Digital Commons Network^™

Role Of Trib3 In Progression And Pathogenesis Of Diabetic Retinopathy, Priyamvada Milind Pitale

All ETDs from UAB

Diabetic retinopathy (DR) is reported to be one of the leading causes of blindness in the United States by Center for Disease Prevention and Control. As the estimated prevalence of the disease will likely triple by 2020, the research in this area should focus on identifying novel targets and therapeutic approaches. One of the therapeutic approaches for DR is the reprograming of retinal metabolism to delay the progression of the disease. The unfolded protein response (UPR) is recognized as a cellular pathway activated in diabetic retina which interacts with key transcription factors to physiologically regulate glucose, lipid homeostasis, and angiogenic …

Novel Hiv Adaptation Strategy Against Host Cd8 T Cell Immunity, Kai Qin

All ETDs from UAB

Since the 1980s, HIV infection has caused millions of death and tremendous economic losses worldwide. Despite great scientific advances, the only effective therapy to date, antiretroviral therapy (ART), merely delays disease progression yet cannot eradicate viral infection. Therefore, an effective HIV vaccine that can prevent the acquisition of infection would be a desirable alternative. The critical role of CD8 T-cell immunity in HIV infection has been well documented and therefore not surprisingly a great deal of effort has been focused on developing an effective CD8 T-cell based HIV vaccine. However, by far, such CD8 T-cell based HIV vaccine trials have …

Investigating Growth-Related Hormones And Their Roles In Metabolism In Fish Skeletal Muscle, Ross Michael Lee Reid

All ETDs from UAB

The endocrine system is essential for the maintenance and regulation of skeletal muscle growth and metabolic processes, as secretions of growth-related hormones directly regulate these systems. The roles of these growth-related hormones are well understood in mammals yet are not well defined in teleosts. Thus, the work outlined in these chapters provides novel insight for the actions of two growth-related hormones, Growth Hormone (GH) and Teneurin C-terminal Associated Peptide (TCAP), in fish skeletal muscle. First, Chapter 2 highlights the work expanding the application of resazurin as a novel method of in vivo metabolic assessment across fish life-stages, which was utilized …

Investigating The Roles Of The Renal Primary Cilium Through The Use Of Intravital Imaging, Dustin Zachary Revell

All ETDs from UAB

Primary cilia are small microtubule based appendages present on nearly every cell type in the mammalian body, and are highly conserved from organisms as simple as algae to humans. Cilia function as complex signaling centers integrating a variety of pathways and play critical roles throughout development and in maintaining homeostasis. Mutations to ciliary proteins in humans result in a wide array of diseases termed ciliopathies, which have a broad range of symptoms affecting nearly every organ in the body. Renal primary cilia are present on the apical side of tubular epithelium, where they project into the lumen and are thought …

Corporate Social Marketing: An Analysis Of Consumer Response To Nike’S Campaign Featuring Colin Kaepernick, Sarah M. Brown, Natasha T. Brison, Gregg Bennett

Global Sport Business Journal

Corporate social responsibility (CSR) is ubiquitous within the sport industry and a common business strategy to enhance brand image. This research focused on corporate social marketing (CSM) and how consumers processed and responded to Nike’s social injustice campaign featuring Colin Kaepernick. A thematic analysis of New York Times readers’ comments was conducted and comments were placed into predetermined categories. Together, attribution theory and the Inoue and Kent (2014) CSM framework were used to create five code categories: (1) corporate attributes, (2) corporate reputation, (3) CSM attributes, (4) cause attributes, (5) consumer behavior. Results demonstrated the campaign had an overall positive …

Bathrooms As A Homeless Rights Issue, Ron S. Hochbaum

McGeorge School of Law Scholarly Articles

Bathrooms are a bellwether of equality. Segregated bathrooms were at the center of the Civil Rights Movement. Accessible bathrooms were at the heart of the Disability Rights Movement. Now, gender-neutral bathrooms or bathrooms assigned by gender, rather than sex, are at the heart of the Transgender Rights Movement.

This Article is the first to examine the right to access bathrooms as it relates to the homeless community. The Article explores the current paradox where cities, counties, and states provide few, if any, public bathrooms for the homeless community and the public at large while criminalizing public urination and defecation.

