Digital Commons Network^™

Development And Implementation Of An Orthopedic Enhanced Recovery After Surgery Protocol, Beth Mccoy

Doctor of Nursing Practice Projects

Abstract

As life expectancy rates have grown and individuals desire a more active lifestyle the number of total hip arthroplasty and total knee arthroplasty surgeries performed has grown significantly. Enhanced recovery after surgery (ERAS) protocols have been shown to decrease the financial impact and improve patient outcomes in total joint surgeries. After a literature review a multidisciplinary team met and developed an ERAS protocol for total joint replacement surgeries to be implemented at a 250-bed community hospital in central Illinois. After an eleven-question pre-test was given to 34 participants consisting of perioperative nursing staff, anesthesia, and surgeons assessing their knowledge …

Determination And Dissection Of Dna-Binding Specificity For The Thermus Thermophilus Hb8 Transcriptional Regulator Tthb099, Kristi Moncja

Master of Science in Chemical Sciences Theses

Transcription factors (TFs) have been extensively researched in certain well-studied organisms but far less so in others. Following the whole-genome sequencing of a new organism, TFs are typically identified through their homology with related proteins in other organisms. However, recent findings demonstrate that structurally similar TFs from distantly related bacteria are not usually evolutionary orthologs. Here we explore TTHB099, a cAMP receptor protein (CRP)-family TF from the extremophile Thermus thermophilus HB8. Using the in vitro iterative selection method Restriction Endonuclease Protection, Selection and Amplification (REPSA), we identified the preferred DNA-binding motif for TTHB099, 5'-TGT(A/g)n(t/c)c(t/c)(a/g)g(a/g)n(T/c)ACA-3', and mapped potential binding sites, and …

How Minority Parents Could Help Children Develop Healthy Eating Behaviors: Parent And Child Perspectives, Chishinga Callender, Denisse Velazquez, Meheret Adera, Jayna M Dave, Norma Olvera, Tzu-An Chen, Shana Alford, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Minority children and children living in under-resourced households are at the greatest risk for obesity and diet-related disparities. Identifying effective strategies to reduce these risks is an important step in child obesity prevention. Parents influence the home environment and play a critical role in child obesity prevention. Eighteen parent–child dyads living in under-resourced Houston area communities participated in a mixed methods study (online surveys, telephone interviews). The purpose of the research reported here was to conduct a secondary analysis of the qualitative data to explore Black/African American and Hispanic parent and child perspectives of the ways in which parents could …

Is There An Association Between Oral Health-Related Quality Of Life And Alzheimer's Disease?, Anastasios Plessas, Martha Paisi

School of Nursing and Midwifery

No abstract provided.

Long-Acting Nanoformulated Antivirals For The Treatment And Prevention Of Hiv-1 And Hbv Infections, Dhruvkumar M. Soni Dr.

Theses & Dissertations

While antiretroviral therapy (ART) has revolutionized treatment and prevention of human immunodeficiency virus type one (HIV-1) infection, regimen adherence, viral mutations, drug toxicities, stigma and pill fatigue are limitations. These have led to the development of long acting (LA) ART. These include, but are not limited to, implantable devices, new chemical entities, prodrug modifications and nanoformulations. To these ends, this thesis focues on the transformation of nucleoside reverse transcriptase inhibitors (NRTIs) into LA parenterals, While elusive, data from our laboratories demonstrated that modifications to the PROdrug and nucleoTide technology (ProTide) enables improvements in drug apparent half-life and tissue and cell …

The Long Return, Diane Bezucha

Capstones

When COVID-19 hit New York in March 2020, the city’s 1,800 public schools were forced to make a sudden pivot to remote instruction. The scramble to transition 1.1 million students to online learning brought unprecedented challenges for principals, teachers, students and families, leaving everyone eager for a return to “normal.”

