Digital Commons Network^™

Comparison Of The Sensititre Yeastone Antifungal Method With The Clsi M27-A3reference Method To Determine The Activity Of Antifungal Agents Against Clinical Isolatesof Candida Spp., Rabi̇ye Altinbaş, Ayşe Bariş, Sümeyye Şen, Recep Öztürk, Nuri̇ Ki̇raz

Turkish Journal of Medical Sciences

Background and aim: Infections caused by Candida species are significantly increasing today, and invasive Candida infections are generally associated with high mortality. Early diagnosis and identification of Candida spp. is important for the determination of antifungal agents that will be used for treatment. The aim of the present study was to provide a better regimen for Candida infections in the future. Materials and methods: The Sensititre YeastOne (SYO) method was compared with The Clinical Laboratory Standards Institute (CLSI) reference broth microdilution (BMD) testing method. Endpoints of minimal inhibitory concentrations (MICs) were determined for both methods. Results: By using both methods, …

Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal

Turkish Journal of Medical Sciences

This special issue of the Turkish Journal of Medical Sciences is dedicated to providing scientific advances in the process of better understanding the SARS-CoV-2 virus that causes the COVID-19 infection. The special issue is published in a special time in which science-based approaches, cocreation-based collaboration, and the effective utilization and integration of competences have a crucial role during the race against time while combating the COVID-19 pandemic. In this process, the Scientific and Technological Research Council of Turkey (TÜBİTAK), which publishes academic journals including the Turkish Journal of Medical Sciences, has taken rapid action to mobilize the research community. This …

Crushing The Curve, The Role Of National And International Institutions And Policy Makersin Covid-19 Pandemic, Zeli̇ha Koçak Tufan, Bi̇rcan Kayaaslan

Turkish Journal of Medical Sciences

Nobody can be fully prepared to a pandemic. Of course there are signs of it, the scientists can predict, alarming speeches can be made. But there are always alarmist people around, maybe that is why sometimes even the most serious warnings may be not considered by the authorities on time. The first patients may be lost without a proper diagnosis. When everybody realizes that there may be a big problem in the horizon, sometimes it is too late. That is why it is very important to monitor contagious diseases and follow the warnings and releases of national and international disease …

Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: Coronavirus Infectious Disease 2019 (COVID-19) is now a pandemic spreading in most countries including Turkey. Materials and methods: The current knowledge of COVID-19 and the virus causing it, SARS-CoV-2, was reviewed. The epidemiology and control in different countries was compared and the differences discussed. Results: The population attack rates and case fatality rates vary from country to country with Lombardy in northern Italy reporting an attack rate in the general population of 0.37% compared to 0.004% in Hong Kong. The differences are caused by different testing strategies and reporting systems. Conclusion: Turkey is early in the outbreak. Different control …

Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç

Turkish Journal of Medical Sciences

Coronaviruses (CoVs) cause a broad spectrum of diseases in domestic and wild animals, poultry, and rodents, ranging from mild to severe enteric, respiratory, and systemic disease, and also cause the common cold or pneumonia in humans. Seven coronavirus species are known to cause human infection, 4 of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. The others namely SARS-CoV (severe acute respiratory syndrome coronavirus), MERS-CoV (Middle East respiratory syndrome coronavirus) were zoonotic in origin and cause severe respiratory illness and fatalities. On 31 December 2019, the existence of patients with pneumonia …

Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz

Turkish Journal of Medical Sciences

COVID-19 pneumonia has high mortality rates. The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. In this review, we discussed the main radiological findings of this infection.

Antiviral Treatment Of Covid-19, Serap Yavuz, Serhat Ünal

Turkish Journal of Medical Sciences

Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 patients have mild or moderate courses, up to 5%-10% can have severe, potentially life threatening course, there is an urgent need for effective drugs. Optimized supportive care remains the mainstay of therapy. There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. Despite the urgent need to find an effective antiviral treatment for COVID-19 through …

Familial Mediterranean Fever, From Pathogenesis To Treatment: A Contemporary Review, Abdurrahman Tufan, Helen Lachmann

Turkish Journal of Medical Sciences

Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin. Over the last few years, we have witnessed several new developments in the pathogenesis, genetic testing, diagnosis, comorbidities, disease related damage and treatment approaches to FMF. Elucidation of some of the pathogenic mechanisms has led to the discovery of pathways involved in inflammatory, metabolic, cardiovascular and degenerative diseases. The use of next generation sequencing in FMF has revealed many new gene variants whose clinical significance may …

