Digital Commons Network^™

Not A Magic Pill: An Educational Model On Antibiotic Prescribing, Christina Rose Leonard

Nursing Capstones

Background: Inappropriate antibiotic prescribing is common in outpatient settings across the United States. The Centers for Disease Control and Prevention has found in studies that nearly 1 in 3 antibiotics prescribed at outpatient facilities is unnecessary. The misuse and overuse of antibiotics is accelerating the process of antibiotic resistance, as well as causing an increase in adverse events, including death. The literature indicates that knowledge plays a major factor in overprescribing, as well as provider attitude and patient expectations.

Objective: Present clinical practice guidelines to providers within a rural family practice clinic setting aimed at improving antibiotic prescribing. Gather information …

On The Robustness Of Cascade Diffusion Under Node Attacks, Alvis Logins, Yuchen Li, Panagiotis Karras

Research Collection School Of Computing and Information Systems

How can we assess a network's ability to maintain its functionality under attacks? Network robustness has been studied extensively in the case of deterministic networks. However, applications such as online information diffusion and the behavior of networked public raise a question of robustness in probabilistic networks. We propose three novel robustness measures for networks hosting a diffusion under the Independent Cascade (IC) model, susceptible to node attacks. The outcome of such a process depends on the selection of its initiators, or seeds, by the seeder, as well as on two factors outside the seeder's discretion: the attack strategy and the …

Optimal Control Of An Epidemic Through Social Distancing, Thomas Kruse, Philipp Strack

Cowles Foundation Discussion Papers

We analyze how to optimally engage in social distancing (SD) in order to minimize the spread of an infectious disease. We identify conditions under which the optimal policy is single-peaked, i.e., first engages in increasingly more social distancing and subsequently decreases its intensity. We show that the optimal policy might delay measures that decrease the transmission rate substantially to create “herd-immunity” and that engaging in social distancing sub-optimally early can increase the number of fatalities. Finally, we find that optimal social distancing can be an effective measure in substantially reducing the death rate of a disease.

Talking Trash In The Big Apple: Mitigating Bird Strikes Near The North Shore Marine Transfer Station, Stephan J. Beffre, Brian E. Washburn

United States Department of Agriculture Wildlife Services: Staff Publications

Anthropogenic activities that concentrate wildlife near airports increases the risk of wildlife–aircraft collisions. Placing waste management facilities, natural areas, golf courses, and other landscape features near airports have the potential to attract wildlife hazardous to aviation. We conducted a 3-year study (March 2013–February 2016) to determine if the implementation of a Wildlife Hazard Mitigation Program (WHMP) would influence the bird use of a waste transfer station located near LaGuardia Airport, New York City, New York, USA. We conducted wildlife surveys during 3 phases: (1) no mitigation program and no waste transfer station, (2) active mitigation and no waste transfer station, …

Community-Acquired Bacterial Pneumonia In Adults: An Update, Vandana Kalwaje Eshwara, Chiranjay Mukhopadhyay, Jordi Rello

Open Access archive

Community-acquired pneumonia (CAP) is the prominent cause of mortality and morbidity with important clinical impact across the globe. India accounts for 23 per cent of global pneumonia burden with case fatality rates between 14 and 30 per cent, and Streptococcus pneumoniae is considered a major bacterial aetiology. Emerging pathogens like Burkholderia pseudomallei is increasingly recognized as an important cause of CAP in Southeast Asian countries. Initial management in the primary care depends on clinical assessment while the hospitalized patients require combinations of clinical scores, chest radiography and various microbiological and biomarker assays. This comprehensive diagnostic approach together with additional sampling …

Granuloma In Marrow With Lurking 'Leuk': Two Happenstances, Saraswathy Sreeram, Sridevi Basavaiah, Nirupama Murali, Prashantha Balanthimogru

Open Access archive

Granulomas are described very rarely in marrow biopsies. They have hardly been reported in association with acute lymphoblastic leukemia. We herein report two cases of ALL associated with granulomas each at different stage of their clinical course that led to a diagnostic and therapeutic dilemma. First case was of a 42-year-old woman diagnosed with tuberculosis who presented with bleeding gums during anti-tubercular therapy. In the second scenario, a 51-year-old man presented with pyrexia of unknown origin and splenomegaly who was put on a trial of ATT. Peripheral smear showed only 1-2% abnormal cells, however, bone marrow aspiration and flow cytometry …

Potency And Breadth Of Human Primary Zikv Immune Sera Shows That Zika Viruses Cluster Antigenically As A Single Serotype, Chad M. Nix, Jonathan Salberg, Felicity J. Coulter, Bettie W. Kareko, Zoe L. Lyski, Brian L. Booty, William B. Messer

