Digital Commons Network^™

Quality Of Life Among Injectable And Oral Disease-Modifying Therapy Users In The Pacific Northwest Multiple Sclerosis Registry., Tamela Stuchiner, Lindsay Lucas, Elizabeth Baraban, Kateri Spinelli, Chiayi Chen, Alden Smith, Lobat Hashemi, Stanley Cohan

Articles, Abstracts, and Reports

BACKGROUND: Nine oral disease-modifying therapies (DMTs) have been approved for the treatment of multiple sclerosis (MS) in the United States. Few studies have examined self-reported quality of life (QoL) and functional status outcomes among patients who switch to oral medications from injectable MS therapies. This study compares self-reported QoL and disability status between participants switching from injectable to oral DMTs, to those who stay on injectable DMTs continuously for the same time period.

METHODS: Longitudinal data were assessed from relapsing MS participants in the Pacific Northwest MS Registry completing a minimum of two surveys between 2012 and 2018 with a …

A Case Of Pembrolizumab-Induced Diabetic Ketoacidosis, Christopher Wagner, Debjit Saha

Advocate Internal Medicine Residents - Lutheran General

No abstract provided.

Missed Connections: Acquired Gerbode Defect After A Second Mitral Valve Surgery, Abdel-Rahman Zakieh, Samer Martini, Faisal Masood, Adib Chaus

Advocate Internal Medicine Residents - Lutheran General

No abstract provided.

Synthesis, Characterization, And Antiproliferative Activity Of Novel Chiral [Quinoxp*Aucl2]+ Complexes, Adedamola S. Arojojoye, R. Tyler Mertens, Samuel Ofori, Sean R. Parkin, Samuel G. Awuah

Chemistry Faculty Publications

Herein is reported the synthesis of two Au(III) complexes bearing the (R,R)-(–)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (R,R-QuinoxP*) or (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxaline (S,S-QuinoxP*) ligands. By reacting two stoichiometric equivalents of HAuCl₄.3H₂O to one equivalent of the corresponding QuinoxP* ligand, (R,R)-(–)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (1) and (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (2) were formed, respectively, in moderate yields. The structure of (S,S)-(+)-2,3-Bis(tert-butylmethylphosphino)quinoxalinedichlorogold(III) tetrachloroaurates(III) (2) was further confirmed by X-ray crystallography. The antiproliferative activities of the two compounds were evaluated in a panel of cell lines and exhibited promising results comparable to auranofin and cisplatin with …

Effects Of Goal Type And Reinforcement Type On Self-Reported Domain-Specific Walking Among Inactive Adults: 2×2 Factorial Randomized Controlled Trial, Mindy L. Mcentee, Alison Cantley, Emily Foreman, Vincent Berardi, Christine B. Phillips, Jane C. Hurley, Melbourne F. Hovell, Steven Hooker, Marc A. Adams

Psychology Faculty Articles and Research

Background: WalkIT Arizona was a 2×2 factorial trial examining the effects of goal type (adaptive versus static) and reinforcement type (immediate versus delayed) to increase moderate to vigorous physical activity (MVPA) among insufficiently active adults. The 12-month intervention combined mobile health (mHealth) technology with behavioral strategies to test scalable population-health approaches to increasing MVPA. Self-reported physical activity provided domain-specific information to help contextualize the intervention effects.

Objective: The aim of this study was to report on the secondary outcomes of self-reported walking for transportation and leisure over the course of the 12-month WalkIT intervention.

Methods: A total of …

Power-Laden (Mis)Understandings Surrounding Written Voluntary Informed Consent Procedures In Postcolonial Southern Africa, Michelle R. Brear

The Qualitative Report

Written voluntary informed consent (VIC) procedures are the standard approach for operationalising the ethical principle of respect for persons’ autonomy in qualitative research. However, achieving fully informed and truly voluntary consent is challenging, particularly in qualitative research and/or postcolonial contexts. Evidence about (mis)understandings (i.e., unintended meanings) surrounding VIC comes primarily from participants in quantitative, biomedical research. I aim to advance knowledge about qualitative research participants’ (mis)understandings of VIC. I used ethnographic methods to document the evolving (mis)understandings participants attached to written VIC procedures in two postcolonial settings, Eswatini and South Africa. All participants provided me consent to document their interactions …

Critical-Emancipatory Workshop Analysis Through Qualitative Analysis Software, Lucimara Fabiana Fornari, Rosa Fonseca

The Qualitative Report

Critical-emancipatory Workshop is a data collection technique and interventional strategy for emancipatory education aimed at participants involved in the research. It usually results in a significant amount of data in text, audio, image and video formats. Taking this into account, qualitative analysis software usage is paramount to data treatment optimization and promotion of results credibility. This research aimed at identifying the potentialities and limits of webQDA for a Critical-emancipatory Workshop qualitative analysis. To this end, a case study based on the researchers' experience was conducted. It revealed that webQDA is a powerful digital tool for broadening and deepening the analysis …

Frequency And Risk Factors Of Acute Kidney Injury During Diabetic Ketoacidosis In Children And Association With Neurocognitive Outcomes, Sage R. Myers, Kimberly S. Quayle, Et Al

Open Access Publications

Importance: Acute kidney injury (AKI) occurs commonly during diabetic ketoacidosis (DKA) in children, but the underlying mechanisms and associations are unclear.

Objective: To investigate risk factors for AKI and its association with neurocognitive outcomes in pediatric DKA.

Design, Setting, and Participants: This cohort study was a secondary analysis of data from the Pediatric Emergency Care Applied Research Network Fluid Therapies Under Investigation in DKA Study, a prospective, multicenter, randomized clinical trial comparing fluid protocols for pediatric DKA in 13 US hospitals. Included DKA episodes occurred among children age younger than 18 years with blood glucose 300 mg/dL or greater and …

Practicing Ethics And Ethics Praxis, Martin Tolich, Emma Tumilty

The Qualitative Report

Purpose - This paper demonstrates the limited efficacy procedural ethics has for qualitative research. Ethics committee’s instructions have a short shelf life given the research question qualitative researchers create is volatile; that is, likely to change due to the inductive, emergent, informant-led nature of qualitative research. Design - This article draws on extensive literature to examine the void between the original research design and the messy reality experienced in the field. We focus on how researchers can practice ethically by recognizing the need for agile and responsive ethics praxis in their work. Findings - This practice describes the researcher, recognizing …

Mothers’ Satisfaction With Childcare Choices And Its Links To Family Involvement And Community Support, Hadeel Shamlan Al-Essa

Individual, Family, and Community Education ETDs

This study examined mothers ’reports on types of childcare arrangement for a preschool-age child, levels of mothers’, fathers’, and relatives’ involvement in childcare at home, maternal satisfaction with childcare arrangement, the influence of socioeconomic status and social support on mothers ’satisfaction with childcare arrangement, and the nature of mothers ’affection, responsiveness, encouragement, and teaching behaviors during mother-child play sessions. The sample consisted of 130 New Mexico mothers from two-parent families with a preschool child. A subsample of four mothers was selected for collecting data on mother-child play interactions through a 10-minute observation session. Analyses suggested that mothers were the primary …

Antibiotics In Prevention And Treatment Of Multi-Drug Resistant (Mdr) Organisms Causing Surgical Site Infection (Ssi), Saranya K. Lakshmi, Hema N. Gowda, Anuradha K

Pharmacology and Clinical Pharmacy Research

Antibiotics play a vital role in prevention and treatment of various infections. But inappropriate antibiotic choice could lead to emergence of multi-drug resistance (MDR) among microorganisms. Since, the antibiotic susceptibility pattern of organisms could vary from place to place; forming a local prophylaxis and treatment protocol could hugely reduce this global burden. The primary objectives of the study were to observe the frequency of multi-drug resistant organisms causing Surgical Site Infections (SSIs) and to study the pattern of antibiotic usage for the prophylaxis and treatment of SSIs. A descriptive study was carried out in general surgical wards of KR hospital, …

2020-12-04 Minutes Of The Executive Committee Of The Academic Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

Winning The Fight For Better Bus Service, Steven Higashide

PSU Transportation Seminars

The "right to the city" depends on the right to access the city, and U.S. regions are marked by profoundly unequal access. One of the clearest manifestations of this is the state of U.S. bus transit. Bus service is simple to improve and has vast potential to better people's lives, but has been constrained by the racist planning and politics that shape every American city.

How can we fulfill the promise of better buses and create abundant transit networks that expand access to opportunity? In this seminar, Higashide unpacks the elements of effective bus service – and cites examples from …

Reflecting On Caqdas And Ethics, Catarina Brandão, António Pedro Costa

The Qualitative Report

As the use of Computer-assisted Qualitative Data Analysis Software (CAQDAS) becomes recurrent in qualitative research, researchers who use this methodological approach need to consider how ethical issues present themselves when we use these types of tools. In this introductory text to the Special Issue of The Qualitative Report, we identify and discuss some of the ethical aspects that we believe are interconnected with CAQDAS. By doing so, we hope to contribute to the reflection on these aspects and the definition of a praxis regarding ethical procedures when using a CAQDAS.

The Pandemic Of Falsity On Online Social Networks And Plausible Cures From Machine Learning, Vishnu Pendyala

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern faculty member elected to serve on American Public Health Association executive board

An Artificial Intelligence-Based, Personalized Smartphone App To Improve Childhood Immunization Coverage And Timelines Among Children In Pakistan: Protocol For A Randomized Controlled Trial, Abdul Momin Kazi, Saad Ahmed Qazi, Sadori Khawaja, Nazia Ahsan, Rao Moueed Ahmed, Muhammad Ayub Khan Mughal, Hussain Kalimuddin, Yasir Rauf, Mehreen Raza, Saima Jamal

Department of Paediatrics and Child Health

Background: The immunization uptake rates in Pakistan are much lower than desired. Major reasons include lack of awareness, parental forgetfulness regarding schedules, and misinformation regarding vaccines. In light of the COVID-19 pandemic and distancing measures, routine childhood immunization (RCI) coverage has been adversely affected, as caregivers avoid tertiary care hospitals or primary health centers. Innovative and cost-effective measures must be taken to understand and deal with the issue of low immunization rates. However, only a few smartphone-based interventions have been carried out in low- and middle-income countries (LMICs) to improve RCI.
Objective: The primary objectives of this study are to …

Approaches To Aggressive B-Cell Lymphomas In Less Fit Patients, Nancy L Bartlett

2020-Current year OA Pubs

Treating unfit patients with aggressive B-cell lymphoma poses the dilemma of balancing potential cure while minimizing toxicity because of frailty and comorbidities. Age greater than 80 years and common comorbidities such as cardiovascular disease and poorly controlled diabetes mellitus often preclude the use of full-dose anthracyclines and steroids, the backbones of standard regimens for aggressive B-cell lymphomas. Assessing patient fitness remains subjective, with no consensus on best practice or how to integrate assessment tools into decision making. Incorporation of prephase steroids for all unfit patients may markedly improve performance status with consideration of standard dose therapy, especially in patients less …

Dipg-52. Phase I Clinical Trial Of Onc201 In Pediatric H3 K27m-Mutant Glioma Or Newly Diagnosed Dipg, Yazmin Odia, Matthew Hall, Doured Daghistani

All Publications

H3 K27M-mutant gliomas often manifest as midline gliomas, have a dismal prognosis, and have no effective treatments. ONC201 efficacy has been shown in high-grade glioma preclinical models and durable responses with single agent ONC201 have been reported in adults with recurrent H3 K27M-mutant gliomas. These observations led to a Phase I pediatric clinical trial of ONC201 dosed by body weight. This multi-center, open-label, 3 + 3 dose-escalation and dose-expansion clinical trial (NCT03416530) for H3 K27M-mutant glioma or non-biopsied DIPG has 6 arms: arms A and E determine the RP2D in pediatric post-radiation (recurrent or not-recurrent) H3 K27M-mutant glioma patients with …