Adjustable Bone Plate: State Of Art, Gazi̇ Huri̇

Turkish Journal of Medical Sciences

Background/aim: The success of treatment of bone fracture and defects are based on a proper contact and compression between the bone fracture fragments. Intraoperative manipulations such as bone compression or distractions are generally done in order to achieve this. However, none of the bone plates currently in routine use allow these manipulations after fixation to the bone, requiring refixation and repeated drilling, and screwing operations. Based on this shortcoming, we designed a novel adjustable bone plate (ABP) system which allows bone shortening and lengthening even after fixation to the bone surface. The aim of the paper is to clarify the …

Alaska National Parks And Indigenous Peoples: Collaboration For A Protected Future, Siobhan Mctiernan

Dissertations and Theses @ UNI

This research examines the relationships between National Parks and Indigenous communities across the state of Alaska. National Parks as a government agency can be perceived in a negative way; but in Alaska, while there are issues and limitations, parks are going beyond policy guidelines to work with communities and help build a resilient future for both the parks and the local people. This work dives into the National Parks policies and practices, projects resulting from engagement of community stakeholders, perceptions of engagement, community capitals, and sustainable development. In particular, the study investigates how these policies, practices, and interactions ultimately contribute …

Consumer Choice Of Counterfeits Or Generic Products: The Case Of Egypt, Mostafa Aboelsoud, Kenzy Seireg

Economics

The counterfeiting market is increasing at an alarming rate because consumers are often unwilling to pay for brand names. This study investigates the factors that influence consumers’ preferences toward counterfeit and generic products by studying Egyptian consumers. By surveying a sample of 271 consumers, our study concluded that demographic variables, perceived risk, and prior experience are insignificant factors in choosing counterfeits or generics, while price, taste and preferences, quality, the price of related products, subjective norms, and expected prices are variables that significantly affect consumer preferences and demand. The research concludes that consumers who care about the quality, expected prices, …

The Clinical Inquiry Process Diagram, Roy E. Brown

VCU Libraries Faculty and Staff Publications

No abstract provided.

Catalog 2020-2021, University Of North Florida

UNF Course Catalogs

No abstract provided.

A Molecular Dynamics Study Of Temperature Dependent Wetting In Alkane-Water Systems, Pauf Neupane

Doctoral Dissertations

“The wetting behavior of aqueous organic systems is of great importance in several environmental and industrial processes such as the formation and growth of atmospheric aerosols, crude oil recovery from an oil field, onsite cleaning of natural gas, and clean-up of oil spills. In this work, we employed molecular dynamics (MD) simulations to explore the temperature dependent wetting behavior of octane and nonane on water in planar interfaces as well as in nanodroplets using PYS alkane and SPC/E and TIP4P/2005 water models.

For planar interfaces, we found unusual wetting behavior of octane and nonane on SPC/E water, but generally not …

Coverage Guided Differential Adversarial Testing Of Deep Learning Systems, Jianmin Guo, Houbing Song, Yue Zhao, Yu Jiang

Publications

Deep learning is increasingly applied to safety-critical application domains such as autonomous cars and medical devices. It is of significant importance to ensure their reliability and robustness. In this paper, we propose DLFuzz, the coverage guided differential adversarial testing framework to guide deep learing systems exposing incorrect behaviors. DLFuzz keeps minutely mutating the input to maximize the neuron coverage and the prediction difference between the original input and the mutated input, without manual labeling effort or cross-referencing oracles from other systems with the same functionality. We also design multiple novel strategies for neuron selection to improve the neuron coverage. The …

Physiological Effects During Aerobatic Flights On Science Astronaut Candidates, Pedro Llanos, Diego M. Garcia

Publications

Spaceflight is considered the last frontier in terms of science, technology, and engineering. But it is also the next frontier in terms of human physiology and performance. After more than 200,000 years humans have evolved under earth’s gravity and atmospheric conditions, spaceflight poses environmental stresses for which human physiology is not adapted. Hypoxia, accelerations, and radiation are among such stressors, our research involves suborbital flights aiming to develop effective countermeasures in order to assure sustainable human space presence. The physiologic baseline of spaceflight participants is subject to great variability driven by age, gender, fitness, and metabolic reserve. The objective of …

Physiological Effects On Scientist Astronaut Candidates: Hypobaric Training Assessment, Pedro Llanos, Diego Garcia

Publications

This paper is addressed to expanding our understanding of the effects of hypoxia training on our bodies to better model its dynamics and leverage some of its implications and effects on human health. Hypoxia training is a recommended practice for military and civilian pilots that allow them to recognize their early hypoxia signs and symptoms, and Scientist Astronaut Candidates (SACs) who underwent hypobaric hypoxia (HH) exposure as part of a training activity for prospective suborbital flight applications. This observational-analytical study describes physiologic responses and symptoms experienced by a SAC group before, during and after HH exposure and proposes a model …

Islam, Emad Hamdeh

Publications

Islam, the religion of 1.2 billion people around the world, provides its followers guidance on how to live according to God’s teachings. The word “Islam” means submission, and in this context, refers to voluntary submission to will and teachings of God. The word Islam stems from the same root word as “peace” salām, by submitting to God one finds inner peace in this world and eternal peace and happiness in the next.

