Digital Commons Network^™

Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors

Journal Articles

Copyright © 2020 American Society for Microbiology. All Rights Reserved. From 2015 to 2017, 11 confirmed brucellosis cases were reported in New York City, leading to 10 Brucella exposure risk events (Brucella events) in 7 clinical laboratories (CLs). Most patients had traveled to countries where brucellosis is endemic and presented with histories and findings consistent with brucellosis. CLs were not notified that specimens might yield a hazardous organism, as the clinicians did not consider brucellosis until they were notified that bacteremia with Brucella was suspected. In 3 Brucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might …

Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors

Journal Articles

© 2019 The Authors Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls …

Treating Covid-19 Positive Cancer Patients With Radiation Therapy: A Case Report From Epicenter Of The Pandemic., B. Parashar, L. Lee, C. Madu, A. Narayana, L. Potters

Journal Articles

The coronavirus disease 2019 (SARS-Cov-2 or COVID-19) pandemic has resulted in unprecedented clinical challenges across the globe. Outcomes of patients with this infection are likely dependent on underlying comorbidities that predict worse outcome in older patients. However, it is unknown whether COVID-19 infected cancer patients receiving radiation therapy (RT) have any different outcome than non-infected patients. We present the first series from our center of COVID-19 infected patients who received RT for malignancy, their outcome, and toxicities.

Covid-19 Induced Myocarditis: A Rare Cause Of Heart Failure., Q. Z. Iqbal, M. A. Haider, S. B. A. Sattar, M. Hanif, I. Javid

Journal Articles

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing lung injury has been well documented in the literature recently. They do so primarily by binding to the membrane-bound form of angiotensin-converting enzyme 2 (ACE-2) receptors. However, since these receptors are also expressed in the heart and blood vessels, coronavirus can also cause damage to these organs by binding to the ACE-2 receptors. A typical case of coronavirus disease 2019 (COVID-19) usually presents with respiratory symptoms like cough and shortness of breath accompanied by fever. The literature regarding this pandemic has been growing and now we know very well that the effect …

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, H. Rhythm, +14 Additional Authors

Journal Articles

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), started in the city of Wuhan late in 2019. Within a few months, the disease spread toward all parts of the world and was declared a pandemic on March 11, 2020. The current health care dilemma worldwide is how to sustain the capacity for quality services not only for those suffering from COVID-19 but also for non-COVID-19 patients, all while protecting physicians, nurses, and other allied health care workers.

Cytokine Storm Of A Different Flavor: The Different Cytokine Signature Of Sars-Cov2 The Cause Of Covid-19 From The Original Sars Outbreak., D. O. Griffin, A. Jensen, M. Khan, J. Chin, K. Chin, J. Saad, R. Parnell, C. Awwad, D. Patel

Journal Articles

We present a case series of three patients with COVID-19 who had a cytokine panel which revealed elevation of interleukin-6 (IL-6), but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8) in contrast to the cytokine signature described in Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS). We also documented evidence of a compromised T-cell IFN-gamma response in two of these patients.

Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin

Journal Articles

© Copyright © 2020 Kwak, Kim, Lee, Kim, Son and Shin. Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-dependent secretion pathway; however, some proteins, including a few danger-associated molecular patterns (DAMPs), are secreted via non-classical ER/Golgi-independent secretion pathways. The evolutionarily conserved high mobility group box1 (HMGB1) is a ubiquitous nuclear protein that can be released by almost all cell types. HMGB1 lacks signal peptide and utilizes diverse non-canonical secretion mechanisms for its extracellular export. Although the post-translational modifications of HMGB1 were demonstrated, the oxidation of HMGB1 and secretion mechanisms are not highlighted yet. We currently investigated that …

Chagas Disease In The New York City Metropolitan Area., C. Zheng, O. Quintero, E. K. Revere, M. B. Oey, F. Espinoza, Y. A. Puius, D. Ramirez-Baron, C. R. Salama, L. F. Hidalgo, H. B. Tanowitz, +5 Additional Authors

Journal Articles

Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chagas disease among the medical community in the United States is poor. Methods:We review our experience managing 60 patients with Chagas disease in hospitals throughout the New York City metropolitan area and describe screening, clinical manifestations, EKG findings, imaging, and treatment. Results:The most common country of origin of our patients was El Salvador (n …

Tumor-Associated Macrophages And Macrophage-Related Immune Checkpoint Expression In Sarcomas, A. R. Dancsok, D. Gao, A. F. Lee, S. E. Steigen, J. Blay, D. M. Thomas, R. G. Maki, T. O. Nielsen, E. G. Demicco

Journal Articles

No abstract provided.

