Digital Commons Network^™

Spleen Participation In Partial Mhc Class Ii Construct Neuroprotection In Stroke, John Brown, Chase Kingsbury, Jea-Young Lee, Arthur A. Vandenbark, Roberto Meza-Romero, Halina Offner, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Pathological progression of stroke in the peripheral and central nervous systems (PNS and CNS) is characterized by multiple converging signalling pathways that exacerbate neuroinflammation-mediated secondary cell death. This creates a need for a novel type of immunotherapy capable of simultaneously lowering the synergistic inflammatory responses in the PNS and CNS, specifically the spleen and brain. Previously, we demonstrated that partial major histocompatibility complex (MHC) class II constructs can be administered subcutaneously to promote histological and behavioural effects that alleviate common symptoms found in a murine model of transient stroke. This MHC class II manipulates T cell cytokine expression in both …

Growing A Healthy Future, Winter 2020-2021

Institute of Agriculture and Natural Resources: Institute Publications

Letter from IANR Vice Chancellor Mike Boehm; University of Nebraska-Lincoln doubles down on commitment to rural communities; Rural Fellows: making an impact on rural communities since 2013; The Rural Poll: giving a voice to rural Nebraskans for 25 years; Rural Poll: Nebraska communities show characteristics of resilience; Thriving index gives rural communities another tool to gauge economic success; CASNR, CEHS graduates bolstering rural Nebraska economies; Angler surveys lead to better understanding of why people fish, better amenities for anglers; Hops, hazelnuts, and hemp: producers, UNL researchers test new crops; Report: agriculture critical to Nebraska economy, state's resilience; Nebraska MEP drives …

State Of The University Annual Report - 2019-2020, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University

Office of the President State of the University Annual Report

No abstract provided.

Covid-19 Campus Update, September 18, 2020, Eastern Michigan University

COVID-19 Campus Updates

No abstract provided.

Bed Bug Management In Healthcare Environments, Josh Shoemaker

Department of Entomology: Distance Master of Science Projects

For my Master’s Project, I propose to develop bed bug training materials that can be used to offer education on bed bug biology and best practices for bed bug control in medical facilities. The materials will include a training program and handouts for use in educating management and technicians who are Pest Management Professionals (PMPs), as well as resources for those professionals to use to train facility personnel.

Background

Bed bugs began to make a comeback as a pest in the US in the late 1990s. Since then, these ectoparasitic insects have become a significant issue for many households and …

Covid-19 And Public Accommodations Under The Americans With Disabilities Act: Getting Americans Safely Back To Restaurants, Theaters, Gyms, And “Normal”, Frank Griffin M.D., J.D.

SLU Law Journal Online

THIS IS A PRELIMINARY EXPEDITED VERSION OF THE OFFICIAL ARTICLE TO BE ORIGINALLY PUBLISHED IN SAINT LOUIS UNIVERSITY LAW JOURNAL VOLUME 65 NUMBER 2

COVID-19 permanently changed the way places of public accommodation like restaurants, theaters, medical facilities, arenas, gyms, and many other proprietors of mainstream American activities must operate in order to accommodate people with newly-defined, COVID-19-related disabilities under Title III of the Americans with Disabilities Act (ADA). The required modifications will affect all patrons and employees of these establishments. Under the ADA, places of public accommodation are barred from discriminating against people with disabilities in the full and …

Interview With Deborah Winslow Of The National Science Foundation, Jerome W. Crowder, Mike Fortun, Rachel Besara, Lindsay Poirier

Statistical and Data Sciences: Faculty Books

Chapter Abstract:

In this chapter the editors interview Dr. Deborah Winslow about her work at the National Science Foundation (NSF) and the evolution of data management plans (DMPs) in Anthropology and the Social, Behavioral and Economic Sciences (SBE). She outlines what the NSF expects to see in a DMP and what not to include. The conversation moves into how anthropologists collaborate with “adjacent disciplines” and how the ideas and terms for data, and the expectations of data change. She emphasizes thinking about the kind of data you will collect and what you plan to do with those data later, in …

