Digital Commons Network^™

Vaccination With Acinetobacter Baumannii Adhesin Abp2d Provides Protection Against Catheter-Associated Urinary Tract Infection, Morgan R Timm, Kevin O Tamadonfar, Taylor M Nye, Jesús Bazán Villicaña, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Scott J Hultgren

2020-Current year OA Pubs

Catheter-associated urinary tract infections (CAUTIs) contribute greatly to the burden of healthcare-associated infections. Acinetobacter baumannii is a Gram-negative bacterium with high levels of antibiotic resistance that is of increasing concern as a CAUTI pathogen. A. baumannii expresses fibrinogen-binding adhesins (Abp1D and Abp2D) that mediate biofilm formation on catheters, which become coated with fibrinogen upon insertion. Here we develop a protein subunit vaccine against the Abp1D and Abp2D receptor binding domains (RBD) and show that vaccination significantly reduces bacterial titers in a female mouse model of CAUTI. We further demonstrate that immunity to Abp2D

Health Maintenance: Oral Health For Primary Care. The Role Of The Inflammatory Process In Periodontitis And Diabetes, Maureen O'Hara, Debra A. Dixon

Internet Journal of Allied Health Sciences and Practice

There is a bidirectional relationship for inflammation with periodontal disease and chronic, systemic diseases. The focus of this review specifically includes diabetes because it is a global health problem. Periodontal disease is reversible in the early stages. The benefit of controlling the inflammatory process associated with periodontitis is a reduction in serum levels of inflammatory mediators, which can improve hemoglobin A1c and other microvascular complications of diabetes. Dental practitioners may be the first health care professional to encounter the patient with diabetes and periodontal complications. Having a relationship with primary care providers in the community is essential for the care …

Improving Intraoperative Antibiotic Stewardship To Reduce Surgical Site Infections: A Quality Improvement, Allyson Nichelle Heard

Doctor of Nursing Practice (DNP) Manuscripts

Purpose: Surgical site infections (SSIs) have been associated with poor pre-surgical incision antibiotic and intraoperative redosing practices and are the leading cause of postoperative readmissions and healthcare-acquired infections. A Quality Improvement (QI) project was developed to evaluate SSIs rates and pre-surgical incision antibiotic dosing and intraoperative redosing practices of anesthesia providers at a Level 1 trauma center in the Midwest. Methods: A pre- and post-intervention knowledge, attitudes, and practices (KAP) survey addressing intraoperative antibiotic stewardship was administered to 138 anesthesia providers. Interventions included education, a reference sheet, and a clinical pathway. Data analysis for surgical procedures involving anesthesia services, …

Increasing Gonorrhea And Chlamydia Testing By Using Universal Trauma-Informed Care And Offering Self-Collected Vaginal Swabs To Patients At A Non-Profit Independent Reproductive Healthcare Center, Dana M. Bloomburg

Doctor of Nursing Practice (DNP) Manuscripts

Background & Significance: The sexually transmitted infection (STI) epidemic in the United States remains a public health concern, with over 2.4 million cases in 2023 (Centers for Disease Control and Prevention [CDC], 2024). Increased screening can help prevent complications and enable treatment for the sexual partners of these asymptomatic infections (CDC, 2024). The American College of Obstetrics and Gynecology recommends that obstetrician-gynecology offices aim to provide universal trauma-informed care (TIC) to all patients (McNicholas et al., 2021). Purpose: Universal TIC practices were used to improve acceptance of gonorrhea and chlamydia (GC/CT) testing among at-risk individuals by adding a self-collected vaginal …

The Lived Experience Of In-Home Social Distancing And Other Preventative Measures Among Covid-19-Positive Individuals And Other Household Members, Jimmette Naytwain Brooks