OHSU-PSU School of Public Health Faculty Publications and Presentations

The recent emergence of Zika virus as an important human pathogen has raised questions about the durability and breadth of Zika virus immunity following natural infection in humans. While global epidemic patterns suggest that Zika infection elicits a protective immune response that is likely to offer long-term protection against repeat infection by other Zika viruses, only one study to date has formally examined the ability of human Zika immune sera to neutralize different Zika viruses. That study was limited because it evaluated human immune sera no more than 13 weeks after Zika virus infection and tested a relatively small number …

Understanding The Role Of Cereblon In Hematopoiesis Through Structural And Functional Analyses, Afua Adutwumwa Akuffo

USF Tampa Graduate Theses and Dissertations

The discovery and implementation of immunomodulatory drugs (IMiD®s) has revolutionized the treatment of many hematological malignancies due to the plethora of IMiD®-induced clinical responses that include anti-angiogenesis, anti-inflammation, and anti-tumor effects, as well as enhanced erythropoiesis, immune modulation and improved metabolism. More ground-breaking was the identification of cereblon as the target of IMiD®s. Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction of neo-substrates by engaging the DDB1-CUL4A-Roc1-RBX1 E3-ubiquitin ligase in human cells but not in mouse cells suggesting that sequence variations in CRBN may cause its inactivation. Therapeutically, CRBN engagers …

Impacts Of The Coronavirus Pandemic On Biodiversity Conservation, Richard T. Corlett, Richard B. Primack, Vincent Devictor, Bea Mass, Varun Goswami, Amanda Bates, Lian Pin Koh, Tracey Reagan, Rafael Loyola, Robin J. Pakeman, Graeme S. Cumming, Anna Pidgeon, David Johns, Robin Roth

Political Science Faculty Publications and Presentations

The COVID-19 pandemic is impacting all parts of human society. Like everyone else, conservation biologists are concerned first with how the pandemic will affect their families, friends, and people around the world. But we also have a duty to think about how it will impact the world's biodiversity and our ability to protect it, as well as how it might affect the training and careers of conservation researchers and practitioners. As editors of Biological Conservation, we have heard first-hand from colleagues, authors, and reviewers around the world about the problems they are facing, and their concerns for their students, their …

Gen Z Perspectives On Climate Change And The Future: Having The Courage To Imagine And Fight For A Better World, Isabelle Graj

Independent Study Project (ISP) Collection

I conducted 6 interviews with Gen Z students to investigate how they think climate change will impact their future and how they frame the issue in general. I communicate my findings and analysis with visual context through a zine, which is a form of alternative media created in the 1930s. Today, zines provide a creative approach to exchange ideas and explain contemporary culture (Gisonny and Freedman, 2006, 26). My zine is not meant to be utterly educational but rather it is meant to convey the emotion, confusion, and chaos associated with my findings. The interviews collectively created an image of …

Parásitos Gastrointestinales De Tierra Del Fuego, Argentina, Sarah Martínez

Independent Study Project (ISP) Collection

Este trabajo intentó encontrar helmintos comunes, especialmente compartidos, en cuatro carnívoros patagónicos del sur con distribuciones geográficas superpuestas y dos carnívoros patagónicos del norte, y esbozar el análisis fecal y los métodos de identificación morfológica para futuros investigadores. El estudiante encontró solo un parásito helminto compartido entre cualquier otra especie y la nutria nativa del sur del río, a pesar de una superposición en el hábitat con el visón americano invasivo, pero esto puede deberse a un bajo recuento de estudios regionales previos de helmintos en cualquiera de las especies. Se encontraron múltiples parásitos en las cuatro especies hospederas de …

Covid 19 In U.S. Migrant Detention Centers: The Call For Freedom In The Face Of A Global Pandemic, Salma Rojas

Independent Study Project (ISP) Collection

My research paper investigates the responses of the U.S. immigration detention system to the COVID 19 pandemic and determines the capacity of the detention centers to keep detained individuals alive and healthy. As I analyze their capacities, I look to past detention center outbreaks, updated public health resources, reports on ICE facility conditions and the testimonies of migrant people who were detained during the COVID 19 crisis. The urgency of the COVID 19 pandemic is why I dedicate part of my paper to what needs to be done to prevent the situation from worsening. In drawing from these various sources, …

