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2020

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Exploring Composite Dataset Biases For Heart Sound Classification, Davoud Shariat Panah, Andrew Hines, Susan Mckeever Jan 2020

Exploring Composite Dataset Biases For Heart Sound Classification, Davoud Shariat Panah, Andrew Hines, Susan Mckeever

Conference papers

In the last few years, the automatic classification of heart sounds has been widely studied as a screening method for heart disease. Some of these studies have achieved high accuracies in heart abnormality prediction. However, for such models to assist clinicians in the detection of heart abnormalities, it is of critical importance that they are generalisable, working on unseen real-world data. Despite the importance of generalisability, the presence of bias in the leading heart sound datasets used in these studies has remained unexplored. In this paper, we explore the presence of potential bias in heart sound datasets. Using a small …


Language Model Co-Occurrence Linking For Interleaved Activity Discovery, Eoin Rogers, Robert J. Ross, John D. Kelleher Jan 2020

Language Model Co-Occurrence Linking For Interleaved Activity Discovery, Eoin Rogers, Robert J. Ross, John D. Kelleher

Conference papers

As ubiquitous computer and sensor systems become abundant, the potential for automatic identification and tracking of human behaviours becomes all the more evident. Annotating complex human behaviour datasets to achieve ground truth for supervised training can however be extremely labour-intensive, and error prone. One possible solution to this problem is activity discovery: the identification of activities in an unlabelled dataset by means of an unsupervised algorithm. This paper presents a novel approach to activity discovery that utilises deep learning based language production models to construct a hierarchical, tree-like structure over a sequential vector of sensor events. Our approach differs from …


Modelling Interleaved Activities Using Language Models, Eoin Rogers, Robert J. Ross, John D. Kelleher Jan 2020

Modelling Interleaved Activities Using Language Models, Eoin Rogers, Robert J. Ross, John D. Kelleher

Conference papers

We propose a new approach to activity discovery, based on the neural language modelling of streaming sensor events. Our approach proceeds in multiple stages: we build binary links between activities using probability distributions generated by a neural language model trained on the dataset, and combine the binary links to produce complex activities. We then use the activities as sensor events, allowing us to build complex hierarchies of activities. We put an emphasis on dealing with interleaving, which represents a major challenge for many existing activity discovery systems. The system is tested on a realistic dataset, demonstrating it as a promising …


Synthesising Tabular Datasets Using Wasserstein Conditional Gans With Gradient Penalty (Wcgan-Gp), Manhar Singh Walia, Brendan Tierney, Susan Mckeever Jan 2020

Synthesising Tabular Datasets Using Wasserstein Conditional Gans With Gradient Penalty (Wcgan-Gp), Manhar Singh Walia, Brendan Tierney, Susan Mckeever

Conference papers

Deep learning based methods based on Generative Adversarial Networks (GANs) have seen remarkable success in data synthesis of images and text. This study investigates the use of GANs for the generation of tabular mixed dataset. We apply Wasserstein Conditional Generative Adversarial Network (WCGAN-GP) to the task of generating tabular synthetic data that is indistinguishable from the real data, without incurring information leakage. The performance of WCGAN-GP is compared against both the ground truth datasets and SMOTE using three labelled real-world datasets from different domains. Our results for WCGAN-GP show that the synthetic data preserves distributions and relationships of the real …


A Framework For Validating And Testing Agent-Based Models: A Case Study From Infectious Diseases Modelling., Elizabeth Hunter, John D. Kelleher Jan 2020

A Framework For Validating And Testing Agent-Based Models: A Case Study From Infectious Diseases Modelling., Elizabeth Hunter, John D. Kelleher

Conference papers

In this paper we present a framework for validating and testing an agent-based model that includes determining the appropriate number of runs to account for variation in model runs, validating the model and showing that the model can be used to learn about the system. To demonstrate the framework we use a case study of an agent-based model for the spread of infectious diseases.


