Digital Commons Network^™

Rituximab-Induced Procalcitonin Elevation, Zachery Bauer, Junior Uduman

MERF 2020 - Case Reports

Procalcitonin has been studied as a marker of bacterial lung infection. It frequently guides clinical practice and antibiotic management. However, procalcitonin is known to have false positive results in certain scenarios. This case describes an 86 year old African American woman with mantle cell lymphoma who presented with acute on chronic dyspnea. Diagnostic tests found a white blood cell count of 632 k/uL (95% lymphocytes) and procalcitonin of 1.29 ng/mL. Computed tomography of the chest demonstrated a right lung consolidation and hilar lymphadenopathy. She was treated empirically for pneumonia with ceftriaxone and azithromycin. Additionally, she received induction chemotherapy with rituximab …

Magnetic Field–Driven Assembly And Reconfiguration Of Multicomponent Supraparticles, A. Al Harraq, J. G. Lee, B. Bharti

Faculty Publications

Suprastructures at the colloidal scale must be assembled with precise control over local interactions to accurately mimic biological complexes. The toughest design requirements include breaking the symmetry of assembly in a simple and reversible fashion to unlock functions and properties so far limited to living matter. We demonstrate a simple experimental technique to program magnetic field–induced interactions between metallodielectric patchy particles and isotropic, nonmagnetic “satellite” particles. By controlling the connectivity, composition, and distribution of building blocks, we show the assembly of three-dimensional, multicomponent supraparticles that can dynamically reconfigure in response to change in external field strength. The local arrangement of …

Protective Clothes And Equipment For Healthcare Workers To Prevent Them Catching Coronavirus And Other Highly Infectious Diseases

Saudi Medical Journal

No abstract provided.

Assessment Of Dual Schistosome Infection Prevalence From Urine In An Endemic Community Of Ghana By Molecular Diagnostic Approach, William K. Anyan, Brittany R. Pulkkila, Clare E. Dyra, Miriam Price, Jean M. Naples, Joseph Quartey, Abraham K. Anang, Nilanjan Lodh

Clinical Lab Sciences Faculty Research and Publications

Schistosomiasis is an important Neglected Tropical Disease caused by blood parasites called schistosomes. In sub-Saharan Africa, two major human schistosomes, namely Schistosoma mansoni and S. haematobium, often occur sympatrically and is responsible for almost 90% of the affected 290 million people worldwide. We have utilized a highly sensitive and specific assay by amplifying species-specific cell-free repeat DNA fragments by polymerase chain reaction to detect either single or dual schistosome infection from a single urine sample from a broad age group. In this study, we have tested filtered urine samples collected from 163 individuals aged 3–63 years, mostly children (median …

Stochastic Modeling Of Zoonotic Disease, Sausan Odatalla

Theses, Dissertations and Culminating Projects

We provide an overview of the mathematical modeling of deterministic and stochastic infectious disease models. These models enable one to understand the outbreak, spread, and extinction of disease. We then focus on stochastic models with a disease reservoir to understand outbreak vulnerability for zoonotic diseases such as Ebola Virus Disease (EVD). Numerical results from a more complicated EVD model are compared with the theoretical results of a simplified stochastic SISk model. We also demonstrate the effect that vaccine has on outbreak vulnerability in a population that is connected to a disease reservoir.

Crimean-Congo Hemorrhagic Fever Virus Endemicity In United Arab Emirates, 2019, Jeremy V. Camp, Dafalla O. Kannan, Babiker Mohammed Osman, Moayyed Sher Shah, Brigitte Howarth, Tamer Khafaga, Pia Weidinger, Noushad Karuvantevida, Jolanta Kolodziejek, Hessa Mazrooei, Nadine Wolf, Tom Loney, Norbert Nowotny

All Works

© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved. We conducted a cross-sectional survey of Crimean-Congo hemorrhagic fever virus (CCHFV) in dromedary camels and attached ticks at 3 locations in the United Arab Emirates. Results revealed a high prevalence of CCHFV-reactive antibodies in camels and viral RNA in ticks and camel serum, suggesting the virus is endemic in this country.

