproductive performance and offspring weaned to maintain a successful livestock enterprise. The objective of these studies was to evaluate the effect of glucogenic precursor supplementation and milk yield on forage digestibility, amino acid utilization, and livestock production. In experiment 1, a metabolism study was conducted …

Toward Sustainable Environmental Quality: Priority Research Questions For Asia, Kenneth M.Y. Leung, Tham C. Hoang

School of Environmental Sustainability: Faculty Publications and Other Works

Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring, and risk‐assessment methodologies are necessary to address the adverse impacts of environmental stressors on ecosystem services and biodiversity, with …