Brexit Election: Forecasting A Conservative Party Victory Through The Pound Using Arima And Facebook's Prophet, James Usher, Pierpaolo Dondio Jan 2020

Brexit Election: Forecasting A Conservative Party Victory Through The Pound Using Arima And Facebook's Prophet, James Usher, Pierpaolo Dondio

Conference papers

On the 30th October, 2019, the markets watched as British Prime Minister, Boris Johnson, took a massive political gamble to call a general election to break the Withdrawal Agreement stalemate in the House of Commons to “Get BREXIT Done”. The pound had been politically sensitive owing to BREXIT uncertainty. With the polls indicating a Conservative win on 4thDecember, 2019, the margin of victory could be observed through increases in the pound. The outcome of a Conservative party victory would benefit the pound by removing the current market turbulence. We look to provide a short-term forecast of the pound. Our approach …


Mutual Information Decay Curves And Hyper-Parameter Grid Search Design For Recurrent Neural Architectures, Abhijit Mahalunkar, John Kelleher Jan 2020

Mutual Information Decay Curves And Hyper-Parameter Grid Search Design For Recurrent Neural Architectures, Abhijit Mahalunkar, John Kelleher

Conference papers

We present an approach to design the grid searches for hyper-parameter optimization for recurrent neural architectures. The basis for this approach is the use of mutual information to analyze long distance dependencies (LDDs) within a dataset. We also report a set of experiments that demonstrate how using this approach, we obtain state-of-the-art results for DilatedRNNs across a range of benchmark datasets.


Novice Learner Experiences In Software Development: A Study Of Freshman Undergraduates, Catherine Higgins, Ciaran O'Leary, Claire Mcavinia, Barry J. Ryan Jan 2020

Novice Learner Experiences In Software Development: A Study Of Freshman Undergraduates, Catherine Higgins, Ciaran O'Leary, Claire Mcavinia, Barry J. Ryan

Conference papers

This paper presents a study that is part of a larger research project aimed at addressing the gap in the provision of educational software development processes for freshman, novice undergraduate learners, to improve proficiency levels. With the aim of understanding how such learners problem solve in software development in the absence of a formal process, this case study examines the experiences and depth of learning acquired by a sample set of novice undergraduates. A novel adaption of the Kirkpatrick framework known as AKM-SOLO is used to frame the evaluation. The study finds that without the scaffolding of an appropriate structured …


Empowering Qualitative Research Methods In Education With Artificial Intelligence, Luca Longo Jan 2020

Empowering Qualitative Research Methods In Education With Artificial Intelligence, Luca Longo

Conference papers

Artificial Intelligence is one of the fastest growing disciplines, disrupting many sectors. Originally mainly for computer scientists and engineers, it has been expanding its horizons and empowering many other disciplines contributing to the development of many novel applications in many sectors. These include medicine and health care, business and finance, psychology and neuroscience, physics and biology to mention a few. However, one of the disciplines in which artificial intelligence has not been fully explored and exploited yet is education. In this discipline, many research methods are employed by scholars, lecturers and practitioners to investigate the impact of different instructional approaches …


Design And Evaluation Of An Adventure Videogame Based In The History Of Mathematics, Mariana Rocha, Pierpaolo Dondio Jan 2020

Design And Evaluation Of An Adventure Videogame Based In The History Of Mathematics, Mariana Rocha, Pierpaolo Dondio

Conference papers

The present paper describes the design and evaluation of an adventure videogame developed to cover the mathematics primary school curriculum. The narrative of the game is based in the history of mathematics and, to win, the player needs to travel through time, starting from the ancient Egypt and finishing at the modern world. To achieve that, the player interacts with real-life characters, such as Pythagoras of Samos, learning about their contributions to the field and using this knowledge to solve puzzles. The aim of the research presented in this paper is to understand the effects of the game on students’ …


Smpl-Based 3d Pedestrian Pose Prediction, Anil Kunchala, Bianca Schoen-Phelan, Mélanie Bouroche, Lorraine D'Arcy Jan 2020

Smpl-Based 3d Pedestrian Pose Prediction, Anil Kunchala, Bianca Schoen-Phelan, Mélanie Bouroche, Lorraine D'Arcy

Conference papers

Modeling human motion is a long-standing problem in computer vision. The rapid development of deep learning technologies for computer vision problems resulted in increased attention in the area of pose prediction due to its vital role in a multitude of applications, for example, behavior analysis, autonomous vehicles, and visual surveillance. In 3D pedestrian pose prediction, joint-rotation-based pose representation is extensively used due to the unconstrained degree of freedom for each joint and its ability to regress the 3D statistical wireframe. However, all the existing joint-rotation-based pose prediction approaches ignore the centrality of the distinct pose parameter components and are consequently …