The Effects Of Farnesol, A Quorum Sensing Molecule From Candida Albicans, On Alcaligenes Faecalis, Savannah Hutson

Undergraduate Honors Theses

Quorum sensing molecules have become a recent focus of study to learn if and how they can be used, both on their own and in conjecture with current antimicrobial methods, as a means of bacterial control. One such quorum sensing molecule is the sesquiterpene alcohol, Farnesol, which is synthesized and released by the fungus, Candida albicans. In most in-vivo cases, our laboratory has shown that Alcaligenes faecalis overtakes C. albicans, preventing its growth. However, as a way to counteract this inhibitory effect, Farnesol may be one way that Candida has found to fight back. In this study, we …

Characterization Of The Broad-Spectrum Inhibitory Capability Of Alcaligenes Faecalis And A. Viscolactis Against Potential Pathogenic Microorganisms, Andrew Fuqua

Undergraduate Honors Theses

The recent rise of multidrug resistant microorganisms has grown from an isolated concern to a massive public health crisis. It has become imperative that scientists look for new ways to combat this issue. Due to the selective pressures of competition, bacteria and other microbes possess a host of defenses and weapons designed to exploit vulnerabilities in other microorganisms. Consequently, the study of these systems and microbial interactions has much to reveal in the search for novel antimicrobial treatments. Previous research from our laboratory has discovered that both Alcaligenes faecalis and Alcaligenes viscolactis, two rarely studied and generally non-virulent bacteria, …

The Effect Of Alcaligenes Faecalis On Inhibition Of Candida Albicans Biofilm And Planktonic Growth, Nausheen A. Siddiqui

Undergraduate Honors Theses

Candida albicans is a fungal microorganism found on the human body and in the environment. An opportunistic pathogen causing local and systemic infection, this fungus is one of the leading causes of nosocomial infections. More alarming is its growing resistance against the limited number of antifungals we have for treatment Candida infections. An area of current research, termed polymicrobial interactions, focuses on how different microorganisms interact with each other for limited space, nutrients, and survival. The current study focuses on attempting to inhibit planktonic and biofilm growth stages by using the benign bacterium Alcaligenes faecalis, previously shown in our …

A Study Of The Polymicrobial Inhibitory Interactions Between Alcaligenes Faecalis And Staphylococcus Aureus, Blakeley Griffin

Undergraduate Honors Theses

Members of the Staphylococcus genus are found as a part of normal microflora in humans and can commonly be found on the skin or in the nasal cavity. However, these microorganisms can cause serious and life-threatening opportunistic infections when there is a break in the physical barrier of skin. These infections have become difficult to treat as resistant strains emerge, particularly Methicillin Resistant Staphylococcus aureus (MRSA). MRSA has become a commonly acquired nosocomial infection which is difficult to treat with conventional antibiotics of the blactam class. Even Vancomycin, a last resort antibiotic, has been ineffective on some infections. Furthermore, …

Climate Migration: Evaluating The Conditions That Breed Conflict, Avery Dillon

Honors Thesis

The prediction that climate change will cause conflict is at its core based on the assumption that climate change will trigger resource scarcity, resulting in displaced peoples and potentially violent conflict. However, the empirical evidence supporting this phenomenon is highly uncertain and at times directly contradictory. In recent decades, some have claimed that climate change’s exacerbation of extreme weather events such as hurricanes, floods, and droughts have already played major roles in conflicts such as the Syrian Civil War (Selby 2019). Others directly dispute this direct effect, arguing instead that climate change has played only a minor role in influencing …

Minutes Of The Monetary Policy Meeting On March 16, 2020, Bank Of Japan/Central Bank Of Japan

Documents

No abstract provided.