Recovering From Covid-19 Building Closures: Guidance Document, David Krause, Cheri Marcham, John Springston, Alex Lebeau, Robert Rottersman, Timothy Froehlig, Bart Ashley

Publications

While the country comes to terms with the inevitable impact that SARS-CoV-2, the virus that causes COVID-19, will have on our lives and communities, public health authorities remain focused on breaking the chain of transmission. Managing the risk has resulted in widespread closures of businesses, schools, universities, resorts, and other facilities deemed “non-essential.” Practically speaking, this means closing buildings and ceasing operations. For building owners and operators, this poses a significant challenge to protect their assets and to ensure they are ready to reoccupy once the pandemic subsides.

Workplace Cleaning For Covid-19: Guidance Document, David Krause,, Cheri Marcham, John Springston, Alex Lebeau, Robert Rottersman, Timothy Froehlig, George (Jerry) Mccaslin

Publications

Critical and essential workplaces operating during this pandemic need to implement procedures to reduce the risk of workers, contractors, vendors, customers, and members of the community becoming infected on their premises. Outside of healthcare and paramedical facilities, the infrastructure and standard practices of infection prevention and control have not been commonplace. Establishing enhanced routine cleaning and disinfection procedures in offices, factories, warehouses, call centers, grocery stores, and other non-healthcare workplaces is a critical step in reducing exposures and infections.

Trust And Healthcare: A Qualitative Analysis Of Trust In Spanish And English Language Group Well-Child Care, Nicolas Muñoz

Yale Medicine Thesis Digital Library

Trust and healthcare: a qualitative analysis of trust in Spanish and English language group well-child care

Nicolas Muñoz, Patricia Nogelo, Benjamin Oldfield, Ada Fenick, Marjorie Rosenthal

Yale Pediatric Primary Care Center and Yale Clinic for Hispanic Children,

Department of Pediatrics

Yale University School of Medicine, New Haven, CT

Background: Trust, in the healthcare setting, is defined as the optimistic belief that providers and systems serve patient’s best interest. It is a multidimensional concept including competence, and value congruence, and exists due to patient vulnerability. Trust has been demonstrated to impact healthcare utilization. In pediatric patients, trust is key for strong …

Algorithms For Inferring Multiple Microbial Networks, Sahar Tavakoli

Electronic Theses and Dissertations, 2020-2023

The interactions among the constituent members of a microbial community play a major role in determining the overall behavior of the community and the abundance levels of its members. These interactions can be modeled using a network whose nodes represent microbial taxa and edges represent pairwise interactions. A microbial network is a weighted graph that is constructed from a sample-taxa count matrix and can be used to model co-occurrences and/or interactions of the constituent members of a microbial community. The nodes in this graph represent microbial taxa and the edges represent pairwise associations amongst these taxa. A microbial network is …

The Relationship Of Cognitive Load And Different Participant Roles On Knowledge Retention In Simulation-Based Learning Among Undergraduate Nursing Students, Amanda Houston

Electronic Theses and Dissertations, 2020-2023

Background: High-fidelity simulation (HFS) is a cognitive load inducing educational tool that gives participants an opportunity to emulate clinical scenarios by assuming various roles. HFS offers opportunities for undergraduate nursing students to build fundamental knowledge that can replace, or enhance, clinical experiences. Cognitive load exists on a spectrum and negatively impacts learning when learners are at either extreme of the spectrum. Cognitive load is comprised of the three subcomponents of intrinsic, extraneous, and germane load. Not much is known about different subcomponents or their ability to prediction immediate knowledge and knowledge retention in students who play fundamentally different roles, as …

Who Am I, And Why Does It Matter? Reflections Of Identity And The Need For Culturally Sustaining Theatre, Bianca Alamo

Electronic Theses and Dissertations, 2020-2023

The question of "who am I" created an involuntary domino effect which led me to my most valued work I have done as a graduate student, serving predominantly Latino/a students in educational theatre settings. This thesis explores three productions I worked on and the questions that have evolved in my understanding of identity and cultural sustainability as a Latina theatre artist and educator working in educational theatre. As an Orlando Repertory teaching artist, I began a residency with HOPE CommUnity Center along with some colleagues. We worked with high school students from their youth group to devise a show titled …

