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Protein Kinase D1 Regulates Metabolic Switch In Pancreatic Cancer Via Modulation Of Mtorc1, Sonam Kumari, Sheema Khan, Radhiki Sekhri, Hassan Mandil, Stephen Behrman, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

BACKGROUND: Protein kinase D1 (PKD1) is a serine–threonine kinase that regulates various functions within the cell. Herein, we report the significance of PKD1 expression in glucose metabolism resulting in pancreatic cancer (PanCa) progression and chemo-resistance.

METHODS: PKD1 expression in PanCa was investigated by using immunohistochemistry. Functional and metabolic assays were utilised to analyse the effect of PKD1 expression/knockdown on associated cellular/molecular changes.

RESULTS: PKD1 expression was detected in human pancreatic intraepithelial neoplasia lesions (MCS=12.9; P < 0.0001) and pancreatic ductal adenocarcinoma samples (MCS=15, P < 0.0001) as compared with faint or no expression in normal pancreatic tissues (MCS= 1.54; P < 0.0001). Our results determine that PKD1 enhances glucose metabolism in PanCa cells, by triggering enhanced tumorigenesis and chemo-resistance. We demonstrate that mTORC1 activation by PKD1 regulates metabolic alterations in PanCa cells. siRNA knockdown of Raptor or treatment with rapamycin inhibited PKD1-accelerated lactate production as well as glucose consumption in cells, which confirms the association of mTORC1 with PKD1-induced metabolic alterations.

CONCLUSION: This study suggests a novel role of PKD1 as a key modulator of the glucose metabolism in PanCa cells accelerating tumorigenesis …

Secure Sharing Of Spatio-Temporal Data Through Name-Based Access Control, Laqin Fan

Electronic Theses and Dissertations Archive

Named Data Networking (NDN) is proposed as a future Internet architecture, which provides name-based data publishing and fetching primitive. Compared to TCP/IP, the benefits of NDN are as follows. NDN removes the need to manage IP address; NDN provides semantically meaningful and structured names; NDN has a stateful and name-based forwarding plane; NDN supports data-centric security and in-network caching. Name-based Access Control is an access control solution proposed over NDN, which is a content-based access control by encrypting data at the time of production directly without relying on a third-party service(i.e., Cloud storage), utilizes NDN’s hierarchical naming convention to express …

Maturity And Well-Being: Consistent Associations Across Samples And Measures, Stephen Reysen, Courtney N. Plante, Truong Quang Lam, Shanmukh V. Kamble, Iva Katzarska-Miller, Natalia Assis, Grace Packard, Eduardo Gregolin Moretti

Journal of Wellness

Introduction: Researchers have noted an association between maturity and well-being. However, this body of research uses different measures and conceptualizations of maturity (e.g., ego development, psychosocial maturity) and often only a few indicators of well-being. In the present research, we examined associations between a single self-rated measure of maturity and a variety of different indicators of well-being. Furthermore, we examined this association across a variety of samples. We hypothesized that maturity will show a positive relationship with measures related to well-being.

Methods: Samples of college students (Studies 1, 3, 4), Star Wars fans (Study 2), and individuals in the U.S., …

Instrumental Quality Attributes Of Alaska Pollock Derived Surimi Gels With Sweet Potato Starch, Kiyonna Williams, Zandra Mikell, Samuel Chetachukwu Adegoke, Reza Tahergorabi

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Starch plays an important role in the formation of the network structure of surimi-starch gels. Alaska Pollock surimi gels were prepared with final moisture of 78%. Sweet potato starch (SPS) and silicon dioxide – inert filler, were added in inverse concentrations to develop treatments of 0% (control), 2%, 4%, 6%, and 8% SPS. Textural properties such as hardness, resilience, cohesiveness, gumminess, and chewiness were positively impacted by SPS. As the concentration of the SPS increased, a non-systematic trend was observed in the Kramer shear force of surimi gels. Total cooking loss and water holding capacity were significantly improved (P < 0.05). Surimi gels showed slight but significant reductions (P < 0.05) in whiteness with SPS addition due to significant decreases (P < 0.05) in L* and an increase in a* values. The Ash content of surimi gels increased with the addition of SPS. These results suggest that SPS can be incorporated into surimi products without compromising quality, which may be useful to manufacturers for marketing surimi products with added health benefits.

Session 2c Shade Grown Coffee In Costa Rica, Jenna Lentz

The Youth Environmental Alliance in Higher Education

Full text available.

This presentation will focus on the role of Agriculture in Costa Rica, specifically the coffee industry. Traditional methods of growing coffee used shade, but as the popularity of coffee grew so did the need to increase production. This led to industrialized, sun-grown plantations that are harming the earth and contributing to climate change.

