Digital Commons Network^™

A Drosophila Screen Identifies Nkcc1 As A Modifier Of Ngly1 Deficiency, Dana M Talsness, Katie G Owings, Emily Coelho, Gaelle Mercenne, John M Pleinis, Raghavendran Partha, Kevin A Hope, Aamir Zuberi, Nathan L Clark, Cathleen Lutz, Aylin R Rodan, Clement Y Chow

Faculty Research 2020

N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears. To model the phenotypic variability observed among patients, we crossed a Drosophila model of NGLY1 deficiency onto a panel of genetically diverse strains. The resulting progeny showed a phenotypic spectrum from 0 to 100% lethality. Association analysis on the lethality phenotype, as well as an evolutionary rate covariation analysis, generated lists of modifying genes, providing insight into NGLY1 function and disease. The top association hit was Ncc69 (human NKCC1/2 …

Important Forms And Technologies For The Development Of Information Competence Of Leadership Of Higher Education Institutions

Central Asian Journal of Education

This article is about theoretical analysis and practical study of the activities of higher education institutions showed that in the consistent study, analysis and evaluation of innovative management of higher education institutions, it is reasonable to take the criteria. Also the concept of "electronic monitoring" in the development of information competence of leadership of higher educational institutions can be clarified electronic monitoring of the process of development of information competence of leadership of higher educational institutions - the functional capacity of ICT by introducing leadership to methods of developing information competence monitoring and evaluating the dynamic growth of the innovation …

2020-12-14_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Rai Doc 20 2020.12.14 Appellant Brief Reply Of Dissenting Shs At Nc Sc

Related Documents for Professor Thompson's book Corporate Valuation in M&A

No abstract provided.

Feasibility Of Continuous Fever Monitoring Using Wearable Devices, Benjamin L. Smarr, Kirstin Aschbacher, Sarah M. Fisher, Anoushka Chowdhary, Stephan Dilchert, Karena Puldon, Adam Rao, Frederick M. Hecht, Ashley E. Mason

Publications and Research

Elevated core temperature constitutes an important biomarker for COVID-19 infection; however, no standards currently exist to monitor fever using wearable peripheral temperature sensors. Evidence that sensors could be used to develop fever monitoring capabilities would enable large-scale health-monitoring research and provide high-temporal resolution data on fever responses across heterogeneous populations. We launched the TemPredict study in March of 2020 to capture continuous physiological data, including peripheral temperature, from a commercially available wearable device during the novel coronavirus pandemic. We coupled these data with symptom reports and COVID-19 diagnosis data. Here we report findings from the first 50 subjects who reported …

Cortical Thickness Estimation In Individuals With Cerebral Small Vessel Disease, Focal Atrophy, And Chronic Stroke Lesions, Miracle Ozzoude, Joel Ramirez, Pradeep Reddy Raamana, Melissa F. Holmes, Kirstin Walker, Christopher J.M. Scott, Fuqiang Gao, Maged Goubran, Donna Kwan, Maria C. Tartaglia, Derek Beaton, Gustavo Saposnik, Ayman Hassan, Jane Lawrence-Dewar, Dariush Dowlatshahi, Stephen C. Strother, Sean Symons, Robert Bartha, Richard H. Swartz, Sandra E. Black

Medical Biophysics Publications

Background: Regional changes to cortical thickness in individuals with neurodegenerative and cerebrovascular diseases (CVD) can be estimated using specialized neuroimaging software. However, the presence of cerebral small vessel disease, focal atrophy, and cortico-subcortical stroke lesions, pose significant challenges that increase the likelihood of misclassification errors and segmentation failures. Purpose: The main goal of this study was to examine a correction procedure developed for enhancing FreeSurfer’s (FS’s) cortical thickness estimation tool, particularly when applied to the most challenging MRI obtained from participants with chronic stroke and CVD, with varying degrees of neurovascular lesions and brain atrophy. Methods: In 155 CVD participants …

Leslie Evans-Sampson V. Pa Dept Of Human Services

2020 Decisions

USDC for the Eastern District of Pennsylvania

State V. Hanchey Appellant's Brief Dckt. 47979

Idaho Supreme Court Records & Briefs, All

No abstract provided.

State V. Hanchey

Idaho Supreme Court Records & Briefs, All

No abstract provided.