Immunotherapy: Therapy Vs. Enhancement, Mariah Daly

Honors Program Theses

The battle against cancer is a long-standing struggle that has resulted in new information and the development of novel medical technologies. Current research aims to figure out a way to reprogram cells and bodily mechanisms to eliminate those cells that are cancerous without destroying healthy cells in the process. Methods which use the body’s own mechanisms, such as immunotherapy, have shown and continue to show potential for specifically targeting cancer cells. Adoptive T cell therapy is one form of immunotherapy that has gained significant attention and focus in the field. Therapies improve conditions up to the normal state of being, …

Color-Changing Device To Improve Adherence To Foley Catheter Replacement Protocols And Reduce Urinary Tract Infection Frequency, Kurt Hill, Alexander Straus, Ms, Bryn Cross, Jason M. Fields, Md

Phase 1

Background: Foley catheter-associated UTI’s (CAUTI’s) represent a driving cause of cystitis, bacteremia and sepsis in the hospital setting. Accordingly, the CDC has identified prolonged indwelling time as the foremost risk factor for CAUTI’s. However, the fundamental design of the Foley has remained unchanged for over eighty years. Hospital-specific protocols do currently exist for the removal of infection-prone catheters; however, in practice it remains commonplace for catheters to be ignored, increasing the risk of life-threatening infection. Our design process addressed this by creating a color-changing alarm device that would alert providers when a catheter has been left in beyond protocol, is …

An Investigation Of Infectious Etiologies Of Sporadic Inclusion Body Myositis, Tyler Kennedy, Michele Meltzer, Md

Phase 1

Introduction: Sporadic inclusion body myositis (sIBM) is a rare, debilitating disease that can significantly lower one’s quality of life. Unfortunately, there are no current effective treatments, as the underlying causes are still unknown. We hypothesize that preceding infections do not cause sporadic inclusion body myositis.

Methods: The study investigated patients with a diagnosis of inclusion body myositis, with a concurrent or previously documented infection. Men represented a larger proportion of the population as they have an increased preponderance of those affected. The primary objective was to discern which infection, if any, could induce the inflammatory and degenerative changes in muscle …

Pulse@Um, Issue 1, 2020, Faculty Of Medicine University Of Malaya

Archival Material (2020s)

No abstract provided.

Milestone@Um, Volume 8, Number 3, 2020, Institute Of Research Management & Monitoring University Of Malaya

Archival Material (2020s)

No abstract provided.

Pulse@Um, Issue 2, 2020, Faculty Of Medicine University Of Malaya

Archival Material (2020s)

No abstract provided.

Pulse@Um, Issue 3, 2020, Faculty Of Medicine University Of Malaya

Archival Material (2020s)

No abstract provided.

Celest Newsletter, Issue 2, 2020, Faculty Of Law University Of Malaya

Archival Material (2020s)

No abstract provided.

Milestone@Um, Volume 8, Number 2, 2020, Institute Of Research Management & Monitoring University Of Malaya

Archival Material (2020s)

No abstract provided.

Milestone@Um, Volume 8, Number 1, 2020, Institute Of Research Management & Monitoring University Of Malaya

Archival Material (2020s)

No abstract provided.

Covid-19 And Farm Animals, Lewis Bollard

General – Farm Animal Issues

Impact on US Meat Consumption

COVID-19’s biggest impact on animals may be how it affects demand for their meat. In the US, panic buying drove fresh meat retail sales up 50-100% in late March. Even with restaurants buying less, Tyson Foods reported “unprecedented” demand, while poultry giant Sanderson Farms added extra shifts at its slaughterhouses. JP Morgan upgraded its recommendation for both companies to overweight, noting that demand may endure because meat is perishable. US wholesale egg prices hit an all-time high, at triple their level in early March. But supply disruptions may stop producers from filling this demand. Dairy …

Supporting Student Mental Health During And After Covid-19, David Bryant Naff, Shenita Williams, Jenna Furman, Melissa Lee

MERC Publications

This report by the Metropolitan Educational Research Consortium (MERC) in the VCU School of Education offers a rapid review of research about supporting student mental health as they return to school during COVID-19. It pulls from literature on natural disasters like hurricane Katrina, the psychological impacts of quarantine, and emergent research on the mental health impacts of the Coronavirus. The report is structured to answer three overarching questions: 1) Why is it important to address the mental health needs of students in schools? 2) How can we expect COVID-19 to impact the mental health of students? 3) What are some …

