Digital Commons Network^™

Multi-Level Small Area Estimation Based On Calibrated Hierarchical Likelihood Approach Through Bias Correction With Applications To Covid-19 Data, Nirosha Rathnayake

Theses & Dissertations

Small area estimation (SAE) has been widely used in a variety of applications to draw estimates in geographic domains represented as a metropolitan area, district, county, or state. The direct estimation methods provide accurate estimates when the sample size of study participants within each area unit is sufficiently large, but it might not always be realistic to have large sample sizes of study participants when considering small geographical regions. Meanwhile, high dimensional socio-ecological data exist at the community level, providing an opportunity for model-based estimation by incorporating rich auxiliary information at the individual and area levels. Thus, it is critical …

Statistical Modeling Of Survival Data Using Frailty Models, Adams Kusi Appiah

Theses & Dissertations

In many clinical trials, time-to-event endpoints are often adopted to demonstrate a clinically convincing effect of treatments appropriately. These variables might be clustered or correlated because of certain common features, such as genetic traits or shared environmental factors or repeated events. Observations from the same cluster are assumed to be correlated because they usually share specific unobserved characteristics. Ignoring the correlations between the survival times may lead to incorrect estimates of parameters of interest and invalid statistical inferences. The scientific interest may lie in the estimation of treatment effect while accounting for the correlated event times. This dissertation proposes a …

Deciphering The Catalytic Mechanism Of Human Manganese Superoxide Dismutase, Jahaun Azadmanesh

Theses & Dissertations

The livelihood of human cells is heavily dependent on the ability to modulate the presence of highly reactive oxygen-based molecules termed reactive oxygen species (ROS). In excess, ROS facilitate oxidative damage to the macromolecules of cellular life. SODs are the major family of antioxidant proteins that prevent the buildup of overwhelming amounts of ROS within cells. Sometimes dubbed the “first line of defense” against oxidative damage, SODs defend against the harmful accumulation of ROS by eliminating superoxide. Superoxide is a ROS itself that is also a precursor to much more harmful ROS molecules. MnSOD is the manganese containing form of …

Targeted Therapies In Select Gastrointestinal Cancers And Cancer Cachexia, Scott Mulder

Theses & Dissertations

Hepatocellular carcinomas exhibit metabolic alterations to support their proliferative and biosynthetic needs. We identified that elevated expression of the mitochondrial oxidative carboxylase, malic enzyme 2 (ME2), correlates with poorer hepatocellular carcinoma patient survival. Hepatocellular carcinoma patient tumors with high ME2 expression exhibit transcriptomic alterations indicative of PI3K/AKT/mTOR and c-Myc signaling as well as elevated central carbon, fatty acid, and redox metabolism pathways. Depletion of ME2 in the hepatocellular carcinoma cell line PLC or in the livers of mice treated with diethylnitrosamine to chemically induce hepatocellular carcinomas, results in impaired proliferation and reduced tumor formation. Additionally, the loss of …

Machine Learning Model Selection For Predicting Global Bathymetry, Nicholas P. Moran

LSU New Orleans Theses and Dissertations

This work is concerned with the viability of Machine Learning (ML) in training models for predicting global bathymetry, and whether there is a best fit model for predicting that bathymetry. The desired result is an investigation of the ability for ML to be used in future prediction models and to experiment with multiple trained models to determine an optimum selection. Ocean features were aggregated from a set of external studies and placed into two minute spatial grids representing the earth's oceans. A set of regression models, classification models, and a novel classification model were then fit to this data and …

Impact Of A Nicu Bedside Reading Initiative On Self-Reported Maternal Stress And Mother-Infant Attachment, Lauren Lorenzi Quigley

Electronic Theses and Dissertations

Premature birth and a corresponding hospitalization in the Neonatal Intensive Care Unit (NICU) presents infants and their families with an array of medical and psychosocial stressors that have the potential to impact neurodevelopment and social-emotional functioning in both the long-and short-term. Research has demonstrated the importance of family-integrated, developmental care interventions and a need for supportive environmental and sensory stimulation for the infant to optimize developmental, social, and emotional outcomes. Engaging parents in bedside care that fosters sensory development, supports cognitive and language skills, and lays a strong foundation for bonding and attachment can be monumental for the dyad. Implementation …

Adaptive Analytics: It’S About Time, Charles Dziuban, Colm Howlin, Patsy Moskal, Tammy Muhs, Connie Johnson, Rachel Griffin, Carissa Hamilton

