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Dean's Research Newsletter, May 2025, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Connectedness Between Music Tokens And Major Asset Classes: Implications For Hedging And Investments Strategies, Ritesh Patel, Muhammad Zubair Chishti, Sun-Yong Choi

American Business Review

This study examines the dynamic connectedness between four music tokens, that is, Audius, CEEK, ROCKI and Viberate and major asset classes, namely, equity, bond, crude oil, Gold, Bitcoin and USD. We used daily data from December 23, 2020, to August 30, 2024. We measure the connectedness using the quantile VAR method and the wavelet quantile correlation approach. The quantile VAR method reveals that assets play receiver and transmitter roles. However, the assets hold a weak relationship, indicating the opportunity for portfolio diversification. Further, the results of wavelet quantile correlation also discovered negative or no relationship among major assets, revealing the …

‭Prevalence Of Potentially Pathogenic Bacteria In Showers At A Long-Term Nursing Care Facility, Joseph Caleb Kulon

Honors Theses

Pathogenic bacteria on environmental surfaces in nursing homes may contribute to the‬ growing burden of healthcare-associated infections (HAIs), particularly as the U.S. population‬ ages and more individuals transition into long-term care. In this study, 70 swab samples were‬ collected from five community shower rooms at a nursing home over three sampling trips. Five‬ common shower surfaces were sampled: the floor drain, shower bench, faucet/valves, shower‬ curtain, and grab bars. Samples were processed in the UTC CIDC microbiology lab and‬ inoculated onto four selective and differential media: Hardy CHROM MRSA agar (for‬ methicillin-resistant‬‭ Staphylococcus aureus‬‭ [MRSA]‬‭ and‬‭ S. pseudintermedius‬‭ [SIM]), mannitol‬ …

Bacterial Contamination Of Wheelchairs In A Long-Term Rehabilitation Facility, Storm A. Welch

Honors Theses

The presence of bacterial contamination on wheelchair surfaces in long-term care facilities poses a significant risk to infection control and patient safety. This study aimed to assess the prevalence and diversity of bacterial species, including Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis (SE), Pseudomonas spp., and enteric bacteria on five key components of wheelchairs at a local long-term care facility. A total of 320 swabs were collected from wheelchair components, including handles for pushing, armrests, seats, wheel handles, and tires. Samples were analyzed using selective culture media, and bacterial species were identified based on colony morphology. The results …

Comparison Of Rt-Qpcr And Rt-Ddpcr On Assessing Model Virus In Wastewater, Wafa Youssfi

Graduate Theses and Dissertations

There is an increasing demand for quantifying viral loads in diverse wastewater systems using polymerase chain reaction (PCR). This study evaluates the performance of two commonly used workflows: reverse transcription quantitative PCR (RT-qPCR) and reverse transcription droplet digital PCR (RT-ddPCR) in wastewater. We compared the two methods by measuring the viral ribonucleic acid (RNA) of a model virus Phi6 in samples collected from various treatment stages at the Westside Wastewater Treatment Facility in Fayetteville, AR. RNA was extracted from real and synthetic wastewater samples and analyzed in parallel using both RT-qPCR and RT-ddPCR. Findings reveal that both methods demonstrated similar …

A Review Of Praziquantel Resistance In Schistosomes And The Future Of Schistosomiasis Control, Gabriela G. Eastham

Senior Honors Theses

Schistosomiasis is a group of both acute and chronic parasitic trematode infections of the genus Schistosoma. Praziquantel (PZQ) has been the drug of choice to treat schistosomiasis for decades. Though it is effective against all three clinically relevant species, heavy reliance on PZQ has led to concerns of schistosome resistance, especially in areas that have implemented this drug in mass drug administration (MDA) programs. Although there is currently insufficient evidence to conclude that schistosomes are becoming resistant to PZQ on a large scale, other control methods are a necessity to best treat and eliminate schistosomiasis. This article summarizes the …

Dirty Dianthus: A Review Of The Microbotryum-Dianthus Plant Pathogen System., Roxanne Kaaren Hayes

