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Fine-Tuning Of Alanyl-Trna Synthetase Quality Control Alleviates Global Dysregulation Of The Proteome, Paul Kelly, Arundhati Kavoor, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One integral step in the transition from a nucleic acid encoded-genome to functional proteins is the aminoacylation of tRNA molecules. To perform this activity, aminoacyl-tRNA synthetases (aaRSs) activate free amino acids in the cell forming an aminoacyl-adenylate before transferring the amino acid on to its cognate tRNA. These newly formed aminoacyl-tRNA (aa-tRNA) can then be used by the ribosome during mRNA decoding. In Escherichia coli, there are twenty aaRSs encoded in the genome, each of which corresponds to one of the twenty proteinogenic amino acids used in translation. Given the shared chemicophysical properties of many amino acids, aaRSs have …

Artificial Nightlight Alters The Predator–Prey Dynamics Of An Apex Carnivore, Mark A. Ditmer, David C. Stoner, Clinton D. Francis, Jesse R. Barber, James D. Forster, David M. Choate, Kirsten E. Ironside, Kathleen M. Longshore, Kent R. Hersey, Randy T. Larsen, Brock R. Mcmillan, Daniel D. Olson, Alyson M. Andreasen, Jon P. Beckmann, P. Brandon Holton, Terry A. Messmer, Neil H. Carter

Life Sciences Faculty Research

Artificial nightlight is increasingly recognized as an important environmental disturbance that influences the habitats and fitness of numerous species. However, its effects on wide‐ranging vertebrates and their interactions remain unclear. Light pollution has the potential to amplify land‐use change, and as such, answering the question of how this sensory stimulant affects behavior and habitat use of species valued for their ecological roles and economic impacts is critical for conservation and land‐use planning. Here, we combined satellite‐derived estimates of light pollution, with GPS‐data from cougars Puma concolor (n = 56), mule deer Odocoileus hemionus (n = 263) and locations of cougar‐killed …

Strategy And Issues Of Ecological Grass Construction In Jilin Province, F. G. Du, W. W. Lu

IGC Proceedings (1977-2023)

No abstract provided.

Comparison Of Multi-Frequency Bioelectrical Impedance And Dual-Energy X-Ray Absorptiometry To Assess Body Composition In College-Aged Adults, Rachel Tauber, Clayton Camic, Shuqi Zhang, Peter Chomentowski Iii

International Journal of Exercise Science

International Journal of Exercise Science 13(4): 1595-1604, 2020. The purpose of this study was to evaluate the validity of whole body percent fat (%BF) and segmental fat-free mass (FFM) using multi-frequency bioelectrical impedance analysis (MF-BIA) and dual-energy x-ray absorptiometry (DEXA) in college-aged adults. Sixty-two participants male (n = 32) and female (n = 30) completed MF-BIA and DEXA measurements following established pre-test guidelines. %BF and segmental FFM (right arm, left arm, trunk, right leg, and left leg) were collected and analyzed. The MF-BIA significantly (p < 0.05) underestimated %BF for all participants, females, and males compared to DEXA. …

Acute Post-Exercise Blood Pressure Responses In Middle-Aged Persons With Elevated Blood Pressure/Stage 1 Hypertension Following Moderate And High-Intensity Isoenergetic Endurance Exercise, Terje Gjøvaag, Hanna Berge, Marianne Olsrud, Boye Welde

International Journal of Exercise Science

International Journal of Exercise Science 13(3): 1532-1548, 2020. This study investigated the acute post-exercise hypotension (PEH) response in persons with elevated blood pressure or stage 1 hypertension following moderate and high-intensity isoenergetic endurance exercise. Twelve middle-aged persons (six females), with resting systolic and diastolic BP of 130±6 and 84±7 mmHg, participated in three bicycle ergometer bouts: 1) Testing of peak aerobic capacity (VO_2peak), 2) Moderate intensity exercise (MOD) at 66% of VO_2peak, 3) High-intensity exercise (INT) at 80% of VO_2peak. All variables were recorded pre-exercise, during exercise and 0, 5, 10, and 30 minutes …

Global Burden Of 369 Diseases And Injuries In 204 Countries And Territories, 1990–2019: A Systematic Analysis For The Global Burden Of Disease Study 2019, Theo Vos, Christopher J L Murray, Arianna Maever L. Amit, Veincent Christian F. Pepito, Gbd 2019 Diseases And Injuries Collaborators, 1026 Co-Authors

Ateneo School of Medicine and Public Health Publications

Background

In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries.

