Digital Commons Network^™

Role Of The Coronavirus Disease 2019 (Covid-19) Pandemic In The Upgrading Of Personal Hygiene. A Cross-Sectional Study In Saudi Arabia, Yosef M. Zakout, Fahmida Khatoon, Mohamad A. Bealy, Nuha Ar. Khalil, Awdah M. Alhazimi

Saudi Medical Journal

Objectives: To assess the role of the Coronavirus Disease 2019 (COVID-19) pandemic in improving personal hygiene in Saudi Arabia. Methods: We administered a questionnaire distributed online between 19 and 28 May 2020 to determine alterations in personal hygiene practices during this pandemic compared to the pre-pandemic phase. Results: We included 211 respondents from the Kingdom of Saudi Arabia (KSA) in this study. Improvement at different levels was detected in all examined personal hygiene items compared to the pre-pandemic stage. The percentages of respondents who always washed their hands after coming back home (34.1%), used soap to wash their hands (58.8%), …

Implementation Of Surgical Site Infection Surveillance In Low- And Middle-Income Countries: A Position Statement For The International Society For Infectious Diseases, Shaheen Mehtar, Anthony Wanyoro, Folasade Ogunsola, Emmanuel A. Ameh, Peter Nthumba, Claire Kilpatrick, Gunturu Revathi, Anastasia Antoniadou, Helen Giamarelou, Anucha Apisarnthanarak

Pathology, East Africa

Surgical site infection (SSI) rates in low- and middle-income countries (LMICs) range from 8 to 30% of procedures, making them the most frequent healthcare-acquired infection (HAI) with substantial morbidity, mortality, and economic impacts. Presented here is an approach to surgical site infection prevention based on surveillance and focused on five critical areas identified by international experts. These five areas include 1. Collecting valid, high-quality data; 2. Linking HAIs to economic incapacity, underscoring the need to prioritize infection prevention activities; 3. Implementing SSI surveillance within infection prevention and control (IPC) programs to enact structural changes, develop procedural skills, and alter healthcare …

Varroa Destructor Mites Vector And Transmit Pathogenic Honey Bee Viruses Acquired From An Artificial Diet, Francisco Posada-Florez, Eugene V. Ryabov, Matthew C. Heerman, Yanping Chen, Jay D. Evans, Daniel E. Sonenshine, Steven C. Cook

Biological Sciences Faculty Publications

The ectoparasitic mite Varroa destructoris one of the most destructive pests of the honey bee (Apis mellifera) and the primary biotic cause of colony collapse in many regions of the world. These mites inflict physical injury on their honey bee hosts from feeding on host hemolymph and fat body cells/cellular components, and serve as the vector for deadly honey bee viruses, including Deformed wing virus (DWV) and the related Varroa destructor virus-1 (VDV-1) (i.e., DWV-like viruses). Studies focused on elucidating the dynamics of Varroa-mediated vectoring and transmission of DWV-like viruses may be confounded by viruses present in …

Patient Engagement: A Key Concept To Surgical Site Infection Reduction In Colorectal Patients, Vanessa Strieff

Master's Projects and Capstones

Abstract

Problem: Colorectal surgery is a procedure with one of the highest surgical site infection (SSI) rates; therefore, necessary efforts were implemented to reduce harm (Harris, 2018). Approximately 60% of these surgical infections are preventable (Ban et al., 2017). SSIs can have severe consequences, including extended length of stay, high morbidity and mortality rates, delayed recovery, and high healthcare costs (Harris, 2018). The financial burden of SSI is substantial.