Walden Dissertations and Doctoral Studies

The novel Coronavirus Disease 2019 (COVID-19), first detected in Wuhan, China, is caused by a new virus strain: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On March 11, 2020, COVID-19 was classified as “the second pandemic of the 21st century” by the World Health Organization. To better control the spread of the virus, governments and communities adopted several established public health protocols to quell the spread of the disease and decrease the resulting morbidity and mortality. Specific measures included masking, hand hygiene, social distancing and disinfection. Though these are proven measures, not much was known about adherence in the home …

Kabasura Kudineer Choornam, A Medicinal Polyherbal Formulation, Modulates Human Macrophage Polarization And Phagocytic Function, Asli Korkmaz, Duygu Ünüvar, Si̇nem Günalp, Derya Göksu Helvaci, Duygu Sağ

Turkish Journal of Biology

Background/aim: Kabasura kudineer choornam (KKC) is a polyherbal formulation of 15 ingredients. It has antiinflammatory and antimicrobial properties and are effective in managing the symptoms of H1N1 swine flu and COVID-19. However, its mechanism of action is not fully understood. In this study, we examined the effect of KKC on the polarization and function of primary human macrophages.

Materials and methods: Human monocyte-derived macrophages (M0 macrophages) pretreated with KKC extract were polarized into M1, M2a, or M2c subtypes. The expression of the M1/M2 polarization markers was analyzed using qPCR, flow cytometry, and ELISA, and the phagocytosis capacity of …

Describing Latent Tuberculosis Infection And Treatment Completion In Virginia: A Social Determinants Of Health Approach, Amber N. Harmon

Electronic Theses and Dissertations

While the treatment of latent tuberculosis infection is a key strategy in tuberculosis elimination nationally and globally, there is a limited understanding of the general prevalence of latent tuberculosis as well as factors related to successful treatment. This dissertation describes the known landscape of latent tuberculosis in Virginia and explores possible factors related to latent tuberculosis infection treatment through three manuscripts. The first manuscript, Chapter 1, outlines the overall proposal for this dissertation research in the style of a National Institute of Health grant proposal. The second manuscript, Chapter 2, describes the current understanding of the factors related to latent …

Homologous And Heterologous Vaccination Regimens With Mrna And Rvsv Platforms Induce Potent Immune Responses Against Sftsv Glycoprotein, Tomaz B. Manzoni, Jonna B. Westover, Kendall A. Lundgreen, Philip D. Hicks, Raegan J. Petch, Jordan T. Ort, Drew Weissman, Steven H. Y. Fan, Scott E. Hensley, Norbert Pardi, Brian B. Gowen, Paul Bates

Animal, Dairy, and Veterinary Science Faculty Publications

Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic bunyavirus with a high case-fatality ratio for which there is no approved vaccine. Studies have assessed different vaccine technologies. However, few studies have yet assessed the immunogenicity of heterologous prime-boost regimens. Methods: Here, we compare a lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA-based vaccine encoding the SFTSV glycoproteins, Gn and Gc, to our recently described recombinant VSV SFTSV (rVSV-SFTSV) vaccine in single dose, homologous, and heterologous prime-boost regimens in mice. Results: We show that all regimens protect from pathogenic SFTSV challenge and elicit strong long-lasting antibody responses. Furthermore, strong cellular …

A Comprehensive Evidence-Based Educational Initiative For Improving Hand Hygiene, Lyanna L. Chan

Master's Projects and Capstones

Abstract

Problem: Healthcare-associated infections (HAIs) are a persistent concern in assisted living facilities, often resulting from inconsistent hand hygiene practices. Although national guidelines exist, adherence remains suboptimal, especially where staff training and compliance monitoring are limited.

Context: This project took place in a 53-bed assisted living facility without a formal system to track or reinforce hand hygiene. The aim was to improve staff knowledge and promote infection prevention through education.

Interventions: A Clinical Nurse Leader (CNL) led an evidence-based hand hygiene education program. The intervention included interactive training, visual reminders, personal sanitizers, and leadership support during clinical huddles.