Electronic Theses and Dissertations

Microbotryum dianthorum is a species complex of smut fungi that act as biotrophic plant pathogens of Dianthus flowering plants. This group of pathogenic fungi are situated within a larger group of fungi that act as biotrophic plant pathogens, some of which are responsible for extensive crop loss in our agricultural system. These pathogens are distinct from other Microbotryum species in their ability to infect not only a single host, but multiple hosts. Their unique ability to parasitize several plant hosts may unlock potential clues about the potential for emergent infection disease in crop systems. Previous work has established that these …

Healthcare Access And Agency In Material Culture: A Specialized Analysis Of Pharmaceutical Artifacts From Louisville’S West End., Sara Marian (Deurell) Ignacio

Electronic Theses and Dissertations

The American Victorian Period of the 1870s to 1920s was a time of significant transitions in medicine. In Louisville, Kentucky, this period saw an influx of Black healthcare professionals and the founding of Louisville National Medical College, the state’s first medical school open to people of color. A number of these professionals lived and/or practiced in the Beecher Terrace study area, which was excavated between 2017 and 2020. Patent medicine brands and archival records were examined qualitatively in order to understand neighborhood and case study household health concerns and consumer choice. Statistical analyses of the medicine bottles recovered during the …

Sars-Cov-2 Modulates Pla2g2d/Pgd2 Signaling To Manipulate Host Immune Response To Increase Disease Severity., Dante L. Hamiel

Electronic Theses and Dissertations

Background: Previous studies suggested that SARS-CoV-2 infection could cause diverse immune and metabolic dysregulations, although the underlying mechanisms remain poorly understood. In addition, viruses may escape the immune response by modulating cellular metabolism, mitochondria, and protein functions indicating that immune or metabolic components may represent novel targets for anti-viral strategies. However, whether immune and metabolic disorders interact or affect each other waits to be determined. On the other hand, previous investigations identified the critical roles of a cell membrane-bound phospholipase PLA₂G2D and its downstream products PGD₂ in regulating the metabolism and inflammation in respiratory system. More importantly, …

D-Mannose Efficacy In Preventing Recurrent Urinary Tract Infections In Women, Miah Lee

Physician Assistant Scholarly Project Posters

• Evaluate the efficacy, safety, and mechanisms of D-mannose, a natural sugar, in preventing and treating UTIs. Evidence from various studies, including randomized controlled trials and pilot research, indicates that D-mannose may reduce UTI recurrence rates and alleviate acute symptoms with comparable efficacy to standard antibiotics. • Recurrent urinary tract infections (rUTIs) are a significant health concern for women, affecting their quality of life and requiring effective and safe prophylactic and therapeutic interventions. • Daily D-mannose demonstrated a significant reduction in recurrence rates for prophylaxis compared to placebo and nitrofurantoin, with fewer adverse effects. • In acute UTI management, D-mannose-based …

Fc Gamma Receptors Facilitate Antigenic Modulation Of Lilrb4 And Function As Predictive Biomarkers In Acute Monocytic Leukemia, Joshua Morse

Dissertations and Theses (Open Access)

Acute monocytic leukemia (monocytic AML) is a subtype of AML marked by a proliferation of abnormal monoblasts. This subtype represents approximately 10% of AML cases. The prognosis of monocytic AML is poor, with a 5-year survival of ~30%. Most patients are diagnosed at an age when they are unlikely to survive first-line non-targeted cytotoxic chemotherapy as a bridge to hematopoietic stem cell transplant (HSCT). Even patients who achieve remission commonly relapse. This population of patients would greatly benefit from precision-targeted therapies but currently there are none approved for monocytic AML.

Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an immune checkpoint expressed …

Expanding Inducible Epithelial Resistance Against Pneumonia: Novel Virus, Novel Receptor, Michael Longmire

Dissertations and Theses (Open Access)

Pneumonia is the leading infectious cause of death worldwide and presents a continuing risk among immunocompromised patients. Our work has been focused for many years on the phenomenon of inducible epithelial resistance, where activation of the innate immune response in the airway epithelium is necessary and sufficient to produce a pathogen-killing but self-protective environment to prevent severe disease. Inducible resistance is pathogen-agnostic and has been demonstrated against an array of respiratory infections. We achieve this using a combination of pattern recognition receptor agonists – Pam2CSK4 and ODN M362 being the current formulation – which produce synergistic levels of pathogen reduction …