For schools in low-income neighborhoods, and those serving students with disabilities, this disruption has been especially difficult. But as the months passed, it became clear that the pandemic was not ending anytime soon. Without clear guidance from the city, schools grappled with the uncertainty of how to safely reopen, and …

Comparison Of Cardiac Muscle Between Male And Female Rats With Exercise And Aging: Analyzing Vitals, Gdnf Expression, Ngf Expression, Rna Expression, Sympathetic Innervation, Parasympathetic Innervation, And Sensory Innervation, Katelyn Kurrie

Honors Theses

The direction of my research-based thesis answers the question of how exercise affects the cardiovascular system with aging in male and female rats. My study would highlight the important differences of the cardiovascular system of both sexes which could lead to sex-specific insight on the cardiovascular disease epidemic which prevails as the most common cause of death in the United States. The studies completed will test the hypothesis: neurotrophic factor will be higher in females than males due to the higher presence of estrogen in females. The trophic factor is predicted to increase in both males and females with regular …

A Rapid Response Vaccine Development Strategy For Newcastle Disease In Poultry, Sr R. Maremagae, Cc C. Bezuidenhout, Am M. Murphy, Ma A. Jarvis, P Naicker, P. J. Lebea

School of Biomedical Sciences

Poultry is a major source of protein in sub-Saharan Africa and many other lower-income regions. Newcastle disease virus (NCDV) comprises a significant threat toward poultry production. While NCDV vaccines are routinely used in developed countries, those used in sub-Saharan Africa are mostly imported and are not specific to locally circulating strains. Indeed, the lack of rapid, field-based NCDV detection and the absence of cost-effective production methods for pure, strain-specific vaccines hampers efficient poultry production throughout these regions. This remains a major problem for both subsistence and commercial farming.The aim for this study was firstly, to develop a field-based isothermal PCR …

Expanding The Boundaries Of Food Policy: The Turn To Equity In New York City, Nevin Cohen, Rositsa Ilieva

Publications and Research

Policymakers acknowledge that the food system is multidimensional and that social determinants affect diet-related health outcomes, yet cities have emphasized programs and policies narrowly connected to food access and nutritional health. Over the past fifteen years, the boundaries of food governance have expanded to include a wider range of issues and domains not previously considered within the purview of food policy, like labor, housing, and education policies. This paper illustrates the processes by which this shift occurs by presenting the case of New York City, which has broadened its food governance to a larger set of issues, requiring cross-sectoral initiatives …

A Clinical Epidemiology And Molecular Attribution Evaluation Of Adenoviruses In Pediatric Acute Gastroenteritis: A Case-Control Study, Kanti Pabbaraju, Raymond Tellier, Xiao-Li Pang, Jianling Xie, Bonita E Lee, Linda Chui, Ran Zhuo, Otto G Vanderkooi, Samina Ali, Phillip I Tarr, Anna Funk, Stephen B Freedman

Open Access Publications

The objective of this study was to characterize the etiological role of human adenovirus (HAdV) serotypes in pediatric gastroenteritis. Using a case-control design, we compared the frequencies of HAdV serotypes between children with ≥3 episodes of vomiting or diarrhea within 24 h and <7 days of symptoms (i.e., cases) and those with no infectious symptoms (i.e., controls). Stool samples and/or rectal swabs underwent molecular serotyping with cycle threshold (Ct) values provided by multiplex real-time reverse transcription-PCR testing. Cases without respiratory symptoms were analyzed to calculate the proportion of disease attributed to individual HAdV serotypes (i.e., attributable fraction). Between December 2014 and August 2018, adenoviruses were detected in 18.8% (629/3,347) of cases and 7.2% (97/1,355) of controls, a difference of 11.6% (95% confidence interval [CI], 9.6%, 13.5%). In 96% (95% CI, 92 to 98%) of HAdV F40/41 detections, the symptoms could be attributed to the identified serotype; when serotypes C1, C2, C5, and C6 were detected, they were responsible for symptoms in 52% (95% CI, 12 to 73%). Ct values were lower among cases than among controls (