Measures: Pre- …

Genetic And Environmental Factors Contributing To The Pathogenesis Of Vertebral Osteomyelitis Caused By Enterococcus Cecorum In Broiler Chicken, Ummu Syauqah Al Musyahadah, Andi Asnayanti, Anh Dang Trieu Do, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Enterococcus cecorum (EC) is the primary cause of Vertebral Osteomyelitis (VO) in poultry, characterized by a hock-sitting posture with legs extended forward. The disease begins with intestinal colonization, where pathogenic strains of E. cecorum establish themselves in the gut within the first week of a bird's lifecycle and translocate to the bloodstream later, reaching the organs, which finally infect the birds' Free Thoracic Vertebrae (FTV). Several factors contribute to the initiation and progression of the disease. Environmental factors such as heat stress, high blood sugar levels, prior infections, overcrowding, and rapid growth conditions weaken immunity and stimulate the emergence of …

Micbg406a Polymorphism Reduces Risk Of Mechanical Ventilation And Death During Viral Acute Lung Injury, Harry Pickering, Narges Alipanah-Lechner, Ernie Chen, Dylan Duchen, Holden T Maecker, Seunghee Kim-Schulze, Ruth R Montgomery, Chris Cotsapas, Hanno Steen, Florian Krammer, Charles R Langelier, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren Ir Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, David J Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Matthew C Altman, Steve Bosinger, Walter Eckalbar, Carolyn S Calfee, Oscar A Aguilar, Elaine F Reed, John R Greenland, Daniel R Calabrese

Faculty, Staff and Students Publications

MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity. Separately, we found a MICB polymorphism (MICBG406A) is associated with decreased ALI risk. We hypothesized this polymorphism would protect against severe SARS-CoV-2 respiratory disease. We analyzed 1,036 patients hospitalized with SARS-CoV-2 infection from IMPACC. Associations between MICBG406A and outcomes were determined by linear regression or Cox proportional hazards models. We also measured immune profiles of peripheral blood and the upper and lower …

Hsp70 Is A Chaperone For Il-33 Activity In Chronic Airway Disease, Omar A. Osorio, Heather E. Raphael, Colin E. Kluender, Ghandi F. Hassan, Lucy S. Cohen, Deborah F. Steinberg, Ella Katz-Kiriakos, Morgan D. Payne, Ethan M. Luo, Jamie L. Hicks, Derek E. Byers, Jennifer Alexander-Brett

2020-Current year OA Pubs

IL-33 is a key driver of type 2 inflammation and implicated in pathology of chronic obstructive pulmonary disease (COPD) and asthma. However, the mechanism for IL-33 secretion and regulation in the context of chronic airway disease is poorly understood. We previously reported an airway disease-associated isoform IL-33Δ34 that escapes nuclear sequestration and is tonically secreted from epithelial cells. Here, we describe how this IL-33Δ34 isoform interacts with HSP70 within cells and is targeted to secretory organelles through coordinated binding to phosphatidylserine (PS) and delivered to compartments for unconventional protein secretion (CUPS). Once secreted, extracellular HSP70 (eHSP70) in complex with IL-33Δ34 …

Examining The Associations Between Racial Identity And Suicidal Ideation Among Black Youth, Aashna Shah, Kennedy Balzen, Ryan M. Hill Phd, Danielle Busby, Jennifer Brown, Estefania Fernandez, Ntsoaki F. Tadi, Carla Sharp

Journal of Applied Research on Children: Informing Policy for Children at Risk

Against the background of increasing rates of suicide among Black youth, researchers have identified the relation Black youth have to their identity as an important factor that may provide insight into the risk of suicide in this population. Preliminary work suggests that racial identity might serve as protective factor for psychological distress, though the literature is somewhat mixed, especially when suicidality is an outcome. Moreover, this research has predominantly concentrated on adults and/or community samples of youth. As yet, the extent to which Black youth’s attitudes and beliefs regarding their Black identity associate with current or past suicide ideation (SI) …