A Putative Cystathionine Beta-Synthase Homolog Of Mycolicibacterium Smegmatis Is Involved In De Novo Cysteine Biosynthesis, Saroj Kumar Mahato

Graduate Theses and Dissertations

Mycobacteria include serious pathogens of humans and animals. Mycolicibacterium smegmatis is a non-pathogenic model that is widely used to study core mycobacterial metabolism. This thesis explores mycobacterial pathways of cysteine biosynthesis by generating and study of genetic mutants of M. smegmatis. Published in vitro biochemical studies had revealed three independent routes to cysteine synthesis in mycobacteria involving separate homologs of cysteine synthase, namely CysK1, CysK2, and CysM. However, in vivo data were lacking. The M. smegmatis genome encodes only a CysM homolog and lacks orthologs for CysK1 or CysK2. The gene that codes for CysM is a part of an …

Development Of An Attenuated Zika Virus By Editing The 5’ Untranslated Region, E. Ashley Thompson

Master's Theses

Zika Virus (ZIKV) is a mosquito-transmitted flavivirus that usually causes no symptoms to mild febrile in humans, and it has been regarded as an insignificant pathogen to public health. However, recent outbreaks of ZIKV infection have revealed that ZIKV can cause severe neurological effects in adults, such as Guillain-Barre Syndrome (GBS), and in infants whose mothers acquired the virus during pregnancy, causing Congenital Zika Syndrome (CZS). Currently, no approved vaccine is available and there is a critical need to develop an effective and safe vaccine. While most vaccine developmental strategies target the viral prM-E protein of ZIKV, we aimed to …

Efficacy Of Antibiotic Therapy In Those Diagnosed With Chronic Lower Back Pain, Alexander Marcel Lee

Physician Assistant Scholarly Project Papers

Chronic back pain affects approximately eight percent of the American population, yet no treatment has been agreed upon universally. Recent studies suggest that between 20-30 percent of lower back pain cases are caused by a low-virulence bacterial infection of the intervertebral disks in those who suffered disc herniation. This scholarly project is to investigate: In patients with chronic lower back pain and Modic changes after disc herniation, what is the effect of antibiotic therapy on reducing pain symptoms compared to placebo. This literature review used the following electronic databases: ClinicalKey, Cochrane Library, Embase, and PubMed. Keywords and mesh terms refined …

Treatment Of Clostridioides Difficile With Fecal Microbiota Transplantation, Brenton Green

Physician Assistant Scholarly Project Papers

Research was performed to discuss the epidemiology and current guidelines of Clostridioides difficile infection (CDI), recurrent C. difficile infection (rCDI), the different modalities of fecal microbiota transplantation (FMT), the donor screening process, as well as the safety and efficacy of treatment. Utilizing Clinical Key, NCBI database, Dynamed Plus, Cochrane Review, and the websites for the CDC and FDA, a literature review was produced, encompassing recent research and human studies related to CDI. Recent studies were preferred, however since C. difficile has sparsely changed, older data was utilized with updates applied accordingly. Articles excluded were due to not meeting the themes …

Effectiveness Of Shingrix Versus Zostavax In Immunocompromised Adults Aged 50 Years And Older., Sandrine Ndetah Rn

Nursing Capstones

No abstract provided.

Non-Narcotic Treatment For Postherpetic Neuralgia, Caitlyn Meehan Rn

Nursing Capstones

No abstract provided.

Herpes Zoster In Pregnancy, Kimberly Svidal Rn

Nursing Capstones

No abstract provided.

