Digital Commons Network^™

Examining Protein-Protein Interactions Within The Esx-4 Secretion System Of Mycobacterium Smegmatis, Sophie Boerboom

CMC Senior Theses

Bacteria use secretion systems to export proteins from inside of the bacterium into the periplasm, extracellular space, or host cell. Within the Mycobacterium genus, the type VII secretion systems (T7SS) transport products across the unusually thick and waxy mycobacterial envelope. T7SS are of particular importance because they are involved in the virulence of pathogenic mycobacteria. Mycobacteria have as many as five distinct T7SS called ESX systems. ESX-1, 3, and 5, have demonstrated roles in viability and virulence in certain pathogenic species like M. tuberculosis and M. marinum. Our research focuses on the ESX-4 apparatus, the ancestral system that gave rise …

Observing The Effects Of Antimalarial Drug Availability On Women’S Work Absenteeism, Rei Imada

CMC Senior Theses

This study aims to provide insight on how availability of antimalarial drugs can help alleviate the economic burden of malaria. Much of the existing literature that looks into the effects of antimalarial drug availability focuses on the associated health benefits, but fails to draw a link to the economic benefits that may also be incurred. Using data from the 2015-2016 Tanzania Demographic and Health Survey and Malaria Indicator Survey, this study performs a series of multiple regressions to observe how increased availability of artemisinin-based combination therapies (ACTs), a front-line antimalarial drug in most African countries, affects likelihood of work absenteeism …

Effects Of Sleep Deprivation And The Link To Alzheimer’S Disease In Night Shift Workers, Aracelia Aldrete

CMC Senior Theses

Alzheimer’s Disease (AD) is a degenerative neurologic disorder that is often defined by beta-amyloid (Aβ) plaques. These Aβ plaques are formed from protein pieces that are incorrectly cleaved from an amyloid precursor protein (APP). These protein segments, cleaved from APP, are toxic due to increased “stickiness”. They cling together to create protofibrils that eventually mature into neuronal plaques. Aβ plaques lead to neuronal cell death causing classic AD symptoms: memory loss, a decline in speech and motor control, and personality changes. One connection between high Aβ plaques levels and AD is chronic sleep loss or disruption. Night shift workers, even …

Corporate Social Responsibility And Corporate Financial Performance: An Examination Into Fortune 500 And Djsi Firms Within Consumer-Facing Industries, Samantha Lee

CMC Senior Theses

This paper examines the relationship between a firm’s Corporate Social Responsibility (CSR) and its Corporate Financial Performance (CFP) in nine consumer-facing industries classified by the Fortune 500. Unlike prior research on the matter, the firms investigated in this study consist only of firms on both the Fortune 500 for the year 2018 and the Dow Jones Sustainability Index (DJSI) between the years 2005-2018 in order to define a clear measurement of CSR. In order to gauge investor and market sentiment, CFP is measured primarily by the firm’s stock performance in comparison to the S&P 500 as a basis. The results …

Surfacing Contexts Of Violence In Novel Forms Of The Reproductive Justice Framework Through Lessons From Latin America: A Study Of Brutality, Migration And Bodily Autonomy And Progressive Solutions For Use In Public Health, Angelica M. Campos

CMC Senior Theses

In the last 5 years, Latin America has witnessed a tenacious wave of pañuelo verde and #NiUnaMenos activism. Sparked by increasing mortality rates associated with unsafe, clandestine abortions and femicide, the praxes and fundamental elements of these social movements have proven themselves useful not only in garnering international attention on issues relating to bodily autonomy, but in the synthesis of their respective sociopolitical solutions as well. In the United States, similar efforts have been spearheaded by the lauded reproductive justice framework, which has often been credited for centering the plight of women of color in both reproduction and social justice. …

Formal Savings Uptake As A Catalyst For Remittances In Sub-Saharan Africa, Jordan Kouassi

CMC Senior Theses

This paper explores the effects of savings account ownership on remittances and payment services in Sub-Saharan Africa through the lens of a field experiment executed in Central Malawi. Remittances are a major form of financial support for SSA and Sub-Saharan Africans. Through the use of a cross section analysis I find a positive significant relationship between account ownership and the likelihood to send and receive a remittance. Specifically, I find account ownership can increase the likelihood of sending a remittance by 8.75 times and increase the likelihood of receiving a remittance by 10.18 times.

