Digital Commons Network^™

Time-To-Completed-Imaging, Survival And Function In Patients With Spinal Epidural Abscess: Description Of A Series Of 34 Patients, 2015–2018, Caroline King, Cameron Fisher, Patrick C.M. Brown, Kelsey C. Priest, Mary Tanski, Peter Sullivan

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction: Spinal epidural abscess (SEA) is a rare and life-threatening infection with increasing incidence over the past two decades. Delays in diagnosis can cause significant morbidity and mortality among patients.

Objective: The objective of this study was to describe trends in time-to-imaging and intervention, risk factors, and outcomes among patients presenting to the emergency department with SEA at a single academic medical center in Portland, Oregon.

Methods: This retrospective cohort study analyzed data from patients with new SEA diagnosis at a single hospital from October 1, 2015 to April 1, 2018. We describe averages to time-to-imaging and …

Hiv Care Continuum Characteristics Among People With Opioid Use Disorder And Hiv In Vietnam: Baseline Results From The Bravo Study, Caroline King, Le Minh Giang, Gavin Bart, Lynn Elizabeth Kunkel, P. Todd Korthuis

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background

Little is known about patient characteristics that contribute to initiating antiretroviral therapy (ART) and achieving viral suppression among HIV people with opioid use disorder in Vietnam. The primary objective of this analysis was to evaluate associations between participant characteristics and the critical steps in the HIV care continuum of ART initiation and HIV viral suppression among people with opioid use disorder and HIV in Vietnam.

Methods

We assessed baseline participant characteristics, ART status, and HIV viral suppression (HIV RNA PCR < 200 copies/mL) enrolled in a clinical trial of HIV clinic-based buprenorphine versus referral for methadone among people with opioid use disorder in Vietnam. We developed logistic regression models to identify characteristics associated with ART status and HIV viral suppression.

Results

Among 283 study participants, 191 (67.5%) were prescribed ART at baseline, and 168 of those on ART (90%) …

Analysis Of Covid-19 Transmission: Low Risk Of Presymptomatic Spread?, Mark K. Slifka, William B. Messer, Ian J. Amanna

OHSU-PSU School of Public Health Faculty Publications and Presentations

More than 6 million confirmed cases of COVID-19 (coronavirus disease 2019) have been identified worldwide and a number of case reports1-5 have indicated that COVID-19 has the potential to be transmitted prior to disease onset. Studies have also shown that infectious virus can be isolated from presymptomatic COVID-19 cases6 and although it is unknown what level of infectious virus is needed to confer efficient transmission potential, detection of infectious virus in the upper respiratory tract indicates that presymptomatic transmission of COVID-19 is plausible. Fear of asymptomatic and presymptomatic transmission of COVID-19 has led to considerable concern among public health policy …

Measuring Research Performance Of The Oldest Medical School Of Pakistan, Shakil Ahmad

Library Philosophy and Practice (e-journal)

This study evaluates the research performance of King Edward Medical University, the oldest school of medical education in Pakistan. Bibliometric indicators are used to assess the research output. A comparison is made with peer universities running under the same government to know King Edward Medical University’s research standing at provincial and country level. The study observes the citation patterns of research publications. The study revealed that researchers in KEMU collaborate with local and international institutes. The highest collaboration is seen with the researchers in Mayo Hospital, Lahore. International research collaboration spans over seventy countries. Trend of publishing in open access …

Covid-19 Research Output In 2020: The Global Perspective Using Scientometric Study, Surulinathi Muthuraj, R. Balasubramani, Amsaveni N

Library Philosophy and Practice (e-journal)

This study presents the global level perspective of COVID-19 research output from January to April 2020, and these analyses include global publication share, patterns of research communication channels, the most productive Sources, Authors and Institutions. Data were extracted from the Web of Science citation database using the search string of “Coronavirus” OR “COVID-19” and limited to 2020, a total of 1658 publications were retrieved, which have received 4804 citations and the overall H-index is 29. On the basis of literature analysis around the world, it is found that the 1658 publications came from 78 Countries. As expected China is the …

Micronutrient Supplementation In Relation To Hair Loss Syndrome In California Mule Deer, Max W. Marquez