Context: This project aimed to explore opportunities for enhancing patient engagement and awareness of SSI preventive measures. After an extensive microsystem analysis, a knowledge gap in patient education on …

Pricing The Global Health Risks Of The Covid-19 Pandemic, W. Kip Viscusi

Vanderbilt Law School Faculty Publications

Policies to address the coronavirus disease 2019 (COVID-19) require a balancing of the health risk reductions and the costs of economic dislocations. Application of the value of a statistical life (VSL) to monetize COVID-19 deaths produces a U.S. mortality cost estimate of $1.4 trillion for deaths in the first half of 2020. This article presents worldwide COVID-19 costs for over 100 countries. The total global mortality cost through July 2, 2020 is $3.5 trillion. The United States accounts for 25% of the deaths, but 41% of the mortality cost. Adjustments for the shorter life expectancy and lower income of the …

U.S. Settler Colonialism, White Supremacy, And The Racially Disparate Impacts Of Covid-19, Monika Batra Kashyap

Faculty Articles

This Essay contextualizes the racially disproportionate impacts of COVID-19 in the United States within a framework of settler colonialism in order to broaden the understanding of how structural inequality is produced, imposed, and maintained. A settler colonialism framework recognizes that the United States is a present-day settler colonial society whose laws, institutions and systems of governance continue to reenact the three processes upon which the United States was built—Indigenous elimination, anti-Black racism, and immigrant exploitation. This Essay connects these foundational processes—and their underlying White supremacist logics—to the disparate health impacts of COVID-19 on Indigenous, Black, and immigrant of color communities …

Apoe-Modified Liposomes Mediate The Antitumour Effect Of Survivin Promoter-Driven Hsvtk In Hepatocellular Carcinoma, Xiuli Mu, Xi Wang, Yan Wei, Chaochao Wen, Qi Zhang, Chunyang Xu, Chang Liu, Chan Zhang, Fanxiu Meng, Na Zhao, Tao Gong, Rui Guo, Gongqin Sun, Gaopeng Li, Hongwei Zhang, Qin Qin, Jun Xu, Xiushan Dong, Lumei Wang, Baofeng Yu

Cell and Molecular Biology Faculty Publications

Hepatocellular carcinoma (HCC) is a prevalent malignant tumour with high global morbidity and mortality associated with its multiple aetiologies, poor prognosis, resistance to chemotherapeutic drugs and high rate of recurrence. Here, we evaluated a gene therapy strategy that targets HCC using the herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) suicide gene system in HCC cell lines and in an in vivo human HCC xenograft mouse model. Apolipoprotein E (ApoE)-modified liposomes were used for targeted gene delivery to the tumour tissue, and the survivin promoter was used to drive HSVtk expression in HCC cells. Our results showed that the survivin promoter was …

Network Analysis As A Tool To Understand Social Development In Spider Monkeys, Emily R. Boeving, Michelle A. Rodrigues, Eliza L. Nelson

Social and Cultural Sciences Faculty Research and Publications

The emerging field of network science has demonstrated that an individual's connectedness within their social network has cascading effects to other dimensions of life. Like humans, spider monkeys live in societies with high fission–fusion dynamics, and are remarkably social. Social network analysis (SNA) is a powerful tool for quantifying connections that may vary as a function of initiating or receiving social behaviors, which has been described as shifting social roles. In primatology, the SNA literature is dominated by work in catarrhines, and has yet to be applied to the study of development in a platyrrhine model. Here, SNA was utilized …

Feasibility And Acceptability Of Implementing Early Infant Diagnosis Of Hiv In Papua New Guinea At The Point Of Care: A Qualitative Exploration Of Health Worker And Key Informant Perspectives, Yasmin Mohamed, Martha Kupul, Janet Gare, Steven G. Badman, Selina Silim, Andrew J. Vallely, Stanley Luchters, Angela Kelly-Hanku

Population Health, East Africa

Introduction: Early infant diagnosis (EID) of HIV and timely initiation of antiretroviral therapy can significantly reduce morbidity and mortality among HIV-positive infants. Access to EID is limited in many low-income and middle-income settings, particularly those in which standard care involves dried blood spots (DBS) sent to centralised laboratories, such as in Papua New Guinea (PNG). We conducted a qualitative exploration of the feasibility and acceptability of implementing a point-of-care (POC) EID test (Xpert HIV-1 Qualitative assay) among health workers and key stakeholders working within the prevention of mother-to-child transmission of HIV (PMTCT) programme in PNG.