A Role For Ct In Covid-19? What Data Really Tell Us So Far, Md Hope, Ca Raptis, A Shah, Mm Hammer, Ts Henry

Journal Articles

No abstract provided.

Teaching Professional Formation In Response To The Covid-19 Pandemic., L. B. Mccullough, J. Coverdale, F. A. Chervenak

Journal Articles

In response to the COVID-19 pandemic, the Association of American Medical Colleges has called for a temporary suspension of clinical teaching activities for medical students. Planning for the continued involvement of learners in patient care during this pandemic should include teaching learners professional formation. The authors provide an ethical framework to guide such teaching, based on the ethical principle of beneficence and the professional virtues of courage and self-sacrifice from professional ethics in medicine. The authors show that these concepts support the conclusion that learners are ethically obligated to accept reasonable, but not unreasonable, risk. Based on this ethical framework, …

Seizure And Covid-19: Association And Review Of Potential Mechanism., R. Joseph, N. Narula, A. Daouk, N. Katyal, S. Acharya, A. Avula, R. Maroun

Journal Articles

Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Though respiratory complication is the primarily reported manifestation though rare, yet serious neurological complications are being frequently reported in the literature. In selected coronavirus disease-2019 (COVID-19) cases neurologic complications may manifest as seizures. In this paper, we have reviewed current literature on seizures linked with SARS- COV 2 infection including published or pre-print original articles, review articles, and case reports. We have discussed the electroencephalogram (EEG), imaging, and Cerebrospinal fluid (CSF) findings in COVID-19 patients …

Diabetes Is Associated With Increased Risk For In-Hospital Mortality In Patients With Covid-19: A Systematic Review And Meta-Analysis Comprising 18,506 Patients, L. Palaiodimos, N. Chamorro-Pareja, D. Karamanis, W. Li, P. D. Zavras, K. M. Chang, P. Mathias, D. G. Kokkinidis

Journal Articles

© 2020, Hellenic Endocrine Society. Purpose: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. The aim of this study was to systematically review and conduct a meta-analysis of the available observational studies reporting the effect of diabetes on mortality among hospitalized patients with COVID-19. Methods: The Medline, Embase, Google Scholar, and medRxiv databases were reviewed for identification of eligible studies. A random effects model meta-analysis was used, and I2 was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: A total …

Nebulized In-Line Endotracheal Dornase Alfa And Albuterol Administered To Mechanically Ventilated Covid-19 Patients: A Case Series., A. G. Weber, A. S. Chau, M. Egeblad, B. J. Barnes, T. Janowitz

Journal Articles

Background Mechanically ventilated patients with coronavirus disease 2019 (COVID-19) have a mortality of 24-53%, in part due to distal mucopurulent secretions interfering with ventilation. Dornase alfa is recombinant human DNase 1 and digests DNA in mucoid sputum. Nebulized dornase alfa is FDA-approved for cystic fibrosis treatment. DNA from neutrophil extracellular traps (NETs) contributes to the viscosity of mucopurulent secretions. NETs are found in the serum of patients with severe COVID-19, and targeting NETs reduces mortality in animal models of acute respiratory distress syndrome (ARDS). Thus, dornase alfa may be beneficial to patients with severe COVID-19, acting as a mucolytic and …

Behavioral Changes Without Respiratory Symptoms As A Presenting Sign Of Covid-19 Encephalitis., T. Rebeiz, K. Lim-Hing, S. Khazanehdari, K. Rebeiz

Journal Articles

The clinical presentation, diagnosis, and treatment of coronavirus disease 2019 (COVID-19) encephalitis are still being characterized. Few case reports describing COVID-19 encephalitis are available in the literature. We present a case of COVID-19 encephalitis who presented with behavioral disturbances without respiratory symptoms.