Cal Poly Humboldt theses and projects

The Jawbone deer herd has been monitored on their wintering grounds since the 1950s and recently began decreasing over the last several years. The decline prompted an investigation into the reasons why. Coinciding with the population decline is the appearance of hair loss syndrome and two species of exotic lice. In order to evaluate the effects of hair loss syndrome and the influence of exotic lice infestation, 38 wild does from the herd were used in a modified-before-after-control-impact study. Does were treated with micronutrients selenium and copper via boluses in winter (December 2013-January 2014). Selenium treatment, at a dose of …

Do Blockchain Technologies Make Us Safer? Do Cryptocurrencies Necessarily Make Us Less Safe?, Sarah Jane Hughes

Articles by Maurer Faculty

This essay is based on a presentation made on January 24, 2020 at the invitation of the Texas Journal of International Law and the Strauss Center for National Security at the University of Texas. That presentation focused on the two questions mentioned in the title of this essay – Do Blockchain Technologies Make Us Safer? And Do Cryptocurrencies Necessarily Make Us Less Safe? The essay presents answers to the two questions: “yes” and “probably yes.” This essay begins with some level-setting on different types of blockchain technologies and of cryptocurrencies, and gives some background materials on global and national responses …

Prevalence Of Chronic Hepatitis B In Oro Province, Papua New Guinea, Alice Unah Lee, Luke Mair, Bob Kevin, Lily Gandi, Olive Tarumuri, Caroline Lee, Sue Huntley, David Carl Hilmers

Faculty, Staff and Students Publications

Chronic hepatitis B (CHB) affects over 250 million people worldwide. In Papua New Guinea, the prevalence of CHB has been estimated to be over 8%, and it is a leading cause of death. To address this problem, an alliance was formed between the government of Oro Province, a large private employer and an Australian nongovernmental organization, which established a CHB test and treatment programme. Between 2014 and 2019, rapid hepatitis B surface antigen testing was performed on 4068 individuals in Oro Province. The crude prevalence rate was 12.98% and was significantly higher in males (15.26%) than females (10.94%) (P < 0.001). The rate was 4.72% among children aged 10 years and under, 12.81% among women of childbearing age (19–35 years) and 18.48% among health-care workers. These results indicate that the rates of vaccination at birth and later among women of childbearing age and health-care workers must be improved to prevent transmission of CHB.

Leveraging Technology To Blend Large-Scale Epidemiologic Surveillance With Social And Behavioral Science Methods: Successes, Challenges, And Lessons Learned Implementing The Unite Longitudinal Cohort Study Of Hiv Risk Factors Among Sexual Minority Men In The United States, H. Jonathon Rendina, Ali J. Talan, Nicola F. Tavella, Jonathan Lopez Matos, Ruben H. Jimenez, S. Scott Jones, Brian Salfas, Drew Westmoreland

Publications and Research

The use of digital technologies to conduct large-scale research with limited interaction (i.e., no in-person contact) and objective endpoints (i.e., biological testing) has significant potential for the field of epidemiology, but limited research to date has been published on the successes and challenges of such approaches. We analyzed data from a cohort study of sexual minority men across the United States, collected using digital strategies during a 10-month period from 2017 to 2018. Overall, 113,874 individuals were screened, of whom 26,000 were invited to the study, 10,691 joined the study, and 7,957 completed all enrollment steps, including return of a …

High Tech, High Risk: Tech Ethics Lessons For The Covid-19 Pandemic Response, Emanuel Moss, Jacob Metcalf

Publications and Research

The COVID-19 pandemic has, in a matter of a few short months, drastically reshaped society around the world. Because of the growing perception of machine learning as a technology capable of addressing large problems at scale, machine learning applications have been seen as desirable interventions in mitigating the risks of the pandemic disease. However, machine learning, like many tools of technocratic governance, is deeply implicated in the social production and distribution of risk and the role of machine learning in the production of risk must be considered as engineers and other technologists develop tools for the current crisis. This paper …

Rapid Deployment Of A Statewide Covid-19 Echo Program For Frontline Clinicians: Early Results And Lessons Learned, Anna Louise Steeves-Reece, Nancy Elder, Tuesday A. Graham, Miriam L. Wolf, Isabel Stock, Melinda M. Davis, Robert D. Stock