Aerosol And Surface Contamination Of Sars-Cov-2 Observed In Quarantine And Isolation Care, Joshua L. Santarpia, Danielle N. Rivera, Vicki L. Herrera, M. Jane Morwitzer, Hannah M. Creager, George W. Santarpia, Kevin K. Crown, David Brett-Major, Elizabeth R. Schnaubelt, M. Jana Broadhurst, James V. Lawler, St. Patrick Reid, John Lowe

Journal Articles: Epidemiology

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China in late 2019, and its resulting coronavirus disease, COVID-19, was declared a pandemic by the World Health Organization on March 11, 2020. The rapid global spread of COVID-19 represents perhaps the most significant public health emergency in a century. As the pandemic progressed, a continued paucity of evidence on routes of SARS-CoV-2 transmission has resulted in shifting infection prevention and control guidelines between classically-defined airborne and droplet precautions. During the initial isolation of 13 individuals with COVID-19 at the University of Nebraska Medical Center, we collected air …

Acute Encephalopathy With Elevated Csf Inflammatory Markers As The Initial Presentation Of Covid-19, Shelli Farhadian, Laura R. Glick, Chantal B. F. Vogels, Jared Thomas, Jennifer Chiarella, Arnau Casanovas-Massana, Jing Zhou, Camila Odio, Pavithra Vijayakumar, Bertie Geng, John Fournier, Santos Bermejo, Joseph R. Fauver, Tara Alpert, Anne L. Wyllie, Cynthia Turcotte, Matthew Steinle, Patrick Paczkowski, Charles Dela Cruz, Craig Wilen, Albert I. Ko, Sean Mackay, Nathan D. Grubaugh, Serena Spudich, Lydia Aoun Barakat

Journal Articles: Epidemiology

BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients.

CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.

CONCLUSION: Our findings …

Tell Me How It Ends: The Path To Nationalizing The U.S. Pharmaceutical Industry, Fran Quigley

University of Michigan Journal of Law Reform

The U.S. medicines system is broken. Millions of Americans suffer and some even die because they cannot afford medicines discovered by government-funded research. At the same time, corporations holding monopoly patent rights to those medicines collect some of the largest profits in modern capitalist history.

It does not have to be this way. The global legacy of treating essential medicines as a public good and the robust U.S. history of government seizure of private property for the public interest reveals a better path: the United States should nationalize its pharmaceutical industry.

U.S. statutory law already provides broad powers for the …

Single Nucleotide Polymorphism (Snps) Study On X-Chromosome In Thai Sle Populations, Krisana Jaiwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Systemic Lupus Erythematosus (SLE) is common autoimmune disease in Thailand which dominantly in females in ratio 9:1 of patients. Previous study has shown that the genetic components especially in X chromosome contributed a lot to the disease development. However, the susceptibility loci in Thai population have not been fully examined. Here, we conducted genome-wide association study (GWAS) on X chromosome using the data from two independent cohorts: primary dataset (controls = 1,683, SLE = 487) and secondary dataset (controls = 1,711, SLE = 455). Through meta-analyzing and imputation base on 1 KGP the two data set, SNP rs1059702 in IRAK1- …

Gardner-Webb, The Magazine 2020, Fall (Volume 55), Noel T. Manning

Gardner-Webb, The Magazine

Gardner-Webb, The Magazine, previously titled The Webb Magazine, focuses on alumni news and campus events from Gardner-Webb College; now Gardner-Webb University. This issue includes articles on the COIVD-19 pandemic, alumnus Clayton King's mission work in Africa, GWU students standing against racism, the installation of new football coach Tre Lamb, the Fay Webb Gardner Collection and O. Max Gardner Foundation, and the Brinkley gift of the GWU Marching Band uniforms.

Issue was awarded the Davey Award. The Davey is sanctioned and judged by the Academy of Interactive and Visual Arts.