Start Of Epidemy In A City: Short-Term Forecast Of Covid-19 With Gmdh-Based Algorithms And Official Medical Statistics, Anna Boldyreva, Mikhail Alexandrov, Olexiy Koshulko, Svetland Popova Jan 2020

Start Of Epidemy In A City: Short-Term Forecast Of Covid-19 With Gmdh-Based Algorithms And Official Medical Statistics, Anna Boldyreva, Mikhail Alexandrov, Olexiy Koshulko, Svetland Popova

Conference papers

The sudden onset and quick development of an unknown epidemic may lead to tragic consequences: panic of population due to victims and unpreparedness of authorities for effectively help to population. These circumstances define extremely high requirements to the tools for short-term operational forecast. Namely, such tools should provide reliable results when model of phenomenon is unknown (factors of disease spreading) and data are limited (time series of observations). GMDH-based algorithms just meet these requirements unlike modern differential or advanced statistical models. In this study we test different algorithms from GMDH Shell platform on the example of Covid-19 epidemic in Moscow …


Brexit: Psychometric Profiling The Political Salubrious Through Machine Learning: Predicting Personality Traits Of Boris Johnson Through Twitter Political Text, James Usher, Pierpaolo Dondio Jan 2020

Brexit: Psychometric Profiling The Political Salubrious Through Machine Learning: Predicting Personality Traits Of Boris Johnson Through Twitter Political Text, James Usher, Pierpaolo Dondio

Conference papers

Whilst the CIA have been using psychometric profiling for decades, Cambridge Analytica showed that people's psychological characteristics can be accurately predicted from their digital footprints, such as their Facebook or Twitter accounts. To exploit this form of psychological assessment from digital footprints, we propose machine learning methods for assessing political personality from Twitter. We have extracted the tweet content of Prime Minster Boris Johnson’s Twitter account and built three predictive personality models based on his Twitter political content. We use a Multi-Layer Perceptron Neural network, a Naive Bayes multinomial model and a Support Machine Vector model to predict the OCEAN …


Brain Disease Detection From Eegs: Comparing Spiking And Recurrent Neural Networks For Non-Stationary Time Series Classification, Hristo Stoev Jan 2020

Brain Disease Detection From Eegs: Comparing Spiking And Recurrent Neural Networks For Non-Stationary Time Series Classification, Hristo Stoev

Dissertations

Modeling non-stationary time series data is a difficult problem area in AI, due to the fact that the statistical properties of the data change as the time series progresses. This complicates the classification of non-stationary time series, which is a method used in the detection of brain diseases from EEGs. Various techniques have been developed in the field of deep learning for tackling this problem, with recurrent neural networks (RNN) approaches utilising Long short-term memory (LSTM) architectures achieving a high degree of success. This study implements a new, spiking neural network-based approach to time series classification for the purpose of …


Content-Based Filtering Recommendation Approach To Label Irish Legal Judgements, Sandesh Gangadhar Jan 2020

Content-Based Filtering Recommendation Approach To Label Irish Legal Judgements, Sandesh Gangadhar

Dissertations

Machine learning approaches are applied across several domains to either simplify or automate tasks which directly result in saved time or cost. Text document labelling is one such task that requires immense human knowledge about the domain and efforts to review, understand and label the documents. The company Stare Decisis summarises legal judgements and labels them as they are made available on Irish public legal source www.courts.ie. This research presents a recommendation-based approach to reduce the time for solicitors at Stare Decisis by reducing many numbers of available labels to pick from to a concentrated few that potentially contains the …


Optimization Of Home Mortgage Mover Predictive Model Applying Geo-Spatial Analysis And Machine Learning Techniques, Natalia Riscovaia Jan 2020

Optimization Of Home Mortgage Mover Predictive Model Applying Geo-Spatial Analysis And Machine Learning Techniques, Natalia Riscovaia

Dissertations

In the last decade digital innovations and online banking services have significantly changed customers banking preferences and behaviour. Banking industry is going through the changes and developments in the provision of banking services that are affecting the structure and the organization of the bank network. However, private home loan, referred as Home Mortgage hereinafter, continue to remain among the products, that customers prefer to have personal interaction about with professional advisors prior making the decision to apply for the loan with financial institution.