Methods

GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two …

Importance Of Palliative Care In End Of Life Planning, Debra Lynn Hagerty Dr.

Center for Social Gerontology Community Conference (2017-2022)

Palliative care is specialized medical care for people living with a serious illness. This type of care is focused on providing relief from the symptoms and stress of the illness. The goal is to improve the quality of life for both the patient and the family. When incorporated early, end of life care is improved. Additionally, there is a cost of care improvement, that palliative care has the capacity to substantially reduce healthcare expenditures among advanced cancer patients. Furthermore, the cost reduction depends on the timing of the palliative care consult.

Clinical Approach To A Request For Phentermine-Topiramate In A Young Woman With A History Of High-Risk Eating Behavior, Erin Spencer

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report appraising Safer DL, Adler S, Dalai SS, et al. A randomized, placebo-controlled crossover trial of phentermine-topiramate ER in patients with binge-eating disorder and bulimia nervosa. Int J Eat Disord. 2019;(September):1-12. https://doi.org/10.1002/eat.23192 to inform the clinical decision of whether or not to prescribe phentermine-topiramate to an overweight 27-year-old woman who endorses risky eating behaviors.

Assessing Motivation And Utilizing Motivational Interviewing In Introductory College Biology For Improved Student Success, William Martin

Together We RISE (Making Excellence Inclusive)

Student motivation, metacognition and engagement are strong predictors of academic success in the undergraduate biology classroom. Implementation of diverse active learning strategies results in increased student engagement and improved student performance. Instructors direct students on behaviors aimed to promote self-reflection and self-efficacy towards academic success yet see varying follow-through from students. This research study assesses motivation in students in two separate but parallel, introductory biology courses required for majors. Students in one course, with traditionally high attrition and serving students from diverse majors, will be compared to a second with low historical attrition and serving a single pre-professional program at …

High Protein Diets, Joshua L. Hudson

Diet, Food, Exercise, and Nutrition (D-FEND)

Understanding the minimum requirements for dietary protein

What does "high" protein diet mean?

Understand when, for whom, and what purpose consuming high protein diet may be beneficial

Interview With Dr. Rosalynn Vega, Rosalynn A. Vega, Chelsey Sandoval

Community Historical Archaeology Project with Schools (CHAPS) Oral Histories

Interview with Dr. Rosalynn Vega, anthropologist and scholar who focuses on Global Health and Migration, regarding research on medical migration in the Rio Grande Valley.

Effects Of Housing System On Dairy Heifer Replacement Cost From Birth To Calving: Evaluating Costs Of Confinement, Dry-Lot, And Pasture-Based Systems And Their Impact On Total Rearing Investment, Anna Catherine Hawkins, Kenneth H. Burdine, Donna M. Amaral-Phillips, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Replacement heifer rearing is critical for the future of dairy operations, to improve genetic merit and maintain herd size. A myriad of options exist on how to manage, feed, and ultimately raise replacement heifers. Pasture is perceived to offer optimal welfare and an economical housing system for replacement animals, but confinement systems are gaining popularity. This study investigates the costs associated with replacement heifer management decisions from birth to calving, considering the factors of housing systems, labor, feed, and health. The objective of this study was to develop an economic model to determine the cost of raising a replacement heifer …

A High-Stringency Blueprint Of The Human Proteome., Subash Adhikari, Edouard C Nice, Eric W Deutsch, Lydie Lane, Gilbert S Omenn, Stephen R Pennington, Young-Ki Paik, Christopher M Overall, Fernando J Corrales, Ileana M Cristea, Jennifer E Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W Chan, Amos Bairoch, James C Waddington, Joshua L Justice, Joshua Labaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C S Nogueira, Gilberto B Domont, Yves Vandenbrouck, Maggie P Y Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P Snyder, Ruedi Aebersold, Mark S Baker