Session 1d Green Imperialism In French Polynesia, Sara Mills

The Youth Environmental Alliance in Higher Education

Full text available.

French Polynesia is currently still partially under French control. As French Polynesia is a SIDS, they are facing extreme weather events and sea level rise. French resource extraction and a nuclear test site have degraded their environment. I will examine the environmental justice components of this situation in relation to eco-governance and development projects.

Spare Parts Surgery For Oncologic Reconstruction To Preserve Local Advancement Flap For Decubitus Ulcer Reconstruction: A Case Report, Emily Zurbuchen, Nathan Foje, Sean Figy

Graduate Medical Education Research Journal

A 58-year-old male presented to our institution with synchronous large left thigh sarcoma and sacral decubitus ulcer requiring oncologic resection and reconstruction. Due to extensive tumor involvement, use of local flap for reconstruction was not feasible. Therefore, a spare parts free fillet flap from the disarticulated lower leg was utilized for reconstruction following oncologic resection. The benefits of this spare parts approach include no donor site morbidity, sufficient tissue padding for later use of prosthesis, and preservation of other flaps for future reconstruction of his sacral decubitus ulcer.

Multi-Digit Auto-Amputation In Setting Of Mixed Connective Tissue Disease, Kishan P. Patel, Jennifer L. Medlin, Michelene Hearth-Holmes

Graduate Medical Education Research Journal

Raynaud’s disease is a cutaneous manifestation often present in various connective tissue and vascular diseases. Depending on the age of onset and acuity of symptoms, the phenomenon can provide clinicians with some insight as to the severity of underlying disease, including the distinction between primary and secondary Raynaud’s. However, this diagnostic approach seems to have its limitations regarding efficacy and timing of treatment. Traditionally, treatment of Raynaud’s has focused on reestablishing blood perfusion to affected tissue, which has previously been achieved with vasodilatory medications and site-specific surgical intervention. In lieu of the severe sequelae of Raynaud’s in the setting of …

Nontuberculous Mycobacterium (Ntm) Infection In Aquatic Workers With Purified Protein Derivative (Ppd) And Gold Quantiferon Tests., Lavanya Ravipati, Sarah A. Howard

Graduate Medical Education Research Journal

Background: Nontuberculous mycobacteria (NTM) infections are commonly caused by Mycobacterium marinum and fortuitum with M. marinum more likely to cause skin infections. Aquatic environments are a potential source of contact with M. marinum and fortuitum. Patients with NTM infections may present with positive tuberculin purified protein derivative (PPD) and/or gold QuantiFERON tests. However, PPD cannot differentiate between NTM infection and other tuberculous infections caused by different mycobacterial strains. We present a patient a marine biologist who was asymptomatic and presented for further evaluation as she has a h/o positive PPD and gold QuantiFERON test.

Methods: Patient informed consent was …

Costs Associated With Recurrent Epistaxis In A Patient With A Ventricular Assist Device, Eric T. Rohe, Evan M. Ryan, Jayme R. Dowdall, Dwight T. Jones

Graduate Medical Education Research Journal

Mucosal bleeding is a well-known complication of having a ventricular assist device and commonly presents with epistaxis. Although the frequency of epistaxis as a complication in patients with a ventricular assist device has been documented in the literature, to our knowledge the cost of this complication has not been reported. This case report examines the financial burden of ventricular assist device-associated epistaxis in a single patient from September 2018 to December 2019 using ICD 10 diagnostic codes. The patient was found to have accumulated $138,020 in costs over 38 encounters. This case report not only highlights the recurrent nature and …

A Case Of Carcinoid Heart Disease And Echocardiographic Findings, Brandon Alex, Jeffrey Songster, Helenmari L. Merritt, Rebecca A. Aron

Graduate Medical Education Research Journal

Abstract: Carcinoid heart disease occurs in approximately 50% of patients with carcinoid syndrome. Right heart involvement resulting in tricuspid regurgitation, tricuspid stenosis, pulmonic regurgitation and pulmonic stenosis is most common. We report a case of tricuspid heart disease resulting in tricuspid regurgitation, tricuspid stenosis, pulmonic regurgitation and pulmonic stenosis.