Palestinian Women’S Agency, Yasmin Khodary

Political Science

In Civil Resistance and Conflict Transformation, Veronique Dudouet divides responses to oppression into two main analytical categories. The first category refers to conventional actions, including party politics, advocacy or diplomacy, dialogue and negotiations, and litigation. The second category is non-intuitional/contentious actions including: first, nonviolent/unarmed/peaceful resistance through protest and persuasion, non-cooperation, disruptive intervention and creative resistance and second, violent/armed resistance through warfare, terrorist attacks, guerrilla insurgency, protest violence and sabotage. These two sub-categories of resistance operate outside the bounds of conventional political channels and are usually employed by an oppressed minority or disempowered majority by an exclusionary national or foreign actor. …

Regional Trends In Birth Weight In Low- And Middle-Income Countries 2013-2018, Irene Marete, Osayame Ekhaguere, Carla M. Bann, Sherri L. Bucher, Paul Nyongesa, Archana B. Patel, Patricia L. Hibberd, Sarah Saleem, Robert L. Goldenberg, Shivaprasad S. Goudar

Community Health Sciences

Background: Birth weight (BW) is a strong predictor of neonatal outcomes. The purpose of this study was to compare BWs between global regions (south Asia, sub-Saharan Africa, Central America) prospectively and to determine if trends exist in BW over time using the population-based maternal and newborn registry (MNHR) of the Global Network for Women'sand Children's Health Research (Global Network).
Methods: The MNHR is a prospective observational population-based registryof six research sites participating in the Global Network (2013-2018), within five low- and middle-income countries (Kenya, Zambia, India, Pakistan, and Guatemala) in threeglobal regions (sub-Saharan Af rica, south Asia, Central America). The …

Association Of Parity With Birthweight And Neonatal Death In Five Sites: The Global Network's Maternal Newborn Health Registry Study, Ana Garces, Wilton Perez, Margo S. Harrison, Kay S. Hwang, Tracy L. Nolen, Robert L. Goldenberg, Archana B. Patel, Patricia L. Hibberd, Adrien Lokangaka, Sarah Saleem

Community Health Sciences

Background: Nulliparity has been associated with lower birth weight (BW) and other adverse pregnancy outcomes, with most of the data coming from high-income countries. In this study, we examined birth weight for gestational age z-scores and neonatal (28-day) mortality in a large prospective cohort of women dated by first trimester ultrasound from multiple sites in low and middle-income countries.
Methods: Pregnant women were recruited during the first trimester of pregnancy and followed through 6 weeks postpartum from Maternal Newborn Health Registry (MNHR) sites in the Democratic Republic of Congo (DRC), Guatemala, Belagavi and Nagpur, India, and Pakistan from 2017 and …

Development Of The Global Network For Women's And Children's Health Research's Socioeconomic Status Index For Use In The Network's Sites In Low And Lower Middle-Income Countries, Archana B. Patel, Carla M. Bann, Ana L. Garces, Nancy F. Krebs, Adrien Lokangaka, Antoinette Tshefu, Carl L. Bose, Sarah Saleem, Robert L. Goldenberg, Shivaprasad S. Goudar

Community Health Sciences

Background: Socioeconomic status (SES) is an important determinant of health globally and an important explanatory variable to assess causality in epidemiological research. The 10th Sustainable Development Goal is to reduce disparities in SES that impact health outcomes globally. It is easier to study SES in high-income countries because household income is representative of the SES. However, it is well recognized that income is poorly reported in low- and middle- income countries (LMIC) and is an unreliable indicator of SES. Therefore, there is a need for a robust index that will help to discriminate the SES of rural households in a …

Why Are The Pakistani Maternal, Fetal And Newborn Outcomes So Poor Compared To Other Low And Middle-Income Countries?, Aleha Aziz, Sarah Saleem, Tracy L. Nolen, Nousheen Akber Pradhan, Elizabeth M. Mcclure, Saleem Jessani, Ana L. Garces, Patricia L. Hibberd, Janet L. Moore, Sameen Siddiqi