The Importance Of Environmental Education: Incorporating Sustainability Into The Gen-Ed Curriculum At Ur, Amanda Brosnan

Environmental Studies Senior Seminar Projects

Climate change and its effects are increasingly salient issues in our world today, and with these issues, is the imperative of adequate environmental education. As an institution of higher learning, University of Richmond (UR) has the unique potential to equip students with the knowledge and tools to combat the imminent climate crisis. The purpose of this study was to explore the possibility of incorporating sustainability into the General Education Curriculum at UR. To accomplish this, three sources of data were analyzed. The core of this study was based on an examination of the ongoing reformation of the General Education curriculum …

Creating Authentic Literacy Tasks Influences Children's Engagement And Motivation, Carly Rothfusz

Innovations and Critical Issues in Teaching and Learning

The academic task assigned to students often dictates what the student will learn, and it plays a vital role of student’s motivation and engagement of learning (Turner & Paris, 1995). Thus, the creation and usage of authentic literacy tasks is critical for students’ learning (Parsons, Malloy, Parsons, & Burrowbridge, 2015). There are three types of motivation to consider: intrinsic motivation, extrinsic motivation, and autonomous motivation. The use of authenticity, student choice, collaboration, and challenge are all components within a task that can promote student engagement and motivation. Project-Based Learning (PBL) is another way to bring in authenticity. Project-based instruction allows …

The Effect Of Drama Based Instruction On Reading Comprehension, Janee Udalla

Innovations and Critical Issues in Teaching and Learning

Educators might believe that classroom drama is comparable to putting on a theatrical production and might avoid it because they fear it will involve time-consuming planning, use of props, and expensive scripts (McMaster, 1998). Unfortunately, this view can discourage educators from using an important teaching tool that can improve students’ reading comprehension skills. However, educators should explore the use of drama-based instruction and the benefits it may provide to their students. The methods teachers implement in the classroom greatly affect the attitudes and learning of their students (Author, 2008). Therefore, the purpose of this article is to identify the benefits …

Innovations And Critical Issues In Teaching And Learning, Volume 1, Issue 2, 2020

Innovations and Critical Issues in Teaching and Learning

Complete text of Innovations and Critical Issues In Teaching and Learning, Volume 1, Issue 2, 2020.

Narrative Analysis Of The Conformance Approach For Evaluating The Enterprise Data Policy, Diane Elizabeth Schmidt

Theses and Dissertations

Organizations around the world are beginning to recognize data and information among their most valuable resources and assets. Just as any business asset, data requires thorough and deliberate care. Data governance is not new, but many organizations and companies finally realize it is a mandatory part of conducting successful business activities. Data governance is an essential part of a data strategy and data management program. Enacting data governance can help companies improve responsiveness, provide employees clarity around roles and responsibilities, and better-managed data assets. The results are more robust products, improved revenue, risk elimination, and fewer costs. Within the data …

Family Perceptions Of Family Engagement: A Qualitative Study To Assist Stakeholders, Candis Ervin

Doctor of Education in Teacher Leadership Dissertations

This qualitative study sought to understand how professional working families with elementary age children perceive family engagement. Through one-on-one interviews, the researcher gained insight on how families define and perceive family engagement. The open-ended, one-on-one, semi-structured interviews included a purposeful sample of 8 participants. An analysis of data included a system of coding to link thoughts across data after reviewing, reflecting, and transcribing interviews. Their rich descriptions provide detailed information that is extremely useful to understanding the complexities of family engagement and its ability to support teachers, students, families and schools.

Findings from the study revealed the importance of families, …

Corporations And The American Polity, Patrick Labossiere

Student Theses and Dissertations

Research on corporate communications’ effects on politics presents an acknowledgement of a relationship between the two topics, leaving a void in the explanation and examination of this topic. The void presents an opening to introduce a conceptual process for how corporations are able to craft communications to influence the American Polity, the democratic social organization within the United States. This research begins with a historical review of how corporations gain prominence in American society, capturing the ability to participate in the democratic social organization of the polity. A qualitative analysis of several conceptual frameworks serves as data, to establish an …

Instructional Case Studies In The Field Of Windfarm Optimization, N. Francesco Baker

Theses and Dissertations

Wind farm layout optimization is a multidisciplinary undertaking, requiring students and researchers to integrate many skillsets in order to optimize turbine placement. There is currently a lack of useful benchmarking exercises for participants in the field to compare the efficacy of their methods. This work details the construction and completion of a set of four case studies meant to satisfy this need, with the hope of providing some insight into useful layout optimization approaches. These case studies are intended to also serve as instructive introductory exercises with which newcomers researching wind energy may incrementally practice and increase their abilities.The first …