The Necessity For Sustainable Development In Indonesia: A Governmental Analysis And Carbon Neutral Coliving Recommendation, Michael Wirth

CMC Senior Theses

This thesis explores two distinct topics: first, Indonesia’s current emissions and implementation of sustainability practices; second, the current state of coliving spaces and a proposal of a sustainable space in Indonesia,. The two topics are connected by the fact that the implementation of sustainability practices within Indonesia are necessary from more than just an environmental standpoint, but also from the economic and governmental perspectives.

We exemplify the necessity for sustainable transition within the country through three critical points: first, we show that Indonesia’s exceptional tourist growth is highly dependent on sustaining the natural wonders within the country; second, current coal …

The Mediating Role Of Positive Emotion Socialization On Maternal Alexithymia’S Detrimental Impact Towards Child’S Adaptive Regulatory Capacity, Madeleine Ding

CMC Senior Theses

The current study examined the relations between maternal alexithymia and child’s negative outcomes in the form of behavioral problems and adaptive regulatory capacity, as indexed by respiratory sinus arrhythmia (RSA). It also explores the main and mediating role of positive emotion socialization. Participants consisted of 155 mother-child dyads within a 25-mile radius of a college in Southern California (Mothers M_age=33.1 years, SD=5.5; Children M_age=42.01 months, SD=4.68; 51% male children). The Toronto Alexithymia Scale-26 (TAS-26) and the Child Behavior Checklist (CBCL) were given to mothers to report on alexithymic traits and their child’s internalizing and externalizing behaviors, …

Children’S Development And Crisis: Comparing Developmental Best Practices Against Aid Program Curricula, Martha Baker

CMC Senior Theses

Using the monitoring, evaluation and learning for adaptive management model (MEL4AM), this paper examines how international organizations translate productive criteria for early childhood development (ECD) into emergency response programming for children. Early childhood is a crucial developmental time in individual’s lives and adverse experiences undermine, among other things, language development, self-regulatory capabilities, and child-caregiver interactions. International aid organizations are operationalizing the research on ECD best practices into site-level programming. This thesis examines whether the developmental needs of these children in crisis are being met through these efforts and offers two in-depth case studies: Sesame Workshop’s intervention for Syrian refugee children …

Republicanism’S Globalist Problem: How The Inevitability Of International Engagement Undermines States’ Capacity For Self-Governance, Andrew R. Ciacci

CMC Senior Theses

This thesis examines the difficulties philosophical theories have in adapting to international issues. This work primarily focuses on the philosophical theory of government known as “Republicanism”. According to republicanism, the government’s overarching goal is to promote freedom, which republicans understand as the ability to pursue choices without being under the arbitrary power of others. After establishing its merits, I lay out the core principles of republicanism as are most clearly articulated in Phillip Pettit’s work, Republicanism: A Theory of Freedom and Government. The second chapter then examines how Pettit applies his own view to analyze the state of Republican freedom …

The Road To Human Emancipation - The Moral And Political Foundations Of Markets, William Shi

CMC Senior Theses

The thesis aims to provide both a real public ideology and the legal and socioeconomic structures to realize Karl Marx’s ideal of human emancipation. Marx argues that in capitalist society, the legal and political superstructure forces the ruling class to represent its interest as the public interest, which legitimizes the massive inequality in resources and social power. To demonstrate how to realize the substantive public interest, the two parts of the thesis have two goals. The first part aims to formulate a rightful candidate to the public ideology of human emancipation, which represents the substantive public interest rather than the …

Examining The Ashley Treatment: A Case Study Of The Bioethical Implications Associated With Growth Attenuation Therapy Through The Lens Of The Capabilities Approach, Allison Hill

CMC Senior Theses

In this paper, I will be addressing the questions: what is the capabilities approach? How does this framework help us to understand how altering our – and our children’s – bodies can assist in achieving equality for minorities? Or does it instead work against accomplishing this goal? How does this framework help us to understand how altering the bodies of people with disabilities can also protects those individuals’ dignity? Or does it do the opposite?