Synthetic Data Generation Using Wasserstein Conditional Gans With Gradient Penalty (Wcgans-Gp), Manhar Singh Walia Jan 2020

Synthetic Data Generation Using Wasserstein Conditional Gans With Gradient Penalty (Wcgans-Gp), Manhar Singh Walia

Dissertations

With data protection requirements becoming stricter, the data privacy has become increasingly important and more crucial than ever. This has led to restrictions on the availability and dissemination of real-world datasets. Synthetic data offers a viable solution to overcome barriers of data access and sharing. Existing data generation methods require a great deal of user-defined rules, manual interactions and domainspecific knowledge. Moreover, they are not able to balance the trade-off between datausability and privacy. Deep learning based methods like GANs have seen remarkable success in synthesizing images by automatically learning the complicated distributions and patterns of real data. But they …


Improving Transfer Learning For Use In Multi-Spectral Data, Yuvraj Sharma Jan 2020

Improving Transfer Learning For Use In Multi-Spectral Data, Yuvraj Sharma

Dissertations

Recently Nasa as well as the European Space Agency have made observational satellites images public. The main reason behind opening it to public is to foster research among university students and corporations alike. Sentinel is a program by the European Space Agency which has plans to release a series of seven satellites in lower earth orbit for observing land and sea patterns. Recently huge datasets have been made public by the Sentinel program. Many advancements have been made in the field of computer vision in the last decade. Krizhevsky, Sutskever & Hinton, 2012, revolutionized the field of image analysis by …


Research And Innovation As A Catalyst For Food System Transformation, A.C.L. Den Boer, K.P.W. Kok, M. Gill, J. Breda, Jean Cahill, C. Callenius, P. Caron, Z. Damianova, M. Gurinovic, L. Lahteenmaki, T. Lang, R. Sonnino, G. Verburg, H. Westhoek, T. Cesuroglu, B.J. Regeer, J.E.W. Broerse Jan 2020

Research And Innovation As A Catalyst For Food System Transformation, A.C.L. Den Boer, K.P.W. Kok, M. Gill, J. Breda, Jean Cahill, C. Callenius, P. Caron, Z. Damianova, M. Gurinovic, L. Lahteenmaki, T. Lang, R. Sonnino, G. Verburg, H. Westhoek, T. Cesuroglu, B.J. Regeer, J.E.W. Broerse

Research and Innovation - Other

Background Food systems are associated with severe and persistent problems worldwide. Governance approaches aiming to foster sustainable transformation of food systems face several challenges due to the complex nature of food systems.

Scope and approach In this commentary we argue that addressing these governance challenges requires the development and adoption of novel research and innovation (R&I) approaches that will provide evidence to inform food system transformation and will serve as catalysts for change. We first elaborate on the complexity of food systems (transformation) and stress the need to move beyond traditional linear R&I approaches to be able to respond to …


Β-Methylumbelliferone Surface Modification And Permeability Investigations At Pentel™ Graphite Electrodes, Susan Warren, Brian Seddon, Ruth Pilkington, Alison Crossely, Philip Holdway, Eithne Dempsey Jan 2020

Β-Methylumbelliferone Surface Modification And Permeability Investigations At Pentel™ Graphite Electrodes, Susan Warren, Brian Seddon, Ruth Pilkington, Alison Crossely, Philip Holdway, Eithne Dempsey

Articles

Electrochemical and micro-imaging analysis of a commercial graphite-composite material is presented following electro-oxidation with β-methylumbelliferone. Charge-transfer surface modification was observed for the graphite electrode, presumed to have arisen from adsorbed interfacial umbelliferone moieties. The molecular permeability of the new surface towards a range of similar, yet size-variable (23 Å3–136 Å3) molecular redox probes is discussed. Red-shift fluorescence in confocal microscopy offers further support for the presence of a surface-bound umbelliferone layer. An SEM-platinum profiling technique was used as an imaging tool to map the umbelliferone surface and size-distribution of electroactive sites.


Audio Interval Retrieval Using Convolutional Neural Networks, Ievgeniia Kuzminykh, Dan Shevchuk, Stavros Shiaeles, Bogdan Ghita Jan 2020

Audio Interval Retrieval Using Convolutional Neural Networks, Ievgeniia Kuzminykh, Dan Shevchuk, Stavros Shiaeles, Bogdan Ghita

School of Engineering, Computing and Mathematics

No abstract provided.