Primary Pulmonary Synovial Sarcoma In A 49-Year-Old Male, Sanket Shah, Praveen Sankrithi, Kunal Shah, Samir Dalia, Mohan Rudrappa

Student Publications

Sarcoma is a malignant tumor arising from the mesenchymal tissues such as striated skeletal and smooth muscles, adipose tissue, bone, cartilage, and synovial tissue. The synovial subset of primary pulmonary sarcoma is very rare and is only described in a handful of cases. Our case describes the diagnostic approach and treatment regimen for a 49-year-old male with no significant past medical history. The diagnosis of a primary pulmonary synovial sarcoma was made through the use of endobronchial ultrasound (EBUS), transbronchial needle aspiration (TBNA), histologic analysis, and immunostaining. The treatment utilized a multimodal approach including resection, chemotherapy, and radiotherapy.

A Digital Program (Hope) For People Living With Cancer During The Covid-19 Pandemic: Protocol For A Feasibility Randomized Controlled Trial, H Wright, F Martin, W Clyne, Cct Clark, Et Al

Peninsula Medical School

Background: During the COVID-19 lockdown period in the United Kingdom that began on March 23, 2020, more than a quarter of a million people with cancer reported worsening mental health. Help to Overcome Problems Effectively (Hope) is a self-management program for people with cancer, designed to provide support for distress, unmet needs, and poor psychological health. In light of social distancing during the COVID-19 pandemic, digital delivery of the Hope Programme has become ever more vital for people with cancer. Previous pre-post studies of the digital Hope Programme have found reduced anxiety and depression and improved well-being for people with …

Two-Year Neurocognitive Responses To First Occupational Lead Exposure, Yu-Ling Yu, Lutgarde Thijs, Nelly Saenen, Jesus D. Melgarejo, Dong-Mei Wei, Wen-Yi Yang, Cai-Guo Yu, Harry A. Roels, Tim S. Nawrot, Gladys E. Maestre, Jan A. Staessen, Zhen-Yu Zhang

School of Medicine Publications

Objectives Lead exposure causes neurocognitive dysfunction in children, but its association with neurocognition in adults at current occupational exposure levels is uncertain mainly due to the lack of longitudinal studies. In the Study for Promotion of Health in Recycling Lead (NCT02243904), we assessed the two-year responses of neurocognitive function among workers without previous known occupational exposure newly hired at lead recycling plants.

Methods Workers completed the digit-symbol test (DST) and Stroop test (ST) at baseline and annual follow-up visits. Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 μg/ dL). Statistical methods included multivariable-adjusted mixed …

Context Matters: Attitudes And Perceptions Of Proposed Bike Lanes In Memphis, Tn, David A. Hudlow

Electronic Theses and Dissertations Archive

This research leverages a City of Memphis dataset of over 1,700 survey responses with over 2,400 comments for understanding how people make decisions regarding support for or opposition to bike lanes in their communities. The survey comments were analyzed using both descriptive and thematic analyses along with unbiased computer-generated topic models. Six primary themes were identified along with six major intersections of these themes that provided important insights for understanding respondents’ perspectives. The primary themes are: People on bikes deserve a space on the road, Danger and safety, Roadway is for cars and drivers, No real need for bike lanes, …

Integrated Management Of Feral Camels In Ngaanyatjarra Aboriginal Lands, Australia, Gordon Sanders, A. Knight

IGC Proceedings (1977-2023)

No abstract provided.

Non-Surgical Correction Of Craniofacial Microsomia With Occlusal Plane Canting, Tzu-Pin Su, Huei-Mei Tsai, Chia-Yi Pan, Yuen-Yung Tsang, Yu-Ling Cheng

Taiwanese Journal of Orthodontics

An adult woman suffered moderate complications of cranio-facial microsomia (CFM) with different severity on both sides of the face. This anomaly leads to short ramal height, condylar pathology, chin deviation and facial asymmetry. The malformed dental arch, open bite and severe canting of the occlusal plane were the reasons for the patient to request the therapy. Orthodontic treatment was performed with pre-adjusted edgewise system assisted by temporal anchorage devices (TADs). These modalities were executed through leveling of the occlusal plane. The improvement was noticed for both better oral function and esthetics.