Antimicrobial Resistance And Molecular Epidemiology Of Escherichia Coli Isolated From Urban And Rural River Systems, Christopher Robert Jossart

Public Health Theses

Antimicrobial resistance (AMR) is an emerging public health issue that threatens the efficacy of antibiotic treatment for bacterial infections and human health. Sources of antimicrobial resistance genes (ARGs) in the environment include wastewater treatment plants and animal feeding operations that discharge waste into waterways, such as rivers and streams. This retrospective descriptive study describes the presence of AMR, and specific ARGs in Escherichia coli isolates from two distinct watersheds, rural and urban, with the use of antimicrobial susceptibility testing, whole-genome sequencing (WGS) to detect ARGs, and multi-locus sequence typing. Antimicrobial susceptibility testing was performed for 143 E. coli isolates, 73 …

A Teenager With Fever, Chest Pain, And Respiratory Distress During The Coronavirus Disease 2019 Pandemic: A Lesson On Anchoring Bias, Michele N. Karn, Nicholas P. Johnson, Susan K. Yaeger, Kimberly L. Fugok

Internal Medicine Faculty Publications

Symptoms of coronavirus disease 2019 overlap with other important illnesses affecting young adults. We report a case of a 17-year old male presenting to the emergency department in the midst of a pandemic with symptoms of coronavirus disease 2019. He had fever, dyspnea, chest pain, and myalgias, with bilateral infiltrates on chest radiograph, and developed septic shock secondary to infectious thromboembolic events. However, his blood cultures grew group G streptococcus secondary to his oropharyngeal infection, and he experienced an infectious thrombus in the internal jugular vein, consistent with the rare but well-described Lemierre's syndrome. This case report calls attention to …

The Struggling Infectious Diseases Fellow: Remediation Challenges And Opportunities, Michael T. Melia, Armando Paez, Gail Reid, Lisa M. Chirch, Vera P. Luther, Brian G. Blackburn, Federico Perez, Emily Abdoler, Daniel R. Kaul, Susan Rehm, Nada Harik, Alice Barsoumian, Anna K. Person, Heather Yun, J. David Beckham, Susan Boruchoff, Paloma F. Cariello, James B. Cutrell, Christopher J. Graber, Dong Heun Lee, Eileen Maziarz, Molly L. Paras, Raymund R. Razonable, Roseanne Ressner, Anne Chen, Brian Chow, Gerome Escota, Erica Herc, Andrew Johnson, Ryan C. Maves, Obinna Nnedu, Heather Clauss, Prathit Kulkarni, Paul S. Pottinger, Jose A. Serpa, Tanaya Bhowmick, Marvin Bittner, Darcy Wooten, Beata Casanas, Rachel Shnekendorf, Emily A. Blumberg

Internal Medicine Faculty Publications

Remediation of struggling learners is a challenge faced by all educators. In recognition of this reality, and in light of contemporary challenges facing infectious diseases (ID) fellowship program directors, the Infectious Diseases Society of America Training Program Directors’ Committee focused the 2018 National Fellowship Program Directors’ Meeting at IDWeek on “Remediation of the Struggling Fellow.” Small group discussions addressed 7 core topics, including feedback and evaluations, performance management and remediation, knowledge deficits, fellow well-being, efficiency and time management, teaching skills, and career development. This manuscript synthesizes those discussions around a competency-based framework to provide program directors and other educators with …

An Evaluation Of Florida’S Zika Response Using The Who Health Systems Framework: Can We Apply These Lessons To Covid-19?, Jennifer Marshall, Blake Scott, Jennifer Delva, Cedrick Ade, Santiago Hernandez, Jaladhikumar Patel, Mantero Moreno-Cheek, Dogeli Rojas, Jean-Paul Tanner, Russell S. Kirby

All publications

Objectives: From 2016 to 2018 Florida documented 1471 cases of Zika virus, 299 of which were pregnant women (Florida Department of Health, https://www.floridahealth.gov/diseases-and-conditions/mosquito-bornediseases/surveillance.html , 2019a). Florida's response required unprecedented rapid and continuous cross-sector communication, adaptation, and coordination. Zika tested public health systems in new ways, particularly for maternal child health populations. The systems are now being challenged again, as the Coronavirus COVID-19 pandemic spreads throughout Florida. This qualitative journey mapping evaluation of Florida's response focused on care for pregnant women and families with infants exposed to Zika virus.

Methods: Fifteen focus groups and interviews were conducted with 33 public health …

Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar

HPD Articles

No abstract provided.

Flucytosine, Inderbir S. Padda, Mayur S. Parmar

HPD Articles

No abstract provided.