Articles, Abstracts, and Reports

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome …

Associations Of Dietary Bioactive Compounds With Maternal Adiposity And Inflammation In Gestational Diabetes: An Update On Observational And Clinical Studies, Dustin W. Davis, Jeannette Crew, Petar Planinic, James M. Alexander, Arpita Basu

School of Medicine Faculty Research

Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. Maternal obesity, oxidative stress, and inflammation have been implicated in GDM. In non-pregnant adults, intakes of dietary bioactive compounds inversely associate with insulin resistance and inflammation. However, associations of dietary bioactive compounds with biomarkers of adiposity, antioxidant vitamin and mineral status, oxidative stress, and inflammation in GDM have not been fully elucidated. We addressed this gap by conducting a semi-quantitative review of observational studies and randomized controlled trials published between 2010 and 2020 and retrieved from Google Scholar, Medline, and PubMed. Our analysis …

Protein Arginine Methyltransferase Prmt5 Regulates Fatty Acid Metabolism And Lipid Droplet Biogenesis In White Adipose Tissues, Zhihao Jia, Feng Yue, Xiyue Chen, Naagarajan Narayanan, Jiamin Qiu, Sabriya A. Syed, Anthony N. Imbalzano, Meng Deng, Peng Yu, Changdeng Hu, Shihuan Kuang

Purdue University Libraries Open Access Publishing Fund

The protein arginine methyltransferase 5 (PRMT5) is an emerging regulator of cancer and stem cells including adipogenic progenitors. Here, a new physiological role of PRMT5 in adipocytes and systemic metabolism is reported. Conditional knockout mice were generated to ablate the Prmt5 gene specifically in adipocytes (Prmt5AKO). The Prmt5AKO mice exhibit sex- and depot-dependent progressive lipodystrophy that is more pronounced in females and in visceral (than subcutaneous) white fat. The lipodystrophy and associated energy imbalance, hyperlipidemia, hepatic steatosis, glucose intolerance, and insulin resistance are exacerbated by high-fat-diet. Mechanistically, Prmt5 methylates and releases the transcription elongation factor SPT5 from Berardinelli-Seip congenital lipodystrophy …

Assessing The Health Information Needs Of Nebraska Public Libraries, Christian I.J. Minter

Posters and Presentations: Leon S. McGoogan Health Sciences Library

OBJECTIVE: McGoogan Health Sciences Library received a subaward from the Network of the National Library of Medicine to provide consumer health information trainings to public library staff in Nebraska. The aim of this project was to assess the health information needs of library patrons and staff to determine the type of trainings that would be most relevant.

METHODS: An online survey was developed based on a similar survey conducted by the Delaware Health and Social Service Library. The survey was distributed by email to library directors and through the Nebraska Library Commission listserv. The survey period was open July 14 …

Covid-19 Deaths In People With Intellectual Disability In The Uk And Ireland: Descriptive Study, Bhathika Perera, Richard Laugharne, William Henley, Abigail Zabel, Kirsten Lamb, David Branford, Ken Courtanay, Regi Alexander, Kiran Purandare, Anusha Wijeratne, Vishwa Radhakrishnan, Eileen Mcnamara, Youshan Daureeawoo, Indermeet Sawhney, Mark Scheepers, Gordon Taylor, Rohit Shankar

Peninsula Medical School

Background: Rapid spread of coronavirus disease 2019 (COVID-19) has affected people with intellectual disability disproportionately. Existing data does not provide enough information to understand factors associated with increased deaths in those with intellectual disability. Establishing who is at high risk is important in developing prevention strategies, given risk factors or comorbidities in people with intellectual disability may be different to those in the general population. Aims: To identify comorbidities, demographic and clinical factors of those individuals with intellectual disability who have died from COVID-19. Method: An observational descriptive case series looking at deaths because of COVID-19 in people with intellectual …

Sure 2020 Undergraduate Science Conference Booklet, Sure Network

Group Reports

The SURE 2020 Conference was the third series of Science Undergraduate Research Experience (SURE) Conferences, following earlier series in 2018 (with three conferences in Dublin, Athlone and Waterford) and in 2019 (with three conferences in Dublin, Sligo and Carlow). The 2020 online conference had a total of 24 oral presentations and 35 poster presentations, and was attended by over 450 students, academic staff, professional body and industry representatives.

The aims of the conference were to:

1. Provide current students with an opportunity to gain an understanding of the work which has been undertaken by recent graduates, and the career opportunities that …

Occupational Therapy Student Readiness For Transition To The Fieldwork Environment: A Pilot Case Study, Pamela Karp

The Open Journal of Occupational Therapy

The classroom and the field represent diverse and unique teaching and learning environments that students are required to navigate successfully. Facilitating student success in these environments requires the efforts of educators and the students themselves. This qualitative pilot study sought to elucidate perspectives regarding student readiness from the viewpoint of occupational therapy academic and fieldwork educators. Data for the study was collected from interviews and a focus group. The results of the study revealed that academic and fieldwork educators value similar characteristics of student readiness for transition to fieldwork. However, there is a need for collaborative strategies between the academic …

The Indiana Statesman, October 15, 2020, Indiana State University

Student Newspaper

Students share thoughts on fall address; Princeton renames residential college; LGBTQ+ Spirit Day: Multicultural Services and Programs promotes anti-bullying; Woman made second false 911 call on bird watcher in Central Park

"Circulation Of Officialdom (Or) A Letter Arrives On My Gov’T Employee Desk", Gabriela Halas

The Goose

"Circulation of officialdom (or) a letter arrives on my gov’t employee desk" by Gabriela Halas

Health And Disease Markers Correlate With Gut Microbiome Composition Across Thousands Of People., Ohad Manor, Chengzhen L Dai, Sergey A Kornilov, Brett Smith, Nathan D Price, Jennifer C Lovejoy, Sean M Gibbons, Andrew T Magis

Articles, Abstracts, and Reports

Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence disease biomarker levels in the blood. Understanding the relationships between gut microbes and host phenotypes are critical for understanding wellness and disease. Here, we examine associations between the gut microbiota and ~150 host phenotypic features across ~3,400 individuals. We identify major axes of taxonomic variance in the gut and a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors, including host-microbe associations that are composition-specific. These results suggest potential opportunities …

Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, Paul Sandifer, Landon Knapp, Maureen Lichtveld, Ruth Manley, David Abramson, Rex Caffey, David Cochran, Tracy Collier, Kristie Ebi, Lawrence Engel, John Farrington, Melissa Finucane, Christine Hale, David Halpern, Emily Harville, Leslie Hart, Yulin Hswen, Barbara Kirkpatrick, Bruce Mcewen, Glenn Morris, Raymond Orbach, Lawrence Palinkas, Melissa Partyka, Dwayne Porter, Aric A. Prather, Teresa Rowles, Geoffrey Scott, Teresa Seeman, Helena Solo-Gabriele, Erik Svendsen, Terry Tincher, Juli Trtanj, Ann Hayward Walker

Faculty Publications

© Copyright © 2020 Sandifer, Knapp, Lichtveld, Manley, Abramson, Caffey, Cochran, Collier, Ebi, Engel, Farrington, Finucane, Hale, Halpern, Harville, Hart, Hswen, Kirkpatrick, McEwen, Morris, Orbach, Palinkas, Partyka, Porter, Prather, Rowles, Scott, Seeman, Solo-Gabriele, Svendsen, Tincher, Trtanj, Walker, Yehuda, Yip, Yoskowitz and Singer. The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human …

Analytical And Experimental Study Of Fatigue-Crack-Growth Ae Signals In Thin Sheet Metals, Roshan Joseph, Victor Giurgiutiu

Faculty Publications

The acoustic emission (AE) method is a very popular and well-developed method for passive structural health monitoring of metallic and composite structures. AE method has been efficiently used for damage source detection and damage characterization in a large variety of structures over the years, such as thin sheet metals. Piezoelectric wafer active sensors (PWASs) are lightweight and inexpensive transducers, which recently drew the attention of the AE research community for AE sensing. The focus of this paper is on understanding the fatigue crack growth AE signals in thin sheet metals recorded using PWAS sensors on the basis of the Lamb …

St. Norbert College Student Awarded First Place In Annual Pitch Contest, St. Norbert College

Press Releases 2020

No abstract provided.