Model Comparison From Ligo-Virgo Data On Gw170817'S Binary Components And Consequences For The Merger Remnant, B. P. Abbott, R. Abbott, Marco Cavaglia, For Full List Of Authors, See Publisher's Website. Jan 2020

Model Comparison From Ligo-Virgo Data On Gw170817'S Binary Components And Consequences For The Merger Remnant, B. P. Abbott, R. Abbott, Marco Cavaglia, For Full List Of Authors, See Publisher's Website.

Physics Faculty Research & Creative Works

GW170817 is the very first observation of gravitational waves originating from the coalescence of two compact objects in the mass range of neutron stars, accompanied by electromagnetic counterparts, and offers an opportunity to directly probe the internal structure of neutron stars. We perform Bayesian model selection on a wide range of theoretical predictions for the neutron star equation of state. For the binary neutron star hypothesis, we find that we cannot rule out the majority of theoretical models considered. In addition, the gravitational-wave data alone does not rule out the possibility that one or both objects were low-mass black holes. …


Robustness Metric For Robust Design Optimization Under Time-And Space-Dependent Uncertainty Through Metamodeling, Xinpeng Wei, Xiaoping Du Jan 2020

Robustness Metric For Robust Design Optimization Under Time-And Space-Dependent Uncertainty Through Metamodeling, Xinpeng Wei, Xiaoping Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Product performance varies with respect to time and space in many engineering applications. This paper discusses how to measure and evaluate the robustness of a product or component when its quality characteristics (QCs) are functions of random variables, random fields, temporal variables, and spatial variables. At first, the existing time-dependent robustness metric is extended to the present time-and space-dependent problem. The robustness metric is derived using the extreme value of the quality characteristics with respect to temporal and spatial variables for the nominal-the-better type quality characteristics. Then, a metamodel-based numerical procedure is developed to evaluate the new robustness metric. The …


Thermal Atomic Layer Deposition Of Silver Metal Films: Synthesis And Characterization Of Thermally Stable Silver Metal Precursors, Harshani Jayabahu Arachchilage Jan 2020

Thermal Atomic Layer Deposition Of Silver Metal Films: Synthesis And Characterization Of Thermally Stable Silver Metal Precursors, Harshani Jayabahu Arachchilage

Wayne State University Dissertations

ABSTRACT

THERMAL ATOMIC LAYER DEPOSITION OF SILVER METAL FILMS: SYNTHESIS AND CHARACTERIZATION OF THERMALLY STABLE SILVER METAL PRECURSORS

by

HARSHANI JAYABAHU ARACHCHILAGE

August 2020

Advisor: Professor Charles H. Winter

Major: Chemistry (Inorganic)

Degree: Doctor of Philosophy

Traditional film deposition techniques such as PVD and CVD are widely used in the microelectronics industry. However, the lack of thickness control and conformality requirements limit these techniques for current and future applications. By contrast, ALD offers the deposition of ultra-thin conformal films with accurate thickness control due to the self-limiting growth behavior. Ag metal has the lowest resistivity (1.59 µΩ cm) of all …


Vietnamese Punctuation Prediction Using Deep Neural Networks, Thuy Pham, Nhu Nguyen, Hong Quang Pham, Han Cao, Binh Nguyen Jan 2020

Vietnamese Punctuation Prediction Using Deep Neural Networks, Thuy Pham, Nhu Nguyen, Hong Quang Pham, Han Cao, Binh Nguyen

Research Collection School Of Computing and Information Systems

Adding appropriate punctuation marks into text is an essential step in speech-to-text where such information is usually not available. While this has been extensively studied for English, there is no large-scale dataset and comprehensive study in the punctuation prediction problem for the Vietnamese language. In this paper, we collect two massive datasets and conduct a benchmark with both traditional methods and deep neural networks. We aim to publish both our data and all implementation codes to facilitate further research, not only in Vietnamese punctuation prediction but also in other related fields. Our project, including datasets and implementation details, is publicly …


Challenges And Trends In Sustainable Corporate Finance: A Bibliometric Systematic Review, Tad Dat Bui, Mohd Helmi Ali, Feng Ming Tsai, Mohammad Iranmanesh, Ming-Lang Tseng, Ming K. Lim Jan 2020

Challenges And Trends In Sustainable Corporate Finance: A Bibliometric Systematic Review, Tad Dat Bui, Mohd Helmi Ali, Feng Ming Tsai, Mohammad Iranmanesh, Ming-Lang Tseng, Ming K. Lim

