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2020

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Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee Jan 2020

Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew Jan 2020

Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacteria, exposed to stress from the environment or competition, release toxins called bacteriocins. Bacteriocins are classified by their mode of cytotoxicity such as pore former, endonuclease, etc. Colicins are the member of bacteriocins produced by Escherichia coli (E.coli). Among several types of colicins cytotoxicity, Pore-forming colicins has been reported in both bacteria and various type of cancer cells. Colicin N is also a pore-forming colicin and the anticancer activity of colicin N has not been extensively reported. Here we examined the cytotoxic effects of colicin N and its domain on cancer cells. The expression and purification of recombinant full-length and …

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Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan Jan 2020

Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human epidermal growth factor (hEGF) is a short polypeptide that has gained clinical importance in the recent decade for wound healing. Currently, plant-based expression system is considered as an alternative viable platform for low-cost recombinant protein production. Hence, this study aims to produce hEGF in Nicotiana benthamiana plants via., transient expression using a geminiviral vector. The hEGF gene constructs were designed into six different constructs. The optimal expression was observed from the construct targeting the endoplasmic reticulum with C-terminal histidine tag at the yield level up to 15.695 µg/g LFW or 0.499% TSP. The plant-produced hEGF was purified by using …

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Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin Jan 2020

Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Anti-RANKL monoclonal antibody is a fully human monoclonal antibody (mAb) available for treatment of osteoporosis. In this study, anti-RANKL mAb was transiently expressed using the Geminiviral expression system in Nicotiana benthamiana. Moreover, the structure of plant-produced mAb was characterized and functional activity was also determined. The result indicated that anti-RANKL mAb was produced with the maximum expression level on 8 days post infiltration and estimated to be 0.5 mg/g leaf fresh weight. The recombinant mAb from crude extracts was purified by using protein A affinity column chromatography. The plant-produced mAb provided in vitro affinity binding with human RANKL, determined by …

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Thailand As A Performative State : An Analysis Of Thailand's Cultural Diplomacy Towards The People's Republic Of China, Natdanai Kietigaroon Jan 2020

Thailand As A Performative State : An Analysis Of Thailand's Cultural Diplomacy Towards The People's Republic Of China, Natdanai Kietigaroon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Thailand as a performative state is a research that looked at the cultural dimensions of Thailand's diplomacy, by taking the alternative view on Thai cultural diplomacy towards PRC. Thai cultural diplomacy, according to existing literature, revolves around promoting Thainess. However, in the case of China, Thailand has been using Chineseness as Thai cultural diplomacy. The research specifically looked at five Thai state actors that are most involved with Chineseness, namely, the royal family, the government, the Ministry of Culture, the Ministry of Foreign Affairs, and the Tourism Authority of Thailand. Two questions were raised in this research. Firstly, how Chineseness …

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กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์จากคอปเปอร์ออกไซด์/รีดิวซ์กราฟีนออกไซด์นาโนคอมพอสิต, นพรัตน์ จันทร์มี Jan 2020

กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์จากคอปเปอร์ออกไซด์/รีดิวซ์กราฟีนออกไซด์นาโนคอมพอสิต, นพรัตน์ จันทร์มี

Chulalongkorn University Theses and Dissertations (Chula ETD)