Community Health Sciences

Background: Pakistan has among the poorest pregnancy outcomes worldwide, significantly worse than many other low-resource countries. The reasons for these differences are not clear. In this study, we compared pregnancy outcomes in Pakistan to other low-resource countries and explored factors that might help explain these differences.
Methods: The Global Network (GN) Maternal Newborn Health Registry (MNHR) is a prospective, population-based observational study that includes all pregnant women and their pregnancy outcomes in defined geographic communities in six low-middle income countries (India, Pakistan, Democratic Republic of Congo, Guatemala, Kenya, Zambia). Study staff enroll women in early pregnancy and follow-up soon after …

Interprofessional Education (Ipe) And Interprofessional Education Collaborative (Ipec) Competencies Of Clinical And Healthcare Administration Undergraduate Students, Shelly Gompf

Dissertations, Theses, and Projects

The healthcare industry is dependent on the successful delivery of effective education to undergraduate healthcare students. Curriculum and instruction, experiences both inside and outside of the classroom, significantly contribute to students' successful development. A critical element for successful healthcare delivery is to continue building a sustainable culture for all healthcare workers that will increase skills for improved ethics and values, inter-disciplinary understanding of roles and responsibilities, interprofessional communication, and teamwork. One teaching approach that continues to produce positive results is interprofessional education (IPE). This teaching method, supported by the experiential learning theory, brings clinical stakeholders together to problem-solve and make …

Metabolite Influence On The Hibernating Arctic Ground Squirrel, Sarah A. Rice

Chemistry and Biochemistry

Hibernation is a state of extreme metabolic plasticity and fasting. How hibernators maintain nitrogen homeostasis and regulate amino acid metabolism and how those metabolites influence hibernation physiology remains unknown. We first utilized three approaches to understand nitrogen homeostasis and amino acid metabolism in hibernation: longitudinal metabolic profiling within individual animals over undisturbed torpor, in vivo amino acid isotope tracing in deep torpor, and ¹⁵N isotope tracing in vivo during arousal from hibernation in Arctic Ground Squirrels (AGS). We observed that in vivo whole body production (WBP) of metabolites in deep torpor are profoundly and selectively suppressed in deep torpor. Metabolic …

Alaska Sea Energy: A Guide For Hydroponic Development, Daniel Blair-Madrid

Rural Development

This guide has been created to help those unfamiliar with the benefits of growing food with hydroponics to gain a deeper understanding of how such techniques can help rural communities with issues of food sovereignty and provide healthy fresh food through every season. It also includes input from communities participating in the project. Rural coastal communities in particular have a unique opportunity of combining both hydroponic techniques and ocean-based fertilization to maximize sustainable food production, thereby reducing reliance on imported food. The instructions contained within this guide will describe various types of hydroponic systems, recommendations for equipment, and how to …

Sea Otter Diet Composition With Respect To Recolonization, Life History, And Season In Southern Southeast Alaska, Nicole Laroche

Fisheries

Until translocation efforts in the 1960s, sea otters (Enhydra lutris) were absent from Southeast Alaska due to extirpation by the fur trade in the 18th and 19th centuries. About 400 sea otters were reintroduced to six Southeast Alaska locations, including two sites near Prince of Wales Island in southern Southeast Alaska. The most recent US Fish and Wildlife Service population count, completed in 2012, estimated that about 25,000 sea otters inhabited Southeast Alaska. Sea otters will reduce invertebrate prey biomass when recolonizing an area. By quantifying sea otter diets and caloric intake according to recolonization patterns, we can better understand …

Zooplankton Community Composition In Relation To Environment And Juvenile Salmon Diets In Icy Strait, Southeast Alaska, Emily A. Fergusson

