Digital Commons Network^™

Protective Effects Of Tiger Milk Mushroom (Lignosus Rhinocerus) Extracts On Oxidative Stress-Induced Neurotoxicity And Aging In Ht22 Cells And C. Elegans, Parinee Kittimongkolsuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lignosus rhinocerus (LR) or Tiger Milk Mushroom, a fork medicinal mushroom, has been reported for several pharmacological effects including asthma treatment, anti-inflammatory, anti-proliferative, immuno-modulating effects, promote neurite outgrowth in PC-12 cells, anti-HIV-1 activity, and antioxidants properties. However, the antioxidant properties have only focus on in vitro and no or few studies have reported their protective effects in mouse hippocampal (HT22) cells and Caenorhabditis elegans (C. elegans). This study aims to investigate the neuroprotective effect of three extracts of LR against oxidative stress in both HT22 cells and. C. elegans as well as longevity in C. elegans. In HT22 cells, we …

Maternal Knowledge, Attitude And Practices On The Dietary Omega 3 And 6 In Children Aged 1-2 Years Old In Labuhanbatu Utara Regency, Indonesia, Sinar Yunita Purba

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Indonesia is one of the countries with low quality human resources including the issue on cognitive performances from brain functioning creativity. In the effort to fulfil Omega 3 and 6 in children aged 1-2 years, the most responsible person to the period are mothers. Therefore, the study aimed to determine the level of maternal knowledge, attitude, and practices and factors associated with the dietary omega 3 and 6 consumption in children aged 1-2 years old in Labuhanbatu Utara, Indonesia. Method: This cross-sectional study was conducted among 428 mothers of children aged 1-2 years using a face-to-face interview with a …

The Inhibitory Effects Of Anthocyanin-Rich Thai Berry Extracts On Carbohydrate Digestion, Glycation And Adipogenesis, Pattamaporn Aksornchu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Several studies have reported the benefits of anthocyanin-rich berries on improving human health. However, the effect of Thai berries on delaying carbohydrate digestion, antioxidant properties, glycation inhibition, and anti-adipogenesis have not been investigated. Therefore, the present study aimed to determine the potential of anthocyanin-rich Thai berry extracts from Antidesma bunius or Mamao (ABE), Lepisanthes rubiginosa or Mahuat (LRE) and Syzygium nervosum or Makiang (SNE) on the inhibition of carbohydrate digestive enzymes, the antioxidant activity, anti-glycation, and anti-adipogenic property. In this study, total phenolics, total anthocyanins, and cyanidin-3-glucoside (C3G) contents of the anthocyanin-rich Thai berry extracts were 237.90-300.91 mg GAE/ g …

Effect Of Rd43 Rice (Oryza Sativa L.) On Starch Digestibility, Physicochemical Properties, Glycemic Responses And Food Applications, Phim On Suklaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

RD43 rice (Oryza sativa L.) is a cross-breed between Khao Jow Hawm Suphan Buri and Supan Buri1. It is characterized as a low amylose content, soft texture, and mild fragrance. However, its potential of metabolic health effect and food application remains unknown. In the present study, daily consumption of RD43 rice containing 14.10 g of undigestible starch for 12 weeks showed a significant reduction in fasting plasma glucose, insulin, HbA1c, and HOMA-IR in prediabetic participants. Furthermore, a significant decrease in body composition including body weight, body mass index, total body fat, and waist circumference was observed after the consumption of …

Development Of A Device To Alert For Breaks To Prevent Musculoskeletal Disorders In The Neck And Low Back Among Office Workers, Pooriput Waongenngarm

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this thesis was to develop a device to alert for breaks to prevent musculoskeletal disorders in the neck and low back among office workers. This thesis was divided into four stages: 1) systematically review to gain insights into the effectiveness of breaks on low back pain, discomfort, and work productivity in office workers; 2) evaluation of the characteristics of perceived discomfort and postural shifts during a 4-hour sitting period; 3) evaluation of the effects of a device to alert for active breaks on preventing neck and low back pain among office workers: 6- and 12-month follow-up; and …