Methods: This qualitative substudy was …

A Statistical Learning Regression Model Utilized To Determine Predictive Factors Of Social Distancing During Covid-19 Pandemic, Timothy A. Smith, Albert J. Boquet, Matthew V. Chin

Publications

In an application of the mathematical theory of statistics, predictive regression modelling can be used to determine if there is a trend to predict the response variable of social distancing in terms of multiple predictor input “predictor” variables. In this study the social distancing is measured as the percentage reduction in average mobility by GPS records, and the mathematical results obtained are interpreted to determine what factors drive that response. This study was done on county level data from the state of Florida during the COVID-19 pandemic, and it is found that the most deterministic predictors are county population density …

Healthcare Innovation From The Inside Out: Leveraging The Human Capital System At Tan Tock Seng Hospital, Kenneth T. Goh, Richard Raymond Smith, Cher Heng Tan, David Dhevarajulu

Research Collection Lee Kong Chian School Of Business

The global pandemic has strained healthcare systems around the world, yet some providers have been able to adapt better and more swiftly than others. One such example is Singapore’s Tan Tock Seng Hospital (TTSH). When Covid-19 broke out, TTSH had to strike a balance between reducing business-as-usual (BAU) services and increasing outbreak-coping capacity. The latter meant that the hospital needed to build isolation rooms, and effectively ramp up its intensive care unit (ICU) capacity and capabilities to adapt to a rapidly evolving global pandemic. Furthermore, hospital management had to make an active push towards ensuring adequate supplies of personal protective …

Exploring The Impact Of Covid-19 On Aviation Industry: A Text Mining Approach, Gottipati Swapna, Kyong Jin Shim, Weiling Angeline Jiang, Sheng Wei Andre Justin Lee

Research Collection School Of Computing and Information Systems

Our study presents a comprehensive analysis of news articles from FlightGlobal website during the first half of 2020. Our analyses reveal useful insights on themes and trends concerning the aviation industry during the COVID-19 period. We applied text mining and NLP techniques to analyse the articles for extracting the aviation themes and article sentiments (positive and negative). Our results show that there is a variation in the sentiment trends for themes aligned with the real-world developments of the pandemic. The article sentiment analysis can offer industry players a quick sense of the nature of developments in the industry. Our article …

Twitter Reveals Human Mobility Dynamics During The Covid-19 Pandemic, Xiao Huang, Zhenlong Li, Yuqin Jiang, Xiaoming Li, Dwayne Porter

Geosciences Faculty Publications and Presentations

The current COVID-19 pandemic raises concerns worldwide, leading to serious health, economic, and social challenges. The rapid spread of the virus at a global scale highlights the need for a more harmonized, less privacy-concerning, easily accessible approach to monitoring the human mobility that has proven to be associated with viral transmission. In this study, we analyzed over 580 million tweets worldwide to see how global collaborative efforts in reducing human mobility are reflected from the user-generated information at the global, country, and U.S. state scale. Considering the multifaceted nature of mobility, we propose two types of distance: the single-day distance …

A One Health Framework To Estimate The Cost Of Antimicrobial Resistance, Chantal Morel, Richard Alm, Christine Årdal, Alessandra Bandera, Giacomo Bruno, Elena Carrara, Giorgio Colombo, Marlieke De Kraker, Sabiha Essack, Isabel Frost, Bruno Gonzalez-Zorn, Herman Goossens, Luca Guardabassi, Stephan Harbarth, Peter Jørgensen, Souha Kanj, Tomislav Kostyanev, Ramanan Laxminarayan, Finola Leonard, Gabriel Levy Hara, Marc Mendelson, Malgorzata Mikulska, Nico Mutters, Kevin Outterson, Jesus Rodriguez Baňo, Evelina Tacconelli, Luigia Scudeller

Faculty Scholarship

Objectives/purpose

The costs attributable to antimicrobial resistance (AMR) remain theoretical and largely unspecified. Current figures fail to capture the full health and economic burden caused by AMR across human, animal, and environmental health; historically many studies have considered only direct costs associated with human infection from a hospital perspective, primarily from high-income countries. The Global Antimicrobial Resistance Platform for ONE-Burden Estimates (GAP-ON€) network has developed a framework to help guide AMR costing exercises in any part of the world as a first step towards more comprehensive analyses for comparing AMR interventions at the local level as well as more harmonized …