Non-State Actors’ Covid-19 Response In Nepal, Jenna Mae Biedscheid

Independent Study Project (ISP) Collection

This research explores the ways in which non-state actors have responded to the COVID-19 pandemic in Nepal and the needs present in the months before drastic increases in cases began on May 11th. In doing so, it describes how social and political inequality within Nepal has caused people experiencing the most need to be left out of early phases of the COVID-19 pandemic relief effort. This research includes a literature review which situates Nepal amidst the global pandemic as well as interviews with non-state actors currently responding in Nepal. It finds that migrant workers, daily wage earners, Dalits, Janajati/Adivasi peoples, …

The Current State Of Research On The Global Amphibian Epidemic, Chytridiomycosis: A Systematic Literature Review And View Into The Future Of The Field, Emily Dealto

Independent Study Project (ISP) Collection

Recent years have shown a rapid decline in global frog populations. Among other issues, one main cause of these declines has been linked to chytridiomycosis, a disease caused by the fungus Batrachochytrium dendrobatidis, or Bd. The discovery of this fungus is relatively recent in the field of herpetology, and thus there is much still unknown about the disease such as its distribution and what causes certain areas and species to be more susceptible to it. A systematic literature review was conducted to see where the state of the research is currently, in order to gain a better view of the …

Two (Or More) Viruses In One Bat: A Systematic Quantitative Literature Review Of Viral Coinfection In Bats, Eli J. Kaufman

Independent Study Project (ISP) Collection

Viral coinfection is an important topic in pathogen dynamics, and can increase viral shedding and change disease outcomes. As bats are carriers of important zoonoses, such as the SARS coronaviruses, rabies, and other deadly viruses, knowing more about their coinfection dynamics is important. This quantitative systematic literature review sought to show how many papers reported bat viral coinfections, and created three databases. The first database, the SQLR database was based on searches for coinfections. The second database, the Astrovirus database was to determine how much of the literature was being missed by examining a single viral family more in depth …

Finding A “True Morocco:” How Tourists Change Moroccan Economies, Infrastructure And Cultures, Emily Federico

Independent Study Project (ISP) Collection

The overall purpose of this study was to research the effects of adventure tourism on rural towns and villages, notably their financial cultural and physical aspects. Issues such as the commodification of lived experiences in a post-colonial context will be examined. The study was conducted via interviews from hotel workers and guides in major tourist cities (Fes, Rabat and Merzouga). I found that most international tourists hailed from Western countries; thus, English or French were the primary languages used in the tourism business. Also, significant modes of craftsmanship that faced a cultural extinction, such as folk music, rugs, and pottery, …

Law In The Time Of Covid-19, Katharina Pistor

Faculty Books

The COVID-19 crisis has ended and upended lives around the globe. In addition to killing over 160,000 people, more than 35,000 in the United States alone, its secondary effects have been as devastating. These secondary effects pose fundamental challenges to the rules that govern our social, political, and economic lives. These rules are the domain of lawyers. Law in the Time of COVID-19 is the product of a joint effort by members of the faculty of Columbia Law School and several law professors from other schools.

This volume offers guidance for thinking about some the most pressing legal issues the …

Machine Learning And Data Mining-Based Methods To Estimate Parity Status And Age Of Wild Mosquito Vectors Of Infectious Diseases From Near-Infrared Spectra, Masabho Peter Milali

Dissertations (1934 -)

Previous studies show that a trained partial least square regresser [sic] (PLSR) from near-infrared spectra classify laboratory and semi-field raised mosquitoes into less than or ≥ to seven days old with an average accuracy of 80%. This dissertation demonstrates that training models on near-infrared spectra (NIRS) using artificial neural network (ANN) as an architecture yields models with higher accuracies than training models using partial least squares (PLS) as an architecture. In addition, irrespective of the model architecture used, direct training of a binary classifier scores higher accuracy than training a regresser and interpreting it as a binary classifier. Furthermore, for …

Covid-19: Beyond Washing Your Hands And Social Distancing, Mark Debeliso, Joseph M. Berning, Carole Carson, Trish Sevene, Chad Harris, Kent J. Adams, Joe Walsh, Mike Climstein

Kinesiology Faculty Publications and Presentations

A pandemic due to the outbreak of the COVID-19 virus was declared as of March 2020. The authors provide perspective towards preventing and/or mitigating the impact of contracting the virus known as COVID-19. The authors posit straightforward strategies that an individual could implement that may decrease the likelihood of developing COVID-19, help lessen the severity of the symptoms related to the COVID-19 and potentially mitigate the transmission of the virus. The authors consider their comments as food for thought and not as professional medical advice. If you believe you have contracted the COVID-19 virus seek the advice of your healthcare …

Social Media Posts' Influence On College Athletes' Protein Knowledge, Kriston T. Love