OHSU-PSU School of Public Health Faculty Publications and Presentations

In a pattern repeated around the country, Oregon reported its first coronavirus patient on February 28, 2020.1 A week later, the governor declared a state of emergency.2 While the media initially focused on efforts to address COVID-19 in large cities, many rural communities were working in parallel to prepare. In these rural areas, there was an increasing concern that the burden of COVID-19 may be particularly dire due to factors such as older populations, higher prevalence of chronic diseases and poverty, and less health care access.3-6 Rural clinicians, especially those working in outpatient settings, are caring for patients during the …

Challenging Aggressive Behaviors Experienced By Personal Support Workers In Comparison To Home Care Workers: Relationships Between Caregiver Experiences And Psychological Health, Kelsey N. Womack, Teala W. Alvord, Caitlyn F. Trullinger-Dwyer, Sean P.M. Rice, Ryan Olson

OHSU-PSU School of Public Health Faculty Publications and Presentations

Personal support workers (PSW) are caregivers for children and adults with intellectual and developmental disabilities (IDDs) or adults experiencing mental illness or other behavioral health conditions. The work can be very meaningful, but many PSWs must prepare for, monitor, and manage challenging behaviors, including aggression. This study was designed to estimate the prevalence of aggression experienced by PSWs in Oregon, and compare it to a previous sample of Oregon home care workers (HCWs). This comparison included an analysis of relationships between exposures to aggression and psychological health factors. PSWs in Oregon (N = 240) were surveyed electronically at a single …

When Are Vaccine Mandates Appropriate?, Dorit R. Reiss, Carmel Shachar

Faculty Scholarship

Vaccine refusal is a serious public health problem, especially in the context of diseases with potential to spark global pandemics, such as Ebola virus disease in the Democratic Republic of the Congo. This article examines whether and when compelling vaccination through mandates and criminalization, for example, are appropriate. It argues that some legal approaches are ethical when they preserve social stability, trust in government, therapeutic research opportunities, or when they diminish disease severity.

The Cancer Curse: Regulatory Failure By Success, Robin C. Feldman

Faculty Scholarship

Since the turn of the millennium, a series of regulatory decisions—unrelated in time and design—has shifted the focus of the pharmaceutical industry toward cancer research and treatment. Regulation, of course, is designed to drive public and private behavior, but the sum of these regulatory actions is driving behavior well beyond governmental design. This phenomenon represents a peculiar form of regulatory failure that cannot be sufficiently explained without contemplating a new form of regulatory failure—failure by success.

As with any great epic tale, the modern saga is full of celebrities and drama, framed by truly heart-wrenching stories. However, with 89 percent …

The Covid-19 Vaccine Dilemma, Dorit R. Reiss

Faculty Scholarship

COVID-19 continues to lead to large numbers of deaths, harms, and financial costs. Without an effective vaccine, those will continue. The pressure to find a vaccine is high; and that pressure places a risk on the safeguards in place to assure that vaccines are safe and effective will be ignored. The United States has an extensive apparatus to oversee vaccine safety before and after licensing, including multiple federal committees and several monitoring systems, and that apparatus gave us, in 2020, an extraordinarily safe vaccine supply. This Article explains the different pressures that push for and against using the same apparatus …

Institutionalizing The Centers For Disease Control And Prevention's Independence, Dorit R. Reiss

Faculty Scholarship

The United States' response to the COVID-19 pandemic was sub­ optimal. One problem in it was the politicization of the public health response. One aspect of that politicization was aggressive political intervention in the Centers for Disease Control and Prevention ( CDC) efforts to provide guidance and help pandemic response. The concern was strong enough that four previous CDC Directors, in an unusual step, published an op-ed calling out political intervention in the CDC. This article proposes two changes to strengthen the CDC's institutional independence: codifying the CDC's role in preventing diseases and reducing harms in a statute, and restructuring …

Digging The Rabbit Hole, Covid-19 Edition: Anti-Vaccine Themes And The Discourse Around Covid-19, Tara C. Smith, Dorit R. Reiss

