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Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with AD and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-β (Aβ) via its N-terminal Aβ binding domain, and facilitates Aβ aggregation. Intracerebroventricular infusion or forced expression of this protein exacerbates neuroinflammation and cognitive dysfunction …

Food & Feelings

In Case You Missed It

DECEMBER 2020

A Snapshot Semester: Students’ Reflections Of Performance And Mental State Throughout A Graduate Course, Bradley D. Borges

Graduate Theses and Dissertations

Graduate students are anecdotally reputed to be among the most stressed groups of young adults. Common sources of stress for graduate students have included coursework, assistantships, finances, career preparation, and family (Wyatt & Oswalt, 2013; Mazzola, Walker, Shockley & Spector, 2011; Oswalt & Riddock, 2007). Guided reflection can be used by educators to assist students in both learning (Boud, Keogh & Walker, 2013; Kolb, 1984) and managing stress (Shoulders, Whitehead, & Morrison, 2018). By understanding how students’ progress through a semester in terms of both their learning and their management of stress, instructors and academic advisors can better anticipate times …

Off-Spec Solutions V. Transporation Investors Appellant's Reply Brief Dckt. 47940

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Recognition To Treatment: The Roles Of Emergency Medical Service Providers And Mobile Intensive Care Nurses In Suspecting Sepsis, Jodee Lejnieks, Cyndie Strader, Linda Chirieleison, Cherry Tanjapatkul, Ahlam Jadalla

General Submissions: Presentations (Oral and Poster)

Local evidence suggested that Emergency Medical Service Providers (EMSPs) and Mobile Intensive Care Nurses (MICNs) are challenged with recognizing sepsis. Early recognition of sepsis in the pre-hospital setting and notification to the receiving hospital may decrease time to treatment (TTT) on arrival, which may improve patient outcomes. The project objective was to improve the recognition of suspected sepsis by EMSPs and MICNs and decrease TTT.

Goal Zero: Eliminating Mislabeled Specimens In The Emergency Department, Michele Samsa, Tracie Henderson

General Submissions: Presentations (Oral and Poster)

This emergency department (ED) noticed an increase in misidentified laboratory specimens noted to be the highest in our hospital region. Misidentified specimens can result in misdiagnosis, medication errors and repeat laboratory (Lab) specimen collection with a direct impact on patient comfort, nurse workload and increased cost can result. This project was developed as a quality improvement project aimed at reducing misidentified laboratory specimens and promote patient safety.

Emergency Department Pediatric Self Efficacy Scale (Pedi-Ed-Se): A Psychometric Study, Elizabeth Molle, Stephanie German

General Submissions: Presentations (Oral and Poster)

Extant literature supports that ED health care providers lack self-efficacy for recognizing and managing pediatric emergencies, particularly in community-based hospital settings. Further, empirical evidence supports that in-situ simulation provides an effective educational venue for improving self-efficacy. However, a gap exists in measuring self-efficacy with a validated and reliable instrument. Therefore, an instrument development research study was done to construct and test the new instrument.

Epinephrine In Anaphylaxis: Assessing Knowledge Gaps In Administration And Strategies To Mitigate Error, Joyce Foresman-Capuzzi, Megan Buckley, Lisa Eckenrode, John Capuzzi

General Submissions: Presentations (Oral and Poster)

Given the low volume, high-risk situation which necessitates Epinephrine treatment in anaphylaxis, gaps in knowledge and practice were observed, resulting in error. A hypothesis was developed that nurses educated prior to 2000 would have a gap in administration knowledge, leading to error potential. This project was designed to identify those gaps and develop education to address them, leading to best practice and enhanced patient safety during a low volume, high risk emergency. Epinephrine is a high-risk drug,in that concentration differs according to diagnosis and has previously been expressed in ratio format, leading to confusion and error. Since the early 2000's, …

Team Up Against Sepsis; 6 Tasks In 60 Minutes, Karin Kloppel, Barbara Richards

General Submissions: Presentations (Oral and Poster)

This project has a three-pronged purpose: 1. Improve compliance with sepsis bundles. 2. Improve early recognition of possible SIRS/Sepsis and reduce sepsis mortality. 3. Improve times in obtaining labs, lactate, 2 blood cultures, IV access, IV fluid resuscitation and initiating antibiotics by 80%. Sepsis is the number one cause of mortality in hospitals nationwide. Our hospital system has identified sepsis mortality reduction as a top priority. Early recognition and treatment through improving sepsis bundle compliance was the selected focus in our 40-bed emergency department.

Blood Sample Hemolysis Prevention: Certified Emergency Nurses Know The Answer, Christian N. Burchill, Spencer Seballos, Edmunds Reineks, Michael P. Phelan

General Submissions: Presentations (Oral and Poster)

Blood sample hemolysis rates in Emergency Departments exceed nationally established benchmarks resulting in patient discomfort, added costs, longer waits, and delayed clinical decision making. Best practices for blood sample hemolysis prevention have been established, and emergency nurses are frequently responsible for phlebotomy.

Obtaining A Reference For Calibrating Broadband Multibeam Seabed Backscatter, Ivan Bodra Guimaraes

Master's Theses and Capstones

Standard calibration procedures for multibeam sonars currently only address the fidelity of the bathymetric data. Equivalent effort is needed to ensure that the acquired seabed backscatter strength measurements are referenced to a similarly precise level. This thesis presents an operational method for acquiring reference seabed backscatter data utilizing multiple pre-calibrated split beam echo sounders covering a wide range (45-450 kHz) of frequencies. This is needed to cover the full range of frequencies utilized by multi-sector multibeam systems operating in continental shelf depths.The method considers both the frequency and the angle of incidence dependence of the backscatter strength of a homogenous …

Physiological And Predicted Metagenomic Analysis Of Soil Aggregate Microbial Communities Under Different Tillage Regimes, Lukas Bernhardt

Master's Theses and Capstones

Soils are spatially heterogeneous environments, and the distribution of microorganisms and carbon is organized at the scale of millimeters in soil aggregates. The physio-chemical environment within macroaggregates and microaggregates differ, which may lead to the selection of microbial communities with different survival and growth strategies- here termed life history strategies. Using an aggregate scale survey of microbial communities in agricultural soils, I show that soil aggregates harbor distinct communities with life history characteristics that align with the Yield, Acquisition, Stress tolerator framework (Y-A-S). Soils collected from an eight- year tillage experiment were isolated into four aggregate size classes and physiological …

Dc-Dc Buck-Boost Converter Design For Energy Harvesting From Exercise Equipment, Nicholas Serres

Electrical Engineering

This project aims to improve energy harvesting efficiency from an exercise machine. Exercise machine energy harvesting has a small immediate impact but can eventually have an immense impact. An elliptical exercise machine energy converter outputs 5V-60V whereas the microinverters require approximately 36V. The buck boost DC-DC converter bridges the gap between the microinverter and the elliptical machine. Increasing the buck-boost controller efficiency increases power production. Greater power efficiency gives the whole system more financial viability, and additionally makes it a greater sustainable energy source.

Programmable Battery Management System, Jason Erbert

Electrical Engineering

Lithium batteries provide excellent energy storage capabilities at a relatively high density; however, precautions must be taken with these high energy devices to ensure safe operation. A battery management system (BMS) provides protection by monitoring cell and pack voltage levels and maintaining them in a specific range. They limit the output current and disable the output in extreme conditions. Most devices in the targeted power range (<1000W) do not allow the user to manipulate the values for maximum current, cut-off voltage, or other limits. This project introduces the Programmable BMS (PBMS), which instead allows the user to select these values through a physical interface. The interface displays measurements including pack voltage and output current, and it reports additional characteristics of interest such as the battery’s temperature, state of charge, and cumulative number of charge cycles. This level of access and control permits users to receive the maximum performance and safety from common lithium battery packs.

A Spitzer Survey Of Deep Drilling Fields To Be Targeted By The Vera C. Rubin Observatory Legacy Survey Of Space And Time, M. Lacy, J. A. Surace, D. Farrah, K. Nyland, J. Afonso, W. N. Brandt, D. L. Clements, C. D. P. Lagos, C. Maraston, J. Pforr, A. Sajina, M. Sako, M. Vaccari, G. Wilson, D. R. Ballantyne, Wayne A. Barkhouse, R. Brunner, R. Cane, T. E. Clarke, M. Cooper, A. Cooray, G. Covone, C. D'Andrea, A. E. Evrard, H. C. Ferguson, J. Frieman, V. Gonzalez-Perez, R. Gupta, E. Hatziminaoglou, J. Huang, P. Jagannathan, M. J. Jarvis, K. M. Jones, A. Kimball, C. Lidman, L. Lubin, L. Marchetti, P. Martini, R. G. Mcmahon, S. Mei, H. Messias, E. J. Murphy, J. A. Newman, R. Nichol, R. P. Norris, S. Oliver, I. Perez-Fournon, W. M. Peters, M. Pierre, E. Polisensky, G. T. Richards, S. E. Ridgway, H. J. A. Röttgering, N. Seymour, R. Shirley, R. Somerville, M. A. Strauss, N. Suntzeff, P. A. Thorman, E. Van Kampen, A. Verma, R. Wechsler, W. M. Wood-Vasey