Fetal Losses Associated With Prrsv, Ppv, And Pcv2 Detection, Em-On Olanratmanee, Pachara Pearodwong, Duangkamol Lewchalermwong, Padet Tummaruk

The Thai Journal of Veterinary Medicine

This study aimed to investigate the prevalence of porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), and porcine circovirus type 2 (PCV2) infections associated with fetal losses in 10 commercial swine herds in Thailand. Samples were collected from 100 sows and included 25 aborted fetuses, 35 mummified fetuses, and 40 stillborn piglets. The average parity number of the sows was 2.8 ± 2.4, ranging from 0 to 11. Fetal age was determined based on either the day of abortion or estimated using crown-rump length, and categorized as ≥70 days. Organs from each case were pooled, homogenized, and tested …

Fournier Gangrene Is Associated With Increased Length Of Stay And Higher Healthcare Costs Compared To Non-Perineal Necrotizing Soft Tissue Infections, Hayato Mitaka, Kristen Mcquerry, Kelsey Karnik, Alexandre R. Marra, Toshio Naito, Patrick Ten Eyck, Paul G. Auwaerter, Yuji Yamada, Takaaki Kobayashi

Biostatistics Faculty Publications

Background: Fournier gangrene (FG) is a necrotizing soft tissue infection (NSTI) of the perineum. Recent retrospective studies from quaternary centers suggest improved outcomes and a potentially less aggressive clinical course for FG than non-perineal NSTIs. However, comprehensive nationwide data remain limited. Methods: This retrospective cohort study analyzed the National Inpatient Sample (2016-2020) to compare outcomes between FG and non-perineal NSTIs. Adult patients undergoing surgical debridement with a diagnosis of FG or NSTI were identified using ICD-10 codes. Outcomes included in-hospital mortality, length of stay (LOS), hospital costs, and home discharge rates. Multivariable regression analyses adjusted for patient demographics, comorbidities, and …

Improving Occupational Health For Tribal Buffalo Workers, Elinor Bowen-Keyes, Mystera M. Samuelson

Posters: 2025 Summer Undergraduate Research Program

Occupational health and safety of Tribal buffalo workers is essential to many Tribal food sovereignty initiatives taking place within Tribal nations across the country, supporting the broader effort to bring the buffalo home. In response to requests from Intertribal Buffalo Council (ITBC) members, we developed occupational health cards identifying top zoonotic disease risks to improve patient–clinician communication. Each card links via QR code to a comprehensive clinician guidance booklet that includes etiologic agents, transmission routes, symptoms, occupation-specific screening questions, and reporting resources. Using a One Health approach, we mapped county-level data for ITBC buffalo herds, including elevation, ecosystem type, and …

First Report Of Fibropapillomatosis And Critical Habitat Use In Green Sea Turtles In Curaçao, M. Tripepi, I. J. R. Van Veghel, A. D. Vreugdenhil, E. Brunelli

College of Life Sciences Faculty Papers

Fibropapillomatosis, a disease affecting green sea turtles (Chelonia mydas), has been documented in many regions of the world, including the Caribbean, but has not been scientifically reported in Curaçao until now. The present study utilized VHF telemetry in Caracas Bay, Curaçao, to track green sea turtles, both healthy and affected by fibropapillomatosis, with the objective of ascertaining their foraging locations. VHF telemetry proved to be a pivotal method for assessing habitat use in areas characterized by limited visibility and high boat traffic, conditions that present significant challenges for divers and snorkellers attempting to access the area. The results …

Chlamydia And Gonorrhea Infections In Genital And Extragenital Samples Among Men And Women, Kristal J. Aaron, Charlotte A. Gaydos, Edward W. Hook, Max Chernesky, Jeanne Moncada, Stephanie N. Taylor, Harold C. Wiesenfeld, Kenneth H. Mayer, Matthew R. Golden, Alexander Boutwell, Barbara Van Der Pol