Fisheries

Zooplankton in the nearshore marine habitat function as an important prey resource for many pelagic fishes, are a major component of the lower tropic level, and serve as a vital ecosystem indicator. Understanding how the zooplankton community changes in response to fluctuations in biophysical factors is critical in a changing climate and is important to understanding the dynamics of commercially important upper-trophic level species that depend nutritionally on zooplankton. The Alaska Fisheries Science Center's Southeast Coastal Monitoring project has surveyed the pelagic ecosystem in eastern Icy Strait monthly from May to August since 1997 to understand how environmental variation affects …

Reproduction And Stress Response Endocrinology In Blue (Balaenoptera Musculus) And Gray (Eschrichtius Robustus) Whales, Valentina Melica

Fisheries

Identification of biomarkers that reflect physiological status is fundamental for assessing population health, as well as providing more accurate estimates of life history parameters. Blue (Balaenoptera musculus) and gray (Eschrichtius robustus) whale populations feed on lower trophic levels and migrate between the eastern Tropical and the eastern North Pacific Ocean. With increasing disturbances (e.g., changing environment and human activities), understanding the stress response, resultant coping mechanisms, and the subsequent effects on reproduction, is of growing importance. While extensive knowledge is available on photo-identification and ecology of these two species, information on physiology is limited and what exists is outdated. This …

Tracing Carbon Sources Of Southern Beaufort Sea And Chukchi Sea Polar Bears Using Stable Isotope Analyses, Malia E.K. Smith

Marine Biology

The Southern Beaufort Sea (SBS) polar bear (Ursus maritimus) subpopulation has declined in response to sea ice loss, while the Chukchi Sea (CS) subpopulation appears stable. The substantial population decline in the SBS subpopulation in recent years is concurrent with increases in the proportion of polar bears coming on shore, and the duration they spend there. Both of these changes have been associated with the loss of access to their primary sea ice habitat, which is mainly used as a platform to hunt seals. The first objective of this study was to determine if the SBS and CS polar bear …

Brain Α-Tocopherol Concentration Is Inversely Associated With Neurofibrillary Tangle Counts In Brain Regions Affected In Earlier Braak Stages: A Cross-Sectional Finding In The Oldest Old, J. Tanprasertsuk, T.M. Scott, M.A. Johnson, L.W. Poon, P.T. Nelson, A. Davey, J.L. Woodard, R. Vishwanathan, A.K. Barbey, K. Barger, X.-D. Wang, E.J. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: Higher vitamin E status has been associated with lower risk of Alzheimer’s disease (AD). However, evidence of the association of vitamin E concentration in neural tissue with AD pathologies is limited. Design: The cross-sectional relationship between the human brain concentrations of α- and γ-tocopherol and the severity of AD pathologies – neurofibrillary tangle (NFT) and neuritic plaque (NP) – was investigated. Setting & Participants: Brains from 43 centenarians (≥ 98 years at death) enrolled in the Phase III of the Georgia Centenarian Study were collected at autopsy. Measurements: Brain α- and γ-tocopherol concentrations (previously reported) …

Association Between Duration Of Residence And Prevalence Of Type 2 Diabetes Among Male South Asian Expatriate Workers In The United Arab Emirates: A Cross-Sectional Study, Syed Mahboob Shah, Lindsay M. Jaacks, Fatima Al-Maskari, Juma Al-Kaabi, Faisal Aziz, Elpidoforos Soteriades, Tom Loney, Hamed Farooqi, Anjum Memon, Raghib Ali

Department of Family Medicine

Expatriates account for about 80% of the total population in the United Arab Emirates (UAE). This study aimed to evaluate the hypothesis that prevalence of type 2 diabetes in male South Asian expatriates increases with increased length of residence in the UAE.
Design, settings and participants: This cross-sectional study recruited a representative sample (n=1375) of male South Asian expatriates aged ≥18 years in Al Ain, UAE. Sociodemographic, anthropometric and lifestyle data were obtained using a pilot-tested adapted version of the WHO STEPS instrument.
Main outcome measures: Duration of residence was used as a marker for acculturation. Type 2 diabetes was …