Current Issues in Emerging eLearning

This article describes a cooperative research partnership among a large public university, a for-profit private institution and their common adaptive learning platform provider. The focus of this work explored adaptive analytics that uses data the investigators describe as metaphorical “digital learning dust” produced by the platform as a matter of course. The information configured itself into acquired knowledge, growth, baseline status and engagement. Two complimentary models evolved. The first, in the public university, captured end-of-course data for predicting success. The second approach, in the private university, formed the basis of a dynamic real-time data analytic algorithm. In both cases the …

Student Perceptions Of The Effectiveness Of Adaptive Courseware For Learning, Patricia O'Sullivan, Christina Forgette, Stephen Monroe, M. Tyler England

Current Issues in Emerging eLearning

Despite the increasing research on the effectiveness of adaptive learning courseware by vendors and academic institutions, there are few published, peer-reviewed studies on adaptive courseware that address the student experience and student perception of this teaching and learning tool. Over the course of two academic years, 2017/2018 and 2018/2019, researchers at the University of Mississippi conducted 16 course-based student focus groups and gathered data from 4 end-of-semester surveys to understand how students are experiencing adaptive courseware and whether or not they find it adds value to their education. Our study found that, although students generally find courseware to be helpful …

Methodising Scots: The Cases Of Allan Ramsay & Thomas Ruddiman, Jeremy J. Smith

Studies in Scottish Literature

Examines the linguistic issues facing editors of two 18th century Scottish editors, Allan Ramsay and Thomas Ruddiman, in modifying or standardizing the language in earlier Scottish poetic manuscripts, arguing that "the editorial process is not—and never has been—“neutral” or “objective” but is rather a hermeneutic act constrained by contemporary conditions of publication and intended audience," and that Ramsay and Ruddiman, like modern editors, were "constrained in quite delicate ways by their historical setting."

The Ethical Challenge For Hipaa’S Privacy Rule In The Genomics Era Of Data Analytics., Reem Shinawi

Electronic Theses and Dissertations

The thesis of this dissertation focuses on the Ethical Challenge for HIPAA’s Privacy Rule in the Genomics Era of Data Analytics. Data Analytics in Genomic Medicine challenges the individuals’ right to privacy. Hence, a balance is needed between the previous centrality of individual privacy and the need for population information to make breakthroughs in Genomic Medicine using Data Analytics. Such a problem demands regulatory solutions. And such solutions require the collaboration of professionals. Genomic Medicine is a field that deals with sensitive genetic information in both medicine, and research, it is essential to view it through HIPAA as it is …

Hcv-Associated Exosomes Upregulate Runxor And Runx1 Expressions To Promote Mdsc Expansion And Suppressive Functions Through Stat3-Mir124 Axis, Bal Krishna Chand Thakuri, Jinyu Zhang, Juan Zhao, Lam N. Nguyen, Lam N.T. Nguyen, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Zeyuan Lu, Xiao Y. Wu, Yong Jiang, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported that myeloid-derived suppressor cells (MDSCs) expand and inhibit host immune responses during chronic viral infections; however, the mechanisms responsible for MDSC differentiation and suppressive functions, in particular the role of RUNXOR-RUNX1, remain unclear. Here, we demonstrated that RUNXOR and RUNX1 expressions are significantly upregulated and associated with elevated levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of …

Immature Platelet Dynamics In Immune-Mediated Thrombocytopenic States, Hollie M. Reeves, Robert W. Maitta

Faculty Scholarship

A major challenge encountered by clinicians is differentiating presentations characterized by significant thrombocytopenia due to overlapping clinical symptoms and signs in the setting of ambiguous laboratory results. Immature platelets represent the youngest platelets that can be measured in peripheral blood by current hematology analyzers. These young platelets are larger, with higher RNA content recently released from the bone marrow. Thrombocytopenic presentations caused directly or indirectly by immune responses can lead to compensatory bone marrow responses seeking to normalize the platelet count; thus obtaining absolute immature platelet counts may be informative while triaging patients. Over the last decade, their use has …

Work-Integrated Learning For Mining Engineering Training And The Employability Nexus In Traditional Research Universities: A Case Of Selected South Africa Universities, Paul Othusitse Dipitso

Journal of Comparative & International Higher Education

No abstract provided.

