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The Launch 2020: A Senior Cabaret, Otterbein Theatre And Dance Department

2020-2021 Season

No abstract provided.

Combating Human Trafficking: Assessing Justice Systems Response, Carly Stephens

Theses

The purpose of this thesis was to examine and assess justice system efforts in combating human trafficking; more specifically sex trafficking. The goal was to understand how efforts of combating human trafficking started, how they progressed, and to explore where efforts remain at this time. Additionally, the goal was to identify and understand what is working in law enforcement, human trafficking courts, and policy. This included identifying issues such as disparity in law enforcement reporting, lack of recognition of sex trafficking, and outdated policies. To assess these issues, this project utilized human trafficking data available through the FBI Uniform Crime …

Direct Measurement Of The Cosmic-Ray Carbon And Oxygen Spectra From 10 Gev/ N To 2.2 Tev/ N With The Calorimetric Electron Telescope On The International Space Station, O. Adriani, Y. Akaike, K. Asano, Y. Asaoka, M. G. Bagliesi, E. Berti, G. Bigongiari, W. R. Binns, M. Bongi, P. Brogi, A. Bruno, J. H. Buckley, N. Cannady, G. Castellini, C. Checchia, M. L. Cherry, G. Collazuol, K. Ebisawa, H. Fuke, S. Gonzi, T. G. Guzik, T. Hams, K. Hibino, M. Ichimura, K. Ioka, W. Ishizaki, M. H. Israel, K. Kasahara, J. Kataoka, R. Kataoka, Y. Katayose, C. Kato, N. Kawanaka

Faculty Publications

In this paper, we present the measurement of the energy spectra of carbon and oxygen in cosmic rays based on observations with the Calorimetric Electron Telescope on the International Space Station from October 2015 to October 2019. Analysis, including the detailed assessment of systematic uncertainties, and results are reported. The energy spectra are measured in kinetic energy per nucleon from 10 GeV/n to 2.2 TeV/n with an all-calorimetric instrument with a total thickness corresponding to 1.3 nuclear interaction length. The observed carbon and oxygen fluxes show a spectral index change of ∼0.15 around 200 GeV/n established with a significance >3σ. …

Seeking Clemency: A Profile On Jacob Rouse, Jocelyn A. Contreras, Sarah Gabrielli

Capstones

Jacob Rouse was 18 years old when he drove the getaway car that would define the rest of his life. He sat in his blue Ford Taurus, waiting to drive his three friends away from the scene of a robbery in Rochester, New York. Jacob was parked about a block away when one of his accomplices shot and killed 22-year-old Herschel Scriven, a local youth pastor and church organist.

He is now seeking clemency.

A Learning Nightmare For An Immigrant Family, Arlyn J. Sorto

Capstones

Just two years after settling in Texas, a Honduran mother and her two kids must grapple with the hardships of remote learning due to limited access to the internet and a language barrier during a global pandemic.

Hips That Harm: When Medical Devices Fail Women, Sophie N. Putka

Capstones

Medical devices that save the lives of thousands of Americans each year advance at a rapid pace - but some of them consistently leave women behind. When it comes to joint replacements and even heart devices, women have worse health outcomes. Behind this preventable problem is a system that overlooks women from start to finish. Female bodies are different from male bodies, but women are often underrepresented in medical trials for device approval. Women’s participation in clinical testing for devices has increased, but there’s rarely a detailed analysis of performance by sex, and even less information on women by race …

Healthcare Policy Analysis: Next Of Kin Contact Information On Driver's Licensse And Its Use In Emergency Notification, Suzanne Sheaffer

Doctor of Nursing Practice (DNP) Manuscripts

Abstract

In Pennsylvania, there has been a rise in unclaimed decedents within Third-Class and Fifth-Class county coroner offices. Decreasing the number of unclaimed decedents in Third-Class and Fifth-Class Pennsylvania coroners offices is the goal for this healthcare policy analysis project. Using the Bardach’s eight step policy analysis problem solving technique, the data and the project outcomes will be presented to Pennsylvania Department of Transportation (PennDOT). Data collection began with a questionnaire sent to all 67 counties to determine who had access to the Pennsylvania driver’s license database entitled Pennsylvania Justice Network (JNET). Fourteen of 67 counties have partial access and …

The Cellular Origin And Molecular Drivers Of Claudin-Low Mammary Cancer, Patrick D. Raedler

Theses & Dissertations

Breast cancers of the claudin-low subtype make up a substantial portion of triple-negative breast cancers and have stem cell-like and mesenchymal features. Although it has been recognized for some time that this breast cancer subtype is highly aggressive and difficult to treat, the molecular drivers and cellular origin of claudin-low breast cancer have been poorly defined. The lack of suitable in vivo models has prohibited the study of tumor initiation and progression of this subtype. In this work, we report two novel mouse models that, upon expression of oncogenic RAS in the mammary epithelium, develop highly metastatic triple-negative mammary tumors …

"Slain Ye Shall Be": Eschatological Morality And The House Of Feanor In Tolkien's The Silmarillion, Ashley Anteau

Honors Projects

This thesis expands on existing research and analysis of the eschatology of J. R. R. Tolkien’s invented mythology, with a critical analysis of how it relates to morality and the overarching exploration of good and evil, primarily in The Silmarillion. By analyzing Tolkien’s medieval and spiritual influences, as well as Tolkien’s unfinished works published posthumously by Christopher Tolkien, it explores the effect of the relationship between morality and mortality on the emotional core of Tolkien’s work. It offers new insights into the text by engaging especially with the often overlooked story of the sons of Feanor, and how this story …

Stakeholders' Perceptions Of Inherent Barriers To The Potential Implementation Of Ultrasound In The Prehospital Setting Between The Saudi Red Crescent Authority And The National Guard Hospital, Maher Alsulami

Electronic Theses and Dissertations

This exploratory study was designed to illuminate both the obstacles and the opportunities inherent in the current medical emergency systems within the kingdom of Saudi Arabia in relation to the possible inclusion of ultrasound machines to assist both Saudi Red Crescent Authority professionals and emergency physicians in the hospital. The research explored the issue of implementing the ultrasound from the perspective of multiple institutions: The Saudi Red Crescent Authority and the National Guard Hospital. The research explored multiple healthcare professionals within both organizations including paramedics, EMTs, emergency doctors, and Saudi Red Crescent station administrators.

The purpose of this qualitative method …

Accurate Quantitation Of Hexavalent Chromium For Reference Standard Certification And Quality Control Testing Using Speciated Isotope Dilution Mass Spectrometry, James E. Henderson

Electronic Theses and Dissertations

The ability to perform accurate, repeatable, and defensible elemental and molecular speciated analysis is immensely significant for measurements that support human health, environmental science, and industry. This is especially true since trivalent chromium [Cr(III)] is necessary for proper nutrition, while hexavalent chromium [Cr(VI)] is extremely toxic, genotoxic, and carcinogenic. The main challenges associated with speciated analysis are related to reactive species that are continuously transformed or converted to other species during sample processing. Accurate determination of Cr(III) and Cr(VI) species require a method that is capable of monitoring and correcting for interconversion, bias, and instrumental error. Traditional quantitative methods, such …

Fluoride Removal With Augmented Bentonite In Drinking Water And Community Perceptions In Arusha, Tanzania, Kara Okular

Electronic Theses and Dissertations

High fluoride concentrations in drinking water affect millions of people around the world. The World Health Organization recommended a fluoride concentration in drinking water of ≤ 1.5 mg/L; fluoride above this concentration can cause long-term dental and skeletal fluorosis. Fluoride imparts no taste to water; therefore, people do not realize that they are ingesting high fluoridated water. Researchers sought to develop a material to remove fluoride from drinking water through sorption. Aluminum was used to form a double ionic layer on the bentonite clay surface. Once mixed in contaminated water, a coagulant, ferric sulfate, was used to separate the bentonite …

Examining The Intersectionality Of Religious Faith, Spirituality, And Healthcare Communication, Felix Okeke

Electronic Theses and Dissertations

This dissertation is my own contribution in responding to the concern raised by certain communication scholars. Their concern was that little research and few publications have been done in the communication field by communication scholars that trace the relationship among religious faith, spirituality, and healthcare communication. While Parrott (2004) describes this apparent neglect as “collective amnesia,” others label it “religion blindness.” Thus, in trying to trace this relationship, this project uses Christian, biblical, and bioethics backgrounds to establish the value, sacredness, and dignity of human life, since these concepts make healthcare and healthcare communication necessary in the first place. These …

Control Of Corrosion On Ss316l Using Surface Initiated Polymers, Alexander Rupprecht

Electronic Theses and Dissertations

Pitting corrosion is arguably one of the most destructive and dangerous forms of corrosion, resulting in damage to structures, the environment, and public health. In addition, damage caused to structures such as bridges, pipelines, and boats, corrosion also has a profound effect on the biomedical community. Implanted metallic devices (i.e., vascular stents and artificial joints) are prone to pitting corrosion caused by aggressive ions present in extracellular fluid. To provide a corrosion-resistant surface on SS316L, films of poly(styrene), poly(methyl acrylate), and poly(methyl methacrylate) were formed using surface-initiated atom transfer radical polymerization (SI-ATRP). The resulting hydrophobic polymer films had a fractional …

Just A Girl In A Man’S World: Factors Affecting Women In Leadership In Law Enforcement, Gina Barras Holland

LSU New Orleans Theses and Dissertations

Federal Bureau of Investigation (FBI) statistics from 2013 revealed that of about 477,000 sworn law enforcement officers at the local level in the United States, only 12% are women; and only 6.2% of those who hold intermediate-level rank are women (U.S. Department of Justice, Bureau of Justice Statistics, Local Police Department, 2013: Personnel, Policies, and Practices, 2015). Although legal mandates have afforded women career opportunities in law enforcement, those mandates have not provided protection within the structures of law enforcement agencies regarding achieving high ranking positions. Women are more likely than men to remain in lower-ranking positions throughout their entire …

Child Protection Services: An Evaluation Of The Current System And Recommendations For Preventing Instances Of Abuse, Sarah Varian

Graduate Teacher Education

Millions of children are reported to Child Protective Services every year, and the services those children receive differ greatly between each state depending on the laws and regulations set in place and what community programs may or may not exist to support them. Research about what factors influence child abuse occurrences and which services best meet the needs of at-risk families is vital to determine the best ways to provide support for families reported for cases of abuse or neglect (Palmer, Maiter, & Manji, 2006; Solomon & Asber, 2012). A review of literature on this topic concluded that currently, Child …

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, And Increase Plasma Β-Hydroxybutyrate, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Donald F. Stec, Matthew C. Donald, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used diet-induced obese mice with non-alcoholic fatty liver disease treated with pegylated bilirubin (bilirubin nanoparticles) or vehicle control to determine the impact on hepatic lipid accumulation. The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein. The bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1. …

Deep Brain Stimulation Of The Subcallosal Cingulate Gyrus In The Treatment Of Treatment Resistant Depression, Megan Caravas, Melanie Sov

Physician Assistant Capstones, 2020-current

Objective: a systematic review to determine the efficacy of deep brain stimulation (DBS) targeting the subcallosal cingulate gyrus (SCG) for the treatment of treatment resistant depression (TRD). Methods: PubMed database was utilized in a search for clinical randomized control trials that were completed after the year 2000, using the terms deep brain stimulation, treatment resistant depression, and subcallosal cingulate gyrus. Results: Three clinical trials were chosen based on specific inclusion criteria as noted in the PRISMA flow chart (Chart 1). The results of the three articles showed various discrepancies. Two of the three studies demonstrated some statistical significance in reduction …

Efficacy Of Mdma-Assisted Psychotherapy In The Treatment Of Chronic Ptsd, Alexis Coleman, Nicole Blixt

Physician Assistant Capstones, 2020-current

Objective: To assess the effectiveness of MDMA-assisted psychotherapy in treating patients with chronic refractory PTSD using a systematic review.

Methods: Literature search was performed on PubMed and PsychINFO using search terms “PTSD” and “MDMA” to identify randomized control trials within the past 10 years.