Research outputs 2014 to 2021

Sustainable corporate finance is an attractive field of study in sustainability literature; however, the literature lacks systematic bibliometric analysis that provides a comprehensive review to clarify state-of-the-art sustainable corporate finance and that discusses new opportunities and potential instructions for further studies. To address this gap, this study adopts a literature review, bibliometric analysis, network analysis and co-wording technique to systematically investigate the Scopus database. In total, 30 keywords listed at least three times are used and are divided into six clusters considering six fields of research, namely, corporate finance in corporate sustainability, sustainable competitive advantages, sustainable stakeholder engagement, circular economy, …


Identifying The Critical Factors Of Sustainable Manufacturing Using The Fuzzy Dematel Method, Luwei Jiang, Tenghao Zhang, Yanfei Feng Jan 2020

Identifying The Critical Factors Of Sustainable Manufacturing Using The Fuzzy Dematel Method, Luwei Jiang, Tenghao Zhang, Yanfei Feng

Research outputs 2014 to 2021

© 2020 Luwei Jiang et al., published by Sciendo 2020. The burgeoning trend of globalization gives rise to the formation of the manufacturing ecosystem. This study aims to identify the critical factors of sustainable manufacturing for countries and regions across the globe finding their unique ecological niches. From the perspective of the ecological niche, we develop an evaluation system of the manufacturing niche. By using the fuzzy Decision-Making Trial and Evaluation Laboratory (DEMATEL) method, the critical factors, and its causal relationships of the manufacturing niche can be quantified and visualized. The results indicate that: (1) the evaluation system of the …


Fusion Of 3d Lidar And Camera Data For Object Detection In Autonomous Vehicle Applications, Xiangmo Zhao, Pengpeng Sun, Zhigang Xu, Haigen Min, Hongkai Yu Jan 2020

Fusion Of 3d Lidar And Camera Data For Object Detection In Autonomous Vehicle Applications, Xiangmo Zhao, Pengpeng Sun, Zhigang Xu, Haigen Min, Hongkai Yu

Computer Science Faculty Publications

It’s critical for an autonomous vehicle to acquire accurate and real-time information of the objects in its vicinity, which will fully guarantee the safety of the passengers and vehicle in various environment. 3D LIDAR can directly obtain the position and geometrical structure of the object within its detection range, while vision camera is very suitable for object recognition. Accordingly, this paper presents a novel object detection and identification method fusing the complementary information of two kind of sensors. We first utilize the 3D LIDAR data to generate accurate object-region proposals effectively. Then, these candidates are mapped into the image space …


Daily Stream Samples Reveal Highly Complex Pesticide Occurrence And Potential Toxicity To Aquatic Life, Julia E. Norman, Barbara J. Mahler, Lisa H. Nowell, Peter C. Van Metre, Mark W. Sandstrom, Mark A. Corbin, Yaorong Qian, James F. Pankow, Wentai Luo, Nicholas B. Fitzgerald, Multiple Additional Authors Jan 2020

Daily Stream Samples Reveal Highly Complex Pesticide Occurrence And Potential Toxicity To Aquatic Life, Julia E. Norman, Barbara J. Mahler, Lisa H. Nowell, Peter C. Van Metre, Mark W. Sandstrom, Mark A. Corbin, Yaorong Qian, James F. Pankow, Wentai Luo, Nicholas B. Fitzgerald, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

Transient, acutely toxic concentrations of pesticides in streams can go undetected by fixed-interval sampling programs. Here we compare temporal patterns in occurrence of current-use pesticides in daily composite samples to those in weekly composite and weekly discrete samples of surface water from 14 small stream sites. Samples were collected over 10–14 weeks at 7 stream sites in each of the Midwestern and Southeastern United States. Samples were analyzed for over 200 pesticides and degradates by direct aqueous injection liquid chromatography with tandem mass spectrometry. Nearly 2 and 3 times as many unique pesticides were detected in daily samples as in …


Synthesis Of Radioluminescent Caf2:Ln Core, Mesoporous Silica Shell Nanoparticles For Use In X-Ray Based Theranostics, Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth Jan 2020

Synthesis Of Radioluminescent Caf2:Ln Core, Mesoporous Silica Shell Nanoparticles For Use In X-Ray Based Theranostics, Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth

Chemistry Faculty Publications and Presentations

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF2 core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu …