Digital Commons Network^™

Molecular Implications Of Muc5ac-Cd44 Axis In Colorectal Cancer Progression And Chemoresistance, Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND: Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, whereas its aberrant expression is observed during development of colon cancer and its precursor lesions. To date, the molecular mechanism of MUC5AC in CRC progression and drug resistance remains obscure.

METHODS: MUC5AC expression was determined in colon tissue microarray by immunohistochemistry. A RNA interference and CRISPR/Cas9-mediated system was used to knockdown/knockout the MUC5AC in CRC cell lines to delineate its role in CRC tumorigenesis using in vitro functional assays and in …

Glp-1 Mediated Diuresis And Natriuresis Are Blunted In Heart Failure And Restored By Selective Afferent Renal Denervation, Kenichi Katsurada, Shyam Sundar Nandi, Hong Zheng, Xuefei Liu, Neeru M. Sharma, Kaushik K. Patel

Journal Articles: Cellular & Integrative Physiology

BACKGROUND: Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis as a negative feedback mechanism in normal rats. However, renal effects of GLP-1 in heart failure (HF) has not been elucidated. The present study was designed to assess GLP-1-induced diuresis and natriuresis in rats with HF and its interactions with renal nerve activity.

METHODS: HF was induced in rats by coronary artery ligation. The direct recording of afferent renal nerve activity (ARNA) with intrapelvic injection of GLP-1 and total …

Nr2e3 Is A Genetic Modifier That Rescues Retinal Degeneration And Promotes Homeostasis In Multiple Models Of Retinitis Pigmentosa, Sujun Li, Shyamtanu Datta, Emily Brabbit, Zoe Love, Victoria Woytowicz, Kyle Flattery, Jessica Capri, Katie Yao, Siqi Wu, Michael Imboden, Arun Upadhyay, Rasappa Arumugham, Wallace B. Thoreson, Margaret M Deangelis, Neena B. Haider

Journal Articles: Ophthalmology

Recent advances in viral vector engineering, as well as an increased understanding of the cellular and molecular mechanism of retinal diseases, have led to the development of novel gene therapy approaches. Furthermore, ease of accessibility and ocular immune privilege makes the retina an ideal target for gene therapies. In this study, the nuclear hormone receptor gene Nr2e3 was evaluated for efficacy as broad-spectrum therapy to attenuate early to intermediate stages of retinal degeneration in five unique mouse models of retinitis pigmentosa (RP). RP is a group of heterogenic inherited retinal diseases associated with over 150 gene mutations, affecting over 1.5 …

Atrioventricular Synchronous Pacing Using A Leadless Ventricular Pacemaker: Results From The Marvel 2 Study, Mario Pascual

All Publications

No abstract provided.

Cardiac Myxoma With Cerebral Metastases And Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Case Report And Review, Manuel Menes, Vitaly Siomin

All Publications

No abstract provided.

Title Ix And Official Policy Liability: Maximizing The Law’S Potential To Hold Education Institutions Accountable For Their Responses To Sexual Misconduct, Erin E. Buzuvis

Faculty Scholarship

Title IX, the federal statute that prohibits sex discrimination in education, plays a key role in institutional accountability for sexual misconduct that is perpetrated by a school’s students, faculty, and staff. The Supreme Court has confirmed that Title IX includes an implied right of action for money damages when the institution had actual notice that sexual harassment had occurred, or was likely to occur, and responded to that threat with deliberate indifference. But the deliberate indifference standard has proven to be a high and unpredictable bar for plaintiffs. For this reason, many institutions required the threat of government enforcement—issued in …

Foreword, Sudha Setty

Faculty Scholarship

In November 2019, the Western New England Law Review held its symposium, On Account of Sex: Women’s Suffrage and the Role of Gender in Politics Today. The symposium articles ask us to look at history to see what factors enabled path-breaking activists to secure the right to vote in a time of immense national turmoil. They also ask us to weigh how history should assess the strategic decisions that ultimately gained political rights for some women, but deliberately excluded Black women and other activists.