The Field Of Tya On The Soccer Field: Using Drama Strategies To Enhance Youth Soccer Coaching Practices, Brittany Caine

Electronic Theses and Dissertations, 2020-2023

This thesis explores best practices for applying drama strategies to coaching youth soccer. How does drama pedagogy translate to sports? Do drama techniques improve youth soccer? How can using drama- based strategies when coaching youth soccer enhance my own coaching abilities and thus improve the quality of youth soccer instruction and experience? This study applies various drama techniques to pre- written coaching curriculum. This manifested in heavily detailed games, supported by pantomime, storytelling, and narrative exploration, all of which further engaged the children in their soccer exercises. This thesis is supplemented by research on best practices regarding youth soccer, as …

Production Development: A Practical Approach To Directing For Educational Theatre, Jill Cicciarelli

Electronic Theses and Dissertations, 2020-2023

The goal of this thesis was to develop a process-based approach for a theatre production with an emphasis in musical theatre at the secondary education level. Many times, a high school theatre instructor is faced with challenges when selecting materials for productions that go beyond the standard mandated curriculum. In a perfect world, the program would have strong enrollment, overflowing funding and community support. This is usually not the case, so how does the director prioritize the necessary practice to find success for a production? What does the instructor do to select material that will be appropriate for the curriculum …

The Art Of Reflection: A Personal Account Of Reflexive Teaching Artistry And Personal Praxis, Kate Kilpatrick

Electronic Theses and Dissertations, 2020-2023

Teaching Artists (that is, artists who teach) are in a constant state of reflection and self-evaluation. Reflexive Teaching Artistry is the ability to apply personal reflection to practice as a means to better support and engage students. Reflection is certainly useful at the culmination of a class or project, but how does reflecting throughout the creative process benefit participants? How can a Teaching Artist's reflections be applied to their practice throughout a creative process to better serve the objectives of a program? Using the lens of Reflexive Teaching Artistry, this thesis examines three unique drama-based projects and the instances of …

Nonlinear Optical Mechanisms In Semiconductors And Enhanced Nonlinearities At Epsilon-Near-Zero, Sepehr Ahmadzadeh Benis

Electronic Theses and Dissertations, 2020-2023

Light does not interact with itself in linear optical materials. Such interactions occur only in non-linear optical (NLO) materials and typically require high intensity optical beams to be signifi-cant. The ever-increasing role of NLO, where intense light may change the properties of the me-dium, has created a pressing demand to invent materials for achieving more efficient light-light and light-matter interaction due to their potential capacity to augment and possibly replace cur-rent technologies with more efficient devices. There are numerous applications of NLO devices in fundamental science, technology, health, and defense such as all-optical computation and sig-nal processing, ultrashort laser technology, …

Lsd1 Promotes Bladder Cancer Progression By Upregulating Lef1 And Enhancing Emt., Qiubo Xie, Tang Tang, Jian Pang, Jing Xu, Xingxia Yang, Linang Wang, Yiqiang Huang, Zhuowei Huang, Gaolei Liu, Dali Tong, Yao Zhang, Luofu Wang, Dianzheng Zhang, Weihua Lan, Qiuli Liu, Jun Jiang

PCOM Scholarly Works

Epithelial-to-mesenchymal transition (EMT) is one of the important underlying molecular mechanisms for most types of cancers including bladder cancer. The precise underlying molecular mechanism in EMT-mediated bladder cancer progression is far from completed. LSD1, a histone lysine-specific demethylase, is known to promote cancer cell proliferation, metastasis, and chemoresistance. We found in this study that LSD1 is highly upregulated in bladder cancer specimens, especially those underwent chemotherapy, and the elevated levels of LSD1 are highly associated with bladder cancer grades, metastasis status, and prognosis. Inhibiting or knockdown LSD1 repressed not only EMT process but also cancer progression. Mechanistically, LSD1 complexes with …

The Vhl/Hif Axis In The Development And Treatment Of Pheochromocytoma/Paraganglioma, Song Peng, Jun Zhang, Xintao Tan, Yiqiang Huang, Jing Xu, Natalie Silk, Dianzheng Zhang, Qiuli Liu, Jun Jiang

PCOM Scholarly Works

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable. Although dysfunction of any one of a panel of more than 20 genes can lead to PPGLs, mutations in genes involved in the VHL/HIF axis including