Insights Into Insular Isolation Of The Bull Shark, Carcharhinus Leucas (Müller And Henle, 1839), In Fijian Waters, Kerstin B J Glaus, Sharon A. Appleyard, Brian Stockwell, Juerg M. Brunnschweiler, Mahmood S. Shivji, Eric Clua, Amandine D. Marie, Ciro Rico

Biology Faculty Articles

The bull shark (Carcharhinus leucas) is a large, mobile, circumglobally distributed high trophic level predator that inhabits a variety of remote islands and continental coastal habitats, including freshwater environments. Here, we hypothesize that the barriers to dispersal created by large oceanic expanses and deep-water trenches result in a heterogeneous distribution of the neutral genetic diversity between island bull shark populations compared to populations sampled in continental locations connected through continuous coastlines of continental shelves. We analyzed 1,494 high-quality neutral single nucleotide polymorphism (SNP) markers in 215 individual bull sharks from widespread locations across the Indian and Pacific Oceans …

Fda Regulation Impact On Early Stage Medical Device Innovation In Academia, Keyana Fariello

Theses

The commercialization of medical products at the university level is a multilayered and challenging process. One barrier to commercialization is the difficulty of meeting Food and Drug Administration (FDA) regulatory requirements. Regulations and standards are undoubtedly necessary to maintain the highest product safety levels, but it creates many obstacles. This paper will analyze how researchers involved with early-stage medical device innovation in a university setting deal with FDA compliance issues and the implications of this engagement for innovation. I conducted an exploratory case study of ten medical product development projects at the Rochester Institute of Technology (RIT). Overall, I found …

State Of Utah, Appellee V. Russell Keith Harper, Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

ON APPEAL FROM A SENTE,7\TC,'E, JUDGMENT, AND COMMITMENT ENTERED ON AUGUST 28, 2019, BY THE HONORABLE DOUGLAS B. THOMAS OF THE SEVENTH JUDICIAL DISTRICT COURT, IN AND FOR CARBON COUNTY, STATE OF UTAH

Jeffrey D. Mann, Assistant Attorney's General

K. ANDREW FITZGERALD

Board Of Directors Meeting Minutes (December 14, 2020), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on December 14, 2020.

Contrast-Enhanced Ultrasound In Association With Serum Biomarkers For Differentiating Combined Hepatocellular-Cholangiocarcinoma From Hepatocellular Carcinoma And Intrahepatic Cholangiocarcinoma., Jie Yang, Ya-Han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu, Qiang Lu

Department of Radiology Faculty Papers

BACKGROUND: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare type of primary liver cancer. Due to its complex histopathological characteristics, the imaging features of CHC can overlap with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

AIM: To investigate the possibility and efficacy of differentiating CHC from HCC and ICC by using contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) and tumor biomarkers.

METHODS: Between January 2016 and December 2019, patients with histologically confirmed CHC, ICC and HCC with chronic liver disease were enrolled. The diagnostic formula for CHC was as follows: (1) LR-5 or LR-M with elevated alpha-fetoprotein …

Interrater Reliability Of Novice Examiners Using A-Mode Ultrasound And Skinfolds To Measure Subcutaneous Body Fat, Dale R. Wagner, Masaru Teramoto

Kinesiology and Health Science Faculty Publications

Examiners with minimal training and skill are often called upon to make body composition assessments using field methods. This study compared the interrater reliability of novice examiners for the skinfold (SKF) and A-mode ultrasound (US) methods of body composition assessment. Undergraduate Kinesiology majors (48 males, 32 females) with minimal training took both SKF and US measurements at three sites (males: chest, abdomen, thigh; females: triceps, suprailiac, thigh). Interrater reliability was significantly better for US compared to SKF at the thigh (ICC_US = 0.975, ICC_SKF = 0.912) and abdomen (ICC_US = 0.984, ICC_SKF = 0.693) for men …

Sybil Defense Using Efficient Resource Burning, Diksha Gupta

Computer Science ETDs

In 1993, Dwork and Naor proposed using computational puzzles, a resource burning mechanism, to combat spam email. In the ensuing three decades, resource burning has broadened to include communication capacity, computer memory, and human effort. It has become a well-established tool in distributed security. Due to the cost attached to utilizing resource burning mechanism, these have not been popularized in domains apart from cryptocurrency.