@Usa Vs. @Realdonaldtrump: The Decline Of Democracy In 280 Characters Or Less, Bryn Edwards

CMC Senior Theses

From threats, to hate speech, to potential criminal statements, Donald Trump has made use of Twitter like no president or world leader before him. His presidency and communication strategy have been defined by his “tweetstorms” and a consequent slew of legal issues. The prolific rate of his tweeting has made large-scale analyses difficult as they quickly become dated.

Nevertheless, this thesis has aimed for a more holistic analysis by uniquely linking trends in his tweeting to its perceived social consequences, situating this work in a long line of analyses of presidential rhetoric and media strategies. Moreover, it assesses Trump’s use …

K-Means Stock Clustering Analysis Based On Historical Price Movements And Financial Ratios, Shu Bin

CMC Senior Theses

The 2015 article Creating Diversified Portfolios Using Cluster Analysis proposes an algorithm that uses the Sharpe ratio and results from K-means clustering conducted on companies' historical financial ratios to generate stock market portfolios. This project seeks to evaluate the performance of the portfolio-building algorithm during the beginning period of the COVID-19 recession. S&P 500 companies' historical stock price movement and their historical return on assets and asset turnover ratios are used as dissimilarity metrics for K-means clustering. After clustering, stock with the highest Sharpe ratio from each cluster is picked to become a part of the portfolio. The economic and …

Policies And Politics Of Reform : The Governmentality Of Structural Adjustment In Urban And Rural Egypt, Gabriel Gluskin-Braun

CMC Senior Theses

This analysis explores the unique and tumultuous approach to reform in Egypt and addresses

the effects of the implementation of neoliberal policy tools. These tools included privatization, price

liberalization, deregulation, and land reform in both urban and rural areas. Based on these effects, this

analysis will argue that the benefits accrued by the political-economic elite created opportunities for

new patronage networks that upheld elite economic privilege through the process of liberalization

while a wide swath of Egyptians suffered the loss of limited privileges and protections from the state

established by Nasr and upheld by his successors. Consequently, the socialist-statist ‘social …

Evaluating Interpersonal Problems In Anorexia Nervosa Through The Lens Of Polyvagal Theory, Marika Morelan

CMC Senior Theses

Eating disorders are an increasingly prevalent issue, especially among young women. While they aren’t a new phenomenon, they are historically under-researched, and remain widely misunderstood. Without understanding the causes underlying these disorders or the mechanisms working to maintain them, treating them successfully has proved to be incredibly difficult. This is especially the case with Anorexia Nervosa. Out of the six eating disorders in the DSM-5, it has the lowest treatment success rate and an alarmingly high relapse rate. Treating the disorder through weight restoration and the extinction of compensatory behaviors alone does not fully resolve the disordered pathology; interpersonal problems …

Can Instagram Do #Good? The Effect Of Instagram Advertising On Positive Body Image, Dhara Singh

CMC Senior Theses

Research on the effects of social media and advertising on body image has predominantly focused on the negative impacts, with limited studies exploring the effects on positive body image. This study investigated whether body positive Instagram advertising images, which aim to promote body acceptance, increase positive body image compared to ideal or neutral (landscape) images. One hundred and thirty participants (66.2% female) were randomly assigned to an image condition and shown a series of neutral, ideal, or body positive Instagram images. Participants’ positive body image was then measured using the Body Appreciation Scale-2 (BAS-2) and Functional Appreciation Scale (FAS). A …

Moral Hazards And Negative Externalities Of Lifesaving Programs: How Naloxone Access Laws And Prescription Drug Monitoring Programs Affect Hiv Transmission, Jeremy Horn

CMC Senior Theses

This paper looks at naloxone access laws and prescription drug monitering programs and see how these programs affect HIV transmission and drug overdose deaths. Using an OLS regression I find that NAL reduces HIV and increases overdose deaths. I also find reducing the number of drug prescriptions increase HIV and overdose deaths because users switch to intravenous methods.

