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Retrospective Evaluation Of Factors Affecting Superovulatory Response In Embryoproduction In Simmental Cattle, Hüseyi̇n Erdem, Hasan Alkan, Tahi̇r Karaşahi̇n, Şükrü Dursun, Fatma Satilmiş, Mehmet Güler

Turkish Journal of Veterinary & Animal Sciences

In the present study, it was aimed to investigate the effect of lactation status, days in milk (DIM), follicle stimulating hormone (FSH) dose, and repeated superstimulations on superovulation response and embryo yield in Simmental cattle. In the present study, 193 Simmental breed cattle (lactating, nonlactating, and heifer) were used as donors, of which 149 were superovulated only once and the other 44 were superovulated for 3 times. Progesterone-based estrus synchronization protocol was applied to the donors. Starting from day 7, FSH was given intramuscularly to donors in decreasing doses twice a day for 4 days. The donors were injected with …

Physiological And Pharmacological Roles Of Melatonin In The Pathophysiologicalcomponents Of Cellular Injury After Ischemic Stroke, Ertuğrul Kiliç, Berrak Çağlayan, Mustafa Caglar Beker

Turkish Journal of Medical Sciences

Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin detoxifies oxygen and nitrogen-based free radicals and oxidizing agents, including the highly toxic hydroxyl-and peroxynitrite radicals, initiating cellular damage. However, the cytoprotective …

Behçet Syndrome As A Construct, Hasan Yazici

Turkish Journal of Medical Sciences

We still do not know the cause(s) of Behçet syndrome. Most probably several, separate disease mechanisms are involved. I, like some others, propose we call it not a disease but a syndrome, a construct with a list of strong and weak elements. I like to think that this frank admission of our ignorance of its cause(s) will be an important semantic stimulus for more meaningful research.

The Negative Effects Of Dry Eye Disease On Quality Of Life And Visual Function, Lee W. Guo, Esen Akpek

Turkish Journal of Medical Sciences

In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry eye involve its impact on quality of life. Although ocular discomfort symptoms are well known to be associated with dry eye, its negative effects on visual function remain underrecognized. This paper reviews these topics within the currently published literature to heighten awareness among clinicians.

Thalamocortical Network Interruption: A Fresh View For Migraine Symptoms, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Migraine is a multifaceted brain disorder where multisensory disturbances are associated with headache. Yet sensory symptoms are conventionally justified by dysfunctions confined to the cerebral cortex, a perspective through the complex interplay of thalamocortical network would provide the entire picture, more pertinent to the central sensory processing. It is important to consider thalamus as a hub that integrates multiple domains via extensive connections among anatomically and functionally separate cortical areas. Accordingly, cortical spreading depression (CSD), implicated in migraine pathophysiology can be seen as a tool to disconnect thalamocortical network by functionally eliminating cerebral cortex. Hence, including thalamic reticular nucleus and …

Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz

Turkish Journal of Medical Sciences

A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …

Adjustable Bone Plate: State Of Art, Gazi̇ Huri̇

Turkish Journal of Medical Sciences

Background/aim: The success of treatment of bone fracture and defects are based on a proper contact and compression between the bone fracture fragments. Intraoperative manipulations such as bone compression or distractions are generally done in order to achieve this. However, none of the bone plates currently in routine use allow these manipulations after fixation to the bone, requiring refixation and repeated drilling, and screwing operations. Based on this shortcoming, we designed a novel adjustable bone plate (ABP) system which allows bone shortening and lengthening even after fixation to the bone surface. The aim of the paper is to clarify the …

Update On Liver Transplantation-Newer Aspects, Rahşan Olga Meti̇n, Cem Şi̇mşek, Ahmet Ömür Gürakar

Turkish Journal of Medical Sciences

Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not enough adequate livers for all the potential patients that could benefit from LT. Despite efforts to expand the donor pool to include living and deceased donors, organ shortage is still a major problem in many countries. To solve this problem, the use of marginal liver grafts has become an inevitable choice. Although the definition of marginal …

Molecular Subtyping Bladder Cancer: Is It Ready For Clinical Practice?, Funda Vakar Lopez

Turkish Journal of Medical Sciences

Bladder cancer, one of the more common cancers, is a heterogeneous disease, both morphologically and clinically. Although histological classification and extent of the disease (staging) guide treatment options, the heterogeneity in responses to therapy highlights the need for better stratification of patients for the appropriate therapy in order to achieve better outcomes. Several molecular classifications of muscle-invasive bladder cancer have been proposed but currently their use in clinical practice is limited by the complexity of the methods used and diversity of the subtypes.

Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in several organs. With the advent of genetic and molecular techniques, mutations in the TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with neurologic symptoms comprising a significant source of morbidity and mortality. In 2012, the diagnostic criteria for TSC were revised by …

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio

Turkish Journal of Medical Sciences

Background/aim: Immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated fibroinflammatory condition, which may involve multiple organs and mostly presents with high serum IgG4 levels and specific histopathological characteristics. As IgG4-RD is a relatively new entity the etiology, prevalence and epidemiologic knowledge is quite limited. Although involvement of almost all anatomical regions has been reported, the most commonly affected regions are pancreas, lacrimal glands, salivary glands, retroperitoneum, orbita, lymph nodes, kidney and lungs. Diagnosis is made with combined evaluation of clinical, radiological and histopathological findings. Typical histopathological features include storiform fibrosis, dense lymphoplasmacytic infiltrates and obliterative phlebitis. Its course is typically marked …

Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer

Turkish Journal of Medical Sciences

Background/aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used for the treatment of various refractory solid tumors during the last two decades. After the demonstration of graft-versus-leukemia (GvL) effect in a leukemic murine model following allo-HSCT from other strains of mice, graft-versus-tumor (GvT) effect in a solid tumor after allo-HSCT has also been reported in a murine model in 1984. Several trials have reported the presence of a GvT effect in patients with various refractory solid tumors, including renal, ovarian and colon cancers, as well as soft tissue sarcomas [1]. The growing data on haploidentical transplants also indicate GvT …

Ankaferd Hemostat: From Molecules To Medicine, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Ankaferd hemostat (ABS; Ankaferd Blood Stopper® , İstanbul, Turkey) is a hemostatic agent having an impact on red blood cell-fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced formation of the protein network by vital erythrocyte aggregation. Vital erythrocyte aggregation occurs with the spectrine, ankyrin, and actin proteins on the membrane of the red blood cells. ABS notably affects cell metabolism and cell cycle mechanisms. Meanwhile, ABS has antiproliferative effects on cancer cells. The aim of this review …

Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan

Turkish Journal of Medical Sciences

Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition …

Sheq: Using The Power Of Emotional Intelligence For Success, Jen Shirkani, Steve Friedlein, Angela Bearor, American Institute Of Certified Public Accountants. Women's Initiatives Executive Committee

Guides, Handbooks and Manuals

No abstract provided.

Chapter 4:Cleaning And Disinfecting, Georgia Southern University

Covid-19 Pandemic: News & Publications (Archived)

• How to Clean and Disinfect

Chapter 5: Monitor Your Health, Georgia Southern University

Covid-19 Pandemic: News & Publications (Archived)

• Monitoring Your Health
• Signs and Symptoms
• When to Seek Emergeny Medical Attention
• Covid-19 Georgia Southern Employee Decision Trees and Guidance
• If Someone in Your Home is Sick

Chapter 7: Resources, Georgia Southern University

Covid-19 Pandemic: News & Publications (Archived)

• Campus Resources
• Additional Resources and Information

Acute Mesenteric Thrombosis: A Hematologist Perspective, Bushra Moiz, Zaid Muslim, Zahraa Farrukh Siddiqui, Hasnain Zafar

Department of Pathology and Laboratory Medicine

No abstract provided.

Kidney Stone Analysis And Spiritual Guides (Pir Faqir): The Known-Unknowns, Lena Jafri, Aysha Habib Khan, Humaira Asif

Department of Pathology and Laboratory Medicine

No abstract provided.

Use Of Pefloxacin As A Surrogate Marker To Detect Ciprofloxacin Susceptibility In Salmonella Enterica Serotypes Typhi And Paratyphi A, Safia Moin, Mohammad Zeeshan, Sidra Laiq, Ahmed Raheem, Afia Zafar

Department of Pathology and Laboratory Medicine

Objective: To determine the use of pefloxacin as a surrogate marker to detect fluoroquinolone (ciprofloxacin) susceptibility against Salmonella enterica serotypes Typhi and Paratyphi A.
Methods: The prospective, descriptive cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from September 2016 to March 2018, and comprised Salmonella Typhi and Paratyphi A isolates of blood cultures. Disk susceptibility tests and broth microdilution to test minimum inhibitory concentration were performed as per standard guidelines. Data was analysed using SPSS 21.
Results: Of the 138 isolates, 91(66%) were intermediate resistant to ciprofloxacin but were resistant to pefloxacin, 42(30%) were resistant to both …

Morphological And Heartwood Variation Of Santalum Macgregorii In Papua New Guinea, T. Page, G. K. Jeffrey, P. Macdonell, D. Hettiarachchi, Mary C. Boyce, A. Lata, L. Oa, G. Rome

Research outputs 2014 to 2021

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Santalum macgregorii (sandalwood), which is endemic to the southern part of Papua New Guinea (PNG), has been heavily exploited for its fragrant heartwood and is classified as threatened across its natural range. Domestication and smallholder agroforestry offer the means to preserve remaining diversity. This study was undertaken to understand the extent of remaining natural variation to support the species’s conservation and domestication. We evaluated morphological, heartwood and essential oil characters in 126 S. macgregorii trees in five populations (districts) in PNG’s Central, Gulf and Western …

Pro-Human Economic Indicators And Their Relationship With Environmental Sustainability In Asean Countries: Analyzing Human Capital Investment, Brain Drain And Immigration Through Panel Data, Soheil Kazemian, Ahmed Abdullah Saad Al-Dhubaibi, Norlaila Md Zin, Zuraidah Mohd Sanusi, Zalina Zainudin

Research outputs 2014 to 2021

© 2020 The focus on the human development indicators has been increasing. A number of studies focusing on the institutional and economic effects of immigration, brain drain and development of human capital through increased investments has been performed. However, the present study evaluates the effects of these variables on the environmental sustainability of the ASEAN countries for the period ranging 1990-2019. The study evaluates the causal and magnitude of these indicators on the environmental sustainability. The study focuses on the evaluation of the data by means of a unit root test, panel cointegration test, estimation procedure and the causality analysis. …

The Experiences Of Western Australian Muslims Within The Current Political And Social Environment, John Lehane

Theses: Doctorates and Masters

The purpose of this research was to examine the experiences of Western Australian (WA) Muslims, within the context of the current Australian political and social climate, with a key focus on how political and social factors, and the vast introduction of Australian antiterrorism legislation, may impact them. Also explored in this inquiry, was how mainstream media and their regular portrayal of Islamic-inspired terrorist attacks, which has at times connected all Muslims to these atrocities, is creating a social division within the Australian community which is difficult to overcome.