Faculty Scholarship

This article draws on a broadcast popular among the anti-vaccine community to map out six themes used by the broadcast to mislead viewers about COVID-19. The themes are the claim that “they” e government and pharma e are lying to you, claims that COVID-19 is an excuse to remove civil liberties, viewing everyone as an expert, claiming that science cannot save us, skewing the science, and a claim that “they” are out to harm the viewers. The article points out that similar themes are used to mislead followers with anti-vaccine information. It highlights the concern that these themes will not …

How Congress Can Help Raise Vaccine Rates, Dorit R. Reiss, Y. Tony Yang

Faculty Scholarship

2019 saw an unusually high number of measles cases, and other preventable disease outbreaks, at least in part linked to vaccines refusal. States are considering legislative responses. This Essay examines what role the federal government can fill in increasing vaccines rates. The Essay suggests that the federal government has an important role to fill in funding research, coordination, and local efforts. It also suggests that a federal school vaccine mandate is likely not the solution: first, such mandates can run into plausible constitutional challenges, and second, there are policy arguments against it. The policy contentions include the unfairness of imposing …

Providing Adolescents With Independent And Confidential Access To Childhood Vaccines: A Proposal To Lower The Age Of Consent, Lois A. Weithorn, Dorit R. Reiss

Faculty Scholarship

The recent rise in rates of nonvaccination and vaccine-preventable diseases and the attendant risks to the public’s health require that lawmakers consider new policy solutions. This Article proposes one such solution. We recommend creation of a limited exception to parental decisionmaking authority by permitting certain older minors to provide legally binding consent for childhood vaccinations and protecting the confidentiality of minors who request vaccination. We analogize this proposed policy to other statutory exceptions that permit certain minors independent access to services relating to contraception, pregnancy, sexually transmitted diseases, mental health and substance abuse, and sexual assault. In this interdisciplinary paper, …

The Zooming Of Federal Civil Litigation, Scott Dodson, Lee Rosenthal, Christopher Dodson

Faculty Scholarship

No abstract provided.

Aging And Efficacy Of Disease-Modifying Therapies In Multiple Sclerosis: A Meta-Analysis Of Clinical Trials, Yinan Zhang, Natalia Gonzalez Caldito, Afsaneh Shirani, Amber Salter, Gary Cutter, William Culpepper, Mitchell Wallin, Peter Kosa, Bibiana Bielekova, Fred Lublin, Olaf Stuve

2020-Current year OA Pubs

Background: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) are approved for the treatment of disease activity and are effective in reducing relapses and new magnetic resonance imaging (MRI) lesions. However, disease activity generally subsides with time, and age-dependent changes in DMT efficacy are not well-established. We aimed to investigate whether age impacts the efficacy of DMTs in treating disease activity in patients with relapsing-remitting MS (RRMS).

Methods: DMT efficacy related to age was assessed through a meta-analysis of clinical trials that evaluated the efficacy of DMTs in RRMS patients as measured by reductions in the annualized relapse rate (ARR), new …

Libraries And Sustainable National Development In Nigeria, Idogbe, Ibukunoluwa M., Philip, Kathryn J. Dept Edutech And Library Science

Library Philosophy and Practice (e-journal)

Nigeria has changed in diverse sectors such as education, politics, agriculture, health, technology and so forth in view of development and modernisation across these sectors. Consequently, the diverse structure of Nigerias federalism is discussed in terms of the various development plans put forward by successive governments. This paper particularly noted the various institutional and special libraries as contributing to these strides with a responsibility of developing a literate community of its patrons. Some of the roles that libraries play in the development of Nigeria have been buttressed through various writers relayed in this paper. The work concludes that there is …

Highly Cited Publications Of Selected Indian Institutes Of Technology (Iits): A Bibliometric Study, Shipra Awasthi, Shiva Kanaujia Sukula

Library Philosophy and Practice (e-journal)

The study highlights the highly cited publications published by selected five Indian Institutes of Technology (IITs) during the period 2010-2020. The IITs are the institutes of eminence and produced the quality scholarly output. They always occupy top positions in the ranking of institutions by different agencies. The data has been collected from the Essential Science Indiactor (ESI) which is a tool of Web of Science database. A total of 468 highly cited articles have been downloaded and analysed. The various parameters considered for the study are the year-wise distribution of articles, subject-wise distribution; the renowned journals published these articles, and …