Mistaken Murder And Written Womanhood: The Evolution Of Evelina Edwards In Late Eighteenth-Century And Early Nineteenth-Century Bath, England, Amanda Mell

CMC Senior Theses

This thesis explores the major themes and literary influences of Jane Austen’s novels through the voice of Evelina Edwards, a fictional girl born in Bath, England in 1784. Over the course of nine years, Evelina reconstructs her social world in a series of diary entries and letters, mirroring the anxieties and concerns of real women during the Regency era. Her writing juxtaposes the novel of manners with mystery, both satirizing trivial concerns and confronting emotional trauma in response to death and social isolation. Class hierarchy and gender roles placed heavy restrictions on women’s freedom, forcing them to carefully calibrate the …

Observing The Effects Of Diversity On Performance In Ugandan Primary Schools, Sydney Baffour

CMC Senior Theses

The goal of all firms is to improve efficiency and performance, and previous literature suggests that diversity among teammates is a mechanism to improve productivity. This research uniquely extends previous understandings of horizontal and vertical diversity by examining school performance metrics as an important indicator of economic outcomes. Using data from the Centre for the Study of African Economies(CSAE) at the University of Oxford, I analyze vertical and horizontal diversity and its effects on teacher groups within Ugandan primary schools. Overall, my results suggest a minimally significant, but positive effect of gender and ethnic diversity on student performance outcomes. My …

A Little Birdy Told Me: Analysis Of The Impact Of Public Tweet Sentiment On Stock Prices, Alexander Novitsky

CMC Senior Theses

The combination of the advent of the internet in 1983 with the Securities and Exchange Commission’s ruling allowing firms the use of social media for public disclosures merged to create a wealth of user data that traders could quickly capitalize on to improve their own predictive stock return models. This thesis analyzes some of the impact that this new data may have on stock return models by comparing a model that uses the Index Price and Yesterday’s Stock Return to one that includes those two factors as well as average tweet Polarity and Subjectivity. This analysis is done with ten …

The Capabilities Approach To Metaphysical Personhood, Mohnish Shah

CMC Senior Theses

It is accepted that humans are persons, but what does this mean? Society equates personhood with legal rights, moral worth, and metaphysical status. But exactly what makes us persons and distinguishes us from non-persons? What does our conception of this distinction and the value and rights we grant to persons but not to non-persons say about the type of creature that we are?

Many philosophers have tried to define metaphysical personhood. However, this thesis argues that current accounts of metaphysical personhood are inadequate. Next, this thesis borrows and modifies Martha Nussbaum’s capabilities approach to human dignity in order to construct …

The Syrian Refugee Crisis Within Europe: A Matter Of Politics, Not Capacity, Anita Frances Shenoi

CMC Senior Theses

This thesis examines factors that enabled the influx of Syrian refugees to the European Union and traces their plight in Europe as one of the greatest humanitarian crises since World War II. The migration of refugees to European countries is a result of Syrians facing religious, racial, and social persecution, and immediate danger from proximity to on the ground conflict in Syria. The Syrian refugee crisis in Europe is occurring, in part, because there is a concentrated effort on behalf of Member States to change the definition of displacement to fit narratives more conducive to each countries’ individual preferences. European …

How Contemporary Curatorial Practice Co-Opts Participatory Art, Caroline S. Eastburn