Physics Faculty Publications

The Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will observe several Deep Drilling Fields (DDFs) to a greater depth and with a more rapid cadence than the main survey. In this paper, we describe the ‘DeepDrill’ survey, which used the Spitzer Space Telescope Infrared Array Camera (IRAC) to observe three of the four currently defined DDFs in two bands, centred on 3.6 and 4.5 μm. These observations expand the area that was covered by an earlier set of observations in these three fields by the Spitzer Extragalactic Representative Volume Survey (SERVS). The combined DeepDrill and …

Geodermatophilaceae Biofilm Formation And Rock Recolonization, Krista Greengrass

Master's Theses and Capstones

The Geodermatophilaceae genera—Geodermatophilus, Blastococcus, and Modestobacter—live on rock surfaces and create biofilms that deteriorate stone architecture and monuments. Their biofilms increase the rate of weathering and erosion but are not well studied. Recently, thirteen strains were isolated, and their genomes sequenced. These new Geodermatophilaceae isolates along with Modestobacter marinus strain BC501 and Blastococcus saxobsidens strain DD2 were used in this study to evaluate biofilm formation under different environmental factors including temperature, light, and salt and heavy metal exposure. Ten isolates were used for experiments to recolonize back onto the rock substrates from which the isolates were obtained. For most of …

Potential For Non-Conventional Use Of Split-Beam Phase Data In Bottom Detection, Leonardo Gomes De Araujo

Master's Theses and Capstones

Because the safety of the navigation depends on accurate knowledge of the submerged features, any improvements in the ability to resolve those features are of major interest. Ultimately this reflects the bottom detection performance of the bathymetric measuring system (most commonly multibeam sonar) utilized. To this end, different algorithms for the detection of the seafloor or other targets have previously been developed, all presenting advantages and disadvantages. The two most common techniques are designed around time-series or angle-series analysis, although by far the most focus has been on time-series. The option of recording both amplitude and phase data of the …

Internal And External Determinants Of The Adoption Levels Of Sustainable Development Policies In The Energy, Industry And Agricultural Sectors Of Turkey, The United States, The Russian Federation, And The People’S Republic Of China, Onur Kolcak

Graduate Liberal Studies Theses and Dissertations

Our planet's natural resources have helped humanity advance and build countless civilizations. We are a fossil fuel civilization and have evolved so that today's production and energy use has become the most crucial part of all modern economies. We cannot function without reliable, resilient, and secure energy sources that help us continuously produce. Human history is full of important events that have tremendously shaped our experience on this planet. These experiences have sometimes forced us to make quick decisions and change our ways, but some of these changes occurred gradually and gave us time to plan and adapt. Adaptability is …

Fostering Place-Based Education And Inclusion In The Classroom Through School Grades, Karina Gonzales-Smith

Student Projects for Graduate Degrees

Place-based education expands the space where students learn by connecting to the outdoors, such as garden-based lessons that are dynamic and have a multidisciplinary curriculum. Students are given the opportunity to learn healthy behaviors, environmentally sustainable practices, and life skills. Inclusion is fostered by giving teachers and students agency in the learning experience. The purpose of this study was to view garden education through the lens of place-based education, critical pedagogy, and social justice. To this end, a lesson plan template was created to facilitate future development of garden-based lessons characterized by responsive curriculum and alignment with academic standards. A …

Emotion Regulation And N2 Amplitude During A Go/Nogo Task: An Erp Study, Emily Tolar

Psychological Science Undergraduate Honors Theses

Emotion regulation is how people respond to and manage their reactions to life experiences, including resolving conflict between variable responses. Past research has associated the N2, an event-related potential associated with resolving response conflict, with both emotion regulation and negative emotion. However, to the best of our knowledge, no one has assessed if different emotion-regulation strategies are differentially associated with N2 activation. To assess this question, we conducted an EEG study with 147 participants. Participants completed the Cognitive Emotion Regulation Questionnaire (CERQ) and then played the go/no-go game as their EEG data was collected. The relationship between N2 amplitude and …

Torts: Covid-19 Pandemic Business Safety Act & Executive Order By The Governor Designating Auxiliary Management Workers And Emergency Management Activities, Angelena Velaj, Troy Viger

Georgia State University Law Review

The Executive Order expanded immunity from liability for volunteer health care workers as emergency management workers performing emergency management activities. The Order was not limited to only COVID-19-related activities. When the legislature reconvened, legislators passed the Georgia COVID-19 Pandemic Business Safety Act, which provided liability limitation to businesses against tort claims arising from the pandemic.

Modeling Neurofibromatosis Type Ii In Zebrafish, Hannah Nuszen

University Honors Program Senior Projects

Neurofibromatosis Type 2 (NF2) is a rare genetic disorder, classified as a neurocutaneous syndrome inherited through an autosomal dominant genetic mutation or deletion of the NF2 gene in humans. The tumor suppressor gene NF2 encodes the cytoskeletal protein MERLIN to promote apoptosis and inhibit abnormal cellular proliferation. Mutations in NF2 lead to a deficiency of functional MERLIN in humans and can result in hearing loss, disability, and premature death. These symptoms are due to uncontrollable growth of schwann cells generating bilateral benign tumors (schwannomas) within the nerve sheath of cranial nerve VIII. Here we seek to understand the function of …

Gods Among Men, Christian Burgos

Legacy Theses & Dissertations (2009 - 2024)

Abstract Gods Among Men is a creative text that functions critically to dissect the genre of superhero fiction and bring forth critiques of our culture of worshipping celebrities and political figures. I cite Woody Evans’ work in my critical introduction as being central to my project. Evans puts forth the idea that superheroes are inherently conservative because they are reactive agents that do not proactively change anything. They instead maintain the status quo. Villains, on the other hand, try to effect change for a different end, one they deem better for society. Through the use of characters, this text demonstrates …

Being Careful : Progressive Era Women And The Movements For Better Reproductive Health Care, Sarah Patterson

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACTFor American and British women, the definition of being healthy changed in the first two decades of the twentieth century. Previously, there had been a resigned acceptance of the fact that a woman’s reproductive capacity often relegated her to a lifetime of suffering and ill health. Certainly, individual women sometimes sought out solutions to their health problems, but there was no concerted social movement to help all women. Then in the Progressive Era that changed. The professionalization of medicine, combined with scientific breakthroughs, such as using Salvarsan to treat syphilis and urine testing to identify eclampsia meant that women could …

Structured Data Mining Networks, Time Series, And Time Series Of Networks, Lin Zhang

Legacy Theses & Dissertations (2009 - 2024)

The rate at which data is generated in modern applications has created an unprecedented demand for novel methods to effectively and efficiently extract insightful patterns. Methods aware of known domain-specific structure in the data tend to be advantageous. In particular, a joint temporal and networked view of observations offers a holistic lens to many real-world systems. Example domains abound: activity of social network users, gene interactions over time, a temporal load of infrastructure networks, and others. Existing analysis and mining approaches for such data exhibit limited quality and scalability due to their sensitivity to noise, missing observations, and the need …

The Relationship Between Group Identification And Perceived Control Under Stressful Conditions, Fanshu Jin

Legacy Theses & Dissertations (2009 - 2024)

Group identification provides important psychological resources. One potential benefit is that it may relieve individuals’ strain in stressful situation by increasing their perceived personal control. The current research explores the different roles that group identification plays in reaction to stressful performance situations. In particular, it investigates the extent to which group identification impacts perceived control in performance contexts. It was hypothesized that activating group identification prior to performing a challenging task will bolster perceptions of personal control, thereby sustaining or improving performance. An experimental study was conducted that manipulated salience of group identification, either before or after exposure to a …

Legal Clinics And The Better Trained Lawyer, Part Ii: A Case Study Of Accomplishments, Challenges And The Future Of Clinical Legal Education, Thomas Geraghty

Northwestern Journal of Law & Social Policy

No abstract provided.

Global Apathy And The Need For A New, Cooperative International Refugee Response, Emily Gleichert

Northwestern Journal of Law & Social Policy

While an increasing number of nations move toward isolationist, nationalist policies, the number of refugees worldwide is climbing to its highest levels since World War II. The United Nations High Commissioner for Refugees (UNHCR) is the international body tasked with protecting this population. However, the office’s traditional solutions for refugees – local integration, resettlement in a third country, and voluntary repatriation – have mostly eluded refugees who spend an average of twenty years in exile. The limitations UNHCR’s structure imposes on the office, specifically in its ability to fund its operations and compel nations to act, have contributed to its …

Three Essays On Health Economics, Jihye Kim

Legacy Theses & Dissertations (2009 - 2024)

This thesis focuses on various factors affecting health of American adults and the elderly based on the Health and Retirement Study (HRS). In chapter 1, I examine the role of educational and racial differences in life expectancy (LE) and health-adjusted life expectancy (HALE) for Americans at ages 45-64 using Health and Retirement Study (HRS) during 2000-2016. I compute severity-weighted prevalence of diseases with comorbidity adjustments based on the Global Burden of Disease (2015), and map onto the information on 17 doctor-diagnosed diseases and four self-rated disabling health conditions from HRS. This approach allows us to evaluate the importance of major …

Predictive Facts, Brent Ferguson

Washington Law Review

A substantial portion of constitutional law rests on untested factual predictions made by the Supreme Court. Such forecasts have played a large role in a wide range of case outcomes, helping the Court decide questions such as whether corporations have the right to spend money on elections and what evidence may be used in criminal cases despite Fourth Amendment violations.

Scholars have not yet studied the frequency of such predictions, the problems they create, or the functions they serve. The literature has looked more closely at court decisions that depend on conclusions of legislative fact—facts not specific to a certain …