Walking School Bus Programs: Implementation Factors, Implementation Outcomes, And Student Outcomes, 2017-2018., Jordan A. Carlson, Chelsea Steel, Carolina M. Bejarano, Marshall T. Beauchamp, Ann M. Davis, James F. Sallis, Jon Kerner, Ross Brownson, Sara Zimmerman

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE AND OBJECTIVES: Walking school bus programs increase children's physical activity through active travel to school; however, research to inform large-scale implementation of such programs is limited. We investigated contextual factors, implementation outcomes, and student outcomes in existing walking school bus programs in the United States and internationally.

INTERVENTION APPROACH: Walking school bus programs involve a group of children walking to school together with an adult leader. On the trip to school, these adults provide social support, address potential traffic and interpersonal safety, and serve as role models to the children while children increase their physical activity levels.

EVALUATION METHODS: …

Identifying Dietary Patterns In Irish Schoolchildren And Their Association With Nutritional Knowledge And Markers Of Health Before And After Intervention, Alison Merrotsy, Aoife L. Mccarthy, Seán Lacey, Tara Coppinger

Publications

The aim of the study was to identify dietary patterns (DP) and examine differences in anthropometric measures, blood pressure (BP), cardiorespiratory fitness and nutritional knowledge of 6- and 10-year-old children at baseline and following a nutrition and physical activity intervention, with respect to DP and treatment group. This is a longitudinal study. Food diary, nutritional knowledge questionnaire and 550-m walk/run test measured dietary intake, nutritional knowledge and cardiorespiratory fitness, respectively. BP, weight, height and waist circumference were also measured and BMI and waist-to-height ratio (WHtR) were derived. All measurements were performed at baseline and following intervention. Two primary schools (one …

Environmental Stewardship Promotes A Sense Of Place: Coral Health Monitoring On Maui, Cynthia Brunold-Conesa

The International Journal of Ecopsychology (IJE)

Environmental stewardship is an integral aspect of the Montessori curriculum. It usually includes care of the school’s setting (classrooms, grounds, gardens, eating areas, etc.) and, depending on each school’s unique situation, ideally extends into the larger environment in which the school is situated. During the 2014-15 school year, our class of Middle School students at Montessori Hale O Keiki (MHOK) were asked to select community service projects that were directly relevant to environmental and/or ecological issues on Maui. For our students, Coral Watch was the perfect project through which to integrate marine science, environmental stewardship, and community service. Through a …

Walking School Bus Programs: Implementation Factors, Implementation Outcomes, And Student Outcomes, 2017-2018, Jordan A Carlson, Chelsea Steel, Carolina M Bejarano, Marshall T Beauchamp, Ann M Davis, James F Sallis, Jon Kerner, Ross Brownson, Sara Zimmerman

Open Access Publications

PURPOSE AND OBJECTIVES: Walking school bus programs increase children's physical activity through active travel to school; however, research to inform large-scale implementation of such programs is limited. We investigated contextual factors, implementation outcomes, and student outcomes in existing walking school bus programs in the United States and internationally.

INTERVENTION APPROACH: Walking school bus programs involve a group of children walking to school together with an adult leader. On the trip to school, these adults provide social support, address potential traffic and interpersonal safety, and serve as role models to the children while children increase their physical activity levels.

EVALUATION METHODS: …

Reclamation Of Saline Soils Through Revegetation In Australia: Plants, Processes And People, E. G. Barrett‐Lennard

IGC Proceedings (1977-2023)

No abstract provided.