Highly Pathogenic Avian Influenza Outbreak Preparedness In The United States: A Scoping Review, Emma J. Gurley

Honors Theses

In order to gauge preparedness for an outbreak of highly pathogenic avian influenza (H5N1) in the United States, a scoping review of the current literature was conducted. This process involved (1) identifying the research question, (2) identifying studies relevant to the topic, (3) selecting studies for inclusion (4) charting the data, and (5) analyzing and reporting the final data. Ultimately, seventeen studies were deemed appropriate for examination within this scoping review and several key themes were identified. The results emphasize the importance of adopting a One Health approach, the key role that vaccination may well play in preventing the spread …

The Effect Of Calorie Restriction On Humoral Responses Towards The Influenza Vaccine, Grayson Kobluk

Celebrating Scholarship and Creativity Day (2018-)

Calorie restriction (CR) - a reduction in caloric intake without malnutrition - has been widely studied for its impact on lifespan and the onset of age-related diseases. Emerging research indicates that CR also influences immune function, though its effects can vary depending on the degree of restriction, duration, and individual characteristics. This study examined how CR effects vaccine-specific antibody responses following influenza vaccination. Male and female mice were maintained on either a control diet or a calorie-restricted diet and vaccinated with an inactivated influenza virus vaccine. Antibody titers were measured 28 days post-vaccination to evaluate the magnitude of the humoral …

Alphamissense Predictions And Clinvar Annotations: A Deep Learning Approach To Uveal Melanoma, David J. Taylor Gonzalez, Mak B. Djulbegovic, Meghan Sharma, Michael Antonietti, Colin K. Kim, Vladimir N. Uversky, Carol L. Karp, Carol L. Shields, Matthew W. Wilson

Wills Eye Hospital Papers

OBJECTIVE: Uveal melanoma (UM) poses significant diagnostic and prognostic challenges due to its variable genetic landscape. We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM.

DESIGN: A cross-sectional bioinformatics exploratory data analysis of genetic mutations from UM cases.

SUBJECTS: Genetic data from patients diagnosed with UM were analyzed, explicitly focusing on missense mutations sourced from the Catalogue of Somatic Mutations in Cancer (COSMIC) database.

METHODS: We identified missense mutations frequently observed in UM using the COSMIC database, assessed their potential pathogenicity using AlphaMissense, and visualized mutations using AlphaFold. Clinical …

The Complete Message Is The Best Message: The Case For Standardizing Wireless Emergency Alerts, Jeannette Sutton, Micki Olson, Hugh Walpole, Lauren B. Cain, Nicholas Waugh, Michele M. Wood

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Standardized messaging for alerts and warnings has been made possible through the use of the Warning Lexicon and workflow. The effectiveness of this approach to motivate protective action behaviors, in comparison with the current standard of practice, has not yet been tested. Using an experimental design to test the effectiveness of the Warning Lexicon, we tested three message types for five hazards: blackouts, law enforcement incidents, infectious diseases, heavy snow, and chemical releases, and found that messages created using the Warning Lexicon contents and workflow produced better messaging outcomes than the current standard of practice. Specifically, participants who received the …

Pelvic Inflammatory Disease, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

A Multi-Tiered Approach To Improving Vaccination: Adjuvanticity, Alternate Routes Of Delivery, And Science Communication, Haley Agnes Bridgewater

Boise State University Theses and Dissertations

Vaccines have been used to prevent infectious disease for over 200 years. While they are an incredible way to prevent loss of life, they can be improved upon. Researchers around the globe are working to improve the immune response and ultimately the protection provided by existing and new vaccines. In this dissertation, I investigate three ways to improve vaccine immune responses: using an adjuvant, using a prime-boost intramammary delivery route in cows, and using microneedle delivery route. Cholera toxin (CT) is a bacterial toxin that has a non-toxic B subunit (CTB) used as a vaccine adjuvant. However, little is known …

Phosphatase Activity And Structure Of The Spoiie Protein In Clostridioides Difficile, Kathryn Wootten