ในงานวิจัยนี้กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ถูกพัฒนาขึ้นโดยใช้นาโนคอมพอสิตของโลหะออกไซด์และรีดิวซ์กราฟีนออกไซด์ ขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนถูกดัดแปรด้วยรีดิวซ์ กราฟีนออกไซด์เพื่อเพิ่มการนำไฟฟ้าและดัดแปรด้วยโลหะออกไซด์ที่มีขนาดในระดับนาโนสองชนิด ได้แก่ คอปเปอร์ออกไซด์ และซิงค์ออกไซด์เพื่อเป็นตัวเร่งทางเคมีไฟฟ้าสำหรับการเกิดออกซิเดชันโดยตรงของกลูโคส โดยศึกษาความเข้มข้นของสารดัดแปรที่เหมาะสมด้วยกล้องจุลทรรศน์อิเล็กตรอนแบบส่องกราด จากนั้นเปรียบเทียบประสิทธิภาพการเร่งปฏิกิริยาของขั้วไฟฟ้าดัดแปรด้วยโลหะออกไซด์ด้วยเทคนิคไซคลิกโวล แทมเมทรีพบว่าขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วยรีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์ให้กระแสสูงสุด จึงเลือกมาใช้เป็นขั้วไฟฟ้าสำหรับกลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ สำหรับการตรวจวัดกลูโคสในตัวอย่างจริง อุปกรณ์รูปแบบใหม่ถูกสร้างขึ้นโดยติดกระดาษพิมพ์แวกซ์ที่เคลือบด้วยโซเดียมไฮดรอกไซด์เพื่อเป็นส่วนป้อนสารตัวอย่างลงบนขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วย รีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์ อุปกรณ์นี้ถูกใช้ตรวจวัดกลูโคสในฟอสเฟตบับเฟอร์ซาลีนแสดงช่วงความเป็นเส้นตรงที่ 0.125 ถึง 7.0 มิลลิโมลาร์ และ 0.031 ถึง 7.0 มิลลิโมลาร์ โดยมีค่าสัมประสิทธิ์สหสัมพันธ์ที่ 0.9940 และ 0.9911 สำหรับการตรวจวัดด้วยเทคนิคไซคลิกโวลแทมเมทรีและเทคนิคแอมเพอโรเมทรี ตามลำดับ นอกจากนี้ขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วยรีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์สามารถคงประสิทธิภาพการตรวจวัดได้ถึง 6 วันภายหลังการเตรียมอุปกรณ์ กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ที่พัฒนาขึ้นนี้จึงสามารถประยุกต์เป็นอุปกรณ์ทางเลือกสำหรับติดตามผู้ป่วยโรคเบาหวานอย่างง่ายโดยไม่ต้องเตรียมตัวอย่าง

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Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak Jan 2020

Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Health care personnel are one of most affected by COVID-19 situation. The aim of this study was to identify the prevalence of stress, depression and suicidal risk and associated factors among health care personnel during COVID-19 second outbreak in Thailand. This study was cross-sectional study, which used secondary data collected during December 17, 2020 to February 23, 2021. Total of 4,970 health care personnel participated in this research. The instruments of this research were ST-5, 9Q and 8Q. Multivariable logistic regression analysis was performed to identify factors associated with stress, depression and suicidal risk outcomes. The prevalence of stress, depression …

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Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman Jan 2020

Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Diagnosis of Pulmonary Rifampicin Resistant Tuberculosis (RR-TB) with the Drug-Susceptibility Test (DST) is costly and time-consuming, and the GeneXpert for rapid diagnosis is not widely available in Indonesia. This study aims to develop an Artificial Neural Network model and evaluate the deployed model performance for RR-TB screening. Methods: A cross-sectional study involved suspected RR-TB patients with complete sputum Lowenstein Jensen DST (reference) and 19 clinical, laboratory, and radiology parameter results, retrieved from medical records in hospitals under the Faculty of Medicine, Hasanuddin University Indonesia, from January 2015-December 2019. The Artificial Neural Network (ANN) models were built along with other …

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Factors Associated With Knowledge And Awareness Of Syphilis Among The Youths Visiting Family Planning Clinics, Bangkok, Thailand, Nutcha Tattanon Jan 2020

Factors Associated With Knowledge And Awareness Of Syphilis Among The Youths Visiting Family Planning Clinics, Bangkok, Thailand, Nutcha Tattanon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Syphilis has been controlled since 1960. However, syphilis is now reappearing in some areas in Africa and South-east Asia including Thailand. In Thailand, syphilis is reappearing in all regions. The most high-risk population is the youth aged 15-24 year. Objective of this study aimed to determine factors associated with knowledge and awareness of syphilis prevention among youths visiting at family planning clinic, Bangkok, Thailand. Method of this study was a cross-sectional study conducted by purposive sampling among the youth aged 15-24 years old who visit at PPAT family planning clinic, Bangkok, Thailand during April-June 2021. Multivariable logistic regression analysis was …