Coronavirus Disease 2019 (Covid-19) Presenting As Purulent Fulminant Myopericarditis And Cardiac Tamponade: A Case Report And Literature Review., A Khatri, F Wallach

Journal Articles

No abstract provided.

Covid-19 In Recent Heart Transplant Recipients: Clinicopathologic Features And Early Outcomes, B. Lima, G. Gibson, S Vullaganti, K. Malhame, S Maybaum, St Hussain, S Shah, Dt Majure, F Wallach, K Jang, V Bijol, Mj Esposito, Ak Williamson, Rm Thomas, Ta Bhuiya, Ha Fernandez, Gr Stevens

Journal Articles

No abstract provided.

Development And Execution Of A Pandemic Preparedness Plan: Therapeutic Medical Physics And Radiation Dosimetry During The Covid-19 Crisis, Ac Riegel, H Chou, J Baker, J Antone, L Potters, Y Cao

Journal Articles

No abstract provided.

3d Printed Alternative To The Standard Synthetic Flocked Nasopharyngeal Swabs Used For Covid-19 Testing., S. J. Decker, T. A. Goldstein, J. M. Ford, M. N. Teng, R. S. Pugliese, G. J. Berry, O. Bloom, D. A. Breining, J. Crawford, K. Kim, +12 Additional Authors

Journal Articles

BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, can be detected in respiratory samples by Real-time Reverse Transcriptase (RT)-PCR or other molecular methods. Accessibility of diagnostic testing for COVID-19 has been limited by intermittent shortages of supplies required for testing, including flocked nasopharyngeal (FLNP) swabs. METHODS:We developed a 3D-printed nasopharyngeal (3DP) swab as a replacement of the FLNP swab. The performance of 3DP and FLNP swabs were compared in a clinical trial of symptomatic patients at three clinical sites (n=291) using three SARS-CoV-2 EUA tests: a modified version of the CDC Real-time Reverse Transcriptase (RT)-PCR Diagnostic …

Cerebellar Infarction Requiring Surgical Decompression In Patient With Covid 19 Pathological Analysis And Brief Review, H. N. Patel, A. Syed, J. S. Lobel, R. Galler, J. Georges, M. Carmody, M. Puumala

Journal Articles

© 2020 The Authors Background: This report and literature review describes a case of a COVID-19 patient who suffered a cerebellar stroke requiring neurosurgical decompression. This is the first reported case of a sub-occipital craniectomy with brain biopsy in a COVID-19 patient showing leptomeningeal venous intimal inflammation. Clinical description: The patient is a 48-year-old SARS-COV-2 positive male with multiple comorbidities, who presented with fevers and respiratory symptoms, and imaging consistent with multifocal pneumonia. On day 5 of admission, the patient had sudden change in mental status, increased C-Reactive Protein, ferritin and elevated Interleukin-6 levels. Head CT showed cerebral infarction from …

Challenges In Abdominal Organ Transplantation During The Covid-19 Pandemic, S. M. Esagian, I. A. Ziogas, D. Giannis, M. H. Hayat, N. Elias, G. Tsoulfas

Journal Articles

© Copyright © 2020 Esagian, Ziogas, Giannis, Hayat, Elias and Tsoulfas. As the coronavirus disease 2019 (COVID-19) outbreak has rapidly evolved into a global pandemic, abdominal organ transplantation programs are currently facing multiple challenges. Transplant candidates and recipients are considered high-risk populations for severe disease and death due to COVID-19 as a result of their numerous underlying comorbidities, advanced age and impaired immune function. Emerging reports of atypical and delayed clinical presentations in these patients generate further concerns for widespread disease transmission to medical personnel and the community. The striking similarities between COVID-19 and other outbreaks that took place over …

Fetal Interventions In The Setting Of The Coronavirus Disease 2019 Pandemic: Statement From The North American Fetal Therapy Network, Mo Bahtiyar, A Baschat, J Deprest, S Emery, Wh Goodnight, A Johnson, L Mccullough, Js Moldenhauer, G Ryan, M Zaretsky, +3 Additional Authors

Journal Articles

No abstract provided.