Results: Two out of the three studies found statistically significant data in the treatment of refractory PTSD. Mithoefer, M. et al and Ot’alora, M. et. al found a statistically significant decrease in CAPS-IV total scores, decrease in depression symptoms, decreased in dissociative symptoms, and increase in sleep quality.

Conclusion: The use of …

Short Term Effects Of Electronic Cigarettes On Pulmonary Function In Healthy Adult Smokers When Compared To Conventional Cigarette Use, Kayleen Lynch, Rachel Bastianelli

Physician Assistant Capstones, 2020-current

Background: Electronic cigarettes (e-cigarettes) first appeared on the U.S. market in 20071 , but to date, little is known about their safety. Concern about long term adverse effects on overall health continues to increase as we explore the potential of e-cigarettes to aid in smoking cessation practices. E-cigarettes have gained popularity and support through this idea that by using them to help patients quit smoking, the benefits of ultimately abstaining from tobacco use will outweigh the harms associated with e-cigarette use¹ . While the idea of reducing tobacco usage by any means possible remains the goal for most providers, …

Lactobacillus Reuteri In The Management Of Infantile Colic, Katherine Evans, Helena Gaitan

Physician Assistant Capstones, 2020-current

Objective: To determine if Lactobacillus reuteri is an effective treatment for infantile colic by reviewing existing literature and performing a systematic analysis. Design: Systematic literature review. Methods: The PubMed database was searched using the terms “Lactobacillus reuteri” and “colic.” The yielded results were refined to only include human clinical trials published within the past 10 years. Results: Chau et al., Savino et al., and Szajewska et al. each found that the average crying times were significantly shorter for the L. reuteri group than they were for the probiotic group on days 7, 14, and 21. All …

Efficacy Of Pulmonary Ultrasound Compared To N-Terminal Prohormone Brain Natriuretic Peptide As A Diagnostic Tool For Congestive Heart Failure In Patients Presenting With Acute Dyspnea In The Emergency Setting, Leah Krohn, Michael Burns

Physician Assistant Capstones, 2020-current

Objective: To determine the efficacy of using pulmonary ultrasound as a diagnostic tool in acute dyspnea of undetermined cause compared to the use of serum N-Terminal prohormone Brain Natriuretic Peptide (NT-proBNP) in the diagnosis of heart failure.

Design: Systematic literature review

Methods: Searches were conducted in PubMed and Scopus using the terms pulmonary ultrasound and congestive heart failure and studies within the last 10 years. Studies that used pulmonary ultrasound compared to BNP as a marker for the diagnosis of heart failure were included.

Results: All three studies found that the use of pulmonary ultrasound was a more specific …

Evaluation Of Hyperhomocysteinemia In The Progression Of Parkinson's Disease, Marisa A. Ducach, Pritpal S. Saggu

Physician Assistant Capstones, 2020-current

Abstract:

Objective:To assess the prevalence of hyperhomocysteinemia in Parkinson’s Disease (PD) and if this elevated serum level can be used as a predictive biomarker in risk assessment for the progression of cognitive decline in PD.

Design:Systematic Literature Review

Methods:A literature search was conducted through Google Scholar and Pubmed using phrases such as, “Parkinson's Disease”, and “homocysteine”, “Parkinson’s progression. Three articles, measuring serum homocysteine levels and cognitive functioning in PD patients, were selected, analyzed, and compared to assess for a relationship between homocysteine levels and cognitive decline in PD.

Results: Elevated homocysteine levels are associated with worse cognitive …

Rilpivirine-Associated Aggregation-Induced Emission Enables Cell-Based Nanoparticle Tracking, Insiya Mukadam

Theses & Dissertations

Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, limitations in drug efficacy, the emergence of viral mutations and the paucity of cell-tissue targeting remain. We posit that to maximize ART potency and therapeutic outcomes newer drug formulations that reach HIV cellular reservoirs need to be created. In a step towards achieving this goal we discovered the aggregation-induced emission (AIE) property of the non-nucleoside reverse transcriptase inhibitor Rilpivirine (RPV) and used it as a platform for drug cell and subcellular tracking. RPV nanocrystals were created with endogenous AIE …

Stress Relaxation In Orthodontic Aligner Plastics; An In Vitro Comparison Study, Kristopher J. Keller

