Digital Commons Network^™

Detection Of Delaminations In Carbon Fiber Reinforced Polymers Embedded With Terfenol-D Particles Using Machine Learning, Christopher Nelon

All Theses

The characterization of the damage state of a system provides insight into its performance and safety during operation. In composite materials, specifically, fiber-reinforced polymers, delaminations form from the evolution of cracks in a matrix that leads to adhesion failure between adjacent laminae. Nondestructive evaluation (NDE) seeks to characterize the state of a material or system during non-operational times. A previously proposed NDE method employs embedded magnetostrictive particles between laminae of carbon fiber reinforced polymer (CFRP) for damage sensing. The phenomenon of magnetostriction couples the mechanical state of a material with its magnetic state so that a change in the local …

Trauma Informed E-Newsletter: Issue 3, Jeanne Williamson, Brianca Smith-Austin

Student Counseling

No abstract provided.

National Coral Reef Management Fellows Newsletter Volume 3 | Issue 2, National Oceanic And Atmospheric Administration (Noaa) Coral Reef Conservation Program

National Coral Reef Management Fellowship Newsletter

No abstract provided.

Teamwork Or Collusion? Changing Antitrust Law To Permit Corporate Action On Climate Change, Dailey C. Koga

Washington Law Review

In an era of apprehension about climate change and the future of our planet, private companies are increasingly recognizing their role in increasing sustainability and lowering carbon emissions. To address this growing concern, some industry leaders are taking unilateral action to implement sustainable practices, but other companies have made agreements to fight emissions together. However, the Sherman Antitrust Act forbids agreements in restraint of trade. Further, antitrust law traditionally has refused to recognize ethical or moral justifications as legitimate reasons to permit anticompetitive agreements. As society’s concern for the planet grows and elected leaders move slower than needed to address …

Sleep Induction By Mechanosensory Stimulation In Drosophila., Arzu Öztürk-Çolak, Sho Inami, Joseph R. Buchler, Patrick D. Mcclanahan, Andri Cruz, Christopher Fang-Yen, Kyunghee Koh

Department of Neuroscience Faculty Papers

People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep induction by monotonous stimulation. Here, we show that gentle vibration promotes sleep in Drosophila in part through habituation. Vibration-induced sleep (VIS) leads to increased homeostatic sleep credit and reduced arousability, and can be suppressed by heightened arousal or reduced GABA signaling. Multiple mechanosensory organs mediate VIS, and the magnitude of VIS depends on vibration frequency …

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Scholarships, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Divalent Cations Mediate Bacterial Tolerance To Carbapenems Via Outer Membrane Stabilization, Richard D. Schargel

McNair Scholars Research Journal

No abstract provided.

Parent Well-Being In Divorce Education, Sharon E. Powell, Sarah Cronin, Ellen Mccann, Jenifer Mcguire, Emily Becher, Eugene Hall

Journal of Family Strengths

Objective. To describe the role of parent well-being in divorce education and to explore the relationship between parent well-being, coparenting, and child outcomes. Design. Data was analyzed using multiple regression from pre, post, and follow-up surveys from 272 parents who took the Parents Forever divorce education course. Results. Changes in positive and negative coparenting significantly predicted changes in child well-being over time, accounting for 8% of the variance in change in child well-being. Parent-well-being significantly predicted changes in child well-being over and above coparenting and, when entered into the regression model, an additional 7.2% of the variance in changes in …

Adverse Event Reporting For Cellular Therapy Products: Current Status And Future Directions, Kathy Loper, Michele W. Sugrue, Jay S. Raval, Joseph Yossi Schwartz, Kevin Land, Mickey Koh, Thilo Mengling, Hildegard Greinix, Jörg P. Halter, Christina M Celluzzi, Maysum Chaudhri

Pathology Research and Scholarship

Adverse event (AE) and adverse reaction (AR) reporting are key components of patient safety and surveillance systems. Review and analysis of this data yields opportunities for process improvement, product information and interventions, and can lead to improved patient outcomes and donor safety overall. AE and AR reporting for cellular therapy products is fragmented and not well characterized in a central reference. This review article, authored by experts from various organizations, serves to summarize the current state of reporting and offers opportunities for streamlining and coordination, as well as key reference for professionals in this field.