To …

[email protected]: Using The Tech Start-Up Concept To Train, Engage, And Inform Students, Stephanie J. Coopman, Ted Coopman

Faculty Publications

Undergraduate and graduate students were enrolled in an upper-division online experiential learning course organized as a technology company start up at a public university in the US. Students participated in an academic department’s social media team, publishing a weekly newsletter and producing and curating content for multiple social media outlets designed for public and university audiences, a website for the department’s students, and a career portal. Responses to survey questions provided support for Experiential Learning Theory’s cyclical learning model. In addition, students viewed the entrepreneurial approach to the team as both liberating and challenging as they engaged with each other …

Economic Activity, International Intervention, And Transitional Governance: A Comparative Case Study Of Somalia, Daniel Bonneau, Joshua C. Hall

Economics Faculty Working Papers Series

This paper investigates the impact of international state-building efforts in Somalia on economic development. We use satellite data on night lights to measure economic activity to deal with nonexistent or poor-quality national income accounts. Using the synthetic control method, we find that the establishment of the Transitional Federal Government in 2004 was associated with economic stagnation relative to the years under statelessness. Using nighttime light emissions, we find economic stagnation regardless of whether we use the total lights emitted from the country or the spread of lights across the country. Our empirical findings are consistent with the idea that the …

Integrated Report 2020; Adapt+Thrive; Aicpa Annual Report, 2020, Association Of International Professional Accountants

AICPA Annual Reports

No abstract provided.

2020 Fall Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

Closed Adoption: An Illusory Promise To Birth Parents And The Changing Landscape Of Sealed Adoption Records, Bryn Baffer

Catholic University Journal of Law and Technology

Imagine spitting into a tube and mailing your DNA off only to discover that you had a sibling who had been adopted by another family or that a parent’s affair had resulted in a half-sibling. For many individuals, these family secrets have been exposed due to direct-to-consumer DNA testing companies, such as 23andMe.

By the 1950s, most states had enacted statutes that sealed adoption record files in order to preserve the privacy of the birth parents, adoptees, and adoptive families. While some states have moved toward granting adoptees access to their adoption records, most states still have some type of …

Cyber Insurance Today: Saving It Before It Needs Saving, Angela Nieves

Catholic University Journal of Law and Technology

Cyber insurance, which covers a company’s losses and costs stemming from a cyberattack, represents a nearly $5 billion global market. But have stakeholders shaped a sustainable model? This article analyzes contrasting claims about the viability of cyber insurance. It proposes measures to ensure the survival of the cyber insurance market, which should be immediately addressed given the current state of the world and the fact that even pre-COVID-19, businesses worldwide stood to lose over $5.2 trillion over the next five years due to cybercrimes. Unless action is taken to mitigate the fallout from cyber events, the cyber insurance market will …

History Of Natural And Anthropogenic Activities In Lake Izabal, Eastern Guatemala: Using Geochemical Evidence To Record Recent Contamination, Elisandra Hernandez

Doctoral Dissertations

”Water is essential for human subsistence. Stable freshwater supplies are needed as a source of food, drinking water, for transportation, recreation and economic development. Despite their recognized importance, anthropogenic activities have altered freshwater ecosystems around the world. Lake Izabal is the habitat for diverse aquatic species of flora and fauna, some of which are endemic and endangered. Its importance notwithstanding, anthropogenic activities developed in Lake Izabal’s catchment in recent years have compromised its status. This study used paleolimnological techniques to link past and recent anthropogenic activities such as mining operations and recent tilapia aquaculture. Relative abundances and concentrations of Pb, …

Tools To Evaluate Nanodiamond-Mediated Delivery Of Tiopronin For Cataract Prevention, Justin Beltz

Doctoral Dissertations

”There is a growing demand for non-surgical means of cataract treatment. This dissertation presents three bodies of work that reflect the early-stage development of eye drop formulations aimed at delaying cataract progression. These formulations consist of the antioxidant 2-mercaptopropionylglycine (MPG) loaded onto nanodiamond particles.