Treatment Effects Of Amitriptyline On Pain Symptoms, Quality Of Life And Heart Rate Variability In Burning Mouth Syndrome Patients, Chanida Chaiworn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research project were 1) To evaluate the effectiveness of amitriptyline therapy on improving pain and the oral health-related quality of life (OHRQoL) in BMS patients when compared to palliative topical therapies (sodium bicarbonate mouthwash). 2) To determine the association between therapy of amitriptyline and heart rate variability (HRV) parameters. 3) To assess the association between pain outcomes and fluctuations in HRV parameters. This project was composed of a retrospective and a prospective study, and subjects were primary BMS patients recruited at the Oral Medicine Clinic, Faculty of Dentistry, In the retrospective study, 20 female participants were …

Analysis Of Chewing Efficiency In Dementia Patients Using Two-Color Chewing Gum Test And The Viewgum Software, Chawisa Thangjittiporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to analyze the relationship between chewing efficacy and severity level of cognitive impairment in dementia patients using a smartphone with ViewGum software for chewing efficiency analysis. Participants (n=70) from the Dementia Clinic, King Chulalongkorn Memorial Hospital, included 38 dementia patients (76.1±9.0 years) and 32 patients (71.8±9.9Years) with mild cognitive impairment (MCI), diagnosed by the medical specialists. The cognitive impairment was assessed by the TMSE (Thai Mental State Examination), and then scored. Participants were assessed for chewing efficacy using the mixing ability test of the two-color chewing gum, followed by an analysis using the ViewGum …

Effect Of Trehalose Solution Spray On Post-Radiation Xerostomia Related Quality Of Life In Head And Neck Cancer Patients, Kulpriya Pravinvongvuthi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Radiotherapy is the standard treatment of head and neck cancer (HNC). The radiation may affect on normal tissue and surrounding salivary gland resulting to xerostomia. Treatment of radiation-related xerostomia focuses on relieving symptoms by using saliva substitutes or saliva stimulants. Because the salivary stimulants have significant side effects, such as sweating, dizziness or increasing urge to urinate, saliva substitutes are preferable. Trehalose solution has been suggested for improve moisture in dry mouth condition and can be used as saliva substitute. The purpose of this study is to evaluate the effectiveness of 10% Trehalose solution spray to improve dry mouth condition …

Retention Force And Wear Characteristic Of Ball And O-Ring Attachment In Chulalongkorn Mini-Implant Overdenture System., Thanakorn Thimkam

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this experimental study was to evaluate wear characteristics and retention force of the RetenDent mini-implant overdenture system (Chulalongkorn product) after the insertion-removal fatigue test. One-piece mini-implants attachment system for overdenture, Osstem MS denture® type implant (OSSTEM, Germany GmbH), and RetenDent mini-implant were tested. All samples were subjected to repeated insertion and removal fatigue cycles by the universal testing machine (E1000, INSTRON Instrument, England). Subjected fatigue cycles were 5500 with 1.00Hz frequency to mimic a 5-year insertion and removal three times per day. The retention force was measured by separating the O-ring from the abutment and recorded with …

Technical And Scale Efficiency Of Public Hospitals In Papua New Guinea, James Noah

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of the study was to estimate the relative technical efficiency of public hospitals in PNG and estimate the magnitudes of output increases and/or input reductions that would have been required to make relatively inefficient hospitals more efficient using Data Envelopment Analysis for 20 hospitals in PNG using the data for 2017. The study is further extended using the Tobit regression analysis to investigate the institutional and contextual factors on hospital efficiencies. The results of the output-oriented DEA BCC Model indicated that the average constant returns to scale technical efficiency score was 79%; the average variable returns to scale …

Determinants Of Health Promotion Service Consumption In Thailand, Pimpa Vitidladda

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite being preventable, noncommunicable diseases (NCDs) rank among leading causes of death in Thailand. Four main groups of NCDs involve cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes. These chronic diseases worsen economic burden and the quality of life. To ease the burden, health promotion service is one of the tools that can directly cope with risk factors of NCDs. Therefore, increasing health promotion service consumption potentially leads to risk reduction of an individual to develop NCDs. Hence, this research aims to identify the factors influencing health promotion service consumption in Thailand along with marginal effects of each factors. The …

Guidelines To Enhance Community Participation In Community Learning Centers In The Kingdom Of Cambodia, Piseth Neak

