Digital Commons Network^™

Traditional Principals’ Reaction To A Charter School Opening, Dana L. Bickmore

Educational Psychology, Leadership, and Higher Education Faculty Research

© 2020 SAGE Publications. Using multiple case studies, I examined how three traditional principals reacted and responded over time to the opening of a charter school in their attendance boundaries. Findings suggest principals’ reactions to competition shifted based on their perceptions of their status and competitive advantage in the market. These perceptual changes were the result of interactions with parents/guardians, staff, teachers, and students. This study has implications for how principals’ perceptions over time may affect engagement in competitive markets.

An Altitude Adjustment: Implementing A Clinical Practice Guideline In The Newborn Nursery At Moderate Altitude, Leeann Blaskowsky

Student Scholarly Projects

Practice Problem: All infants undergo many changes at birth, but for some, the transition from intrauterine to extrauterine life presents more of a challenge, especially at altitude. Despite continuing research, neonatal prescribing guidelines for oxygen therapy remain ambiguous.

PICOT: For term and late preterm infants requiring oxygen beyond transition, does a clinical practice guideline compared to practice without a guideline, provide consistent, evidence-based care, support the mother-infant dyad, and impact nursing perceptions over a six-week pilot period?

Evidence: Birth at moderate altitude presents the newly born with less oxygen than those delivered at sea level. Several studies …

Transition Of Care For Discharged Patients, Rolando Ramos

Student Scholarly Projects

Practice Problem: The 30-day readmission rate for patients discharged from the hospital and returned to their primary care in a clinical office setting (21%) was higher than the national average readmission rate (17%). The high readmission rate suggested patients were receiving transitional care that was fragmented and non-standardized. Therefore, the implementation of a collaborative transition of care practice was vital to reduce avoidable readmissions.

PICOT: The PICOT question that guided this project was, “In adult patients with chronic conditions, what is the effect of a transition of care practice, versus a non-standardized practice, on reducing 30-day readmissions, within a …

Reducing Suicide By Providing Cognitive Behavioral Therapy For Suicide Prevention, Wendy Larkin

Student Scholarly Projects

Veteran suicide is a serious and persistent national problem, which demands an effective treatment intervention. This Evidence-Based Practice project (EBP) addressed the question: Do patients with a psychiatric in-patient diagnosis of suicide ideation, who after discharge self-elect outpatient Cognitive Behavioral Therapy-Suicide Prevention (CBT-SP) treatment over a 6-week time frame, reduce the likelihood of hospital readmission for suicidal ideation vs. patients who decline CBT-SP treatment and elect Treatment as Usual (TAU)? The literature is prolific in validating that CBT-SP is successful in determining the effectiveness of CBT-SP vs. TAU in reducing suicidal behaviors in adults.

Hospital readmission data were collected on …

Stress Levels In Cal Poly Student-Athletes Versus Non-Student-Athletes, Anthony Dean Mattle

Social Sciences

Comparative study between Cal Poly student-athletes and non-student athletes examining perceived stress levels and the prominence of six specific stressors (Schoolwork, money, future success, family, extracurricular, and time management). The data found no statistical significance between perceived stress levels and status as either an athlete or non-athlete. However, the data did show that status as an athlete or non-athlete had a statistical significance on where students ranked extracurricular activities among the six stressors.

A.C. Moyer Eye-Cap Manufacturing, Thais Bertolus, Alexa Steidl, Hana Welsh, Jarod Kinney, Maya Willis

Mechanical Engineering

A.C. Moyer company has been making eye caps as a family business since 1947. Eye caps are a product used during the embalming process. Currently the machines being used to produce the eye caps are outdated and unsafe. We are a team of 5 mechanical engineering students tasked with either designing new machines or updating the existing machines to make the manufacturing process more efficient, automated, and safer. This document describes the design process, provides background, relevant research, establishes project objectives, and defines plans for project implementation.