Native And Non-Native Sources Of Carbohydrate Correlate With Abundance Of An Invasive Ant, Lori Lach, Benjamin Hoffmann, Melinda L. Moir

Biosecurity Research Articles

Invasive species threaten many ecological communities and predicting which communities and sites are invasible remains a key goal of invasion ecology. Although invasive ants often reach high abundances in association with plant-based carbohydrate resources, the source and provenance of these resources are rarely investigated. We characterized carbohydrate resources across ten sites with a range of yellow crazy ant abundance in Arnhem Land, Australia and New Caledonia to determine whether yellow crazy ant (Anoplolepis gracilipes) abundance and trophic position correlate with carbohydrate availability, as well as the relative importance of native and non-native sources of carbohydrates to ant diet. …

Does Covid-19 Contribute To Development Of Neurological Disease?, Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Shasthara Paneyala, Duraisamy Patteswari, Meena K. Sakharkar, Hamdan Hamdan, David M. Ojcius, Srinivasa R. Bolla, Musthafa M. Essa, Saravana B. Chidambaram, M. Walid Qoronfleh

All Dugoni School of Dentistry Faculty Articles

Background: Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem. Methods: This is a literature review article. The research design method is an evidence-based rapid review. The present discourse aim is first to scrutinize and assess the available literature on …

The Effects Of Exercise On Breastmilk Composition And Supply: A Critical Literature Review, Jewell Mcroy

Masters Theses, 2020-current

It is well established that breastfeeding provides dual benefits to both the mother and the infant and is the preferred method of providing nutrients to infants essential for growth and development. Participating in regular physical exercise is also well-supported by research to be beneficial to one’s overall health and quality of life. Currently there are no physical activity guidelines developed for women who are postpartum and breastfeeding. An online database search was conducted; three articles met the inclusion criteria and were included within the review. Studies were included if there were direct measures of human breastmilk composition, supply/volume, and included …

Efficient Alternative Food Systems For Earth And Space, Kyle A. Alvarado

Engineering

Alternative foods are a source of human-edible calories derived from an unconventional source or process. This thesis includes two alternative foods: (i) crops grown under low-tech greenhouses in low sunlight environments and (ii) hydrogen-oxidizing bacteria (HOB) in space and Earth refuges, such as to repopulate the Earth. The purpose of alternative foods is to ensure food security for human survival. During a global catastrophic risk (GCR) scenario, such as nuclear winter or super volcanic eruption, the sun may be obscured, causing lack of crop production and therefore global food shortages. The purpose of this thesis was to improve the cost …

Technoference: Parent Mobile Device Use And Implications For Children And Parent-Child Relationships., Brandon T. Mcdaniel Phd

Health Services and Informatics Research

The increase in the prevalence of smartphones and mobile devices has spurred changes in the caregiving environment of infants and young children, as phones and mobile devices are used at times during caregiving and in caregiving spaces. This use could create disruptions and cause distractions during parenting (termed technoference). This article summarizes the potential impacts on parent responsiveness and the experiences of infants and young children. Yet, it also warns that it is important to consider the reason for and type of parent use. Finally, the article ends with practical tips for working with parents concerning mobile device use.

Spawning Migration Characteristics And Ecology Of Eulachon (Thaleichthys Pacificus), Robert E. Spangler

Fisheries

Eulachon Thaleichthys pacificus has experienced dramatic reductions in their distribution and abundance along the west coast of North America. This prompted the listing of this species as "Threatened" under the U.S. Endangered Species Act (ESA) of 1973 for populations found in the southern portions of their range, but not in Alaska. Key gaps in knowledge of Eulachon spawning ecology exist that impede population monitoring efforts and habitat protection. Currently, many monitoring efforts ignore estuaries as possible spawning habitat leading to inaccurate estimates of population abundance and trends. Furthermore, estuaries are not designated as critical spawning habitat for Eulachon. This is …