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study aims to 1) analyze components of community participation in the CLCs in Cambodia; 2) study current states and desirable needs of community participation in enhancing community participation in the CLCs in Cambodia; 3) propose guidelines to enhance community participation in the CLCs in Cambodia. A semi-structured interview with 5 Cambodian experts has been employed, and all the keywords have been coded to analyze community participation components in the CLCs. Moreover, this research utilized a survey with the selected samples of 28 CLC committee members and 197 people using stratified random sampling by analyzing data through Means (x̅), Standard …

A Study Of Customers' Willingness To Purchase Organic Fresh Milk In Thailand, Jeerawan Punwaree

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, most consumers often are care about health due to the COVID-19 and personal needs. Dairy products are specific products that are generally consumed by every age group, from children, teenagers, adults, to the elderly. Organic milk could provide an advantageous alternative for health conscious consumers as it must be certified by government agencies prior to market launching. There are many studies supported that organic milk is more beneficial than conventional milk. Theory of Planned Behavior (TPB) was applied to study the factors affected consumers' willingness to purchase organic fresh milk in Thailand. Through the questionnaire method and analysis by …

Effect Of An Educational Intervention On Coronary Artery Disease Knowledge In Men And Women At Risk For Coronary Artery Disease, Rochelle Anderson-Doyley

Doctor of Nursing Practice Projects

Background

Coronary artery disease (CAD) is the leading cause of death in the United States. The management of CAD, a preventable disease, has significant implications for health and wellness outcomes in the United States. Decades of research have examined the role and effectiveness of an educational intervention in promoting the patient's knowledge of and ability to manage risk factors for CAD. This project examined the effectiveness of an educational tool implemented in a primary care setting in improving patients' knowledge about CAD risk factors.

Method

The research design was a non-experimental one-group pre-test and post-test design. After receiving institutional review …

Video Advance Directives: Growth And Benefits Of Audiovisual Recording, Thaddeus Mason Pope

SMU Law Review

No abstract provided.

Can The Carbon And Nitrogen Isotope Values Of Offspring Be Used As A Proxy For Their Mother's Diet? Using Foetal Physiology To Interpret Bulk Tissue And Amino Acid Δ15N Values, Nico Lübcker, John P. Whiteman, Seth D. Newsome, Robert P. Millar, P.J. Nico De Bruyn

Biological Sciences Faculty Publications

The measurement of bulk tissue nitrogen (δ¹⁵N) and carbon isotope values (δ¹³C) chronologically along biologically inert tissues sampled from offspring can provide a longitudinal record of their mothers' foraging habits. This study tested the important assumption that mother-offspring stable isotope values are positively and linearly correlated. In addition, any change in the mother-offspring bulk tissues and individual amino acids that occurred during gestation was investigated. Whiskers sampled from southern elephant seal pups (Mirounga leonina) and temporally overlapping whiskers from their mothers were analyzed. This included n = 1895 chronologically subsampled whisker segments for bulk …

Gastrointestinal Dysfunction In Parkinson's Disease, Michal Lubomski, Ryan L. Davis, Carolyn M. Sue

Medical Papers and Journal Articles

Background: Gastrointestinal (GI) dysfunction is prevalent in Parkinson’s disease (PD). Symptoms are evident throughout the disease course, affect the length of the GI tract and impact on patient quality of life and management. We clarify real-life differences in the frequency and severity of GI symptoms in a cohort of PD and healthy control (HC) subjects.

Methods: 103 PD patients were compared to 81 HC subjects. Outcome measures collected from validated questionnaires included constipation severity, upper and lower GI symptoms and physical activity.

Results: PD patients were three-times more likely to experience constipation than HC subjects, (78.6% vs …

Three Tools For Managing Vertigo In The Frontline, Vincent A. Van Vugt, Allison S. Young, Andrew P. Bradshaw, Benjamin Nham, Margot Woods, Miriam S. Welgampola

Medical Papers and Journal Articles

Vertigo is a challenging symptom in general practice. With access to three tools – a focused history, eye examination and a management algorithm – a large proportion of vertiginous patients could be managed effectively by GPs. This practical guide seeks to increase the skills and confidence of frontline practitioners when managing vertigo.

Bridging The Digital Divide: A Risk-Based “Telehealth Needs” Scoring Model For Patient Outcome Prediction, Cindy Ann Crump

Theses and Dissertations

The purpose of the research was to develop a predictive model of the effect of patient characteristics on outcomes and resource utilization in telehealth interventions for chronic disease management. Clinical studies have shown high variability in telehealth across settings and populations. The central hypothesis of this study was that patient characteristics, including disease type, illness severity, demographic information, and socio-technical preferences play a role in determining telehealth intervention outcomes. A non-experimental, retrospective study evaluated the feasibility of creating a Telehealth Needs score using Medicare and Medicaid claims data from 2016 to 2017. Claims were summarized into de-identified cases to train …

A Randomized Trial Of Cbt4cbt For Women In Residential Treatment For Substance Use Disorders, Sydney S. Kelpin

Theses and Dissertations

Women with substance use disorders (SUD) face unique barriers to substance use treatment, and as a result, are less likely than their male counterparts to seek treatment for the disorder. Cognitive behavioral therapy (CBT) is an evidence-based treatment known to reduce relapse rates by teaching clients to recognize and respond to their cues for substance use. Recent research suggests CBT may be particularly of benefit to women. Despite the effectiveness of CBT, its dissemination in clinical practice is limited due to a range of barriers (e.g., time, cost). Computer-based training for cognitive behavioral therapy (CBT4CBT) offers an opportunity to improve …

Characteristics Of Alveolar Bone Marrow Cells From Patients Undergoing Dental Extractions Or Dental Implant Therapy, Meng H. Lee

Theses and Dissertations

Alveolar bone marrow stromal cells (aBMSCs) play important roles in craniofacial wound healing. To establish an easy, efficient and reliable method to harvest aBMSCs, we compared three different methods: extraction socket aspiration, osteotomy aspiration and bone core digestion. Samples of aBMSC were collected from two groups of subjects. Group 1 (dental extraction): after dental extraction, 22.5-gauge needles were used to collect 0.5-1cc marrow aspirate. Group 2 (dental implant): during implant surgeries, bone core and 0.5-1cc marrow aspirate were obtained from the osteotomy. Samples were cultured in petri dishes and attached cells were expanded. The population doubling time (PDT), surface markers, …

Psychometric Developments Of The Ace-Iq: Understanding The Trauma History Of Latine Immigrants, Jorli K. Swingen Dr.

Theses and Dissertations

Adverse childhood experiences (ACEs) have a profound effect on an individual’s physical and mental health. The World Health Organization has recently updated the ACE questionnaire so it could be used with international populations. The Adverse Childhood Experiences-International Questionnaire (ACE-IQ), has not been translated to Spanish or used with Latine immigrants.

This study translated the ACE-IQ into Spanish, evaluated the psychometric properties of the questionnaire, and collected data on 184 four adult English Language Learners in Chesterfield County, VA.

There is evidence of internal consistency for the ACE-IQ as a whole (α = .908) and within subscales. Three factors were identified …

A Cost-Effectiveness Analysis Of Early Literacy Growth In Public Pre-Kindergarten Programs, Bruce A. Fillman

Theses and Dissertations

Student early literacy readiness is predictive of later academic success and pre-k programs are a proven intervention to develop early literacy; however, the cost of pre-k programs differs greatly. These differences in cost are related to the opportunities and services included within each program. This study examined four pre-k programs offered within a large school system in Virginia to determine if there were differences in students’ early literacy growth by program attended and evaluated the ratio of cost to achievement of each pre-k program to determine their cost-effectiveness. To do this, two one-way analyses of variances (ANOVAs) were conducted to …

Repeat Full Mouth Dental Rehabilitation Under General Anesthesia For Medicaid Eligible Healthy Children Who Are High Caries Risk, Lajoi E. Wiggins

Theses and Dissertations

Purpose: To evaluate the treatment of healthy children who are high caries risk and of low socioeconomic status and who require repeat full mouth dental rehabilitation (FMDR) under general anesthesia (GA).