An Examination Of Meat Consumption As A Pro-Environmental Behavior And Its Weak Correlation To Delay Discounting, Sarah Parkinson

Theses

This study presented meat consumption as an environmentally relevant behavior (ERB) and examined how the delay to an environmental loss might affect peoples’ decisions to eat meat. Participants completed a delay discounting survey where they selected what percentage of meat they would eliminate from their diet based on varying delays to rising sea levels flooding of their neighborhood. After watching a brief educational video, participants completed the survey a second time to examine whether the video had any influence on discounting rates in the post-survey. Participants also completed the 27-Item Monetary Choice Questionnaire (MCQ; Kirby & Marakovic, 1996) in order …

The Effect Of Nutritional Programming On Gut Microbiota In Broodstock And Progeny Fish, Samuel Patula

Theses

Aquaculture is currently the fastest growing animal production sector. Because the aquaculture sector is growing at rapid rates, certain materials for feed, specifically marine protein sources, are becoming increasingly expensive and unsustainable. To counteract the reliance on fishmeal (FM) and other marine protein sources in the industry plant protein (PP), specifically soybean meal (SBM), has been investigated to replace FM as a protein source. Unfortunately, SBM when given in high quantities (greater than 30%) has been shown to negatively affect fish performance including retarded growth, intestinal inflammation, reduction of spawn quality, as well as dysbiosis in the gut microbiome, most …

女夷救忠臣 : 《血影石》中的性别、疆界與華夷辯證, Chiung-Yun E. Liu

嶺南學報 Lingnan Journal of Chinese Studies

清初蘇州派劇作家朱佐朝《血影石》傳奇，敘寫八百媳婦國跨海向中國興兵,拯救明初“靖難”忠臣之家。本文由此出發，考察晚明清初文學敘寫華夷互動，當中内/外、自我/他者之間的關係如何安排，史地知識之實與建構想像之虚，彼此如何交錯轉换。本文首先將《血影石》與晚明小説《英烈傳》及《西洋記》對照分析，以見晚明清初小説戲曲中，華夷關係想像内涵的異同變化。其次聚焦《血影石》，分析劇作家如何在性别、華夷、政治錯综的場域中，調度轉化陰/陽、中原/異域、野蠻/文明符號，使原處從屬地位的“女”、“夷”得到角色動能，成爲救援行動的關鍵力量，並自海洋邊緣，以八百媳婦國爲中心，重構出另一套世界地理秩序，與中華視野下的華夷觀相抗衡。

In the seventeenth-century chuanqi play Xieying shi 血影石 (The Rock with Shadows of Blood), the tributary state of the Ming Empire, Babai xifu guo 八百媳婦國 (Lanna Kingdom, primarily in modem Northern Thailand) leads a joint fleet of the states in the southern and western oceans to “correct” the moral failings of the Ming Empire in China. After the civil war, the victorious Yongle Emperor usurps the throne from his young nephew, the Jianwen Emperor, executes the latter’s loyal ministers and persecutes their families. This play raises the questions as to what defines Yi (the foreign barbarian) as opposed to …

The Superfgd Prototype Charged Particle Beam Tests, A. Blondel, M. Bogomilov, S. Bordoni, F. Cadoux, D. Douqa, K. Dugas, T. Ekelof, Y. Favre, S. Fedotov, K. Fransson, R. Fujita, E. Gramstad, A. K. Ichikawa, S. Ilieva, K. Iwamoto, C. Jesús-Valls, C. K. Jung, S. P. Kasetti, M. Khabibullin, A. Khotjantsev, A. Korzenev, A. Kostin, Y. Kudenko, T. Kutter, T. Lux, L. Maret, T. Matsubara, A. Mefodiev

Faculty Publications

A novel scintillator detector, the SuperFGD, has been selected as the main neutrino target for an upgrade of the T2K experiment ND280 near detector. The detector design will allow nearly 4π coverage for neutrino interactions at the near detector and will provide lower energy thresholds, significantly reducing systematic errors for the experiment. The SuperFGD is made of optically-isolated scintillator cubes of size 10×10×10 mm3, providing the required spatial and energy resolution to reduce systematic uncertainties for future T2K runs. The SuperFGD for T2K will have close to two million cubes in a 1920 × 560 × 1840 mm3 volume. A …