Theses & Dissertations

The purpose of this study was to ascertain if repeated stresses from extension cycling would result in accumulated damage in aligner materials and affect force delivery. A secondary goal was to identify potential differences in mechanical behavior present among orthodontic aligner polymers. Four thermoplastic polymers (Essix ACE, Taglus, Zendura, and Zendura FLX) were thermoformed, cut into strips, and extension cycled to 0.4 millimeters in a 37C water bath. Force decay, maximum and minimum force, and elastic modulus were measured during cycling. Additional samples were subjected to controlled tension until failure, allowing the measurement of yield strength, ultimate strength, and elastic …

Ypfs Lessons Learned Oral History Project: An Interview With Sohail Khan, Sohail Khan, Steven H. Kasoff, Matthew A. Lieber

Documents

Suggested Citation Form: Khan, Sohail, 2020. “Lessons Learned Interview."Interview by Steven H. Kasoff and Matt A. Lieber. Yale Program on Financial Stability Lessons Learned Oral History Project. December 18, 2020. Transcript. https://ypfs.som.yale.edu/library/ypfs-lesson-learned-oral-history-project-interview-sohail-khan

A Numerical And Experimental Study Of Lid Driven Square Cavity Flow For Laminar And Turbulent Cases, Abdullah Bin Naeem

LSU New Orleans Theses and Dissertations

Experimental and numerical studies are performed on steady and unsteady lid-driven cavity flow for laminar flow regime. In the experiments, a PIV and an LDA were employed to measure the global and local velocities, respectively inside a cavity of AR 1.0. The velocity vector plots and streamline plots which represent unsteady circulation patterns are obtained using the PIV. The steady local velocities measured with LDA are then used to calibrate the PIV measurements. The numerical study is performed using a commercial CFD solver. For turbulent flow simulation RANS equations with K-Epsilon closure model were used. From the PIV calibration study, …

Body Snatching In Philadelphia: A Social And Cultural History, 1762-1883, Timothy R. Dewysockie

Theses and Dissertations

In 18th-century Philadelphia the first medical school in the thirteen British colonies was established. However, cadavers for dissection could only be obtained involuntarily, a posthumous punishment generally reserved for murderers and suicides. Body snatching, the disinterment of corpses for dissection, immediately became a problem because legal sources of "subjects" did not meet demand. Body snatching was resisted in popular representations and the actions of everyday citizens in riots, petitions, and other forms of protest. However, in the late 19th century the requisition of "unclaimed" bodies for dissection - that is, dead "paupers" - became enshrined in Pennsylvania's 1883 Anatomy Act, …

Dna Polymerase Ε: Replication Error Prevention And Consequences Of A Cancer-Associated Mutation, Chelsea R. Bulock

Theses & Dissertations

Genome integrity is necessary to prevent mutations and disease. During eukaryotic DNA replication, DNA polymerases ε (Polε) and δ (Polδ) synthesize the leading and lagging strand, respectively. Polε and Polδ also have exonuclease activity that acts in series with post-replicative mismatch repair (MMR) to remove replication errors. Defects in proofreading and MMR lead to an increase in mutations and cause cancer in humans. This dissertation focuses on several unresolved issues involving the relationship between Polε and Polδ in replication error avoidance. First, despite an abundance of data supporting the one-strand-one-polymerase replication fork model, defects in the fidelity of Polε have …

Anti-Muc4Β Antibodies As A Novel Therapeutic Modality For The Treatment Of Pancreatic Cancer, Catherine Orzechowski

Theses & Dissertations

The deregulation of cell surface glycoproteins, such as mucins, is a hallmark of many tumors of epithelial origin. The transmembrane mucin MUC4, is differentially overexpressed in several malignancies, including pancreatic, breast, ovarian, lung, cervical, and head and neck cancers. Of all the aforementioned cancers, the role of MUC4 has been the most thoroughly in pancreatic cancer (PC), which is the 4th leading cause of cancer-related deaths in the United States. While MUC4 is undetectable in the normal or inflamed pancreas (pancreatitis), its expression progressively increases during PC progression and its higher expression correlates with poor survival. The role of MUC4 …