A Noteworthy Case Report Of Neuroborreliosis In An Unvaccinated Pediatric Patient., Amber R Walker, Teresita Morales-Yurick

Neuroscience Articles

INTRODUCTION: Lyme disease typically presents with viral-like symptoms and a pathognomonic rash. With disease progression, symptoms of nervous system involvement usually include facial nerve palsy and meningitis, but other atypical neurologic manifestations have less commonly been documented.

CASE REPORT: A six-year-old male presented with prolonged fevers, rash, headache, and non-specific neurologic symptoms. The diagnosis of neuroborreliosis with meningitis and polyradiculitis was confirmed with laboratory evaluation and lumbar puncture.

CONCLUSION: Neuroborreliosis is a disseminated form of Lyme disease. While meningitis is a common sign, the presentation of polyradiculitis in children is rare and can lead to misdiagnosis and delay in treatment.

State: The Magazine Of Illinois State University, November 2020, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

Is World Malaria Day An Effective Awareness Campaign? An Evaluation Of Public Interest In Malaria During World Malaria Day, J. Michael Anderson, Aaron Stafford, Austin L. Johnson, Micah Hartwell, Samuel Jellison, Matt Vassar

Student Publications

Objective: We retrospectively analysed the relative search interest of malaria to (1) assess the relationship between Internet searches for malaria and rates of infection in 11 countries considered 'high burden' by WHO in 2019 and to (2) determine the ability of World Malaria Day on April 25 to generate interest in the disease.

Methods: Using Google Trends, we sought to determine the relative popularity of the topic of Malaria over 4 years (2015-2019). Worldwide and country-specific searches for 'malaria' were used to assess the influence the international awareness day has on global and local interest in malaria. In order to …

Characterization Of Glycan Determinants That Mediate Recognition Of The Major Wuchereria Bancrofti Circulating Antigen By Diagnostic Antibodies, Marla I Hertz, Amy Rush, Thomas B Nutman, Gary J Weil, Sasisekhar Bennuru, Philip J Budge

2020-Current year OA Pubs

The Global Program to Eliminate Lymphatic Filariasis (GPELF) relies heavily on a rapid diagnostic test (RDT) to a Wuchereria bancrofti circulating filarial antigen (Wb-CFA) to identify endemic areas and for determining when mass drug administration can stop. The antigen contains a carbohydrate epitope that is recognized by monoclonal antibody AD12. Og4C3, a monoclonal antibody that is used in a commercial ELISA for Wb-CFA recognizes the same moiety. Despite its diagnostic importance, little is known about the structure and function of this "AD12 epitope". It is also present on other W. bancrofti glycoproteins and on glycoproteins of other filarial worms, but …

Fatal Covid-19 Infection In A Patient With Long-Chain 3-Hydroxyacyl-Coa Dehydrogenase Deficiency: A Case Report, Parith Wongkittichote, James R Watson, Jennifer M Leonard, Elizabeth R Toolan, Patricia I Dickson, Dorothy K Grange

2020-Current year OA Pubs

Long-chain fatty-acyl CoA dehydrogenase deficiency (LCHADD) is an inborn error of long chain fatty acid oxidation with various features including hypoketotic hypoglycemia, recurrent rhabdomyolysis, pigmentary retinopathy, peripheral neuropathy, cardiomyopathy, and arrhythmias. Various stresses trigger metabolic decompensation. Coronavirus disease 2019 (COVID-19) is a pandemic caused by the RNA virus SARS-CoV-2 with diverse presentations ranging from respiratory symptoms to myocarditis. We report a case of a patient with LCHADD who initially presented with typical metabolic decompensation symptoms including nausea, vomiting, and rhabdomyolysis in addition to mild cough, and was found to have COVID-19. She developed acute respiratory failure and refractory hypotension from …