Evolution Of The Epigenetic Landscape In Childhood B Acute Lymphoblastic Leukemia And Its Role In Drug Resistance, Shella Saint Fleur-Lominy, Nikki A. Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H. Choi, Xiaotu Ma, Jun J. Yang, Stephen Kelly, Elizabeth Raetz, Richard C. Harvey, Cheryl Willman, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown, Kylie M. Getz, Cem Meydan, Christopher E. Mason, Aristotelis Tsirigos, William Carroll

Pathology Research and Scholarship

Although B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children and while highly curable, it remains a leading cause of cancer-related mortality. The outgrowth of tumor subclones carrying mutations in genes responsible for resistance to therapy has led to a Darwinian model of clonal selection. Previous work has indicated that alterations in the epigenome might contribute to clonal selection, yet the extent to which the chromatin state is altered under the selective pressures of therapy is unknown. To address this, we performed chromatin immunoprecipitation, gene expression analysis, and enhanced reduced representation bisulfite sequencing on a cohort of …

Survival Analysis Of Colorectal Cancer Patients With Liver Metastasis, Brandon O’Grady

Dissertations and Theses (Open Access)

Background- Colorectal cancer is the third most common cancer in the world. I investigated the survival rates among colorectal cancer patients diagnosed with hepatic metastasis to see if any variables are associated colorectal risk and survival. Methods- Patients were diagnosed from 2000-2019 and collected through MD Anderson’s database. A descriptive analysis, univariate analysis, Kaplan-Meier with Mantel log-rank test, Cox proportion hazard regression and a Stratified Cox Model was performed to investigate death. A competing risk regression was implemented to investigate liver recurrence. Results- There was a clear difference in the survival outcome between liver surgery patients and non-liver surgery patients …

Applications Of Statistical Methods Studying The Impact Of Mobilization Regimes On The Total Collection Yield Of Hematologic Stem Cell, Mengchen Ding

Dissertations and Theses (Open Access)

Hematologic malignancies are cancers that develop in the blood, bone marrow, and lymph nodes. Hematopoietic stem cell transplantation (HSCT) is a critical therapeutic approach that contributes to offer a potential cure for hematologic cancers and other hematologic disorders by replacing abnormal bone marrow with healthy bone marrow components to help bone marrow function recovery. Peripheral blood is the primary resource for collecting hematopoietic stem cells (HSCs). The collection yield of HSCs is critical for successful transplantation. Few articles have discussed this topic that the collection of stem cells not only from healthy donors but also from donors with a hematologic …

The Comparative Effect Of Automated Reminders/Recalls Interventions On The Appointments Rate Of Adolescent Wellness Care Visit, Biai Dominique Elmir Digbeu

Dissertations and Theses (Open Access)

An Adolescent Wellness Care (AWC) visit is an annual preventive doctor visit predestined to assess the overall health of adolescents aged between 12 and 21 years old. Compared to their younger counterparts, adolescents who are using public insurance are at risk of not completing AWC visits due to several factors related to age or providers disparities in their living environment. This research was a quasiexperimental study aiming to compare two methods of automated Reminders/Recalls (RR) interventions, ‘phone-only’ versus ‘phone-and-text’, in order to evaluate which method is more effective in helping parents/guardians or young adults to schedule an AWC visit. A …

2020-December-Postgraduates Honored At Virtual Ceremony, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

East Tennessee State University Bill Gatton College of Pharmacy honored its postgraduate pharmacy residents and fellows on Thursday night in a virtual graduation ceremony.  

Speakers included Dr. Brian Noland, ETSU president; Dr. Debbie Byrd, dean of the pharmacy school; Dr. David Linville, executive vice provost for academics and health; and Dr. Ralph Lugo, professor and chair of the Department of Pharmacy Practice. 

In addition, program directors shared remarks and presented the graduates with program certificates. They included Dr. Katelyn Alexander, community pharmacy residency program director; Dr. Brian Cross, ambulatory care residency program director; Dr. David Stewart, internal medicine residency program …

2020-December-01-A New Look Expanded Services For The Nave Center, University Marketing And Communication, East Tennessee State University

ETSU News

ELIZABETHTON (Dec. 1, 2020)  – The East Tennessee State University Center for Audiology and Speech-Language Pathology at the Nave Center underwent extensive renovations this year, expanding services offered at the interdisciplinary, interprofessional clinic located in Elizabethton.

This facility has served as an academic space for ETSU since 1976 and has transformed over the years into an interdisciplinary clinic with multiple areas of practice that serves community health care needs and educates ETSU students who are pursuing a variety of careers in the rehabilitative and diagnostic health sciences.