School of Medicine Faculty Publications

Background For people who have anal and/or oral sex, many programs recommend genital and extragenital (defined here as anorectal and oropharyngeal) screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) to identify all potential sites of infection. Methods We assessed genital and extragenital CT and NG prevalence among people reporting extragenital sexual exposure. Results Among 343 gay and bisexual men who reported sex with men (GBMSM), 42 (12.2%) had CT with positivity of 3.5%, 9.3% and 1.8% in the genital, anal, and oral samples, respectively. In this same group, 55 (16.0%) had NG with positivity of 5.2%, 8.5%, and 7.6% …

Epidemiology, Clinical And Microbiological Characteristics, And Outcomes Of Enterococcus Bacteraemia: A 5-Year-Experience Of A University Hospital In Oman, Mohammed Al Abri, Hashim Ba Wazir

Sultan Qaboos University Medical Journal

Objectives: This study aimed to describe the prevalence, clinical characteristics and outcomes of bacteraemia caused by Enterococcus species at a university hospital in Oman. Methods: This observational retrospective study was conducted over a 5-year period from 2015 to 2019 at Sultan Qaboos University Hospital, Muscat, Oman. Adult patients (18 years and above) with bacteraemia caused by Enterococcus species were included. Data were collected retrospectively from the hospital information system using a standardised data collection form. Results: A total of 142 cases of bacteraemia were observed, with E. faecalis being isolated in the majority of cases (n = 88, 62%) compared …

Histologic And Immune Characterization Of Cutaneous Immune-Related Adverse Events Induced By Immune Checkpoint Inhibitors, Omar Pacha, Anisha B Patel, Jonathan L Curry, Cara L Haymaker, Nejla Ozirmak Lermi, Dzifa Yawa Duose, Ken Chen, Joud Hajjar, Aung Naing

Faculty, Staff and Student Publications

Background: Although immune checkpoint inhibitors (ICIs) are efficacious, they often cause immune-related adverse events (irAEs), most commonly cutaneous irAEs (CirAEs). The mechanisms underlying CirAEs remain unclear.

Methods: Attempting to better understand their mechanisms and histology we conducted a prospective study of 15 patients with advanced cancers treated with ICIs who developed grade 2 or higher CirAEs. Clinical and histologic characterization of biopsy specimens of CirAEs was performed. Histologic analysis of patient biopsy specimens were subdivided by epidermal reaction patterns that included spongiotic, lichenoid, and interface dermatitis patterns. A targeted RNA expression assay was used to identify immune markers in CirAE …

From Gametes To Genes: Genetic Quality Assessment Of Anuran Cryopreserved Spermatozoa And Derived Embryos, Trinity Isabella Kassuhn

Theses and Dissertations

Sperm cryopreservation is an important tool within the suite of assisted reproductive technologies (ART) as it enables long-term storage of genetically valuable gametes. However, knowledge of the diagnostic criteria for assessing sperm quality and the genetic consequences of using cryopreserved sperm in amphibians is limited. This gap has raised concerns in captive breeding and reintroduction programs regarding the potential impact that cryopreserved sperm and the derived embryos may have on a population. The thesis aims to investigate how sperm cryopreservation affects the genetic material in both sperm and resulting embryos, with implications for in situ and ex situ amphibian populations. …

Microbiomics Of Amazonian Fishes And Associations With Human Pathogens (Mycobacterium Ulcerans), Matthew Edwin Scott

Theses and Dissertations

The Amazon Rainforest and Guiana Shield are recognized as two of the most biodiverse ecosystems on Earth, particularly when considering macroorganisms. Relatively little attention has been paid to the microbiological diversity within rainforest ecosystems, or to the interactions among macro- and microbiological communities. To this end, I characterized the effects of habitat and host phylogenic parameters on the gut microbiome of freshwater fishes along the coast and within the Approuague River watershed in French Guiana. The results indicate a river continuum effect on the microbial composition of fishes, as well as a similar continuum pattern along the coast of French …