Cataractogenesis is linked to oxidative damage to lens proteins. To investigate the potential of MPG for protection against oxidative damage, A549 cells were incubated in 0.6 mM tert-butylhydroperoxide (tBHP). Cells exposed to tBHP without MPG exhibited elevated levels of reactive oxygen species, which led to the depletion of the vital antioxidant glutathione and, ultimately, apoptosis. Co-administration …

Modulation Of Parasympathetic Reactivation Post-Exercise Via Slow Breathing, Brent Burg

CSB and SJU Distinguished Thesis

During exercise sympathetic nervous activity increases and parasympathetic nervous activity decreases to fuel energy demands. Heart rate variability (HRV) indicates activity of the autonomic nervous system and the balance of its two branches. Slow breathing (SB) (6 breaths/minute) increases parasympathetic activity both spontaneously during practice and at rest after long-term practice. Thus, SB may increase parasympathetic activity after exercise. PURPOSE: This study aimed to determine whether post-exercise SB increases parasympathetic activity as measured by HRV. METHODS: Ten recreationally active college aged males (21 +/-1 years old) completed the study. A VO2max test was used to determine 70% of VO2max for …

Impacts Of Media Communication To Motivate State Level Policy Action: The Case Of The Colorado River Basin, Abigail Rader

CSB and SJU Distinguished Thesis

The cultivation of life within the American Southwest would not have been possible without the Colorado River Basin. The water in the basin today maintains 40 million people and one-twelfth the American economy. As a result of the significance of this river, the Colorado is one of the most regulated waters in the world, yet drought concerns continue to proliferate due to climate change. Drawing from communication and political science literature, the media have frequently been cited as impacting the policy agenda, particularly local media. This paper addresses how the frequency of The Denver Post news reporting and its framing …

The Impact Of Nutrition Education On Serving Size Comprehension In College-Age Female Students, Carisa Hilton

CSB and SJU Distinguished Thesis

Background: Nutrition Facts labels are a low-cost informational tool with the potential for encouraging healthful purchasing and eating habits. The use of nutrition labels on packaged foods can promote healthier dietary choices; however, systematic reviews show that consumers may not frequently use nutrition labels to make food choices and do not effectively measure an appropriate serving size, leading to nutrient over-/underconsumption. Objective: The goal of this study was to investigate how female college students use the Nutrition Facts label and measurement tools to estimate one recommended serving size, and if varying nutrition education tools improve serving size accuracy …

Electrospinning Piezoelectric Fibers For Biocompatible Devices, Bahareh Azimi, Mario Milazzo, Andrea Lazzeri, Stefano Berrettini, M. Jasim Uddin, Zhao Qin, Markus J. Buehler, Serena Danti

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

The field of nanotechnology has been gaining great success due to its potential in developing new generations of nanoscale materials with unprecedented properties and enhanced biological responses. This is particularly exciting using nanofibers, as their mechanical and topographic characteristics can approach those found in naturally occurring biological materials. Electrospinning is a key technique to manufacture ultrafine fibers and fiber meshes with multifunctional features, such as piezoelectricity, to be available on a smaller length scale, thus comparable to subcellular scale, which makes their use increasingly appealing for biomedical applications. These include biocompatible fiber-based devices as smart scaffolds, biosensors, energy harvesters, and …

Development And Testing Of Artificial Membranes For Rearing Of Rhipicephalus Microplus, The Southern Cattle Fever Tick, Ann T. Vacek, John A. Goolsby, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The southern cattle fever tick, Rhipicephalus microplus, is a livestock pest worldwide in tropical and subtropical climates, including South Texas, and can vector Babesia spp., the causal agents of bovine babesiosis. Artificial rearing methods for R. microplus are needed, especially for rearing specialist tick parasitoids that are under evaluation for classical biological control. In this study, we tested the efficiency of artificial feeding of R. microplus larvae, nymphs, and adults on a siliconized substrate (goldbeater’s membrane, lens paper, or Hemotek), or on nonsiliconized goldbeater’s membrane or Hemotek. Other variables tested were a warm water bath, incubator, positioning blood above or …

Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study, Ravindra Kamble, Manasi Kulkarni, Swati Korake, Abhishek Pawar, Krishnat Dhekale

The Thai Journal of Pharmaceutical Sciences

Aim: This work was aimed to develop a carrier system of poly(lactic-co-glycolic acid) (PLGA) by using polyethylene glycol (PEG) for longer action in various diseases by preparing a di-block copolymer by using Risperidone (RSP) as a drug. Methodology: PLG.

Measuring The Potential Antioxidant Activity Of Methyl Gallate: Molecular Docking Study, Sutomo S, Mohammad Rizki Fadhil Pratama

The Thai Journal of Pharmaceutical Sciences

Objectives: This study aims to obtain predictions of the interactions that occur between methyl gallate and various antioxidant receptors while comparing it with gallic acid as its parent compound. Materials and Methods: The protein crystal structures of.