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Effect Of Social Media Model To Improve Sexual Health Literacy Among Secondary School Female Students In Southern Provinces, Thailand: A Quasi Experimental Study, Premyuda Narkarat Jan 2020

Effect Of Social Media Model To Improve Sexual Health Literacy Among Secondary School Female Students In Southern Provinces, Thailand: A Quasi Experimental Study, Premyuda Narkarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background/Objectives: Adolescent pregnancy is one of major public health issues globally and in Thailand. Female adolescents are at high risk of sexual and reproductive health problems like unintended pregnancies, abortion, childbirth related complications including sexually transmitted diseases (STDs) and AIDS due to poor sexual health literacy (SHL). Sexual health literacy (SHL) is one of very important factors to prevent teenage pregnancy. The aim was to examine the effect of social media model to improve sexual health literacy among secondary school female students in southern provinces of Thailand. Method: This study employed a quasi-experimental research design using two groups the intervention …

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Improving Routine Immunization Coverage Through Strengthening Interpersonal Comminication Skills Of Primary Health Care Workers In Rural Local Government Areas In Kebbi State Nigeria, Saudat Abdullahi Basheer Jan 2020

Improving Routine Immunization Coverage Through Strengthening Interpersonal Comminication Skills Of Primary Health Care Workers In Rural Local Government Areas In Kebbi State Nigeria, Saudat Abdullahi Basheer

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: In 2015, Kebbi state was among the four (4) states in northwestern Nigeria that have low routine immunization performance in the country. National Nutrition and Health Survey 2015 report indicated that only 7.8% of the eligible children have received three doses of DPT/Penta and measles coverage was 14.7%. There was no documented research to investigate the effect of interpersonal communication skills on routine immunization services in Kebbi state Nigeria. The objective of this study, therefore, was to examine the effect of vaccination education on improving mothers' knowledge and uptake of routine immunization services among children in the rural LGAs …

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Knowledge, Attitude, And Practice Towards Social Distancing Among Undergraduate Students In Medical Fields During Rapid Rise Of Covid-19 In Samarinda City, Indonesia : A Cross Sectional Study, Siti Hadijah Aspan Jan 2020

Knowledge, Attitude, And Practice Towards Social Distancing Among Undergraduate Students In Medical Fields During Rapid Rise Of Covid-19 In Samarinda City, Indonesia : A Cross Sectional Study, Siti Hadijah Aspan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Social distancing is health guidelines recommended by World Health Organization (WHO) for controlling the COVID-19 transmission. Undergraduate students in medical fields had responsibility in spreading accurate health promotion during this prolong pandemic. This study aimed to determine the practice of social distancing and its associated factors, to find out the reasons for not practicing social distancing along with the source of social distancing information used by undergraduate students in medical fields in Samarinda, Indonesia. This cross-sectional online survey study (April to May 2021) involved 422 undergraduate students from medicine, public health and pharmacy faculty using convenience sampling technique. Binary logistic …

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A Social Ecology Of Sexual Health And Well-Being Among Older Gay Men And Transgender Women In Chiang Mai, Thailand: A Qualitative Study, Suchon Tepjan Jan 2020

A Social Ecology Of Sexual Health And Well-Being Among Older Gay Men And Transgender Women In Chiang Mai, Thailand: A Qualitative Study, Suchon Tepjan

Chulalongkorn University Theses and Dissertations (Chula ETD)

With increasing ageing populations in Thailand, including sexually diverse communities, there has been little attention to older gay men and transgender women regarding their sexual health and well-being. Several international studies indicated that these communities have been underserved, especially in countries that lack human rights to protect against social and cultural stigma. The well-being of this population, that had experienced discrimination, victimization, and identity concealment in their early years, could have been better understood through open-ended exploration. This study explores the social-ecological factors contributing to the sexual health of older gay men and transgender women in Chiang Mai. This qualitative …

