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2020

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Ultrafast Spin-Currents And Charge Conversion At 3d-5d Interfaces Probed By Time-Domain Terahertz Spectroscopy, T. H. Dang, J. Hawecker, E. Rongione, G. Baez Flores, D. Q. To, J. C. Rojas-Sanchez, H. Nong, J. Mangeney, J. Tignon, F. Godel, S. Collin, P. Seneor, M. Bibes, A. Fert, M. Anane, J. M. George, L. Vila, M. Cosset-Cheneau, D. Dolfi, R. Lebrun, P. Bortolotti, Kirill Belashchenko, S. Dhillon, H. Jaffrès Dec 2020

Ultrafast Spin-Currents And Charge Conversion At 3d-5d Interfaces Probed By Time-Domain Terahertz Spectroscopy, T. H. Dang, J. Hawecker, E. Rongione, G. Baez Flores, D. Q. To, J. C. Rojas-Sanchez, H. Nong, J. Mangeney, J. Tignon, F. Godel, S. Collin, P. Seneor, M. Bibes, A. Fert, M. Anane, J. M. George, L. Vila, M. Cosset-Cheneau, D. Dolfi, R. Lebrun, P. Bortolotti, Kirill Belashchenko, S. Dhillon, H. Jaffrès

Kirill Belashchenko Publications

Spintronic structures are extensively investigated for their spin-orbit torque properties, required for magnetic commutation functionalities. Current progress in these materials is dependent on the interface engineering for the optimization of spin transmission. Here, we advance the analysis of ultrafast spin-charge conversion phenomena at ferromagnetic-Transition metal interfaces due to their inverse spin-Hall effect properties. In particular, the intrinsic inverse spin-Hall effect of Pt-based systems and extrinsic inverse spin-Hall effect of Au:W and Au:Ta in NiFe/Au:(W,Ta) bilayers are investigated. The spin-charge conversion is probed by complementary techniques-ultrafast THz time-domain spectroscopy in the dynamic regime for THz pulse emission and ferromagnetic resonance spin-pumping …


Impacts Of Environmental Conditions On Fleas In Black-Tailed Prairie Dog Burrows, Julia E. Poje, Tonie Rocke, Michael D. Samuel Dec 2020

Impacts Of Environmental Conditions On Fleas In Black-Tailed Prairie Dog Burrows, Julia E. Poje, Tonie Rocke, Michael D. Samuel

United States Geological Survey: Staff Publications

Sylvatic plague, caused by the bacterium Yersinia pestis and transmitted by fleas, occurs in prairie dogs of the western United States. Outbreaks can devastate prairie dog communities, often causing nearly 100% mortality. Three competent flea vectors, prairie dog specialists Oropsylla hirsuta and O. tuberculata, and generalist Pulex simulans, are found on prairie dogs and in their burrows. Fleas are affected by climate, which varies across the range of black-tailed prairie dogs (Cynomys ludovicianus), but these effects may be ameliorated somewhat due to the burrowing habits of prairie dogs. Our goal was to assess how temperature and precipitation …


How Do Monetary Incentives Influence Prosocial Fundraising? An Empirical Investigation Of Matching Subsidies On Crowdfunding, Zhiyuan Gao Dec 2020

How Do Monetary Incentives Influence Prosocial Fundraising? An Empirical Investigation Of Matching Subsidies On Crowdfunding, Zhiyuan Gao

Dissertations and Theses Collection (Open Access)

Monetary incentives, such as matching subsidies, are widely used in traditional fundraising and crowdfunding platforms to boost funding activities and improve funding outcomes. However, its effectiveness on prosocial fundraising is still unclear from both theoretical (Bénabou and Tirole, 2006; Frey, 1997; Meier, 2007a) and empirical studies (Ariely et al., 2009; Karlan and List, 2007; Rondeau and List, 2008). This dissertation aims to examine the effectiveness of matching subsidies on prosocial fundraising in the crowdfunding context. Specifically, I study how the presence of matching subsidies affects overall funding outcomes and funding dynamics in the online prosocial crowdfunding environment.

The first essay …


Exploring The Niche Of Rickettsia Montanensis (Rickettsiales: Rickettsiaceae) Infection Of The American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches, Catherine A. Lippi, Holly Gaff, Alexis L. White, Heidi K. St. John, Allen L. Richards, Sadie J. Ryan Dec 2020

Exploring The Niche Of Rickettsia Montanensis (Rickettsiales: Rickettsiaceae) Infection Of The American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches, Catherine A. Lippi, Holly Gaff, Alexis L. White, Heidi K. St. John, Allen L. Richards, Sadie J. Ryan

Biological Sciences Faculty Publications

The American dog tick, Dermacentor variabilis (Say) (Acari: Ixodidae), is a vector for several human diseasecausing pathogens such as tularemia, Rocky Mountain spotted fever, and the understudied spotted fever group rickettsiae (SFGR) infection caused by Rickettsia montanensis. It is important for public health planning and intervention to understand the distribution of this tick and pathogen encounter risk. Risk is often described in terms of vector distribution, but greatest risk may be concentrated where more vectors are positive for a given pathogen. When assessing species distributions, the choice of modeling framework and spatial layers used to make predictions are important. …


Offshore Wind Energy And Benthic Habitat Changes Lessons From Block Island Wind Farm, Zoë L. Hutchison, Monique Lafrance Bartley, Steven Degraer, Paul English, Anwar Khan, Julia Livermore, Bob Rumes, John W. King Dec 2020

Offshore Wind Energy And Benthic Habitat Changes Lessons From Block Island Wind Farm, Zoë L. Hutchison, Monique Lafrance Bartley, Steven Degraer, Paul English, Anwar Khan, Julia Livermore, Bob Rumes, John W. King

Graduate School of Oceanography Faculty Publications

The Block Island Wind Farm (BIWF), situated offshore of Block Island, Rhode Island, is the first commercial offshore wind farm (OWF) in the United States. We briefly review pre-siting studies, which provide contextual information about the benthic habitats and fish in the Block Island Sound area before the BIWF jacket foundations were installed in 2015. We focus on benthic monitoring that took place within the BIWF. This monitoring allowed for assessments of spatiotemporal changes in sediment grain size, organic enrichment, and macrofauna, as well as the colonization of the jacket structures, up to four years post-installation. The greatest benthic modifications …


Robust Maximum Coverage Facility Location Problem With Drones Considering Uncertainties In Battery Availability And Consumption, Darshan Chauhan, Avinash Unnikrishnan, Miguel Figliozzi, Stephen D. Boyles Dec 2020

Robust Maximum Coverage Facility Location Problem With Drones Considering Uncertainties In Battery Availability And Consumption, Darshan Chauhan, Avinash Unnikrishnan, Miguel Figliozzi, Stephen D. Boyles

Civil and Environmental Engineering Faculty Publications and Presentations

Given a set of spatially distributed demand for a specific commodity, potential facility locations, and drones, an agency is tasked with locating a prespecified number of facilities and assigning drones to them to serve the demand while respecting drone range constraints. The agency seeks to maximize the demand served while considering uncertainties in initial battery availability and battery consumption. The facilities have a limited supply of the commodity being distributed and also act as a launching site for drones. Drones undertake one-to-one trips (from located facility to demand location and back) until their available battery energy is exhausted. This paper …


Investigating The Timing Of Initial Louann Salt Flow And Its Relationship With The Gilbertown Fault Zone, Southwest Alabama, Avery Rosenbalm Dec 2020

Investigating The Timing Of Initial Louann Salt Flow And Its Relationship With The Gilbertown Fault Zone, Southwest Alabama, Avery Rosenbalm

Master's Theses

The Mesozoic Louann Salt extends through the northern GOM, extending onshore from eastern Texas to western Alabama and Florida. Along the landward terminus of the salt is a system of peripheral faults, including the Gilbertown Fault Zone bordering the Mississippi Interior Salt Basin to the north and east. This study sought to constrain the timing of fault movement and determine its relationship to the baswinward evacuation of Louann Salt through the use of a 3D seismic survey and well logs. By mapping Mesozoic formations and the peripheral fault system, lateral changes in formation thickness were used to generate fault expansion …


Stability Analysis Of Krylov Subspace Spectral Methods For The 1-D Wave Equation In Inhomogeneous Media, Bailey Rester Dec 2020

Stability Analysis Of Krylov Subspace Spectral Methods For The 1-D Wave Equation In Inhomogeneous Media, Bailey Rester

Master's Theses

Krylov subspace spectral (KSS) methods are high-order accurate, explicit time-stepping methods for partial differential equations (PDEs) that also possess the stability characteristic of implicit methods. Unlike other time-stepping approaches, KSS methods compute each Fourier coefficient of the solution from an individualized approximation of the solution operator of the PDE. As a result, KSS methods scale effectively to higher spatial resolution. This thesis will present a stability analysis of a first-order KSS method applied to the wave equation in inhomogeneous media.


Spatially Directed Functionalization By Co-Electropolymerization Of Two 3,4-Ethylenedioxythiophene Derivatives On Microelectrodes Within An Array, Benjamin J. Jones, Carol Korzeniewski, Jefferson H. Franco, Shelley D. Minteer, Ingrid Fritsch Dec 2020

Spatially Directed Functionalization By Co-Electropolymerization Of Two 3,4-Ethylenedioxythiophene Derivatives On Microelectrodes Within An Array, Benjamin J. Jones, Carol Korzeniewski, Jefferson H. Franco, Shelley D. Minteer, Ingrid Fritsch

Chemistry & Biochemistry Faculty Publications and Presentations

Electrodeposited conductive copolymer films with predictable relative properties (quantities of functional groups for further modification and capacitance) are of interest in sensors, organic electronic materials and energy applications. Potentiodynamic copolymerization of films in aqueous solutions of two different thiophene derivatives, (2,3-dihydrothieno[3,4-b]dioxin-2-yl) methanol (1) and 4-((2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)-methoxy)-4-oxobutanoic acid (2), containing 0.02 M total monomer (0, 25, 34, 50, 66, 75, 100 mol% 2), 0.05 M sodium dodecyl sulfate, and 0.1 M LiClO4, on gold microelectrodes in an array was investigated. Decreasing monomer deposited (m) from 0 to 100 mol% 2 is attributed to a decreasing pH that inhibits electropolymerization. Molar ratios of …


Oer Ellipses And Traditional Rapanui Houses On Easter Island, Cynthia Huffman Ph.D. Dec 2020

Oer Ellipses And Traditional Rapanui Houses On Easter Island, Cynthia Huffman Ph.D.

Faculty Submissions

This worksheet activity is appropriate for secondary students in a class studying conic sections or students in a college algebra class. The first part of the activity gives an algebraic review of ellipses with exercises while the second part finds the equation of an ellipse corresponding to a Rapanui boat house foundation.


Rethinking Resource Allocation: Fairness And Computability, Andrew Searns Dec 2020

Rethinking Resource Allocation: Fairness And Computability, Andrew Searns

Theses

In the field of multiagent systems, one important problem is fairly allocating items among a set of agents. The gold standard fairness property is envy-freeness whereby each agent prefers the bundle allocated to them over any other bundle. For indivisible goods, envy-freeness cannot be guaranteed: consider two agents and one item. In the context of indivisible goods, one key fairness notion which has gained significant attention in recent years is the maximin share guarantee (MMS). MMS extends the cut-and-choose protocol to multiple agents by guaranteeing each agent as much value as if they divided items into bundles but chose last. …


Strain Control Of Layer-Resolved Negative Capacitance In Superlattices, Raymond Walter, Sergey Prosandeev, Charles Paillard, L. Bellaiche Dec 2020

Strain Control Of Layer-Resolved Negative Capacitance In Superlattices, Raymond Walter, Sergey Prosandeev, Charles Paillard, L. Bellaiche

Physics Faculty Publications and Presentations

Negative capacitance in BaTiO3/SrTiO3 superlattices is investigated by Monte Carlo simulations in an atomistic effective Hamiltonian model, using fluctuation formulas for responses to the local macroscopic field that incorporates depolarizing fields. We show that epitaxial strain can tune the negative capacitance of the BaTiO3 ferroelectric layer and the overall capacitance of the system. In addition, we predict and explain an original switching of the negative capacitance from the BaTiO3 layer to the SrTiO3 layer at low temperatures for intermediate strains.


The Life Of An Elementary School Principal: An Autoethnography, Catherine Ruth Tamayo Dec 2020

The Life Of An Elementary School Principal: An Autoethnography, Catherine Ruth Tamayo

Electronic Theses, Projects, and Dissertations

This study was designed to provide insight into the daily life of administrators with the hope it would help to identify potential causes of principals leaving the profession within five years. Additionally, the study helps to prepare and inform educators and district leaders in how to support principals. It can also assist is preparing future principals for their administrative roles and what best supports participants to become successful administrators.

This study utilized a qualitative inquiry model as an autoethnography and is able to shed light on real life experiences. Data collection consisted of a journal of daily occurrences, a reflective …


Monitoring The Spatial Spread Of Covid-19 And Effectiveness Of Control Measures Through Human Movement Data: Proposal For A Predictive Model Using Big Data Analytics, Zhenlong Li, Xiaoming Li, Dwayne Porter Ph.D., Jiajia Zhang Ph.D., Yuqin Jiang, Bankole Olatosi Ph.D., Sharon Weissman Dec 2020

Monitoring The Spatial Spread Of Covid-19 And Effectiveness Of Control Measures Through Human Movement Data: Proposal For A Predictive Model Using Big Data Analytics, Zhenlong Li, Xiaoming Li, Dwayne Porter Ph.D., Jiajia Zhang Ph.D., Yuqin Jiang, Bankole Olatosi Ph.D., Sharon Weissman

Faculty Publications

Background: Human movement is one of the forces that drive the spatial spread of infectious diseases. To date, reducing and tracking human movement during the COVID-19 pandemic has proven effective in limiting the spread of the virus. Existing methods for monitoring and modeling the spatial spread of infectious diseases rely on various data sources as proxies of human movement, such as airline travel data, mobile phone data, and banknote tracking. However, intrinsic limitations of these data sources prevent us from systematic monitoring and analyses of human movement on different spatial scales (from local to global). Objective: Big data from social …


Exploring Student Perceptions Of Flipgrid In Online Courses, Patrick R. Lowenthal, Robert L. Moore Dec 2020

Exploring Student Perceptions Of Flipgrid In Online Courses, Patrick R. Lowenthal, Robert L. Moore

STEMPS Faculty Publications

Asynchronous video-based discussions have affordances that can address some of the constraints of asynchronous text-based discussions. However, little research has been conducted on the use of asynchronous video-based discussions in online courses. As a result, the purpose of this exploratory study was to investigate students’ perceptions of using Flipgrid for asynchronous video-based discussions in fully online courses. We used a cross-sectional survey design to survey 79 students who used Flipgrid in a fully online course. Students overall reported that they liked using Flipgrid, it was easy to use, and that it helped improve social presence. In this paper, we will …


Montclair Magazine (Fall/Winter 2020), Montclair State University Dec 2020

Montclair Magazine (Fall/Winter 2020), Montclair State University

Montclair: The magazine of Montclair State University

No abstract provided.


2020 Summer-Fall Graduate Recognition Program, Propulsion Research Center, Robert Frederick Dec 2020

2020 Summer-Fall Graduate Recognition Program, Propulsion Research Center, Robert Frederick

PRC Graduate Recognition

This program includes the graduate recognition program for summer and fall 2020. Includes photographs, upcoming events, recent publications, and student profiles.


7th Annual Sustainability Report, Saint Mary's College Of California Dec 2020

7th Annual Sustainability Report, Saint Mary's College Of California

Sustainability Report

No abstract provided.


Effects Of Ca Doping On Structural And Optical Properties Of Pzt Nanopowders, K. H. Omran, M. Mostafa, M. S. Abd El-Sadek, O. M. Hemeda, R. Ubic Dec 2020

Effects Of Ca Doping On Structural And Optical Properties Of Pzt Nanopowders, K. H. Omran, M. Mostafa, M. S. Abd El-Sadek, O. M. Hemeda, R. Ubic

Materials Science and Engineering Faculty Publications and Presentations

The influence of the addition of calcium ions (Ca2+) in the Pb(1-x)CaxZr0.52Ti0.48O3 system (PCZT) for x = 0.05, 0.10, 0.15, 0.20, and 0.25 on the structural and optical properties was systematically studied. The compositions were synthesized through a polymerized-complex approach based on the Pechini polymeric precursor route. The solubility limit of calcium ions within the PCZT lattice is in between x = 0.10 and x = 0.15, at which a CaTiO3 secondary phase is detected. The Goldschmidt tolerance factors, modified tolerance factors, and the effective vacancy sizes were …


Long-Term Neurocognitive And Educational Outcomes Of Neonatal Insults In Kilifi, Kenya, Dorcas N. Magai, Hans M. Koot, Paul Mwangi, Esther Chongwo, Charles R. Newton, Amina Abubakar Dec 2020

Long-Term Neurocognitive And Educational Outcomes Of Neonatal Insults In Kilifi, Kenya, Dorcas N. Magai, Hans M. Koot, Paul Mwangi, Esther Chongwo, Charles R. Newton, Amina Abubakar

Institute for Human Development, East Africa

Background: There is little data on the long-term neurocognitive and educational outcomes among school-aged survivors of neonatal jaundice (NNJ) and hypoxic-ischemic encephalopathy (HIE) in Africa. This study investigates the long-term neurocognitive and educational outcomes and the correlates of these outcomes in school-aged survivors of NNJ or HIE in Kilifi, Kenya.

Methods: We conducted a cross-sectional study on neurocognitive and educational outcomes among school-aged survivors (6–12 years) of NNJ (n = 134) and HIE (n = 107) and compared them to a community comparison group (n = 134). We assessed nonverbal intelligence, planning, working memory, attention, syntax, pragmatics, wordfinding, …


Constraining Viscous Protoplanetary Disk Models Using Alma Kinematic Observations, Ian Rabago Dec 2020

Constraining Viscous Protoplanetary Disk Models Using Alma Kinematic Observations, Ian Rabago

UNLV Theses, Dissertations, Professional Papers, and Capstones

Recent molecular line observations by ALMA have revealed the 3D velocity structure of protoplanetary disks, providing new insight on the mechanisms of disk accretion and ring/gap formation. Although the constant α viscous disk model has been widely used to describe the disk surface density evolution, it may not adequately describe the gas velocity at different disk heights. By carrying out viscous hydrodynamic simulations, we confirm that the vertical velocity structure varies considerably between these models. On the other hand, the surface density evolution of the disk is only dependent on the vertically integrated stress, and does not depend on a …


Characterization Of A Packaged Triboelectric Harvester Under Simulated Gait Loading For Total Knee Replacement, Nabid Aunjum Hossain, Geofrey George Yamomo, Ryan Willing, Shahrzad Towfighian Dec 2020

Characterization Of A Packaged Triboelectric Harvester Under Simulated Gait Loading For Total Knee Replacement, Nabid Aunjum Hossain, Geofrey George Yamomo, Ryan Willing, Shahrzad Towfighian

Mechanical Engineering Faculty Scholarship

Load sensing total knee replacement (TKR) implants are useful tools for monitoring prosthesis health and providing quantitative data to support patient claims of pain or instability. Powering such devices throughout the entire life of the knee replacement, however, is a challenge, and selfpowered telemetry via energy harvesting is an attractive solution. Herein, we implemented vertical contact mode triboelectric energy harvesters inside a knee implant package to generate the power required for embedded digitization and communications circuitry. The harvesters produce small-scale electric power from physiologically relevant loads transmitted through the knee. Experiments were performed on a joint motion simulator with an …


Rethinking Race In The 21st Century, A New Approach For Future World-Making: Looking Back To Move Forward, Dylan Tarleton Dec 2020

Rethinking Race In The 21st Century, A New Approach For Future World-Making: Looking Back To Move Forward, Dylan Tarleton

Binghamton University Undergraduate Journal

Color blindness, the end of race, and white privilege are but a few phrases that begin to capture the messy confusion of a zeitgeist that is 21st century discussions on race. At a time when race is such a necessary topic to delve into, it seems that there is a lack of history injected into the conversation. Race becomes an external motor of history, racism pathological and immovable. An unthinking decision. In other words, race and racism, from the standpoint of an organizer or academic in the 21st century, becomes near impossible to break down and work against. …


December 2020 News Releases, University Of Montana--Missoula. Office Of University Relations Dec 2020

December 2020 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.


Differentially Expressed Genes And Their Clinical Significance In Ischaemic Stroke: An In-Silico Study, Muni Rubens Dec 2020

Differentially Expressed Genes And Their Clinical Significance In Ischaemic Stroke: An In-Silico Study, Muni Rubens

All Publications

No abstract provided.


Timing Of Deformation Along The Iron Springs Thrust, Southern Sevier Fold-And-Thrust Belt, Utah: Evidence For An Extensive Thrusting Event In The Mid-Cretaceous, J. Daniel Quick, John Patrick Hogan, Michael Wizevich, Jonathan Obrist-Farner, James L. Crowley Dec 2020

Timing Of Deformation Along The Iron Springs Thrust, Southern Sevier Fold-And-Thrust Belt, Utah: Evidence For An Extensive Thrusting Event In The Mid-Cretaceous, J. Daniel Quick, John Patrick Hogan, Michael Wizevich, Jonathan Obrist-Farner, James L. Crowley

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The temporal and spatial distribution of strain associated with the Sevier orogeny in western North America is significantly different in the southern end of the belt, at the latitude of Las Vegas, Nevada, than farther to the north at the latitude of Salt Lake City, Utah. Reasons for these differences have been speculative as a lack of temporal constraints on thrusting in the intervening region hindered along-strike correlation across the belt. We determined a crystallization age of 100.18 ± 0.04 Ma for zircons extracted from a recently recognized dacite lapilli ash-fall tuff near the base of the synorogenic Iron Springs …


Micro-Annulus Generation Under Downhole Conditions: Insights From Three-Dimensional Staged Finite Element Analysis Of Cement Hardening And Wellbore Operations, Weicheng Zhang, Andreas Eckert Dec 2020

Micro-Annulus Generation Under Downhole Conditions: Insights From Three-Dimensional Staged Finite Element Analysis Of Cement Hardening And Wellbore Operations, Weicheng Zhang, Andreas Eckert

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

A micro-annulus (MA) is defined as a high permeability zone or gap initiating/occurring at the casing-cement and cement-formation interfaces during the wellbore life span. An MA can significantly compromise wellbore integrity by establishing enhanced fluid flow pathways. This study uses a staged finite element approach to simulate wellbore integrity during various loading steps of wellbore operations under downhole conditions. Particular emphasis is placed on the processes of cement poro-elastic property evolution, volume variation, and pore pressure variation as part of the cement hardening step. The resulting state of stress during the life cycle of a typical injection well (i.e. hardening, …


Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism, Keith Michel Dec 2020

Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism, Keith Michel

Dissertations and Theses (Open Access)

Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly polarized nuclear magnetic moment. This polarization is created in a polarizer separate from the imaging magnet, and decays continuously towards a non-detectable thermal equilibrium once the imaging agent is removed from the polarizer and administered by intravenous injection. Specialized imaging strategies are therefore needed to extract as much information as possible from the HP signal during its limited lifetime.

In …


Development Of Computational To Ols To Target Microrna, Luo Song Dec 2020

Development Of Computational To Ols To Target Microrna, Luo Song

Dissertations and Theses (Open Access)

MicroRNAs (a.k.a, miRNAs) play an important role in disease development. However, few of their structures have been determined and structure-based computational methods remain challenging in accurately predicting their interactions with small molecules. To address this issue, my thesis is to develop integrated approaches to screening for novel inhibitors by targeting specific structure motifs in miRNAs. The project starts with implementing a tool to find potential miRNA targets with desired motifs. I combined both sequence information of miRNAs and known RNA structure data from Protein Data Bank (PDB) to predict the miRNA structure and identify the motif to target, then I …


Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru Dec 2020

Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru

Dissertations and Theses (Open Access)

Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.

Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, …