Stochastic Delay Differential Equations With Applications In Ecology And Epidemics, Hebatallah Jamil Alsakaji

Dissertations

Mathematical modeling with delay differential equations (DDEs) is widely used for analysis and predictions in various areas of life sciences, such as population dynamics, epidemiology, immunology, physiology, and neural networks. The memory or time-delays, in these models, are related to the duration of certain hidden processes like the stages of the life cycle, the time between infection of a cell and the production of new viruses, the duration of the infectious period, the immune period, and so on. In ordinary differential equations (ODEs), the unknown state and its derivatives are evaluated at the same time instant. In DDEs, however, the …

Modeling And Controlling Epidemic Outbreaks: The Role Of Population Size, Model Heterogeneity And Fast Response In The Case Of Measles, Kezban Yagci Sokat, Benjamin Armbruster

Faculty Research, Scholarly, and Creative Activity

Modelers typically use detailed simulation models and vary the fraction vaccinated to study outbreak control. However, there is currently no guidance for modelers on how much detail (i.e., heterogeneity) is necessary and how large a population to simulate. We provide theoretical and numerical guidance for those decisions and also analyze the benefit of a faster public health response through a stochastic simulation model in the case of measles in the United States. Theoretically, we prove that the outbreak size converges as the simulation population increases and that the outbreaks are slightly larger with a heterogeneous community structure. We find that …

Organizational Readiness Assessment In Acute And Long-Term Care Has Important Implications For Antibiotic Stewardship For Asymptomatic Bacteriuria, Melanie C Goebel, Barbara W Trautner, Yiqun Wang, John N Van, Laura M Dillon, Payal K Patel, Dimitri M Drekonja, Christopher J Graber, Bhavarth S Shukla, Paola Lichtenberger, Christian D Helfrich, Anne Sales, Larissa Grigoryan

Faculty, Staff and Students Publications

BACKGROUND: Prior to implementing an antibiotic stewardship intervention for asymptomatic bacteriuria (ASB), we assessed institutional barriers to change using the Organizational Readiness to Change Assessment.

METHODS: Surveys were self-administered on paper in inpatient medicine and long-term care units at 4 Veterans Affairs facilities. Participants included providers, nurses, and pharmacists. The survey included 7 subscales: evidence (perceived strength of evidence) and six context subscales (favorability of organizational context). Responses were scored on a 5-point Likert-type scale.

RESULTS: One hundred four surveys were completed (response rate = 69.3%). Overall, the evidence subscale had the highest score; the resources subscale (mean 2.8) was …

Donor And Transplant Candidate Selection For Solid Organ Transplantation During The Covid-19 Pandemic, N Thao N Galvan, Nicolas F Moreno, Jay E Garza, Susan Bourgeois, Marion Hemmersbach-Miller, Bhamidipati Murthy, Katherine Timmins, Christine A O'Mahony, James Anton, Andrew Civitello, Puneet Garcha, Gabe Loor, Kenneth Liao, Alexis Shaffi, John Vierling, Rise Stribling, Abbas Rana, John A Goss

Faculty, Staff and Students Publications

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus responsible for a worldwide pandemic has forced drastic changes in medical practice in an alarmingly short period of time. Caregivers must modify their strategies as well as optimize the utilization of resources to ensure public and patient safety. For organ transplantation, in particular, the loss of lifesaving organs for transplantation could lead to increased waitlist mortality. The priority is to select uninfected donors to transplant uninfected recipients while maintaining safety for health care systems in the backdrop of a virulent pandemic. We do not yet have a standard approach to evaluating …

Chronic Ulcers And Malnutrition In An African Patient\, Timothy G Singer, Monica A Bray, Audrey Chan, Saki Ikeda, Brittany Walters, Maren Y Fuller, Carla Falco