Theses and Dissertations

This research aimed to examine how Instagram can be used as a means of education for collegiate athletes and their knowledge of protein. More specifically this research aimed to compare the prior knowledge about protein that collegiate athletes have to the knowledge they may have retained after being exposed to posts on Instagram about protein. It also aimed to determine the knowledge of protein collegiate athletes already had and if their sport and year in school influenced their protein knowledge. This study surveyed Division I collegiate athletes on their social media use and knowledge of protein before and after being …

Exosomes In Transmission And Blocking Of Arthropod-Borne Flaviviral Infection And Pathogenesis, Wenshuo Zhou

Biomedical Sciences Theses & Dissertations

Vector-borne diseases (VBDs) are human illnesses that are transmitted by vectors such as ticks, mosquitoes, and fleas. These arthropods transmit infectious pathogens such as viruses, protozoa, and bacteria, to humans during their blood-feeding. According to the estimation of the WHO, billions of people are affected by VBDs worldwide, and about 700,000 deaths are reported annually. Currently, very few reliable VBDs control approaches and vaccines available to treat various VBDs. Additionally, approaches to control arthropod’ proliferation and migration are difficult to develop. Furthermore, molecular determinants and mechanisms for the transmission are poorly understood. This work describes two studies identifying the novel …

Checkmate: Exploring Father-Son Communication Regarding Reproduction And Sexual Health In Males With Cystic Fibrosis, Dianna C. Sanderson

Theses and Dissertations

Cystic fibrosis (CF) is a heritable monogenic condition with allelic heterogeneity. A variety of sequence alterations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene results clinically in multisystem disease including a reduced reproductive capacity in affected males. Knowledge of reproductive capacity is often disclosed to parents by medical providers and to affected male children by medical providers and their parents. Despite advanced technology and therapeutics yielding the benefits of increased life expectancy and quality of life, males affected with CF largely remain uninformed in broader areas of sexual health and particularly in how their concept of masculine …

Development Of Natural Product-Derived Cationic Polymers For Biomaterial Applications, Moumita Sharmin Jui

Theses and Dissertations

In this thesis, multicyclic natural products and metallocene-containing polymers were synthesized for biomedical applications.

Chapter 1 describes the overall background, the recent development of natural product-based antimicrobial biomaterial and metallocene containing polymer for biomedical application. Afterward, the primary research objectives of my research are illustrated.

In chapter 2, a multicyclic natural product derived guanidine-based facially amphiphilic homopolymers and copolymers were synthesized. Cholic acid is one of the bile acid derivatives used to prepare facially amphiphilic moieties. A neutral polyethylene glycol (PEG) component was used to prepare copolymers with cholic acid. Reversible-addition fragmentation chain transfer (RAFT) polymerization technique was used to …

Association Between Sulfur-Metabolizing Bacterial Communities In Stool And Risk Of Distal Colorectal Cancer In Men, Long H. Nguyen, Wenjie Ma, Dong D. Wang, Yin Cao, Himel Mallick, Teklu K. Gerbaba, Jason Lloyd-Price, Galeb Abu-Ali, A. Brantley Hall, Daniel Sikavi, David A. Drew, Raaj S. Mehta, Cesar Arze, Amit D. Joshi, Yan Yan, Tobyn Branck, Casey Dulong, Kerry L. Ivey, Shuji Ogino, Eric B. Rimm, Mingyang Song, Wendy S. Garrett, Jacques Izard, Cutis Huttenhower, Andrew T. Chan

Department of Food Science and Technology: Faculty Publications

Background and aims: Sulfur-metabolizing microbes, which convert dietary sources of sulfur into genotoxic hydrogen sulfide (H₂S), have been associated with development of colorectal cancer (CRC). We identified a dietary pattern associated with sulfur-metabolizing bacteria in stool and then investigated its association with risk of incident CRC using data from a large prospective study of men.

Methods: We collected data from 51,529 men enrolled in the Health Professionals Follow-up Study since 1986 to determine the association between sulfur-metabolizing bacteria in stool and risk of CRC over 26 years of follow-up. First, in a subcohort of 307 healthy men, we …

Integrating The Ecosystem Services Framework To Define Dysbiosis Of The Breastfed Infant Gut: The Role Of B. Infantis And Human Milk Oligosaccharides, Rebbeca M. Duar, Bethany M. Henrick, Giorgio Casaburi, Steven A. Frese