Role Of Library Professionals In Satisfying User Needs During Pandemic Phase, Sumaira Baba, Sofi Gh.Mohiuddin Jeelani, Dr Shabir Ahmed Ganaie

Library Philosophy and Practice (e-journal)

Libraries are considered as treasures of knowledge providing access to huge variety of materials (books, journals, manuscripts, audio/visual etc.) with the help of institutions to which these (libraries) are associated. But, the preservation of such knowledge (material) is also of prime importance in order to make these resources (material) available for information seekers. In this whole process of collection, storage as well as dissemination of (knowledge), library professionals (librarians) has a great role to play. Which cannot be separated at any cost. Even at the time of pandemic, their (library professionals) role need to be very much vibrant to benefit …

Mapping And Visualization Of Indian Research Landscape On Coronavirus Disease 2019(Covid-19): A Bibliometric Study, Sidhartha Sahoo, Shriram Pandey, R. K. Mahapatra

Library Philosophy and Practice (e-journal)

Structure Abstract

Purpose

This work aimed at demonstrating India’s scientific contribution on Covid-19 research and analyzes the emerging research pattern using various bibliometric parameters.

Design/methodology/approach

Indian publications data on Covid-19 research were retrieved from SCOPUS database using structured query. VOSviewer & CiteSpace data visualization tools are used to generate citation, co-citation map and keyword clusters for better understanding of the research pattern. The leading institutions, most productive journal, prominent researchers are identified and analyzed further to reflect the collaborative nature.

Key Findings

Between January to September, 2020, a total of 3465 research documents were published pertaining to Covid-19. A larger …

Vaccines And Ip Preparedness In The Coronavirus Outbreak, Ana Santos Rutschman

All Faculty Scholarship

The COVID-19 pandemic has shed renewed light on the importance of research and development (R&D) on biopharmaceutical products needed to prevent or lessen the burden posed by outbreaks of infectious diseases. Among these, the need for new vaccines has become of paramount importance. While a race to develop different types of vaccines unfolds at unusual speed, there are still significant shortcomings in the ecosystem that leads to the production and dissemination of vaccines targeting infectious diseases like COVID-19.

The Mosaic Of Coronavirus Vaccine Development: Systemic Failures In Vaccine Innovation, Ana Santos Rutschman

All Faculty Scholarship

Scientists are racing to develop vaccines against the novel coronavirus. While some vaccine candidates may enter the market in record time, the current vaccine innovation ecosystem exposes governance lacunas at both the international and domestic levels.

The Problem With Relying On Profit-Driven Models To Produce Pandemic Drugs, Ana Santos Rutschman

All Faculty Scholarship

The longstanding problems of relying on a market response to a pandemic are becoming readily apparent in the United States, which has quickly become the epicenter of the COVID-19 outbreak. The problems are particularly pronounced in pharmaceutical markets, where we are pinning our hopes for both cures and vaccines. In previous work we have shown how characteristics of healthcare markets in the United States create a divergence between the private incentives of for-profit companies and public health needs, leading to sub-optimal health outcomes in what is a uniquely market-driven healthcare system. In this Essay, written as the COVID-19 pandemic unfolds, …

The Reemergence Of Vaccine Nationalism, Ana Santos Rutschman

All Faculty Scholarship

This short essay explores the reemergence of vaccine nationalism during the COVID-19 pandemic. The essay traces the pre-COVID origins of vaccine nationalism and explains how it can have detrimental effects on equitable access to newly developed vaccines.

Substance Use Disorder, Discrimination, And The Cares Act: Using Disability Law To Strengthen New Protections, Kelly K. Dineen, Elizabeth Pendo

All Faculty Scholarship

The COVID-19 pandemic is having devastating consequences for people with substance use disorders (SUD). SUD is a chronic health condition—like people with other chronic health conditions, people with SUD experience periods of remission and periods of exacerbation and relapse. Unlike people with most other chronic conditions, people with SUD who experience a relapse may face criminal charges and incarceration. They are chronically disadvantaged by pervasive social stigma, discrimination, and structural inequities. People with SUD are also at higher risk for both contracting the SARS-CoV-19 virus and experiencing poorer outcomes. Meanwhile, there are early indications that pandemic conditions have led to …