Assessment Of Antimicrobial Activity Of Moxifloxacin.Hcl From Gastro Retentive Formulations, Raghavendra Kumar Gunda, A. Vijayalakshmi, K. Masilamani

The Thai Journal of Pharmaceutical Sciences

Purpose: The objective of the present study is to assess the antimicrobial activity of gastroretentive formulation for moxifloxacin HCl and in vitro antimicrobial evaluation using the cup-plate method. Materials and Methods: Gastroretentive floating tabl.

Development And Validation Of Rp-Hplc Method For Simultaneous Determination Of Ondansetron Hydrochloride And Granisetron Hydrochloride In Their Admixtures With Pantoprazole Sodium, Al Montaser Hamed Bellah, Abdel Maaboud Ismail Mohamed, Niveen Abdel-Latif Mohamed

The Thai Journal of Pharmaceutical Sciences

Objective: Development of rapid and sensitive high-performance liquid chromatography method for the quantification of ondansetron hydrochloride and granisetron hydrochloride in their admixtures with pantoprazole sodium in its dosage form using ketorolac .

The Effects Of Ball Mill Processing On The Physicochemical Properties Of Glutinous Rice Starch, Weeraya Tharanon, Jomjai Peerapattana

The Thai Journal of Pharmaceutical Sciences

Glutinous rice starch (GRS) (Oryza sativa L.) is a product derived from a staple food that is commonly cultivated and consumed in Asia. This study investigates the effect of physical modification by planetary ball mill processing on some physicochemical .

Anti-Tyrosinase And Anti-Melanogenic Potential Of Shallots (Allium Ascalonicum) From Various Cultivation Sites In Thailand, Thidarat Phetmanee, Thaniya Wunnakup, Thitiya Lukkunaprasit, Fameera Madaka, Sukanya Settharaksa, Narisa Kamkaen, Nirun Vipunnqeun, Laksana Charoenchai

The Thai Journal of Pharmaceutical Sciences

Objectives: The present study aimed to investigate the anti-tyrosinase effect of shallots (Allium ascalonicum) in Thailand and to prepare an optimised shallot extract for use as a skin-lightening agent. Materials and Methods: Aqueous and ethanolic shallo.

In Silico Discovery Of Potential Diagnostic Biomarkers Of Lung Cancer, Ruzianisra Mohamed, Raja Nur Hidayah Raja Hasnan

The Thai Journal of Pharmaceutical Sciences

Introduction: Understanding hub genes implicated in lung cancer (LC) metastasis will help in finding effective ways to diagnose and cure cancer. Accurate identification of protein biomarkers helps in improving the prognosis of LC. Here, the focus of this.

Progress In Erectile Dysfunction Therapy Through Drug Delivery System, Mayuri Shitole, Shailesh Dugam, Rahul Tade, Neha Desai, Sopan Nangare

The Thai Journal of Pharmaceutical Sciences

A man’s aptitude to acquire and continue an erection is frequently equated with masculinity and virility and can greatly influence men’s confidence. The sexual healthiness is a significant determinant of the worth of life. Erectile dysfunction (ED) a...

In Silico Screening Of Natural Compounds To Identify Lead As Interleukin 17a Receptor Blockers As Antihypertensive Agents, Jimish R. Patel, Hirak V. Joshi, Ujashkumar A. Shah, Jayvadan K. Patel

The Thai Journal of Pharmaceutical Sciences

Objectives: Nature gives disease and nature gives the medicine. Natural products have exhibited paramount sources of novel drugs. Due to this, natural products have gained a dominant role in drug design and discovery. Interleukin 17 (IL-17) is a potent p.

Chemical Composition Of The Essential Oil Of Several Iris Species, Olha Mykhailenko N/A, Volodymyr Kovalyov, Tetyana Orlova

The Thai Journal of Pharmaceutical Sciences

The essential oil was obtained by a steam distillation from the dried leaves of Iris germanica L., Iris versicolor L., Iris graminea L., and Iris halophila Pall. (Iridaceae) and was investigated by a gas chromatography-mass spectrometry (GC/MS) method. I.

Anthelmintic Activity Of Mansoa Alliacea Against Pheretima Posthuma: In Vitro And In Silico Approach, D.S. N. B. K. Prasanth, S. K. Aminabee, Atmakuri Lakshmana Rao, Nayudu Teja, Koti Bhargavi, Chigurupati Monika, Boppudi Pujitha, Tera Sandhya, Agastya Lalitha, Siva Prasad Panda

The Thai Journal of Pharmaceutical Sciences

Objectives: Mansoa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea a.