A generic qualitative methodology was utilised to best capture the lived experiences …

Barriers To Ghanaian Midwives’ Ability To Provide Quality Care: A Glaserian Grounded Theory Study, Yakubu Ismaila

Theses: Doctorates and Masters

The midwifery model of care that promotes the employment of trained and regulated midwives for the provision of maternal and neonatal care has been found to be beneficial, especially in Low and Middle-Income Countries that have high maternal and neonatal mortalities. Midwives in those setting are however, facing a myriad of barriers which negatively affect their ability to provide optimal care. Although Ghana is implementing the midwifery model of care, maternal and neonatal mortality remains high in the country. Little is known from the point of view of midwives, who are the primary providers of maternal and neonatal care, about …

Reply To Lipworth Et Al., Angela M. Moran, Sanjay Ramakrishnan, Catherine A. Borg, Clare M. Connolly, Simon Couillard, Christine M. Mwasuku, Ian D. Pavord, Timothy S.C. Hinks, Lauri Lehtimӓki

Research outputs 2014 to 2021

We thank Dr. Lipworth and colleagues for their interest in our work published recently in the Journal (1). They rightly point out that the biology of asthma attacks is more complex than blood eosinophils alone and that corticosteroids have a wide range of other potentially relevant antiinflammatory effects. However, local treatment with inhaled corticosteroids (ICS) is usually the mainstay of patients with frequent eosinophilic exacerbations, and therefore in the great majority of patients, the key question is what oral corticosteroids (OCS) add to ICS in an acute attack (2) and whether this effect is seen with benralizumab. We suggest that …

Muscular And Physical Response To An Agility And Repeated Sprint Tests According To The Level Of Competition In Futsal Players, Jorge García-Unanue, José Luis Felipe, David Bishop, Enrique Colino, Esther Ubago-Guisado, Jorge López-Fernández, Enrique Hernando, Leonor Gallardo, Javier Sánchez-Sánchez

Research outputs 2014 to 2021

© Copyright © 2020 García-Unanue, Felipe, Bishop, Colino, Ubago-Guisado, López-Fernández, Hernando, Gallardo and Sánchez-Sánchez. The aim of this study was to evaluate the neuromuscular response to an agility and repeated sprint ability (RSA) test according to the level of competition in futsal players. A total of 33 players from two elite teams and one amateur team participated in the study. The participants completed an agility t-test, a 30 m-speed test, and a RSA test. A countermovement jump (CMJ) test and a tensiomyography test of the rectus femoris (RF) and biceps femoris (BF) of both legs were carried out before and …

Distribution And Evolution Of Fukushima Dai-Ichi Derived 137cs, 90sr, And 129i In Surface Seawater Off The Coast Of Japan, Jennifer A. Kenyon, Ken O. Buesseler, Núria Casacuberta, Maxi Castrillejo, Shigeyoshi Otosaka, Pere Masqué, Jessica A. Drysdale, Steven M. Pike, Virginie Sanial

Research outputs 2014 to 2021

© 2020 American Chemical Society. The Fukushima Dai-ichi Nuclear Power Plants (FDNPPs) accident in 2011 led to an unprecedented release of radionuclides into the environment. Particularly important are 90Sr and 137Cs due to their known health detriments and long half-lives (T1/2 ≈ 30 y) relative to ecological systems. These radionuclides can be combined with the longer-lived 129I (T1/2 = 15.7 My) to trace hydrologic, atmospheric, oceanic, and geochemical processes. This study seeks to evaluate 137Cs, 90Sr, and 129I concentrations in seawater off the coast of Japan, reconcile the sources of contaminated waters, and assess the application of 137Cs/90Sr, 129I/137Cs, and …

Pilot Study On The Reliability Of The Coach's Eye: Identifying Talent Throughout A 4-Day Cadet Judo Campp, Alexandra H. Roberts, Daniel Greenwood, Clare Humberstone, Annette J. Raynor

Research outputs 2014 to 2021

A typical assumption found in talent identification literature is that different coaches, given the same athletes and circumstances, will identify the same subset of athletes as “talented”. However, while coaches play a major role during talent identification in practical sport settings, there is limited empirical research exploring the processes which underpin this. The purpose of this study was to explore the reliability of “the coach's eye” during the assessment of talent in a group of athletes. Specifically, this project compared inter-coach agreement between nine judo coaches (ages 35.8 ± 10.6 years) with varying levels of experience (12.9 ± 8.9 years) …