“A Moral Imperative To Prevent Aids”: Race And Religion In Atlanta’S Aids Activism, 1981-1993, Madison Bailey

Honors Theses

The early years of the AIDS epidemic marked a tumultuous period of American history, calling into question the authority of doctors and the ability of scientists to cure disease. Already marginalized groups, such as gay men and intravenous drug users, appeared to be most vulnerable to a deadly virus with no cure or effective treatments. In the face of discrimination, activists rose up to provide necessary services for AIDS patients and advocate on their behalf. This activism uniquely characterized the early AIDS epidemic and permanently changed the field of biomedical research. The current historiography of AIDS activism tends to focus …

Exosomes From Embryonic Stem Cells As A Prophylactic Vaccine Against Lung Cancer., Shuhan Meng

Electronic Theses and Dissertations

The antigenic similarity between embryos and tumors has raised the idea of using embryonic materials as a preventative vaccine against neoplastic disease. Indeed, a previous study reported that a vaccine comprised of allogeneic murine embryonic stem cells (ESCs) and murine fibroblasts expressing immune-stimulatory granulocyte macrophage-colony stimulating factor (GM-CSF) successfully blocked the outgrowth of an implantable lung cancer (Lewis lung carcinoma; LLC) and lung tumors caused by a combination of a mutagen followed by chronic pulmonary inflammation. However, such a vaccine is obviously impractical for application to humans. The use of fibroblasts to produce GM-CSF is needlessly complicated, and intact live …

Fusobacterium Nucleatum: A Rare Presentation Of Hepatic Abscesses, Meghan Gwinn, Erica Herc

MERF 2020 - Case Reports

Fusobacterium nucleatum is a facultative anaerobic gram-negative bacillus found in the oral cavity, gastrointestinal tract, and genitourinary tract. Fusobacterium nucleatum is a rare cause of hepatic abscesses and empyema. We describe a case of Fusobacterium liver abscess and empyema, resulting in extensive thrombophlebitis in intraabdominal and extremity veins. A 78-year-old female with past medical history significant for bicytopenia and tooth repair 8 months prior presented with mild diarrhea and fatigue. She was febrile, tachycardic, and tachypneic. On physical exam, she had mild epigastric tenderness and bilateral lower extremity pitting edema. Labs were notable for an AKI and elevated LFTs. Imaging …

Hypercoagulability In Covid-19: A Rare Case Of Dic In Sars-Cov2 In The Emergency Department, Naureen Farook, Stephanie Stokes-Buzzelli

MERF 2020 - Case Reports

Although SARS-CoV2 is increasingly being considered a systemic disease, there have been very few case reports documenting DIC as a rare but fatal consequence of the SARS-CoV2 syndrome. We present our patient scenario as an example of severe COVID sepsis in the ED and DIC. 67-year old nursing home resident with CAD, DM, HTN, and seizures presents to our ED resus room with altered mental status and hypoxia after a reported fall from bed. He was tachycardic to 110 and required a nonrebreather at 15L saturating at 96%. His physical exam revealed GCS 10, no focal neurologic deficits, dry mucous …

Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland, S. Travis King, Kayla R. Stover, Kathey Rumley, Shawn H. Macvane, Jenna Swindler, Scott Kincaid, Trisha Branan, David Cluck, Benjamin Britt, Kelly E. Pillinger, Bruce M. Jones, Virginia Fleming, V. Paul Dimondi, Sandy Estrada, Brad Crane, Brian Odle, Majdi N. Al-Hasan, Julie Ann Justo

ETSU Faculty Works

Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Definitive 3GC therapy was compared to definitive therapy with other non-3GC antibiotics. Multivariable Cox proportional hazards regression evaluated the impact of …

The Delayed Effect Of Temperature On The Risk Of Hospitalization Due To Covid-19: Evidence From Mumbai, India, Vipin Nair, Rahul Thekkedath, Paduthol Godan Sankaran

Open Access archive

Meteorological factors and climatic variability have an immense influence on the transmission of infectious diseases and significantly impact human health. Present study quantifies the delayed effect of atmospheric temperature on the risk of hospitalization due to the Coronavirus disease 2019 (COVID-19) with adjusting the effects of other environmental factors in Mumbai, India. The daily reported data of the number of hospitalized COVID-19 positive cases and the environmental factors at Mumbai, Maharashtra, India were collected and analyzed to quantify the main and the delayed effects. Exploratory data analysis and Distributed Linear and Non-linear lag Model (DLNM) with Generalized Additive Model (GAM) …