Vertical Maxillary Excess Complicated With Mutilated Dentition Treated By An Interdisciplinary Approach, Shao-Ching Su, Huei-Mei Tsai, Ming-Jeaun Su, Yi-Min Liu

Taiwanese Journal of Orthodontics

Vertical skeletal dysplasia can lead to excessive lower facial height and maxillary teeth elongation with gum exposure. Patients usually have long face, steep mandibular plane angle, usually with mandibular retrognathism. The clinical manifestations include narrow nose, narrow upper dental arch, excessive incisal display, a significant backward and downward rotated mandible as well as vertical maxillary excess (VME). Traditional classifications which mainly based on sagittal jaw relation is inadequate in describing the vertical skeletal discrepancy. The patient also suffered from multiple missing posterior teeth, that requires an interdisciplinary dental care. The main treatment objectives are to normalize overjet and overbite, improve …

Surgery First And Atypical Extraction For A Skeletal Class Iii With Severe Anterior Open Bite And Severe Crowding— Three-Year Stability, Sutthinee Ruschasetkul, Thatchawee Borikanphanitphaisan, Yi-Chin Wang

Taiwanese Journal of Orthodontics

This case report features a successful combined surgical-orthodontic treatment of a patient with skeletal Class III malocclusion with severe anterior open bite and severe mandibular crowding. Clinical examination revealed concave profile with long-face deformity caused by retrognathic maxilla and excessive vertical growth of mandible, maxillary crowding despite absence of maxillary first premolars, mandibular incisor retroclination, deep curve of Spee, and blocked-out mandibular canines. The treatment involved surgery-first approach with extraction of lower right first premolar and atypical extraction of lower left canine due to its poor periodontal support. Harmonized facial profile, pleasing smile, good occlusal interdigitation as well as skeletal …

Clinical Effectiveness Of Using Clear Aligners In Orthodontic Treatment, Chih-Ling Lin, Yi-Chin Wang, Yuh-Jia Hsieh, Yun-Fang Chen, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Purpose: To assess the clinical treatment effectiveness of clear aligners in orthodontic tooth movements.

Methods: The database of Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and Scopus were searched from Jan 2015 to Jan 2020. The National Institute for Health and Clinical Excellence assessment tool was used for the methodological quality of included studies.

Results: The literature review yielded 166 articles after removal of duplicates, and an additional 2 articles were included from hand search of the bibliographies of included articles and relevant reviews. Fifteen studies were included in the systematic review. One study was randomized …

Effect Of Angular Insertion Of Orthodontic Miniscrews On Primary Stability, Prajak Jariyapongpaiboon, Jirawan Chartpitak

Taiwanese Journal of Orthodontics

Purpose: Infrazygomatic crest (IZC) miniscrews have useful clinical applications. They are applied with angular insertion to the bone surface. However, appropriate angles for the maximum stability of the miniscrew have not yet been well documented. This study aimed to compare the primary stability of different angles of orthodontic miniscrew insertion by analyzing maximum insertion torque (MIT) and pull out strength (PS).

Materials and methods: Sixty miniscrew implants were divided into 3 groups which underwent different angular insertion, with 20 samples in each group. Three pairs of bearing devices were constructed with an angulation of 30, 40 or 50 degrees. An …

The Honeysuckle Issue, Amanda Wibel, Madyson Vanhoose, Ava Jones, Katie Karr, Ashton Shephard

Runkle Woods Symposia

Our group will be discussing the Wright State University Woods. We will reveal tips on how to make the trails in the Wright State University Woods more accessible and ADA compliant as well as how to educate the community about wildlife and plant species in the woods.