CMC Senior Theses

Instagram users post photos in art exhibitions all of the time. Contemporary art curators and museums have a role to play in this new phenomenon. Programming and curating participatory art exhibitions allows for the perfect art selfie which draws in visitors from around the world. But, how do curators and museums affect the significance of these artworks by placing them within the Instagram age? This thesis uses the three exhibitions as case studies: Yayoi Kusama: Infinity Mirrors at the Broad Museum in Los Angeles, Take Me (I'm Yours) at the Jewish Museum in New York, and "Hélio Oiticica: To Organize …

Industrial Policy For Regional Development In Lithuania, Guoda Terleckaite

CMC Senior Theses

Lithuania is internationally recognized as a high-income developed country, but the high standard of living is limited only to a small minority of citizens. While the capital is emerging as a financial center and a hub for information technology, cities in the Western and Central parts of Lithuania are rapidly declining. Formerly industrial regions, Šiauliai, Panevėžys, Alytus, Utena, Tauragė, Telšiai and Marijampolė, now suffer from massive emigration, brain drain, high unemployment rates, and an increased risk of poverty and social exclusion among residents. Unlike larger cities, poorer counties have not been magnets for foreign direct investment and have benefited little …

The Political Economy Of State Minimum Wage Laws And Legislator Voting Behavior, Sophia Helland

CMC Senior Theses

The Median Voter Theorem is a key concept in political economy, one that has been tested numerous times in the literature. However, it remains unclear the extent to which legislators respond to the needs of their district on a bill-by-bill basis. This paper seeks to understand the role of ideology and of local economic pressures that a state legislator faces when deciding how to vote on minimum wage legislation. Although some papers have examined legislator voting behavior on specific issues, this paper uses state legislatures and minimum wage bills to innovate on this existing literature in two key ways. First, …

Visualizing Participatory Politics: The Communal Power Of Street Art In Revolutionary Egypt, Warring Syria, And Divided Lebanon, Erin Baranko

CMC Senior Theses

This thesis examines the role of street art in the uprisings in the Middle East and North Africa in 2011 in order to investigate the extent to which the political struggle was also a visual struggle. Through analysis of murals and graffiti, it seeks to address how revolutionary politics are created, consumed, and witnessed in images. In Egypt, protesters created street art that coopted public space in order to circumvent the state’s authority and subvert the state’s legitimacy. Due to its accessible nature, street art also democratized the protest process, facilitating a truly popular revolutionary movement. In Syria, citizens used …

The Noxious Market Of Division 1 College Football, Bryan Carlen

CMC Senior Theses

This paper is made up of four sections. The first will explain Satz’ framework for identifying and treating noxious markets, as well as how it was developed, and the second will make the case for viewing D1 football as a labor market. The second section will lay out who’s involved, what their incentives are, and what they must do to earn these incentives. The third section will then apply Satz’ framework to the market at hand, as well as address a gap in her theory regarding her concept of weak agency. The paper will then conclude with policy guidelines that, …

Populism: An Exploration Into The American Case Through The Academic Literature, Data Analysis, And Fiction, Maxwell Knowles

CMC Senior Theses

The twenty-first century has seen a rise in populist leadership and rhetoric throughout the globe, with the United States standing as one powerful case. This thesis hopes to develop the “story” of populism from multiple perspectives, attempting to not only inform but change the way we approach the populist movement in America, and perhaps, the world. In Part I, I summarize and blend much of the core literature written on populism and economic change, developing the story that populism in America today has its roots in the significant techno-economic and cultural paradigmatic shifts of the 1970s. Social media and an …

Determining The Antibacterial Activity And Mode Of Action Of Tirandamycin, Hailey Bouchard

CMC Senior Theses

Tirandamycin is a small molecule natural product that has been isolated from various species of marine and terrestrial Streptomyces. The natural product has shown antibacterial activity against an array of Gram-positive and Gram-negative bacteria, showing promise as a pharmaceutical drug. Tirandamycin has 14 known derivatives, many of which have been created synthetically. Some of its derivatives are particularly potent against the high-risk bacteria vancomycin-resistant Enterococcus faecium, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae and Escherichia coli. However, the antibacterial potency of these derivatives has not been tested systematically leading to the possibility of discovering more potent …