These historical accounts help us consider how the right to vote is faring, particularly after …

Freedom Of Journalism In International Human Rights Law, Edward L. Carter, Rosalie Westenskow

Faculty Publications

Contemporary attacks of various types have prompted calls for stronger public support and legal protections for journalism. Around the world, journalism faces not only government regulation that affects editorial content but also economic and corporate pressures as well as lack of public understanding of its societal functions. In the United States, courts and even journalism organizations have been reluctant to define journalism or single it out for special protection. But international human rights law presents a possible solution. This article discusses the international human rights law provisions that protect individuals engaged in journalism. The United Nations Human Rights Committee has …

In An Era Of Uncertainty: Impact Of Covid-19on Dental Education, Wendy C. Birmingham, Man Hung, Frank W. Licari, Eric S. Hon, Evelyn Lauren, Sharon Su, Lori L. Wadsworth, Jane H. Lassetter, Tyler C. Graff, William Harman, William B. Carroll, Martin S. Lipsky

Faculty Publications

Purpose/Objectives:The coronavirus disease 2019 (COVID-19) pandemicarguably represents the worst public health crisis of the 21stcentury. However,no empirical study currently exists in the literature that examines the impact ofthe COVID-19 pandemic on dental education. This study evaluated the impactof COVID-19 on dental education and dental students’ experience.Methods:An anonymous online survey was administrated to professionaldental students that focused on their experiences related to COVID-19. Thesurvey included questions about student demographics, protocols for schoolreopening and student perceptions of institutional responses, student concerns,and psychological impacts.Results:Among the 145 respondents, 92.4% were pre-doctoral dental studentsand 7.6% were orthodontic residents; 48.2% were female and 12.6% students livedalone …

Restructuring Vs. Bankruptcy, Jason Roderick Donaldson, Edward R. Morrison, Giorgia Piacentino, Xiaobo Yu

Faculty Scholarship

We develop a model of a firm in financial distress. Distress can be mitigated by filing for bankruptcy, which is costly, or preempted by restructuring, which is impeded by a collective action problem. We find that bankruptcy and restructuring are complements, not substitutes: Reducing bankruptcy costs facilitates restructuring, rather than crowding it out. And so does making bankruptcy more debtor-friendly, under a condition that seems likely to hold now in the United States. The model gives new perspectives on current relief policies (e.g., subsidized loans to firms in bankruptcy) and on long-standing legal debates (e.g., the efficiency of the absolute …

For Coöperation And The Abolition Of Capital, Or, How To Get Beyond Our Extractive Punitive Society And Achieve A Just Society, Bernard E. Harcourt

Faculty Scholarship

In hindsight, the term "capitalism" was always a misnomer, coined paradoxically by its critics in the nineteenth century. The term misleadingly suggests that the existence of capital produces a unique economic system or that capital itself is governed by economic laws. But that's an illusion. In truth, we do not live today in a system in which capital dictates our economic circumstances. Instead, we live under the tyranny of what I would call "tournament dirigisme": a type of state-directed gladiator sport where our political leaders bestow spoils on the wealthy, privileged elite.

We need to displace this tournament dirigisme with …

The Proportionality Rule And Mental Health Harm In War, Sarah Knuckey, Alex Moorehead, Audrey Mccalley, Adam Brown

Faculty Scholarship

The foundational international humanitarian law rule of proportionality — that parties to an armed conflict may not attack where civilian harm would be excessive in relation to the anticipated military advantage — is normally interpreted to encompass civilian physical injuries only. Attacks may cause significant mental harms also, yet current interpretations of the law lag behind science in understanding and recognizing these kinds of harms. This article analyzes legal, public health, psychology, and neuroscience research to assess the extent to which mental health harms should and could be taken into account in proportionality assessments.

All Faiths & None: A Guide To Protecting Religious Liberty For Everyone, Elizabeth Reiner Platt, Katherine M. Franke, Keisha E. Mckenzie, Katharine Rhodes Henderson

Faculty Scholarship

Religious liberty rights have been immeasurably damaged over the past several years — often in the name of protecting religious liberty.

Government officials have embraced Islamophobic policies and rhetoric; shut the door on refugees fleeing religious persecution; elevated the religious rights of their political allies over the rights — religious and otherwise — of other communities; used religion as a tool of economic deregulation; and denigrated the beliefs of religious minorities, atheists, and religious progressives.

To achieve true freedom for those of all faiths and none, a complete overhaul of religious liberty policy, and a new understanding of what this …

Letter To Council Members Regarding Council Draft 4, Jane C. Ginsburg

Faculty Scholarship

We understand that the ALI Council will consider Council Draft 4 (CD4) of the Restatement of the Law, Copyright (Copyright Restatement) project at its meeting on January 16-17, 2020. We appreciate the opportunity to provide comments on CD4. We hope that you will give careful consideration to these comments and send CD4 back to the Reporters to address the problems we describe below.