First Results On Protodune-Sp Liquid Argon Time Projection Chamber Performance From A Beam Test At The Cern Neutrino Platform, B. Abi, A. Abed Abud, R. Acciarri, M. A. Acero, G. Adamov, M. Adamowski, D. Adams, P. Adrien, M. Adinolfi, Z. Ahmad, J. Ahmed, T. Alion, S. Alonso Monsalve, C. Alt, J. Anderson, C. Andreopoulos, M. P. Andrews, F. Andrianala, S. Andringa, A. Ankowski, M. Antonova, S. Antusch, A. Aranda-Fernandez, A. Ariga, L. O. Arnold, M. A. Arroyave, J. Asaadi, A. Aurisano

Faculty Publications

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the …

Qcm Sensor Arrays, Electroanalytical Techniques And Nir Spectroscopy Coupled To Multivariate Analysis For Quality Assessment Of Food Products, Raw Materials, Ingredients And Foodborne Pathogen Detection: Challenges And Breakthroughs†, David K. Bwambok, Noureen Siraj, Samantha Macchi, Nathaniel E. Larm, Gary A. Baker, Rocío L. Pérez, Caitlan E. Ayala, Charuksha Walgama, David Pollard, Jason D. Rodriguez, Souvik Banerjee, Brianda Elzey, Isiah M. Warner, Sayo O. Fakayode

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Quality checks, assessments, and the assurance of food products, raw materials, and food ingredients is critically important to ensure the safeguard of foods of high quality for safety and public health. Nevertheless, quality checks, assessments, and the assurance of food products along distribution and supply chains is impacted by various challenges. For instance, the development of portable, sensitive, low-cost, and robust instrumentation that is capable of real-time, accurate, and sensitive analysis, quality checks, assessments, and the assurance of food products in the field and/or in the production line in a food …

The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen

Faculty Publications

© 2020 The Authors. Conservation Biology published by Wiley Periodicals LLC on behalf of Society for Conservation Biology The ecological impacts of extreme climatic events on population dynamics and community composition are profound and predominantly negative. Using extensive data of an ecological model system, we tested whether predictions from ecological models remain robust when environmental conditions are outside the bounds of observation. We observed a 10-fold demographic decline of the Glanville fritillary butterfly (Melitaea cinxia) metapopulation on the Åland islands, Finland in the summer of 2018 and used climatic and satellite data to demonstrate that this year was an anomaly …

Fungicide Resistance In Cercospora Species Causing Cercospora Leaf Blight And Purple Seed Stain Of Soybean In Argentina, Francisco J. Sautua, Vinson P. Doyle, Paul P. Price, Alejandro Porfiri, Paula Fernandez, Maria M. Scandiani, Marcelo A. Carmona

Faculty Publications

Cercospora species cause cercospora leaf blight (CLB) and purple seed stain (PSS) on soybean. Because there are few resistant soybean varieties available, CLB/PSS management relies heavily upon fungicide applications. Sensitivity of 62 Argentinian Cercospora isolates to demethylation inhibitor (DMI), methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI), succinate dehydrogenase inhibitor (SDHI) fungicides, and mancozeb was determined in this study. All isolates were sensitive to difenoconazole, epoxiconazole, prothioconazole, tebuconazole, and cyproconazole (EC50 values ranged from 0.006 to 2.4 µg/ml). In contrast, 51% of the tested isolates were sensitive (EC50 values ranged from 0.003 to 0.2 µg/ml), and 49% were highly resistant …

Larval Movement And Survival Of Helicoverpa Zea (Boddie) In Seed Blends Of Non-Bt And Bt Maize Containing Agrisure Viptera® Trait: Implications For Resistance Management, M. Dimase, I. Oyediran, S. Brown, W. Walker, J. Guo, W. Yu, Y. Zhang, J. Chen, Z. Wen, F. Huang

Faculty Publications

A seed blend refuge has been used to host susceptible insects for Bt maize insect resistance management (IRM) in the U.S. Maize Belt. One major concern in the use of seed blends is that larval movement among non-Bt and Bt plants could cause additional mortalities of susceptible insects. To address this concern, three caged-field trials were conducted to evaluate larval movement and survival of the corn earworm, Helicoverpa zea (Boddie), in eight seed blends of Cry1Ab/Vip3A maize with 0–30% non-Bt refuges. Each plot consisted of five rows and 21 plants in each row. Each plot was infested on the ear …

Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma

Faculty Publications

Computer-based testing is an expanding use of technology offering advantages to teachers and students. We studied Calculus II classes for science, technology, engineering, and mathematics majors using different testing modes. Three sections with 324 students employed: paper-and-pencil testing, computer-based testing, and both. Computer tests gave immediate feedback and allowed multiple submissions and pooling. Paper-and-pencil tests (PPTs) required work and explanation allowing inspection of high cognitive demand tasks. Each test mode used the strength of its method. Students were given the same lecture by the same instructor on the same day and the same homework assignments and due dates. The design …

Improving Tolerance Control On Modular Construction Project With 3d Laser Scanning And Bim: A Case Study Of Removable Floodwall Project, Huimin Li, Chengyi Zhang, Siyuan Song, Sevilay Demirkesen, Ruidong Chang

Faculty Publications

Quality control is essential to a successful modular construction project and should be enhanced throughout the project from design to construction and installation. The current methods for analyzing the assembly quality of a removable floodwall heavily rely on manual inspection and contact-type measurements, which are time-consuming and costly. This study presents a systematic and practical approach to improve quality control of the prefabricated modular construction projects by integrating building information modeling (BIM) with three-dimensional (3D) laser scanning technology. The study starts with a thorough literature review of current quality control methods in modular construction. Firstly, the critical quality control procedure …

Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu

Division of Basic Science Faculty Publications

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin 4 channel, and inhibits GE-ERαvlVMH neurons through opening the ATP-sensitive potassium channel. Further, we show that GI-ERαvlVMH neurons preferentially project to the medioposterior arcuate nucleus of the hypothalamus (mpARH) and GE-ERαvlVMH neurons preferentially project to the dorsal Raphe nuclei (DRN). Activation of ERαvlVMH …

Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa

Division of Basic Science Faculty Publications

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body …

Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin

Clinical Research Faculty Publications

Accurately quantifying dietary intake is essential to understanding the effect of diet on health and evaluating the efficacy of dietary interventions. Self-report methods (e.g., food records) are frequently utilized despite evident inaccuracy of these methods at assessing energy and nutrient intake. Methods that assess food intake via images of foods have overcome many of the limitations of traditional self-report. In cafeteria settings, digital photography has proven to be unobtrusive and accurate and is the method of choice for assessing food provision, plate waste, and food intake. In free-living conditions, image capture of food selection and plate waste via the user’s …

Genetic Variation In Lean Body Mass, Changes Of Appetite And Weight Loss In Response To Diet Interventions: The Pounds Lost Trial, Xiang Li, Tao Zhou, Hao Ma, Yoriko Heianza, Catherine M. Champagne, Donald A. Williamson, George A. Bray, Frank M. Sacks, Lu Qi

Population and Public Health Science Faculty Publications

Aim: To investigate whether the genetic risk score (GRS) for lean body mass (LBM) modified the effects of weight-loss diets on changes in appetite and adiposity among overweight and obese individuals. Participants and Methods: In the 2-year Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) trial, we included 692 adults who were randomly assigned to one of four diets varying in macronutrient intake. A GRS was calculated using five single nucleotide polymorphisms associated with LBM. Results: The LBM-GRS was not associated with the baseline LBM measured by dual-energy x-ray absorptiometry in a subgroup (50%) of the study population. We found …

Zinc Finger Transcription Factor Zbtb16 Coordinates The Response To Energy Deficit In The Mouse Hypothalamus, Helia Cheng, Schuyler J. Pablico, Jisu Lee, Ji Suk Chang, Sangho Yu

Division of Basic Science Faculty Publications

The central nervous system controls feeding behavior and energy expenditure in response to various internal and external stimuli to maintain energy balance. Here we report that the newly identified transcription factor zinc finger and BTB domain containing 16 (Zbtb16) is induced by energy deficit in the paraventricular (PVH) and arcuate (ARC) nuclei of the hypothalamus via glucocorticoid (GC) signaling. In the PVH, Zbtb16 is expressed in the anterior half of the PVH and co-expressed with many neuronal markers such as corticotropin-releasing hormone (Crh), thyrotropin-releasing hormone (Trh), oxytocin (Oxt), arginine vasopressin (Avp), and nitric oxide synthase 1 (Nos1). Knockdown (KD) of …