Faculty, Staff and Students Publications

An 11-year-old female with a congenitally malformed left hand, sickle-cell trait, asthma, and history of appendicitis was transferred from Zambia for evaluation and treatment of widespread suppurative and ulcerative skin lesions that typically appeared following trauma to her skin. The ulcers first presented 3 years earlier but had markedly worsened in the 9 months prior to transfer, spreading circumferentially on her extremities and abdomen at the site of an appendectomy. They were painful and did not resolve with multiple courses of intravenous (IV) antibiotics and close management by a Pediatric Infectious Disease specialist working for a non-governmental organization (NGO) in …

"Some Statistical Data On Urban Waste Collection In The City Of Prizren And Ways To Evaluate Them In Useful Products", Sami Gashi, Besa Veseli, Vehebi Sofiu

UBT International Conference

The development of society is related to the high consumption of a variety of food products, the use of electro-household appliances, furniture, and its furnishing, clothing, plastic materials, etc. The increase of urban waste is considered both from the social development and the increase of the population, for example, Prishtina 1,116,355 tons/year, Prizren 90,858 tons/year, Peja 41,748 tons/year, Mitrovica 64,663 tons/year. The increase in urban waste will affect our environment (soil, water, and air). Even though our city is endangered by their lack of treatment, their quantity is constantly increasing. We need to change the concept that waste is worthless. …

Investigational Anti Sars-Covid 19 Medication, Gazmend Temaj, Kumrije Sopi Xharra, Shefki Xharra, Angelika Moder, Jasmin Nurkovic, Hilada Hefic, Rifat Hadziselimovic

UBT International Conference

The newly identified severe acute respiratory syndrome coronavirus-2 (SARS-CoV- 2) that originated in December 2019 in Wuhan, China. By July 2020, the WHO reported over 17 million confirmed cases in over 200 countries around the globe. This review discusses how the COVID-19 pandemic may affect healthy people, structure and replication cycle of SARS- CoV-2; targets and therapeutics SARS- CoV-2 and anti-COVID drugs: strategies and perspectives.

Pharmacogenetics- Gene And Sars-Covid 19 Medication, Gazmend Temaj, Kumrije Sopi Xharra, Shefki Xharra, Angelika Moder, Jasmin Nurkovic, Hilada Hefic, Hilada Hefic, Rifat Hadziselimovic

UBT International Conference

An analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes collected from the patients worldwide has identified mutations in the virus that could aid in drug and vaccine development. The researchers found that the virus’s genetic diversity in most countries is similar to what it is globally, suggesting that it was introduced repeatedly by many infected people in each country rather than by a “patient zero.” The genetic analysis found 198 mutations that have occurred more than once. “Mutations in themselves are not a bad thing it is nothing to suggest SARS-CoV-2 is mutating faster or slower than expected. …

Attitudes Of Citizens Of The Republic Of Kosovo And The Identification Of Overcoming Mechanisms During The Covid-19-Coronavirus Period, Nausika Hoxha

UBT International Conference

The purpose of the research is to identify the overcoming mechanisms to citizens of Kosovo and how they feel during the quarantine. The research was conducted with quantitative design and 1053 participants, variated age 19-65, while the administration of the non- standardized questionnaire was online and consisted of 22 questions and 3 of them were opened questions. The analysis of the data was performed depending on the frequency obtained from the results of the online platform in a descriptive form, by which a questionnaire was administered where they present the percentages and graphs from the answers of the participants. The …

2020-10-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Use Of Penalized Regression Analysis To Identify County-Level Demographic And Socioeconomic Variables Predictive Of Increased Covid-19 Cumulative Case Rates In The State Of Georgia, Holly L. Richmond, Joana Tome, Haresh Rochani, Isaac Chun-Hai Fung, Gulzar H. Shah, Jessica S. Schwind

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Systemic inequity concerning the social determinants of health has been known to affect morbidity and mortality for decades. Significant attention has focused on the individual-level demographic and co-morbid factors associated with rates and mortality of COVID-19. However, less attention has been given to the county-level social determinants of health that are the main drivers of health inequities. To identify the degree to which social determinants of health predict COVID-19 cumulative case rates at the county-level in Georgia, we performed a sequential, cross-sectional ecologic analysis using a diverse set of socioeconomic and demographic variables. Lasso regression was used to identify variables …