Urinary Pneumococcal Serotype Detection Among Children With And Without Community-Acquired Pneumonia, Lilliam Ambroggio, Lindsay R Grant, Jillian M Cotter, Samuel R Dominguez, Daniel Olson, Sara R Saporta-Keating, Cody Bender, Mohammad Ali, Kathleen Grice, Gonzalo Lerner, Michael W Pride, Ashley Miller, Maria J Tort, Annaellis Vaughan, Elizabeth Temte, Alec Edid, Alejandro Cané, Kristina G Hulten, Jill Stein, Bradford D Gessner, Edwin J Asturias

Faculty, Staff and Students Publications

Background: Urinary antigen detection (UAD) assays can address diagnostic challenges with culture-based identification of S. pneumoniae. We aimed to evaluate the utility of Pfizer's UAD1 and UAD2 assays for pneumococcal serotype surveillance in children with community acquired pneumonia (CAP) or upper respiratory tract infections (URI).

Methods: From March 2021-December 2023, children 3 months to 5 years who presented to the Children's Hospital Colorado Emergency Department with respiratory symptoms were enrolled as CAP or URI; healthy children served as controls. Nasal swabs were tested for pneumococcus by PCR. UAD assays identified pneumococcal serotypes from urine. Groups were compared using descriptive statistics. …

Tet2-Mutant Myeloid Cells Mitigate Alzheimer’S Disease Progression Via Cns Infiltration And Enhanced Phagocytosis In Mice, Katie A Matatall, Trisha K Wathan, Minh Nguyen, Hu Chen, Alexandra Mcdonald, Guantong Qi, Julia A Belk, Marcus A Florez, Duy T Le, Temitope Olarinde, Caitlyn Vlasschaert, Marco M Buttigieg, Chih-Wei Fan, Saul Carcamo, Ruoqiong Cao, Daniel E Kennedy, Arushana A Maknojia, Apoorva Thatavarty, Josaura V Fernandez Sanchez, Hind Bouzid, Surabi Veeraragavan, Susan Crocker, Margaret A Goodell, Antony Rodriguez, Siddhartha Jaiswal, Michael J Rauh, Eirini P Papapetrou, Samuele G Marro, Katherine Y King

Faculty, Staff and Students Publications

Clonal hematopoiesis (CH) is associated with many age-related diseases, but its interaction with Alzheimer's disease (AD) remains unclear. Here, we show that TET2-mutant CH is associated with a 47% reduced risk of late-onset AD (LOAD) in the UK Biobank, whereas other drivers of CH do not confer protection. In a mouse model of AD, transplantation of Tet2-mutant bone marrow reduced cognitive decline and β-amyloid plaque formation, effects not observed with Dnmt3a-mutant marrow. Bone-marrow-derived microglia-like cells were detected at an increased rate in Tet2-mutant marrow recipients, and TET2-mutant human induced pluripotent stem cell (iPSC)-derived microglia were more phagocytic and hyperinflammatory than …

Role Of Patient-Reported Measures (Prms) In Addressing Ethical Challenges During Telemedicine Consultation: A Narrative Review, Asiya Attar, Kasturi Shukla

Patient Experience Journal

Introduction: Telemedicine has revolutionized medical care delivery by emphasizing on Patient-Centred Care (PCC). Patient Reported Measures (PRMs) can assist in providing PCC since it assesses the treatment outcomes and patient experience. However, using PRMs is not just limited to gauging clinical efficiency; it can also play a role in addressing the ethical challenges in telemedicine. Yet this aspect of PRMs remains underexplored. Method: Literature search was conducted using a combination of keywords from the Google Scholar, Scopus, and Web of Science databases. 126 peer-reviewed journal articles in English from 2015 to 2024 were screened, and 34 relevant full-text …

Dengue At Photharam Hospital: One Among Ten Clinical Trial Sites Of The World's First Dengue Vaccine, Anongrat Tiawilai, Chawin Tiawilai, Thawat Tiawilai, Nattachai Srisawat, Umaporn Limothai, Terapong Tantawichien, Usa Thisyakorn

Chulalongkorn Medical Journal

Background: Dengue, a viral disease transmitted by vectors, is widespread worldwide, impacting more than 120 nations. In 2019, a concerning 5.2 million dengue cases were reported, with Asia bearing 70% of the global burden. Half of the global population faces the risk of dengue.