Neurolytic Celiac Plexus Blockade In Patients With Upper Intraabdominal Malignancies: An Evidence-Based Narrative Review, Kevin Wong, Apollo A. Stack, Madhuri Are

Graduate Medical Education Research Journal

Background: Cancer-related abdominal pain is a common symptom associated with upper intra-abdominal carcinoma, especially in patients with advanced disease and it has posed a significant therapeutic challenge to medical practitioners. Typically, cancer pain can be managed by following the World Health Organization 3-step analgesic ladder. However, analgesic use of opioids, the mainstay treatment for moderate-to-severe cancer-related pain, may be ineffective in a subset of cancer patients. Escalation of dosage may be limited by opioid-induced side effects. The aim of this study was to review the literature addressing the effect of neurolytic celiac plexus block (NCPB) on the palliation of pain …

Internet Transparency Of Local Men’S Health Clinics In Nebraska, Jinfeng Jiang, Jordan Stegman, Christopher M. Deibert

Graduate Medical Education Research Journal

An overview of Men’s Health Clinics offering Testosterone Therapy in a Midwest State.

Introduction/ Background – Since 2001, there has been a 300% increase in the use of Testosterone therapy. However, there remains limited published data on the demographics of facilities and providers that advertise this service. This study aims to look at such demographics of advertised Men’s health clinics in Nebraska.

Methods/ Materials – An internet search was conducted with the phrases “Nebraska Male health clinics, Nebraska Low T/testosterone, Nebraska Hormone Replacement Therapy”. All clinics that were found offering Testosterone therapy with Men’s health in their mission statement were …

Personal Finance Skills Among Health Professionals: Piloting A Student-Led Finance Curriculum And A Review Of The Current Landscape, Jeremy Payne, Stephen Haller, Laura E. Flores, Jared Baxter, Walker Payton, Kari Nelson

Graduate Medical Education Research Journal

Introduction

Despite high costs of education, extended lengths of training, and rapidly increasing student debt, personal finance is an often-overlooked topic within professional school curricula. Due to the combination of high debt burden and poor financial literacy, professional students report low confidence and high stress regarding their personal finances. While some medical schools have begun to integrate financial education into their formal training, others provide little to no resources to combat this growing issue.

Methods

To address this gap and provide financial education opportunities, the Financial Development Club (FDC) was founded by students at the University of Nebraska Medical Center. …

Customized Blister Packaging For Patients Living With Hiv: Assessment Of Patient Attitudes And Satisfaction, Holly Groteluschen, Harlan Sayles, Rebecca Osborn, Joshua P. Havens, Sara Bares, Jasmine R. Marcelin

Graduate Medical Education Research Journal

Adherence to antiretroviral medication results in reduced HIV transmission and improved health outcomes, yet challenges with medication adherence remain. A Collaborative Care Program was developed with a community pharmacy integrating a multi-dose adherence packaging service. We surveyed program participants to assess their satisfaction with this program and found an overall positive sentiment toward the program, that the program helped with reducing missed doses, and all patients would recommend the program to others.

The Uncharted Waters Of Graduate Medical Education During A Pandemic, Chandrakanth Are

Graduate Medical Education Research Journal

No abstract provided.

The Yakuza: Organized Crime In Japan, Darlene N. Moorman

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Examining organized crime groups should not be purely economic; in other words, the culture, social structure, political contexts, and so on, are also critical in an insightful analysis of any organized crime group. For this paper, the Japanese yakuza are considered both in an economic viewpoint, such as how they make money, but also in other areas, such as its syndicates' notable cultural contributions and specific social characteristics. Moreover, this paper explores the dynamic changing of the organization overtime, especially in regards to its shifting relationship with the Japanese government.

Foreign Investments In Disputed Maritime Zones: Maritime Disputes As Events Of Force Majeure In International Law And International Investment Contracts, Hazem M. Kassem

BAU Journal - Journal of Legal Studies - مجلة الدراسات القانونية

Sovereign rights in Exclusive economic zones and Continental shelves are functionally limited to the economic exploitation of these zones. Moreover, in the case of disputed maritime zones these sovereign rights are neither exclusive nor necessarily constant. Nevertheless, states are still expected to provide the investments established in these zones the same treatment they should provide in their territories where they exercise full and constant sovereignty. If a host state agrees to the establishment of an investment in a maritime zone that become later contested, do the occurrence of the contestation and the hazards arising from such contestation relief the host …

Data Literacy On The Road: Setting Up A Large-Scale Data Literacy Initiative In The Databuzz Project, Tom Seymoens, Leo Van Audenhove, Wendy Van Den Broeck, Ilse Mariën

Journal of Media Literacy Education

This paper presents the DataBuzz Project. DataBuzz is a high-tech, mobile educational lab, which is housed in a 13-meter electric bus. Its specific goal is to increase the data literacy of different segments of society in the Brussels region through inclusive and participatory games and workshops. In this paper, we will explore how to carry out practical data literacy initiatives geared to the general public. We discuss the different interactive workshops, which have been specifically developed for DataBuzz. We highlight the background, design choices, and execution of this large-scale data literacy initiative. We describe the factors that need …

Rapid Shifts In Educators’ Perceptions Of Data Literacy Priorities, Kristin Fontichiaro, Melissa P. Johnston