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Association Between Smartphone Addiction And Mental Health Among High School Students In Bangkok, Thailand: A Cross-Sectional Study, Suphasuta Doungraksa Jan 2020

Association Between Smartphone Addiction And Mental Health Among High School Students In Bangkok, Thailand: A Cross-Sectional Study, Suphasuta Doungraksa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The technology today is rapidly and continuously intervening into people's lives, and when people become too addict to electronic devices has shown series of abnormality of health problems which including both physical and mental. As it mentioned, the study aims to examine the relationship of smartphone addiction and mental health specifically in depression, anxiety, and stress. This study aims to investigate the relationship between smartphone addiction and mental health among high school students in Bangkok, Thailand. There were sample of 420 high school students in Bangkok, Thailand who participated in self-administrated questionnaires for a cross-sectional study of smartphone addiction and …

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Maternal Knowledge, Attitude And Practices On The Dietary Omega 3 And 6 In Children Aged 1-2 Years Old In Labuhanbatu Utara Regency, Indonesia, Sinar Yunita Purba Jan 2020

Maternal Knowledge, Attitude And Practices On The Dietary Omega 3 And 6 In Children Aged 1-2 Years Old In Labuhanbatu Utara Regency, Indonesia, Sinar Yunita Purba

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Indonesia is one of the countries with low quality human resources including the issue on cognitive performances from brain functioning creativity. In the effort to fulfil Omega 3 and 6 in children aged 1-2 years, the most responsible person to the period are mothers. Therefore, the study aimed to determine the level of maternal knowledge, attitude, and practices and factors associated with the dietary omega 3 and 6 consumption in children aged 1-2 years old in Labuhanbatu Utara, Indonesia. Method: This cross-sectional study was conducted among 428 mothers of children aged 1-2 years using a face-to-face interview with a …

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Relationships Between Language Proficiency And Economic Mobility Of Myanmar Migrant Workers In Bangkok, Aung Ko Min Jan 2020

Relationships Between Language Proficiency And Economic Mobility Of Myanmar Migrant Workers In Bangkok, Aung Ko Min

Chulalongkorn University Theses and Dissertations (Chula ETD)

Thailand has been the recipient of foreign migrant workers from neighboring countries for decades. Among them, the majority are from Myanmar. Myanmar migrant workers have been significant parts of the agriculture, manufacturing, and service sectors. In Thailand, they usually earn decent wages comparing to wages in their home countries. However, their incomes and working conditions in Thailand largely depend on several factors. Thus, this research aims to study the relationship between Thai language proficiency and the income of Myanmar migrants in Bangkok. Several studies claim that the employment opportunities of migrants depend primarily on their levels of education and technical …

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"A Tropical Home": Myanmar And Reinterpretation Of Traditional Architecture To Contemporary Cultural Center In Bagan, Hein Min Thaung Jan 2020

"A Tropical Home": Myanmar And Reinterpretation Of Traditional Architecture To Contemporary Cultural Center In Bagan, Hein Min Thaung

Chulalongkorn University Theses and Dissertations (Chula ETD)

This architectural design research study is about the understanding of the architectural tradition by means of chosen geometrical framework, or 'Taxis' in the Greek language, spatial compositions, sensuality experiences, local materials and construction techniques. The objective is to see the possibilities of reinterpreting analytical drawings of Ananda Temple, Thatbyinyu Temple and a Burmese traditional house in order to synthesis the analyses upon the contemporary architectural design process. Literature Reviews and Case Studies have been done upon the theory, practice, and philosophy of contemporary architects whose design processes are reflected on the history, human experience, and memory of the site. The …

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Sonic Architecture: Auditory Illusion Of A Visual Memory In The Shophouse 1527 For "A Lost Kitchen", Thanatchaporn Nateekulcharoen Jan 2020