Objectives: The goal of this research was to illustrate the epidemiological pattern of dengue patients admitted to Photharam Hospital in Ratchaburi province, Thailand, one of the ten clinical trial sites for the world's first dengue vaccine.

Methods: Data from dengue patients admitted to Photharam Hospital, a provincial healthcare center in Ratchaburi province, Thailand, covering the period …

Rethinking Self-Diagnosis: Bridging Doctor And Patient Perspectives, Melis Dursun Ugras, Guzin Sen, Asli Gunay

Nordes Conference Series

The rise of digital health technologies has reshaped the patient’s role in healthcare, enabling greater autonomy in managing health and making medical decisions. Self-diagnosis tools, including AI-driven applications, symptom checkers, and online health platforms, allow individuals to assess symptoms and explore potential conditions before consulting a healthcare professional. While these tools offer increased access to health information, they also raise concerns about misinformation, misinterpretation, and their impact on patient-provider relationships. This study examines how both patients and healthcare professionals perceive self-diagnosis, identifying tension points and shared concerns that shape its role in healthcare interactions. To explore these perspectives, we conducted …

An In-Depth Exploration Into College Students’ Information Acquisition And Evaluation Behaviors During The Covid-19 Infodemic, Nien-Tsu Nancy Chen, Kimmy Kee, Bianca T. Villalobos, Miriam Ortiz, Hyesun Lee

Psychological Science Faculty Publications

Introduction: This study examines how vaccination-inclined and vaccination-hesitant U.S. college students acquired and evaluated COVID-19 vaccination information.

Methods: In 2021, we conducted 26 focus group discussions and used thematic analysis to identify patterns in information acquisition behaviors and trust in information sources.

Results: Findings revealed mismatches between frequently used and most trusted sources. Public health agencies were highly trusted but not commonly consulted first. In contrast, social media were frequently used for information scanning despite being the least trusted. Interpersonal sources (e.g., family) were identified as both a most and least trusted source. They were trusted for their good intention …

Evaluating The Effectiveness Of The Comprehensive Unit-Based Safety Program In Reducing Hospital-Acquired Infections, Peta Ann Anderson

Walden Dissertations and Doctoral Studies

This doctoral project is an evaluation of a quality improvement initiative that applied a mixed method approach to evaluate the impact of the Comprehensive Unit-based Safety Program (CUSP) on hand hygiene (HH) compliance and healthcare-associated infection rates. The project was conducted in the United States of America (USA), Florida in an acute care hospital. The practice problem addressed was the persistent low adherence to HH protocols among healthcare staff, a critical issue in nursing practice due to its direct link to preventable patient harm. Quantitative data demonstrated a substantial reduction in infection rates following the implementation of the CUSP program. …

The Association Between Unemployment, Income, Education, Healthcare Access, Mental Health And High-Risk Hiv Behavior In The United States, Tia Smith

Walden Dissertations and Doctoral Studies

High-risk HIV behavior remains a critical public health concern in the United States, particularly among socioeconomically and psychologically vulnerable populations. Despite extensive prevention efforts, a gap persists in understanding how structural and mental health factors jointly contribute to HIV risk. This study addresses that gap by examining the association between socioeconomic status (SES), including income, education, employment, and healthcare access, and mental health status (diagnosis of depression and days of poor mental health) on high-risk HIV behavior at the individual level. Guided by the social determinants of health (SDOH) theoretical framework, the study utilized secondary data for over 40,000 adults …