During the summer, former classrooms and lab spaces were transformed into additional SLP …

2020-December-01-Enjoy Retirement, University Marketing And Communication, East Tennessee State University

ETSU News

Congratulations to the following members of the East Tennessee State University family who retired in December.  Thank you for your service!

Fred J. Alsop III – Professor, Biological Sciences, 48 years

Gary D. Burkette – Professor, Accountancy, 28 years

Mary Elizabeth Cradic – Office Manager, Office of the President, 27 years

Bruce Dalton – Professor, Social Work, 17 years

Joseph G. Disque – Professor, Counseling and Human Services, 26 years

Edward J. Dwyer – Professor, Curriculum and Instruction, 44 years

Brian G. Evanshen – Research Specialist, Environmental Health, 30 years

Richard J. Felts – Boiler Mechanic, Power House Operations, 22 …

2020-December-01-Governors School Applications, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – The Governor’s School for the Scientific Exploration of Tennessee Heritage, offered by the East Tennessee State University Center of Excellence for Appalachian Studies and Services, is now accepting applications for summer 2021. The School will run from May 30-June 25.

Students live on the ETSU campus and earn three hours of college credit. Rising juniors and seniors in Tennessee high schools or home schools are eligible to apply, but applications must be submitted through the school counselor. Interested students should see their school counselor. The deadline for applications is January 15, 2021. More information is available at …

2020-December-01-Going Places, University Marketing And Communication, East Tennessee State University

ETSU News

Rebecca Fugate is a family-focused solutions counselor with the Center for Community Outreach and Applied Research. She was previously a travel counselor with World Travel Service Inc. She holds an M.A. in psychology-clinical counseling from The Citadel.

Bridget Garland is an assistant HIPAA compliance officer in the Office of HIPAA Compliance and Security after serving ETSU Physicians as EHR director. She holds a master’s degree in English from ETSU.

Brianne A. Hayes is the bursar in Business and Finance after serving as bursar at the University of Memphis. She holds a B.S. degree in accounting from the University of South …

2020-December-01-Quinn Wins Sodexo Sweepstakes, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – Quinn Daniels, a student at East Tennessee State University, was recently named one of 30 randomly selected winners in Sodexo’s “Spread the Joy Sweepstakes” as part of its fall resident dining promotion series.

This national prize sweepstakes focused on positive things that may be spread – like joy to others – giving students across the United States the chance to win one of 30 $500 donations made in their names to the campus food pantry or local hunger-related charity of their choice. According to Sodexo, “this comes at a time when food pantries are deeply in need …

Covid-19 Reflections On Resilience And Reform In The Child Welfare System, Robert Latham, Kele Stewart

Articles

No abstract provided.

Illuminating False Light: Assessing The Case For The False Light Tort In Canada, Fraser Duncan

Dalhousie Law Journal

The false light tort has been the most contentious of the four privacy torts recognized in many US states, receiving criticism for its uncertain connection to privacy interests, its overlap with defamation and its chilling effect on free speech. While the tort has not previously received much judicial or scholarly attention in Canada, the recent decision of the Ontario Superior Court of Justice in Yenovkian v Gulian recognized false light as a cause of action in the province. This article cautions other Canadian common law courts against following suit through an analysis of the nature, history, and criticisms of the …

Coordination And Privacy Preservation In Multi-Agent Systems, Huan Gao

All Dissertations

This dissertation considers two key problems in multi-agent systems: coordination (including both synchronization and desynchronization) and privacy preservation.

For coordination in multi-agent systems, we focus on synchronization/desynchronization of distributed pulse-coupled oscillator (PCO) networks and their applications in collective motion coordination. Pulse-coupled oscillators were originally proposed to model synchronization in biological systems such as flashing fireflies and firing neurons. In recent years, with proven scalability, simplicity, accuracy, and robustness, the PCO based synchronization strategy has become a powerful clock synchronization primitive for wireless sensor networks. Driven by these increased applications in biological networks and wireless sensor networks, synchronization of pulse-coupled oscillators …

Analyzing Basket Trials Under Multisource Exchangeability Assumptions, Michael J. Kane, Nan Chen, Alexander M. Kaizer, Xun Jiang, H Amy Xia, Brian P. Hobbs