Sonic Architecture: Auditory Illusion Of A Visual Memory In The Shophouse 1527 For "A Lost Kitchen", Thanatchaporn Nateekulcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis is a study of sound in relation to a theory of "EVERYDAY LIFE." It is a supplement to Paul Connerton's view on architecture and memories written in a book entitled How Societies Remember. The ideas are that, first of all, objects, imageries, data can be converted to sound and vice versa. Secondly, sound is considered to be visual memories that exists in space and time. Lastly, it is possible to create a space of sound to exhibit a past life of a built environ. The intention of this study is to document the visual memories of the lost …

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Metaphors In U.S. Same-Sex Marriage Discourse: A Corpus-Based Study, Pongbodin Amarinthnukrowh Jan 2020

Metaphors In U.S. Same-Sex Marriage Discourse: A Corpus-Based Study, Pongbodin Amarinthnukrowh

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aims to investigate metaphorical patterns in the US legalization of same-sex marriage discourse to shed light on how metaphor is employed to conceptualize same-sex marriage controversies. To this end, a specialized corpus which contains 254 news articles published in 2015 was compiled. The metaphorical expressions in the corpus were analyzed with both "Conceptual Metaphor Theory" (CMT) and "Conceptual Blending Theory" (CBT) to cover not simply the pedestrian uses of metaphors, but also the wild and creative expressions. Specifically, while conventional metaphors were analyzed following the CMT traditions, novel metaphors were analyzed through the lens of blending. The results …

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Representations Of The Body In British Science-Fiction Novels From The Late Nineteenth To The Early Twentieth Century: A Study Of Edward Bulwer-Lytton's The Coming Race, H.G. Wells' The Time Machine And Aldous Huxley's Brave New World, Kornnop Jaroenvong Jan 2020

Representations Of The Body In British Science-Fiction Novels From The Late Nineteenth To The Early Twentieth Century: A Study Of Edward Bulwer-Lytton's The Coming Race, H.G. Wells' The Time Machine And Aldous Huxley's Brave New World, Kornnop Jaroenvong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Many critics have suggested that most of the non-human characters in late-Victorian British science-fiction novels reflect social alienation and the cultural fear of physical, mental and moral degeneration. However, by relying on the concept of critical posthumanism in the twentieth and twenty-first centuries that attempts to debunk anthropocentrism and emphasise the significance of non-human otherness, this thesis studies representations of the body in three British science-fiction novels: Edward Bulwer-Lytton's The Coming Race (1871), H.G. Wells' The Time Machine (1895) and Aldous Huxley's Brave New World (1932), which provide speculative visions of what humans will be in the future. It demonstrates …

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Factores Que Afectan La Motivacion En El Aprendizaje De Espanol Por Parte De Los Aumnos De Balac, Kamonchat Jantarat Jan 2020

Factores Que Afectan La Motivacion En El Aprendizaje De Espanol Por Parte De Los Aumnos De Balac, Kamonchat Jantarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research presents the factors affecting motivation in the learning of Spanish of students in the Bachelor of Arts in Language and Culture (International Program). Having a dual-objective, firstly, it aims to find out and analyze the motivating and demotivating factors that affect international program Bachelor of Arts in Language and Culture (BALAC) students learning Spanish. Secondly, it aims to find strategies to promote student’s motivation in their learning of the Spanish language. A questionnaire on motivation and semi-structured interviews was used as a research instrument to find out the different aspects related to motivation. The questionnaire was distributed to …

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Adjektiv-Substantiv-Kollokationen Im Bereich Des Tourismus: Eine Korpusbasierte Untersuchung Am Beispiel Von Ortsbeschreibungen In Reiseführern Über Thailand, Suphichaya Plengplang Jan 2020