Common Article 1 And The Duty To "Ensure Respect", Michael N. Schmitt, Sean Watts

International Law Studies

Common Article 1 to the four 1949 Geneva Conventions requires Parties to those instruments to “respect and to ensure respect for the present Convention in all circumstances.” The provision is a corollary to the general international legal obligation of States to honor their treaty commitments, expressed classically in the maxim pacta sunt servanda.

Yet, academics and private organizations now use Common Article 1 as a vehicle to reimagine States’ enforcement obligations under the Geneva Conventions. Reinterpreting the article beyond its original meaning, they claim the article includes an “external” obligation—a duty on the part of all States to use …

The Impact Of Second Step On First Grader Self-Regulation, Yassmin Al-Hadhramy

Dissertations, Theses, and Projects

Many studies have been conducted to identify the correlation between self-regulation and learning. What has proven to be certain is that higher levels of self-regulation yield results of higher levels of learning. The question that remains for many teachers is how do we increase self-regulation in children? This study examines the impact of Second Step on first grader self-regulation. Second Step is a social and emotional learning curriculum that teaches students self-regulation through focusing on working memory, attention, and inhibitory control. The first graders in this study were taught one Second Step lesson a week for 6 weeks. A pre …

Using Inquiry To Raise Engagement During Third Grade Instruction, Andrew Ellingson

Dissertations, Theses, and Projects

The purpose of this study is to research the effects that using inquiry-based strategies have on independent reading time engagement and reading achievement for third grade students. The research will begin by identifying the level of engagement and reading achievement of a third-grade class. A third-grade class will receive lessons on using the inquiry process, and then they will be able to take control of their learning and will be able to read and create projects based off what they are interested in. This study will examine if these strategies and options will boost engagement for these third-grade students, which …

Suppression Of Micat In Mouse Small Intestinal Myocytes By General Anaesthetic Ketamine And Its Recovery By Trpc4 Agonist (-)-Englerin A, Mariia I. Melnyk, Dariia O. Dryn, Lina T. Al Kury, Dmytro O. Dziuba, Alexander V. Zholos

All Works

© Copyright © 2020 Melnyk, Dryn, Kury, Dziuba and Zholos. A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupling in the gut is of special interest. Here we aimed to characterize the effects of one of the most commonly used “dissociative anesthetics”, ketamine, on mICAT. Patch-clamp and tensiometry techniques were used to investigate the mechanisms of the inhibitory effects of ketamine on mICAT in single mouse ileal myocytes, as well as …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …

Comparison Of Cardiac Muscle Between Male And Female Rats With Exercise And Aging: Analyzing Vitals, Gdnf Expression, Ngf Expression, Rna Expression, Sympathetic Innervation, Parasympathetic Innervation, And Sensory Innervation, Katelyn Kurrie

Honors Theses

The direction of my research-based thesis answers the question of how exercise affects the cardiovascular system with aging in male and female rats. My study would highlight the important differences of the cardiovascular system of both sexes which could lead to sex-specific insight on the cardiovascular disease epidemic which prevails as the most common cause of death in the United States. The studies completed will test the hypothesis: neurotrophic factor will be higher in females than males due to the higher presence of estrogen in females. The trophic factor is predicted to increase in both males and females with regular …

Asian Values And Democratic Viability: A Study Of The Effects Of Political Values On Thai Support For Democracy, Marisa Gonzalez-Mabbutt

Undergraduate Honors Theses

Despite research found in the World Values Survey which indicates high global support for democracy, certain regions of the world have struggled to solidify or even introduce democratic institutions. Existing explanations such as the Asian Values Theory show mixed results that political culture in Asian countries decreases support for democracy. These studies also fail to look at country-specific political cultures within countries like Thailand, where national values play a distinct role in the political arena and could affect democratic support. Moreover, previous research has not disaggregated how competing values at the national, regional, and global levels can affect support for …

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

Improving Nurse Resilience, Brandon Hedgspeth

Doctor of Nursing Practice Projects

The national average nurse turnover rate was 18.2% in 2017 (Ackerson & Stiles, 2018). A contributing factor for nursing turnout rates was nurse burnout and compassion fatigue (Barratt, 2018; Cleary, Kornhaber, Thapa, West, & Visentin, 2018; Cope, Jones, & Hendricks, 2016; Magtibay, Chesak, Coughlin, & Sood, 2017; Delaney, 2018; Manomenidis, Panagopoulou, & Montgomery, 2019; Poulsen, 2015). Improvement in nurse resilience was revealed to reduce burnout and compassion fatigue in nurses (Ackerson & Stiles; Delaney). The primary goal of this quality improvement project was to evaluate the use and impact of resiliency education on the resiliency of nurses in the hospital …