Biological Sciences Undergraduate Honors Theses

Clostridioides difficile is a major cause of severe gastrointestinal infections and diseases, particularly in healthcare settings. Because of its ability to produce infectious endospores by sporulation, the protein SpoIIE, which is known to play a role in the regulation of this process, is being explored as a potential therapeutic target. In order to gain better insight into the structure and function of this protein, a concentrated and purified sample of the protein must be obtained. The goal of this study was to determine the conditions that would yield the highest amount of SpoIIE. The density of the cultures of bacteria …

The Impact Of Stigma On Individuals Affected By Leprosy: A Pilot Study, Mardo Tarr

Capstone Experience: Master of Public Health

Background: Leprosy, while a treatable condition, continues to be associated with significant stigma, which adversely influences the physical, psychological, social, and economic well-being of affected individuals throughout their lives. The stigma linked to leprosy leads to social exclusion, mental health difficulties, and obstacles to accessing healthcare and employment opportunities (Brakel et al., 2019; Sermrittirong & Van Brakel, 2014). This research employs Life Course Theory to describe the long-term experiences of stigma, coping strategies, and social support individuals living with leprosy. By synthesizing findings from existing literature and conducting a qualitative interview, the study offers an in-depth understanding of how various …

Restoring Trust In Public Health: An Analysis Of The Lasting Implications Of The Covid-19 Pandemic Response On Community Trust In Public Health In Nebraska, Kerri Dittrich

Capstone Experience: Master of Public Health

Background and Significance

Public trust is essential for effective public health efforts. In Nebraska, as in many regions, the pandemic response exposed strengths and vulnerabilities in the public health system. Misinformation, political discourse, inconsistent messaging, and poor communication contributed to growing mistrust, threatening the long-term success of public health programs and initiatives. While national trends have been studied, Nebraska-specific research remains limited.

Methods

An original descriptive survey was designed and administered to public health professionals in Nebraska to assess their perceptions of public trust in the local public health system before and after the COVID-19 pandemic. The survey also explored …

Severe Acute Malnutrtion Among Children Under Five In South Sudan, Rhoda Elia Iburu Kenyi

Capstone Experience: Master of Public Health

Severe acute malnutrition (SAM) is a life-threatening condition characterized by severe wasting. The World Health Organization defines SAM as a low weight-for-height Z-score (WHZ) less than -3 standard deviation (SD) from the median growth standard or the presence of edema of both feet and/or mid-upper arm circumference (MUAC) less than 115mm. SAM is a significant public health concern affecting children under five in developing countries, with South Sudan being one of the most severely affected regions. Persistent food insecurity, weak healthcare systems, and ongoing conflict contribute to the high SAM prevalence in the region, where political, religious, and social divisions, …

Active Shooter And Radiological Contamination Full-Scale Exercise, Elise M. Lowe

Capstone Experience: Master of Public Health

Planning and conducting exercises in rural settings highlights the unique features and challenges of emergency preparedness in rural America. Exercise designers must employ creative solutions to plan for player/controller contingencies, limited resources, and patient management across large geographical areas. This paper outlines the process by which a full-scale mass casualty exercise was conducted in a small Wyoming town. It analyzes some of the major problems encountered in rural exercise development and the solutions employed. The focus is on the success and failures of the exercise design based on direct observation/participation, hotwash forms, the after-action review, and direct feedback from participants. …

The Weaponization Of Medicine In Arkansas Prison Farms, 1960s-1970s, Grace E. Marr

History Undergraduate Honors Theses

The Arkansas State Penitentiary provides a case study for medical care in prisons during a transformational period. Isolation and state non-involvement in Arkansas allowed the creation of an independent culture in which harrowing abuses flourished. Medical providers could be prisoners themselves, operating the hospital and blood bank creating a complicated hierarchy. By examining medical provisions at the Cummins and Tucker Prison Farms during the 1960s to 1970s, this thesis reveals a system where the lines between treatment and torture and medical practitioner and imprisoned were blurred.