Adjektiv-Substantiv-Kollokationen Im Bereich Des Tourismus: Eine Korpusbasierte Untersuchung Am Beispiel Von Ortsbeschreibungen In Reiseführern Über Thailand, Suphichaya Plengplang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Die vorliegende Arbeit untersucht die Adjektiv-Substantiv-Kollokationen in Ortsbe-schreibungen in ausgewahlten Reisefuhrern uber Thailand. Hierbei handelt es sich um vier etablierte Reisefuhrer von vier Verlagen. Das Untersuchungskorpus umfasst insgesamt 446.580 Tokens und 38.824 Worttypen. Die Konkordanz-Software AntConc 3.5.8 wird zunachst fur die Herausfilterung einer Liste von Substantiven eingesetzt, die als Suchworter verwendet warden, wobei jedes Suchwort mindesten 100-mal im Korpus vorkommen muss. Aus 105 ausgewahlten Suchwortern warden schlieBlich 8.563 Adjektiv-Substantiv-Kollokationen ermittelt. Die Adjektiv-Substantiv-Kollokationen mit mindestens zwei Adjektivattributen werden nach Schmidts Typen der Attribuierungskomplikationen analysiert. Im Korpus lassen sich vier Typen von Attribuierungskomplikationen feststellen, namlich Koordination, Koordination mit Unterordnung, Gleichstufigkeit und Gleichstufigkeit …

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Biological Effects Of Epigallocatechin Gallate During The Protection Of The Submandibular Gland After Injury, Erni Sulistiyani Jan 2020

Biological Effects Of Epigallocatechin Gallate During The Protection Of The Submandibular Gland After Injury, Erni Sulistiyani

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: When radiotherapy is delivered to head and neck cancer (HNC) patients, the salivary gland (SG) secretory epithelia can be irreversibly injured in up to 60% of the individuals, leading to dry mouth or xerostomia. Radiotherapy’s effectiveness in suppressing HNC growth is correlated with an increase in free radicals that produce DNA damage to the tumor and neighboring organs like the SG. Epigallocatechin gallate (EGCG) is one of the most abundant polyphenols present in green tea leaves and a well-known antioxidant. In previous in vitro study using genetically modified immortal SG cell lines, EGCG protected SG cells from γ-radiation. However, …

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Development Of Measurement Scales Of Consumer-Based Brand Equity For Small And Medium Enterprises, Nitcha Chokpitakkul Jan 2020

Development Of Measurement Scales Of Consumer-Based Brand Equity For Small And Medium Enterprises, Nitcha Chokpitakkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study had two research objectives: (1) to develop and validate a generalizable model for measuring consumer-based brand equity within the SME setting, and (2) to examine the relationship between SME brand equity and consumer response factors. Three steps were conducted in sequence to achieve the research purposes. Firstly, qualitative data from documents of forty awarded SME brands and actual consumers varying in their demographic characteristics were collected by three techniques including document analysis, semi-structured interview, and focus group to get a pool of 41 initial items of SME brand equity. Secondly, the items derived from the first step were …

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The Immunomodulatory Roles Of Supracrestal Gingival Connective Tissue-Derived Human Mesenchymal Stromal Cells In The Polarization Of Macrophages, Jirawit Inthayat Jan 2020

The Immunomodulatory Roles Of Supracrestal Gingival Connective Tissue-Derived Human Mesenchymal Stromal Cells In The Polarization Of Macrophages, Jirawit Inthayat

Chulalongkorn University Theses and Dissertations (Chula ETD)

MSCs exert their immunomodulatory effects on various immune cells by cell-cell contact and cytokines secretion. Our previous study has demonstrated that supracrestal gingival connective tissue-derived mesenchymal stem cells (SG-MSCs) were recognized to be a good candidate for periodontal regeneration. SG-MSCs showed the similar potential to PDL-MSCs and held significant advantage over PDL-MSCs by which a tooth extraction is not required. In terms of immunomodulatory properties, the effect of SG-MSCs on macrophage has never been explored. This study was aimed to investigate the effects of SG-MSCs on macrophages by cocultured SG-MSCs and THP-1-derived macrophages (THP-1-MPs) in direct cell-cell contact condition. Briefly, …

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Prevalence Of Enterococcus Faecalis And Candida Albicans In Teeth Requiring Endodontic Retreatment, Sopida Thipung Jan 2020