“I Said, You Are Gods”: Pastoral Motives Manifest In Patristic Citations Of Psalm 82:6, Charles Schulz

Doctor of Philosophy Dissertation

The early church fathers frequently cited Ps. 82:6 (LXX 81:6), “I said, You are gods and all sons of the Most High,” a passage Jesus himself quoted (John 10:34) to defend his own title as the Son of God. Scholars agree that the patristic use of verse underwrote the developing doctrine of deification, which promised that Christians would become “gods” in some sense by bearing God’s image and likeness and participating in Christ and his saving work. In order to deepen and focus our understanding of the significance and role of this passage for patristic theology—and particularly for pastoral practice—this …

Multiomics Characterization Of Preterm Birth In Low- And Middle-Income Countries., Fyezah Jehan, Sunil Sazawal, Abdullah H. Baqui, Muhammad Imran Nisar, Usha Dhingra, Rasheda Khanam, Muhammad Ilyas, Arup Dutta, Dipak K. Mitra, Usma Mehmood, Saikat Deb, Arif Mahmud, Aneeta Hotwani, Said Mohammed Ali, Sayedur Rahman, Ambreen Nizar, Shaali Makame Ame, Mamun Ibne Moin, Sajid Muhammad, Aishwarya Chauhan, Nazma Begum, Waqasuddin Khan, Sayan Das, Salahuddin Ahmed, Tarik Hasan, Javairia Khalid, Syed Jafar Raza Rizvi, Mohammed Hamad Juma, Nabidul Haque Chowdhury, Furqan Kabir, Fahad Aftab, Abdul Quaiyum, Alexander Manu, Sachiyo Yoshida, Rajiv Bahl, Anisur Rahman, Jesmin Pervin, Jennifer Winston, Patrick Musonda, Jeffrey S. A. Stringer, James A. Litch, Mohammad Sajjad Ghaemi, Mira N. Moufarrej, Kévin Contrepois, Songjie Chen, Ina A. Stelzer, Natalie Stanley, Alan L. Chang, Ghaith Bany Hammad, Ronald J. Wong, Candace Liu, Cecele C. Quaintance, Anthony Culos, Camilo Espinosa, Maria Xenochristou, Martin Becker, Ramin Fallahzadeh, Edward Ganio, Amy S. Tsai, Dyani Gaudilliere, Eileen S. Tsai, Xiaoyuan Han, Kazuo Ando, Martha Tingle, Ivana Maric, Paul H. Wise, Virginia D. Winn, Maurice L. Druzin, Ronald S. Gibbs, Gary L. Darmstadt, Jeffrey C. Murray, Gary M. Shaw, David K. Stevenson, Michael P. Snyder, Stephen R. Quake, Martin S. Angst, Brice Gaudilliere, Nima Aghaeepour

All Dugoni School of Dentistry Faculty Articles

Importance: Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection and guide therapeutic studies.

Objective: To investigate the ability of transcriptomics and proteomics profiling of plasma and metabolomics analysis of urine to identify early biological measurements associated with PTB.

Design, Setting, and Participants: This diagnostic/prognostic study analyzed plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in …

A Federated Deep Autoencoder For Detecting Iot Cyber Attacks, Christopher M. Regan

Master of Science in Computer Science Theses

Internet of Things (IoT) devices are mass-produced and rapidly released to the public in a rough state. IoT devices are produced by various companies satisfying various goals, such as monitoring the environment, senor trigger cameras, on-demand electrical switches. These IoT devices are produced by companies to meet a market demand quickly, producing a rough software solution that customers or other enterprises willingly buy with the expectation they will have software updates after production. These IoT devices are often heterogeneous in nature, only to receive updates at infrequently intervals, and can remain out of sight on a home or office network …

Malta V. 801-803 Llc

All Decisions

No abstract provided.

1 Beach 105 Realty, Llc V. Murphy

All Decisions

No abstract provided.

State V. Rodriguez Appellant's Reply Brief Dckt. 47748

Not Reported

No abstract provided.

State V. Lowder Respondent's Brief Dckt. 47763

Not Reported

No abstract provided.

Action Collection Service Inc. V. Black Respondent's Brief Dckt. 47864

Not Reported

No abstract provided.