Journal of Media Literacy Education

To meet the challenges of a data-driven society, high school students need new arrays of literacy skills. In the United States, school librarians, who work across disciplines, are well-positioned to help students improve their data practice, but they first need new domain knowledge. This article presents findings from an evaluating survey and session evaluation data from a virtual data literacy conference, which were part of a federally-funded project to develop data literacy skills among high school librarians and educators. Findings indicated a noticeable shift in participant perceptions of the need and urgency for data literacy instruction across content areas and …

The Importance Of Consulting Children And Young People About Data Literacy, Judy Robertson, E. Kay M. Tisdall

Journal of Media Literacy Education

Given the importance of data skills to the economy and the skills shortage within data science, educational policy makers have identified the importance of including technical and analytical data skills in the school curriculum. An equally important aim is to educate children and young people to become data citizens who are aware of the current uses of data in society, able to use data to make decisions in their lives, and are actively engaged in critiquing the societal implications of future uses of data. The paper will explore the meanings of data citizenship, in light of the findings of a …

Data (Il)Literacy Education As A Hidden Curriculum Of The Datafication Of Education, Pekka Mertala

Journal of Media Literacy Education

This position paper uses the concept of “hidden curriculum” as a heuristic device to analyze everyday data-related practices in formal education. Grounded in a careful reading of the theoretical literature, this paper argues that the everyday data-related practices of contemporary education can be approached as functional forms of data literacy education: deeds with unintentional educational consequences for students’ relationships with data and datafication. More precisely, this paper suggests that everyday data-related practices represent data as cognitive authority and naturalize the routines of all-pervading data collection. These routines lead to what is here referred to as “data (il)literacy” – an uncritical, …

Prd-2 Directly Regulates Casein Kinase I And Counteracts Nonsense-Mediated Decay In The Neurospora Circadian Clock., Christina M Kelliher, Randy Lambreghts, Qijun Xiang, Christopher L. Baker, Jennifer J Loros, Jay C Dunlap

Faculty Research 2020

No abstract provided.

Students Create New Award To Honor Outstanding Faculty Efforts This Fall, Anna Cohen

Featured News Story

Over 150 students nominated 92 professors to receive 'Hybrid Hero' Awards from the Student Senate Academic Affairs Committee.

Assessment Methodology Of Preschool Education System Management, N.D. Salikhov

Central Asian Problems of Modern Science and Education

The article describes in detail the assessment of the management of the preschool education system and the existing organization of preschool education, the assessment of the activities of managers and staff, the assessment of the rating based on the results obtained.

Nonlinearities And The Determinants Of Inequality: New Panel Evidence, Antonio Francesco Gravina, Matteo Lanzafame

Fondazione Eni Enrico Mattei Working Papers

Relying on data for a panel of 90 economies over 1970-2015 and System-GMM estimates, we extend the standard Kuznets-curve empirical framework to investigate how financial development, globalisation and technology affect income inequality. Our findings reveal the presence of significant nonlinearities, consistent with either U-shaped or inverted U-shaped relationships. As such, depending on whether a certain threshold value is achieved, the same determinants of income distribution can exert opposite effects in different countries. Globalisation is associated to increasing inequality in most advanced economies, but to falling disparities for the large majority of emerging economies. Further, while the effects for advanced economies …

Welfare Costs Of Catastrophes: Lost Consumption And Lost Lives, Ian W. R. Martin, Robert S. Pindyck

Fondazione Eni Enrico Mattei Working Papers

Most of the literature on the economics of catastrophes assumes that such events cause a reduction in the stream of consumption, as opposed to widespread fatalities. Here we show how to incorporate death in a model of catastrophe avoidance, and how a catastrophic loss of life can be expressed as a welfare-equivalent drop in consumption. We examine how potential fatalities affect the policy interdependence of catastrophic events and “willingness to pay" (WTP) to avoid them. Using estimates of the “value of a statistical life" (VSL), we find the WTP to avoid major pandemics, and show it is large (10% or …

Individual And Team Sports Edc 230, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Cvc's Plans For Spring 2021

St. Norbert Times

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Faculty Senate Minutes December 2020, Uno Faculty Senate

Faculty Senate Minutes

These are the official minutes of the Faculty Senate Meetings at the University of Nebraska - Omaha (UNO) for Academic year 2020-2021. The Faculty Senate supports faculty governance and believes that shared governance is essential to creating productive and rewarding environment for faculty and students. The Faculty Senate is a representative body of members elected by the faculty of the various academic departments and units of UNO. The Faculty Senate features representation from each academic college, Criss Library , and Omaha-base University of Nebraska – Lincoln (UNL) colleges.