The Narrative Effects Of Cure On Representations Of Disability In The Medical Procedural And Body Horror Genres, Will Schuessler

FCRH Honors Program Theses

In disability studies, “cure” can refer both to literal cures and to the cultural belief that disabilities are problems with the body that can and should be solved through these medical interventions. In recent years, disability scholars have written about this topic of cure critically, but an academic media analysis approach to cure has yet to be taken, despite the prevalence of narratives where disabled characters are cured. This thesis explores how cure shapes disabled stories that are told through film and television, by viewing a sample of over 50 films and 70 episodes of television focused on disabled characters …

Genomic Diversity Of Salmonella Enterica Serotype Braenderup In New York State, Nicole Zac Soligno

Biological Sciences

The Gram-negative Salmonella enterica (family Enterobacteriaceae) is a common foodborne pathogen mainly isolated from foods of animal origin. Salmonella can be transmitted to humans, causing diverse symptoms, from self-limiting gastrointestinal diseases to more fatal typhoid fever. The young, elderly, and Individuals with weakened immune systems are especially at risk from salmonellosis. Salmonella is a concern to public health and the food industry throughout the world, and its severity depends largely on its serotype, a classification based on the unique combination of surface antigens. In this study, I aimed to elucidate the population structure and antimicrobial resistance determinants of S. enterica …

Serological Evaluation For Leptospirosis On Samples Received By The Connecticut Veterinary Medical Diagnostic Laboratory (Cvmdl), Hayden R. Samuels

Honors Scholar Theses

Leptospirosis is a globally distributed zoonotic disease caused by pathogenic species of Leptospira, motile spirochetes capable of infecting humans and animals. Transmission typically occurs through contact with water or soil contaminated by the urine of reservoirs or infected animals. Although leptospirosis is considered a neglected tropical disease, its geographic range is expanding due to climate change and urbanization. Surveillance remains limited in many regions, especially in the United States. This study aimed to assess the seroprevalence and serovar diversity of Leptospira exposure in a variety of domestic and wild animals submitted to the Connecticut Veterinary Medical Diagnostic Laboratory (CVMDL). …

Increasing Accessibility And Enhancing Value Of Two University Small Vertebrate Collections Through Digitization And Online Database Publication, Chloe Smotherman

Masters Theses and Doctoral Dissertations

Natural history collections (NHCs) are widely considered to be an exceptionally valuable resource and a critical foundation for research. Of the thousands of collections maintained today, the majority are considered small with a local or taxonomic focus. Collaboration among smaller NHCs through online publication contributes a largely underutilized resource for collections-based research. Past digitization efforts have resulted in the mobilization of collections data that enhance their preexisting value without significant additional costs. With this project I digitized and published the mammal collection (2,525 records) and, separately, the ornithology collection (403 records). Upon publication these records are the only mammal and …

Mathematical Model For Tripledemic Disease (Covid-19, Rsv, And Influenza), Foster Opoku

Masters Theses and Doctoral Dissertations

The concurrent circulation of COVID-19, Influenza (Flu), and Respiratory Syncytial Virus (RSV), collectively termed the ”Tripledemic,” poses substantial public health challenges due to their overlapping transmission patterns and compounded healthcare demands. The discovery of COVID-19 vaccines such as Moderna (mRNA-1273, Spikevax) and Johnson & Johnson’s, among other vaccines, has reduced COVID-19 cases but has not completely eradicated the disease. In the 2022-2023 season, the world witnessed a ”tripledemic” of Flu, COVID-19, and RSV. We propose Susceptible-Infectious-Recovered (SIR) and SusceptibleExposed-Infectious-Recovered (SEIR) mathematical models to estimate transmission rates, compute the basic reproduction number, forecast infections, and analyze seasonal variations and comparative transmission …

Implementing And Evaluating An Ai-Powered Visual Decision Support System To Improve Antibiotic Usage Among Physicians With A Built-In Early Warning System, Akua Sekyiwaa Osei-Nkwantabisa

Theses and Dissertations

The widespread misuse and excessive prescription of antibiotics have played a pivotal role in the emergence and proliferation of antibiotic-resistant bacteria, posing a critical global public health crisis. Addressing this challenge necessitates innovative solutions that enhance antimicrobial stewardship. This study presents the development and implementation of a visual decision support system designed to monitor and optimize antibiotic usage among healthcare providers. The proposed system integrates advanced machine learning algorithms with real-time data analytics to provide a dynamic, evidence-based decision support tool. Specifically, a neural network model was developed after evaluating multiple machine learning approaches, including Random Forest, Logistic Regression and …