Pretreatment Out-Of-Pocket Expenses For Presumptive Multidrug-Resistant Tuberculosis Patients, India, 2016-2017, Priya Rathi, Kalpita Shringarpure, Bhaskaran Unnikrishnan, Vineet Kumar Chadha

Open Access archive

In India, under the National Tuberculosis Elimination Programme, the government provides free treatment for multidrug-resistant tuberculosis; however, many patients seek care elsewhere, which is costly. To determine those out-of-pocket expenses, we interviewed 40 presumptive patients and found that they spent more than their median annual income before registering for the government program.

The Pacific Sentinel, May 2020, Portland State University. Student Publications Board

The Pacific Sentinel

Editor: Jake Johnson

Articles in this issue include:

• Letter from the Editor
• Ongoing Crisis in Yemen
• Coronavirus Updates
• Squashing Coronavirus Will Take Time
• There Is No “Chinese Virus”
• An Unequal Pandemic
• Do Not Go Gently Into That Pandemic
• The Coronavirus Outbreak Reveals the Flaws of Our Social Safety N
• Language, Thought, Freedom, and the Soul
• Stop Going on Twitter
• Crocheting COVID-19
• Isolation in the Time of Coronavirus
• Animal Crossing: New Horizons Review
• Mysteries, Wonder Boys, and Other Phenomena

Regulation Of Weak Acid-Dependent Cell Death By The Msaabcr Operon During Biofilm Formation Of Staphylococcus Aureus, Sarah-Elizabeth M. Polley

Honors Theses

Staphylococcus aureus is a dangerous human pathogen and a leading cause of both nosocomial and community-associated infections. Infection by S. aureus is a growing health concern due to the emergence of antibiotic resistance and the capability to form robust biofilms. Major constituents of the biofilm extracellular matrix are demonstrated to be released via controlled autolysis of a subpopulation of the biofilm. As indicated in past studies, the programmed cell death (PCD) of S. aureus grown in a biofilm microenvironment is potentiated by the buildup of acetate, a byproduct of glucose metabolism, which causes cytoplasmic acidification. Furthermore, it has been shown …

De Novo Identification Of Toxicants That Cause Irreparable Damage To Parasitic Nematode Intestinal Cells, Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Christina A. Bulman, Brenda Beerntsen, Joseph F. Urban Jr, Judy Sakanari, Makedonka Mitreva

Open Access Publications

Efforts to identify new drugs for therapeutic and preventive treatments against parasitic nematodes have gained increasing interest with expanding pathogen omics databases and drug databases from which new anthelmintic compounds might be identified. Here, a novel approach focused on integrating a pan-Nematoda multi-omics data targeted to a specific nematode organ system (the intestinal tract) with evidence-based filtering and chemogenomic screening was undertaken. Based on de novo computational target prioritization of the 3,564 conserved intestine genes in A. suum, exocytosis was identified as a high priority pathway, and predicted inhibitors of exocytosis were tested using the large roundworm (Ascaris suum larval …

Association Of Micronutrient Inadequacy And Body Mass Index In Young Adults, Taylor Peabody

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Background

Micronutrient inadequacy has been found at higher levels in overweight and obese individuals in a broad range of ages relative to healthy weight. Insufficient micronutrient levels can have a negative impact on physical and mental health along with excess weight.

Objective

Due to health consequences related to inadequate micronutrient intake and the understanding that the general population not only fails to meet the majority of micronutrient recommendations, but is also overweight or obese, the objective of this study is to first, determine if young adults in the Northwest Arkansas Region are consuming adequate levels of micronutrients and second, if …