Lessons From The Prekindergarten Movement, Clare Huntington

Faculty Scholarship

I am deeply grateful for the ambition of Nancy Dowd’s book, Reimagining Equality. Professor Dowd offers a powerful and essential vision for addressing the entrenched inequalities that pervade our society. And she is unapologetic about the breadth and depth of change needed to achieve this vision. I do not want to distract from her inspiring call for a New Deal for Children by introducing questions about political feasibility, but thinking about what is possible in the here and now is a useful place to begin the conversation about systemic change.

So, what is possible in this era of Trump? …

An Opening: Advocating For Equity In A Polarized America, Olatunde C.A. Johnson

Faculty Scholarship

American society is facing a daunting array of political and social challenges. The ascendance of Trump reflects deep political fissures that seem to have calcified over the last four years. Blatant racist appeals have become part of ordinary politics and our core democratic foundations have been shaken by the emergence of an ethno-nationalist populist ethic that is skeptical of government and evidence based expertise. The killings by police of unarmed black people, and the convulsive protests in response, made plain the persistence of racism. The pandemic has further ravaged our society: exposing pre-existing race- and class-based inequalities, and — by …

Privacy And Pandemics, Clarisa Long

Faculty Scholarship

The beginning of 2020 marked an unexpected turn for the world, the global pandemic of COVID-19 has affected every aspect of life. It has also created an unprecedented opportunity for governments to justify the expansion of their surveillance and collection of data. The foregoing essay, which was first published in Faculty Publications at Scholarship Archive of the Columbia Law School focuses on two types of data collection – governmental mass collection of nonanonymized location data and state-collected nonanonymized data on people's health and immunity status. Several countries have applied one or both practices and it is relevant to look into …

On The Rhetorical Grotesque: A Mode For Strange Times, Richard Benjamin Crosby

Faculty Publications

This essay argues that the successful political careers of certain populist leaders rhetorically enact what scholars have long recognized in art, literature, and entertainment as the grotesque. The grotesque provides a theoretically rich means for describing the vulgar and chaotic public behaviors that take strong hold among anti-elite audiences at certain points in history. By closely reading comments from political leaders cast in the grotesque mold, including Silvio Berlusconi, Hugo Chavez, and Donald Trump, this essay explains not only what the grotesque is, but also when and how it is likely to find traction in a political culture ripe for …

Apocalypse Now: Covid-19 And The Sf Imaginary, Gerry Canavan, Jennifer Cooke, Caroline Edwards

English Faculty Research and Publications

The following conversation was conducted via Google Docs between 1st May and 23rd June 2020. The participants were Gerry Canavan (Marquette University), Jennifer Cooke (Loughborough University) and Caroline Edwards (Birkbeck College, London). Gerry is President of the SFRA; his books include Green Planets: Ecology and Science Fiction (2014), co-edited with Kim Stanley Robinson, Octavia E. Butler (2016), and most recently The Cambridge History of Science Fiction (2019), co-edited with Eric Carl Link. Jennifer is a poet and academic; her first book was on Legacies of Plague in Literature, Theory, and Film (2009) while her most recent is Contemporary Feminist Life-Writing: …

Simulating Gender: Student Learning In Clinical Nursing Simulations, Lillian Campbell

English Faculty Research and Publications

No abstract provided.

Which Covid-19? Whose Crisis?, Gerry Canavan

English Faculty Research and Publications

The article focuses on emergence of coronavirus since December 2019 and dissolution of condition of capitalism that has been globally suffering. Topics discussed include production of social distancing, virtual learning and economic impact payment by the pandemic, risk of Blacks due to the intergenerational poverty and households impacted due to lockdowns.

Keats In And Out Of Place: Reviews Of Keats's Negative Capability And Keats's Places, Ben Pladek

English Faculty Research and Publications

No abstract provided.

Doesn't Everybody Want To Be Healthy?, Jana L. Wardian Phd

Journal Articles: Hospital Medicine

No abstract provided.