Immunotherapies For Covid-19: Lessons Learned From Sepsis, Ke Remy, Sc Brakenridge, B Francois, T Daix, Cs Deutschman, G Monneret, R Jeannet, Pf Laterre, Rs Hotchkiss, Ll Moldawer

Journal Articles

No abstract provided.

Neutrophil Extracellular Traps In Covid-19., Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo, Ja Madison, C Blair, A Weber, Bj Barnes, M Egeblad, Rj Woods, Y Kanthi, Js Knight

Journal Articles

No abstract provided.

Scientific And Standardization Committee Communication: Clinical Guidance On The Diagnosis, Prevention And Treatment Of Venous Thromboembolism In Hospitalized Patients With Covid-19., Ac Spyropoulos, Jh Levy, W Ageno, Jm Connors, Bj Hunt, T Iba, M Levi, Cm Samama, D Giannis, Jd Douketis, +1 Additional Author

Journal Articles

No abstract provided.

Cerebral Venous Thrombosis: A Typical Presentation Of Covid-19 In The Young, De Klein, R Libman, C Kirsch, R Arora

Journal Articles

No abstract provided.

Treatment Of Clostridioides Difficile With Fecal Microbiota Transplantation, Brenton Green

Physician Assistant Scholarly Project Posters

Research was performed to discuss the epidemiology and current guidelines of Clostridioides difficile infection (CDI), recurrent C. difficile infection (rCDI), the different modalities of fecal microbiota transplantation (FMT), the donor screening process, as well as the safety and efficacy of treatment.

• Utilizing Clinical Key, NCBI database, Dynamed Plus, Cochrane Review, and the websites for the CDC and FDA, a literature review encompassing recent research and human studies relating to CDI.

• Recent studies within five years were preferred, however since C. difficile has sparsely changed, older data was utilized with updates applied accordingly.

• Oral antibiotics are intended for …

Structural Insight Into The Mechanism Of N-Linked Glycosylation By Oligosaccharyltransferase, Smita Mohanty, Bharat P. Chaudhary, David Zoetewey

Faculty and Staff Works

Asparagine-linked glycosylation, also known as N-linked glycosylation is an essential and highly conserved post-translational protein modification that occurs in all three domains of life. This modification is essential for specific molecular recognition, protein folding, sorting in the endoplasmic reticulum, cell–cell communication, and stability. Defects in N-linked glycosylation results in a class of inherited diseases known as congenital disorders of glycosylation (CDG). N-linked glycosylation occurs in the endoplasmic reticulum (ER) lumen by a membrane associated enzyme complex called the oligosaccharyltransferase (OST). In the central step of this reaction, an oligosaccharide group is transferred from a lipid-linked dolichol pyrophosphate donor to the …

An Evaluation Of The Usda's Policy To Reduce Listeria Illnesses In Ready‐To‐Eat Meat And Poultry Products, Travis Minor, Matt Parrett

United States Food and Drug Administration: Publications

Using 1998–2008 data collected by the Centers for Disease Control and Prevention on foodborne illnesses and outbreaks, we examine the economic impact of the United States Department of Agriculture's proposed and final rules to reduce the incidence of Listeria monocytogenes (Lm) in ready‐to‐ eat meat and poultry products. Using a difference‐in‐ differences approach, we find that these rules together reduced meat‐related Lm illnesses by about 60 per year, which we attribute to reductions in both the number and average size of meat‐related Lm outbreaks. We then monetize this illness reduction using an underreporting and underdiagnosis multiplier of 2.3 and an …

Perivascular Macrophages In The Neonatal Macaque Brain Undergo Massive Necroptosis After Simian Immunodeficiency Virus Infection, Diana G. Bohannon, Yueying Wang, Colin H. Reinhart, Julian B. Hattler, Jiangtao Luo, Hamid R. Okhravi, Jianshui Zhang, Qingsheng Li, Marcelo J. Kuroda, Woong-Ki Kim

Nebraska Center for Virology: Faculty Publications

We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in myeloid cell populations that are the known target of SIV and HIV in the brain contribute to the lack of neonatal susceptibility to lentivirus-induced encephalitis. Using immunohistochemistry and immunofluorescence microscopy, we examined the frontal cortices from uninfected and SIV-infected infant and adult macaques (n = 8/ea) as well as adults with SIVE (n = 4) to determine differences in myeloid …