In this dissertation, we design efficient resource burning based Sybil defense techniques for permissionless systems. As a first step, we identify existing resource burning mechanisms in literature in Chapter 2. Additionally, we enumerate numerous open problems …

Newborn Screening For Congenital Hypothyroidism: Improvement In Short-Term Follow-Up By Audit And Monitoring, Hafsa Majid, Sibtain Ahmed, Imran Siddiqui, Khadija N Humayun, Hussain Karimi, Aysha Habib Khan

Department of Pathology and Laboratory Medicine

Objective: Newborn screening for congenital hypothyroidism (CH) at our hospital during this study was by measurement of thyroid stimulating hormone (TSH) in serum samples. This audit was conducted over a 2 year period, to determine the compliance of reporting of results greater than the screening cutoffs for serum TSH. Gaps of non-compliance were identified, and re-audit was undertaken after the corrective actions were taken.
Results: The critical limit was defined as serum TSH (≥ 20 µIU/ml) following consultation with a pediatric endocrinologist. All results above this limit were reported urgently to physicians. During the audit period, 27,407 tests were performed, …

Conversational Ontology Operator: Patient-Centric Vaccine Dialogue Management Engine For Spoken Conversational Agents, Muhammad Amith, Rebecca Z Lin, Licong Cui, Dennis Wang, Anna Zhu, Grace Xiong, Hua Xu, Kirk Roberts, Cui Tao

2020-Current year OA Pubs

BACKGROUND: Previously, we introduced our Patient Health Information Dialogue Ontology (PHIDO) that manages the dialogue and contextual information of the session between an agent and a health consumer. In this study, we take the next step and introduce the Conversational Ontology Operator (COO), the software engine harnessing PHIDO. We also developed a question-answering subsystem called Frankenstein Ontology Question-Answering for User-centric Systems (FOQUS) to support the dialogue interaction.

METHODS: We tested both the dialogue engine and the question-answering system using application-based competency questions and questions furnished from our previous Wizard of OZ simulation trials.

RESULTS: Our results revealed that the dialogue …

Blast-Induced Liquefaction And Downdrag Development On A Micropile Foundation, Cameron Mark Lusvardi

Theses and Dissertations

Frequently, deep foundations extend through potentially liquefiable soils. When liquefaction occurs in cohesionless soils surrounding a deep foundation, the skin-friction in the liquefied layer is compromised. After cyclical forces suspend and pore pressures dissipate, effective stress rebuilds and the liquefied soil consolidates. When the settlement of the soil exceeds the downward movement of the foundation, downdrag develops. To investigate the loss and redevelopment of skin-friction, strain was measured on an instrumented micropile during a blast-induced liquefaction test in Mirabello, Italy. The soil profile where the micropile was installed consisted of clay to a depth of 6m underlain by a medium …

Elusive Diagnosis Of Behcet's Disease In Setting Of Painless Vision Loss, Arti A. Patel, Amelia Stutman, Prarak Patel, Madhavi Capoccia

Student Publications

Behcet's disease is a chronic, idiopathic vasculitis with multisystem involvement commonly characterized by the classic triad of oral lesions, genital ulcerations, and uveitis. We discuss the case of a 22-year-old woman with a long-standing history of oral ulcers and vulvovaginal burning who presented with acute painless uveitis. With this presentation, there was an initial concern for infectious retinitis for which she was started on systemic antiviral therapy. Subsequent infectious disease workup was ultimately negative. Given her medical history and current presentation, she was diagnosed and treated for an acute inflammatory episode of ocular Behcet's disease. The patient's vision returned to …

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

• 1. Georgia Southern has updated its quarantine guidance
• 2. CDC offers guidance to mitigate the spread of COVID-19 during the holiday season
• 3. CARES Center will be available during the break
• 4. Keep up with Eagle athletics
• 5. Fall 2020 commencement ceremonies continue this week

Watering The Landscape: Make It Easier With Evapotranspiration (Et), Candace Schaible, Kelly Kopp, Helen Muntz

All Current Publications

The American lawn is our nation’s single largest irrigated “crop” (Lindsey, 2005). In Utah, roughly 65% of our drinking water is applied to residential and commercial landscapes (Center for Water Efficient Landscaping, 2020). Landscapes are typically overwatered, which is why residential and commercial landscape watering is estimated to be one of the largest sources of potential water conservation in the urban setting (Endter-Wada et al., 2008). Plant materials also provide many environmental benefits, such as erosion control, water filtration, and temperature reduction. Knowing how much water to apply to the landscape can be a challenge and is one reason many …