Preconception Counseling For Women With Diabetes, Abegail L. Hubberd, Nina A. Watson, Ellen Cobb, Jana L. Wardian Phd, Connie C. Morrow, Tom J. Sauerwein

Journal Articles: Hospital Medicine

"Quality Improvement Success Stories" are published by the American Diabetes Association in collaboration with the American College of Physicians, Inc., and the National Diabetes Education Program. This series is intended to highlight best practices and strategies from programs and clinics that have successfully improved the quality of care for people with diabetes or related conditions. Each article in the series is reviewed and follows a standard format developed by the editors of

The Choice Should Be Yours: Diabetes-Related Distress By Insulin Delivery Method For People With Type 1 Diabetes, Jana L. Wardian Phd, Mark W. True, Irene Folaron, Jeff Colburn, Joshua M. Tate, Darrick J. Beckman

Journal Articles: Hospital Medicine

Background: American Diabetes Association (ADA) recommends psychosocial assessment for people with diabetes, including diabetes-related distress. Elevated diabetes-related distress is associated with poor self-management, lower medication adherence, and poorer quality of life. Insulin delivery methods are multiple daily injections (MDI) or continuous subcutaneous insulin infusion (CSII). Because people with type 1 diabetes mellitus (T1DM) require comprehensive insulin therapy to manage blood glucose, we explored the association of insulin delivery methods and diabetes distress in this group. Methods: The U.S. Air Force Diabetes Center of Excellence (DCOE), a specialty clinic for adults who are Military Health System beneficiaries, administers the validated 17-item …

A High Docosahexaenoic Acid Diet Alters The Lung Inflammatory Response To Acute Dust Exposure, Edward C. Dominguez, Art J. Heires, Jacqueline A. Pavlik, Tricia D. Larsen, Stephanie Guardado, Joseph H. Sisson, Michelle L. Baack, Debra J. Romberger, Tara M. Nordgren

Journal Articles: Internal Medicine

Agricultural workers are at risk for the development of acute and chronic lung diseases due to their exposure to organic agricultural dusts. A diet intervention using the omega-3 fatty acid docosahexaenoic acid (DHA) has been shown to be an effective therapeutic approach for alleviating a dust-induced inflammatory response. We thus hypothesized a high-DHA diet would alter the dust-induced inflammatory response through the increased production of specialized pro-resolving mediators (SPMs). Mice were pre-treated with a DHA-rich diet 4 weeks before being intranasally challenged with a single dose of an extract made from dust collected from a concentrated swine feeding operation (HDE). …

Age-Related Visual Dynamics In Hiv-Infected Adults With Cognitive Impairment., Boman R. Groff, Alex I. Wiesman, Michael T. Rezich, Jennifer O'Neill, Kevin R. Robertson, Howard S. Fox, Susan Swindells, Tony W. Wilson

Journal Articles: Internal Medicine

OBJECTIVE: To investigate whether aging differentially affects neural activity serving visuospatial processing in a large functional neuroimaging study of HIV-infected participants and to determine whether such aging effects are attributable to differences in the duration of HIV infection.

METHODS: A total of 170 participants, including 93 uninfected controls and 77 HIV-infected participants, underwent neuropsychological assessment followed by neuroimaging with magnetoencephalography (MEG). Time-frequency analysis of the MEG data followed by advanced image reconstruction of neural oscillatory activity and whole-brain statistical analyses were used to examine interactions between age, HIV infection, and cognitive status. Post hoc testing for a mediation effect of …

Myd88 Regulates A Prolonged Adaptation Response To Environmental Dust Exposure-Induced Lung Disease, Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian, Jill A. Poole

Journal Articles: Internal Medicine

BACKGROUND: Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor protein myeloid differentiation factor88 (MyD88) is fundamental in regulating acute inflammatory responses to organic dust extract (ODE), yet its role in repetitive exposures is unknown and could inform future strategies.

METHODS: Wild-type (WT) and MyD88 knockout (KO) mice were exposed intranasally to ODE or saline daily for 3 weeks (repetitive exposure). Repetitively exposed animals were also subsequently rested with no treatments for 4 weeks followed by single rechallenge with saline/ODE.

RESULTS: Repetitive …

Feasibility Of Fluoroscopy-Free Endovascular Navigation In Subjects Of Different Ages, Blake Marmie, Christian Sanderfer, Paul Aylward, Alexey Kamenskiy, Jason N. Mactaggart

EMET Projects

No abstract provided.

Customized Blister Packaging For Patients Living With Hiv: Assessment Of Patient Attitudes And Satisfaction, Holly Groteluschen, Harlan Sayles, Joshua P. Havens, Sara Bares, Jasmine Marcelin

EMET Projects

No abstract provided.