The R Journal

Basket designs are prospective clinical trials that are devised with the hypothesis that the presence of selected molecular features determine a patient’s subsequent response to a particular “targeted” treatment strategy. Basket trials are designed to enroll multiple clinical subpopulations to which it is assumed that the therapy in question offers beneficial efficacy in the presence of the targeted molecular profile. The treatment, however, may not offer acceptable efficacy to all subpopulations enrolled. Moreover, for rare disease settings, such as oncology wherein these trials have become popular, marginal measures of statistical evidence are difficult to interpret for sparsely enrolled subpopulations. Consequently, …

A Graphical Eda Tool With Ggplot2: Brinton, Pere Millán-Martínez, Ramon Oller

The R Journal

We present brinton package, which we developed for graphical exploratory data analysis in R. Based on ggplot2, gridExtra and rmarkdown, brinton package introduces wideplot() graphics for exploring the structure of a dataset through a grid of variables and graphic types. It also introduces longplot() graphics, which present the entire catalog of available graphics for representing a particular variable using a grid of graphic types and variations on these types. Finally, it introduces the plotup() function, which complements the previous two functions in that it presents a particular graphic for a specific variable of a dataset. This set of functions is …

Aquadtree: An R Package For Quadtree Anonymization Of Point Data, Raymond Lagonigro, Ramon Oller, Joan Carles Martori

The R Journal

The demand for precise data for analytical purposes grows rapidly among the research community and decision makers as more geographic information is being collected. Laws protecting data privacy are being enforced to prevent data disclosure. Statistical institutes and agencies need methods to preserve confidentiality while maintaining accuracy when disclosing geographic data. In this paper we present the AQuadtree package, a software intended to produce and deal with official spatial data making data privacy and accuracy compatible. The lack of specific methods in R to anonymize spatial data motivated the development of this package, providing an automatic aggregation tool to anonymize …

Kspm: A Package For Kernel Semi-Parametric Models, Catherine Schramm, Sébastien Jacquemont, Karim Oualkacha, Aurélie Labbe, Celia M. T. Greenwood

The R Journal

Kernel semi-parametric models and their equivalence with linear mixed models provide analysts with the flexibility of machine learning methods and a foundation for inference and tests of hypothesis. These models are not impacted by the number of predictor variables, since the kernel trick transforms them to a kernel matrix whose size only depends on the number of subjects. Hence, methods based on this model are appealing and numerous, however only a few R programs are available and none includes a complete set of features. Here, we present the KSPM package to fit the kernel semi-parametric model and its extensions in …

Ordinalclust: An R Package To Analyze Ordinal Data, Margot Selosse, Julien Jacques, Christophe Biernacki

The R Journal

Ordinal data are used in many domains, especially when measurements are collected from people through observations, tests, or questionnaires. ordinalClust is an innovative R package dedicated to ordinal data that provides tools for modeling, clustering, co-clustering and classifying such data. Ordinal data are modeled using the BOS distribution, which is a model with two meaningful parameters referred to as "position" and "precision". The former indicates the mode of the distribution and the latter describes how scattered the data are around the mode: the user is able to easily interpret the distribution of their data when given these two parameters. The …

A Fast And Scalable Implementation Method For Competing Risks Data With The R Package Fastcmprsk, Eric S. Kawaguchi, Jenny I. Shen, Gang Li, Marc A. Suchard

The R Journal

Advancements in medical informatics tools and high-throughput biological experimentation make large-scale biomedical data routinely accessible to researchers. Competing risks data are typical in biomedical studies where individuals are at risk to more than one cause (type of event) which can preclude the others from happening. The Fine and Gray (1999) proportional subdistribution hazards model is a popular and well-appreciated model for competing risks data and is currently implemented in a number of statistical software packages. However, current implementations are not computationally scalable for large-scale competing risks data. We have developed an R package, fastcmprsk, that uses a novel forward-backward scan …

Six Years Of Shiny In Research: Collaborative Development Of Web Tools In R, Peter Kasprzak, Lachlan Mitchell, Olena Kravchuk, Andy Timmins

The R Journal

The use of Shiny in research publications is investigated over the six and a half years since the appearance of this popular web application framework for R, which has been utilised in many varied research areas. While it is demonstrated that the complexity of Shiny applications is limited by the background architecture, and real security concerns exist for novice app developers, the collaborative benefits are worth attention from the wider research community. Shiny simplifies the use of complex methodologies for people of different specialities, at the level of proficiency appropriate for the end user. This enables a diverse community of …