Department of Food Science and Technology: Faculty Publications

Mounting evidence supports a connection between the composition of the infant gut microbiome and long-term health. In fact, aberrant microbiome compositions during key developmental windows in early life are associated with increased disease risk; therefore, making pertinent modifications to the microbiome during infancy offers significant promise to improve human health. There is growing support for integrating the concept of ecosystem services (the provision of benefits from ecosystems to humans) in linking specific microbiome functions to human well-being. This framework is widely applied in conservation efforts of macro-ecosystems and offers a systematic approach to guide restoration actions aimed to recover critical …

A New Genus And Two New Species Of Unarmed Hymenolepidid Cestodes (Cestoda: Hymenolepididae) From Geomyid Rodents In Mexico And Costa Rica, Scott Lyell Gardner, Altangerel Tsogtsaikhan Dursahinhan, Mariel Campbell, S. Elizabeth Rácz

Scott L. Gardner Publications

Two new cestodes of the family Hymenolepididae are described from two species of rodents of the family Geomyidae collected in Mexico and Costa Rica. One new species of Hymenolepis is described from Cratogeomys planiceps Merriam 1895 from near Toluca, Mexico and another that we allocate to a new genus is described from Heterogeomys heterodus (Peters, 1865) from near Irazú Volcano, Costa Rica. Hymenolepis s. str. includes those Hymenolepididae with an apical organ, with no hooks on suckers or apical organ, and three testes. Hobergia irazuensis n. gen., n. sp. includes a hymenolepidid with an apical organ, unarmed scolex, small …

Renal Histopathology Spectrum In Children With Kidney Diseases In Saudi Arabia, 1998-2017, Khalid Alhasan, Noura M. Aloudah, Amaar A. Bakhit, Yassin M. Alhamad, Kechrid M. Chihabeddine, Talal A. Alfaadhel, Tariq E. Aljohani, Hanadi M. Alhozali, Abdulkareem O. Alsuwaida

Saudi Medical Journal

Objectives: To identify the trends in the diagnostic frequency of glomerular disease subtypes by renal biopsy in children in Saudi Arabia over the last 20 years. Methods: In this retrospective observational study, we identified all patients aged <18 years for whom native kidney biopsy was performed between 1998 and 2017. The period during which biopsy was performed (1998-2004, 2005-2011, and 2012-2017) and the demographic information and their association with the prevalence of various glomerular disease subtypes were our primary outcomes. Results: A total of 326 cases with renal biopsy were analyzed; the mean age of participants being 11 years and 45.4% of them were girls. Unexpectedly, secondary glomerulonephritis accounted for 42.3% of the cases, and lupus nephritis was the most common cause noted in 20.7% of the cases. The minimal change and focal segmental glomerulosclerosis were the most common glomerulonephritis in 59% of the cases. The frequency of membranoproliferative glomerulonephritis and mesangioproliferative glomerulonephritis significantly decreased from 15% and 17% in the period prior to 2004 to 3.3% ( p =0.003) and 1.7% in 2012-2017 ( p <0.001). Conclusions: We found a considerable shift in the frequency of many glomerular disease subtypes in 1998-2017, which make clinical predication of the underlying etiology challenging for clinician. Renal biopsy still remains a critical diagnostic procedure for managing a considerable proportion of renal diseases.

Shortage Of Personal Protective Equipment Endangering Health Workers Worldwide

Saudi Medical Journal

No abstract provided.

Catastrophic Risk: Waking Up To The Reality Of A Pandemic?, W. Kip Viscusi, Jamison Pike, Jason F. Shogren, David Aadland, David Finnoff, Alexandre Skiba, Peter Daszak

Vanderbilt Law School Faculty Publications

Will a major shock awaken the US citizens to the threat of catastrophic pandemic risk? Using a natural experiment administered both before and after the 2014 West African Ebola Outbreak, our evidence suggests “no.” Our results show that prior to the Ebola scare, the US citizens were relatively complacent and placed a low relative priority on public spending to prepare for a pandemic disease outbreak relative to an environmental disaster risk (e.g., Fukushima) or a terrorist attack (e.g., 9/11). After the Ebola scare, the average citizen did not over-react to the risk. This flat reaction was unexpected given the well-known …

The Current State Of Migrant Health In Morocco: Pre-And Peri-Covid-19 Pandemic, Layla Babahaji

Independent Study Project (ISP) Collection

In the early 21st century, Morocco transitioned from being a predominantly transit migration country into both a transit and destination country for migrants. In 2013, the Moroccan government took significant steps to adapt the healthcare system in better integrating migrants in its policies. The government implemented the National Strategy on Immigration and Asylum that improved access to public health care for migrants. Recently, in March of 2020, Morocco declared a state of medical emergency due to the current COVID-19 pandemic that continues today. This paper addresses the effects of the COVID-19 pandemic on the current state of migrant health in …