Prevalence Of Enterococcus Faecalis And Candida Albicans In Teeth Requiring Endodontic Retreatment, Sopida Thipung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Endodontic failures are mainly caused by persistence of microorganisms in the root canal system. Enterococcus faecalis has been reported as the most commonly isolated species from root canals with endodontic treatment failure in many studies, but was not the dominant species in others. Recent studies showed that Candida albicans is found together with Enterococcus faecalis within infected root canals in a polymicrobial community and both species can form biofilm. Therefore, this study aims to investigate the prevalence of Enterococcus faecalis and/or Candida albicans in root canals requiring retreatment by using both culture-based and polymerase chain reaction (PCR) techniques, and examine …

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Effect Of Endothelin-1 On Cyclooxygenase-2 Gene Expression And Prostaglandin E2 Synthesis In Human Periodontal Fibroblasts, Supachai Unmanatakoon Jan 2020

Effect Of Endothelin-1 On Cyclooxygenase-2 Gene Expression And Prostaglandin E2 Synthesis In Human Periodontal Fibroblasts, Supachai Unmanatakoon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this study is to clarify the effect of endothelin-1 on COX-2 mRNA expression and PGE2 production from human periodontal ligament fibroblasts. Effect of various concentration of ET-1 on cell viability of primary human periodontal ligament fibroblasts was determined by an MTT assay. Then, primary human periodontal ligament fibroblasts were treated with 10 pM ET-1 for 0.5, 1, 2, 4 hours to investigate the time-course effect. Furthermore, to investigate the dose-response effect, periodontal ligament fibroblasts were treated with 1, 10, 100 pM ET-1 for 1 hour. The untreated cells were set as control. RNA extraction followed by cDNA …

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Comparative Gene Expression Analysis Of Human Dental Pulp Cells From Maxillary And Mandibular Teeth, Thira Faruangsaeng Jan 2020

Comparative Gene Expression Analysis Of Human Dental Pulp Cells From Maxillary And Mandibular Teeth, Thira Faruangsaeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective : Given the anatomical and locational differences between the maxillary and mandibular teeth, it is possible that there are differences in gene expression patterns of dental pulp cells within those teeth. This study evaluates and compares the gene expression profiles of the maxillary and mandibular human teeth with the aim of finding differences in gene expression patterns of dental pulp cells by RNA-Sequencing technique. Methods : The upper and lower premolar and molar teeth obtained from the same participant were employed. Two pairs of opposing premolar teeth and two pairs of opposing molar teeth were isolated, cultured, and subjected …

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Effect Of Ultrasonic Treatment On The Transverse Strength Of Relined Denture Base With Autopolymerizing Acrylic Hard Reline Material, Tithiporn Arunwichit Jan 2020

Effect Of Ultrasonic Treatment On The Transverse Strength Of Relined Denture Base With Autopolymerizing Acrylic Hard Reline Material, Tithiporn Arunwichit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated the effect of ultrasonic treatment and surface treatments on transverse strength of denture bases which relined with auto-polymerizing acrylic resin. The study groups, ninety heat-polymerized acrylic resins (64×10×2 mm) were divided by three surface treatments: no surface treatment (N), applied MMA for 180 seconds (MM), applied MF-MA for 15 seconds (MF). They were relined with auto-polymerized acrylic resin to create 64×10×3.3 mm specimens. Then, they were divided further by ultrasonic which were no ultrasonic (X), ultrasonic in water (W), ultrasonic in 30% ethanol (E). As a result, all test groups were classified as NX, NW, NE, MMX, …

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Determinants Of Health Promotion Service Consumption In Thailand, Pimpa Vitidladda Jan 2020

Determinants Of Health Promotion Service Consumption In Thailand, Pimpa Vitidladda

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite being preventable, noncommunicable diseases (NCDs) rank among leading causes of death in Thailand. Four main groups of NCDs involve cardiovascular diseases, cancers, chronic respiratory diseases, and diabetes. These chronic diseases worsen economic burden and the quality of life. To ease the burden, health promotion service is one of the tools that can directly cope with risk factors of NCDs. Therefore, increasing health promotion service consumption potentially leads to risk reduction of an individual to develop NCDs. Hence, this research aims to identify the factors influencing health promotion service consumption in Thailand along with marginal effects of each factors. The …

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