Methods: A retrospective chart review was performed on healthy Medicaid eligible patients who were initially between 18 months - 6 years of age who underwent FMDR under GA in the OR more than once at the Virginia Commonwealth University (VCU) School of Dentistry, Department of Pediatric Dentistry from January 2008 to December 2018. Biographical information for each patient was gathered into a REDCap™ Survey. Statistical analysis, chi-squared test with …

Strategies And Devices For Improving Respiratory Drug Delivery To Infants And Children With Cystic Fibrosis, Karl Bass

Theses and Dissertations

Cystic Fibrosis (CF) is a degenerative disease, which causes thickening of the airway surface liquid and reduced mucociliary clearance, which provides an ideal habitat for bacterial infections. Early treatment of CF in children can prevent chronic infection, improve quality of life, and increase life expectancy. The most predominant bacteria found in CF-diseased lungs is Pseudomonas aeruginosa (Pa), which can be treated with inhaled tobramycin. Excipient enhanced growth (EEG) powder formulations are well suited for administering tobramycin to children, as the EEG approach provides minimal upper airway loss and targeted drug delivery. This method uses an initially small aerosol for high …

Examining Body Mass Index And Sepsis Mortality At One Year After Sepsis, Jamie D. Robinson

Theses and Dissertations

Introduction: Sepsis is a serious and life-threatening syndrome affecting 1.7 million Americans annually and resulting in approximately 270,000 deaths. An “obesity paradox” where obese individuals have lower sepsis mortality than their non-obese counterparts has been described. The problem is that the longevity of the effect is unknown, and few studies have examined the obesity paradox after 1-2 months post-diagnosis.

Methods: This retrospective cohort study examined clinical, demographic, and biomarker variables thought to affect sepsis mortality at three-time points: 30 days, 180 days, and at one year post-sepsis diagnosis in order to shed light on specific factors that might define …

Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey

Theses and Dissertations

Diseases and disorders in the human body are considered abnormalities of proper cellular function. Understanding the signal transduction mechanisms that cause these abnormalities is crucial to developing earlier detection methods, better treatment options and effective cures. While current diagnostic procedures are powerful tools in diagnosing diseases, they are ineffective in informing physicians on the real-time behavior of the signal transduction mechanisms associated with diseases and disorders. Currently, disease progression is monitored over time through routine patient visits and testing by one or more of the above techniques. By developing an approach that can monitor structural and conformational changes of proteins …

Education Support For Foster Care Youth: The Impact Of Federal Spending On Employment Outcomes, Carlisle C. Bates

Theses and Dissertations

This study examined the extent to which supportive services funded through the federal John H. Chafee Foster Care Independence Program (CFCP) are associated with academic success and employment in foster care youth. Studies suggest that this group experiences poorer employment outcomes (Gypen, Vanderfaeillie, De Maeyer, Belenger, & Van Holen, 2017; Okpych & Courtney, 2014) and earn less money annually (Gypen et al., 2017; Okpych & Courtney, 2014; Pecora, 2012). Despite a 29.4-billion-dollar annual budget for foster care services, individuals with a foster care history struggle after they transition out of care.

The CFCP is intended to help states improve education …

Characterization Of The Gonococcal Calprotectin Zn-Acquisition System, Tdfh, And The Efficacy Of Metal Starvation For Treating Gonococcal Disease, Michael T. Kammerman

Theses and Dissertations

Abstract

Characterization of the Gonococcal Calprotectin Zn-Acquisition System, TdfH, and the Efficacy of Metal Starvation for Treating Gonococcal Disease.

By Michael T. Kammerman, B.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2020

Major Director: Cynthia Nau Cornelissen, Ph.D.

Professor, Department of Microbiology and Immunology

Neisseria gonorrhoeae, the bacterial agent that is responsible for the human disease gonorrhea, has had a steady increase in the number of infections per year. In 2018 the WHO estimated over 87 million infections occurred world-wide, and the CDC …

Effects Of Gestational Ozone Exposure On Privileged Placental And Brain Barrier Integrity, Alexander I. Hamm

Theses and Dissertations

Ambient outdoor ozone, a common of component of photochemical smog and urban air pollution, is linked to various neurological and vascular pathologies. Its immediate reaction with lung surfactant after inhalation results in complete reactivity of the gas, with no active ozone passing into circulation. This indicates the presence of secondary and tertiary mediators in ozone-related systemic pathologies after pulmonary insult. In vasculature, ozone exposure is associated with an acute hypertensive phenotype apparent at least 24 hours after dose, such as experienced on a hot summer afternoon in a large metropolitan area like Los Angeles or Mexico City. However, the effects …