Outpatient Screening Of Health Status Among Postbariatric Patients During The Covid-19 Pandemic In Sao Paulo, Brazil, Karla Fabiana Goessler, Carolina Ferreira Nicoletti, Diego Augusto Nunes Rezende, Sofia Mendes Sieczkowska, Gabriel Perri Esteves, Rafael Genario, Gersiel Nascimento De Oliveira Júnior, Kamila Meireles, Ana Jéssica Pinto, Michele Nakahara-Melo, Roberto De Cleva, Marco Aurélio Santo, John P. Kirwan, Hamilton Roschel, Bruno Gualano

Division of Basic Science Faculty Publications

No abstract provided.

Effect Of Overeating Dietary Protein At Different Levels On Circulating Lipids And Liver Lipid: The Proof Study, George A. Bray, Leanne M. Redman, Jennifer Rood, Elizabeth De Jonge, Steven R. Smith

Clinical Research Faculty Publications

Background: During overeating, a low protein diet slowed the rate of weight gain and increased the energy cost of the added weight, suggesting that low protein diets reduced energy efficiency. The Protein Overfeeding (PROOF) study explored the metabolic changes to low and high protein diets, and this sub-study examined the changes in body composition and blood lipids when eating high and low protein diets during overeating. Methods: Twenty-three healthy volunteers (M = 14; F = 9) participated in an 8-week, parallel arm study where they were overfed by ~40% with diets containing 5% (LPD = low protein diet), 15% (NPD …

Author Correction: Multimodal Hippocampal Subfield Grading For Alzheimer’S Disease Classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/S41598-019-49970-9), Kilian Hett, Vinh Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue

Clinical Research Faculty Publications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser

Clinical Research Faculty Publications

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain …

A Telescope Gwas Analysis Strategy, Based On Snps-Genes-Pathways Ensamble And On Multivariate Algorithms, To Characterize Late Onset Alzheimer’S Disease, Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Uberti, Michael W. Weiner, Paul Aisen, Ronald Petersen, Jack R. Clifford, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue

Clinical Research Faculty Publications

Genome–wide association studies (GWAS) have revealed a plethora of putative susceptibility genes for Alzheimer’s disease (AD), with the sole exception of APOE gene unequivocally validated in independent study. Considering that the etiology of complex diseases like AD could depend on functional multiple genes interaction network, here we proposed an alternative GWAS analysis strategy based on (i) multivariate methods and on a (ii) telescope approach, in order to guarantee the identification of correlated variables, and reveal their connections at three biological connected levels. Specifically as multivariate methods, we employed two machine learning algorithms and a genetic association test and we considered …

Long-Term Change In Physiological Markers And Cognitive Performance In Type 2 Diabetes: The Look Ahead Study, Owen T. Carmichael, Rebecca H. Neiberg, Gareth R. Dutton, Kathleen M. Hayden, Edward Horton, F. Xavier Pi-Sunyer, Karen C. Johnson, Stephen R. Rapp, Adam P. Spira, Mark A. Espeland

Clinical Research Faculty Publications

Context: The effects of physiological improvements on cognitive function among persons with type 2 diabetes mellitus (T2DM) are not fully understood. Objective: To determine whether improvements in physiological markers (body weight, blood sugar control, and physical activity) during intensive lifestyle intervention (ILI) are associated with enhancements in cognitive function in older adults with T2DM. Design: Multisite randomized controlled trial. Setting: Academic research centers. Patients or Other Participants: Participants were aged 45-76 years, with T2DM. Intervention: The Action for Health in Diabetes (Look AHEAD) study, a randomized, controlled clinical trial of ILI. Main Outcome Measure: Two to 3 cognitive assessments were …

Functional Brain Architecture Is Associated With The Rate Of Tau Accumulation In Alzheimer’S Disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff

Clinical Research Faculty Publications

In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher …

Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer's Disease, Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli

Clinical Research Faculty Publications

Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer’s disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ …