Digital Commons Network^™

Misuse Of Prescription Stimulants And Their Effect On Cognition, Zachary Friederichs

Theses and Graduate Projects

Prescription stimulants like Adderall and Ritalin are increasingly being diverted and misused by college students who fail to recognize the potential health risks in an effort to improve academic performance. The main aim of this literature review is to address the prevalence of their misuse, the effects they have on cognition, and adverse side effects that are typically associated with their use. Despite being frequently referred to as "cognitive enhancers" or "smart pills," results from studies on these m􏰗edications remain mixed/unclear as to whether cognitive domains such as memory, executive function, and processing speed are actually enhanced. However, not surprisingly, …

In Adults With Difficult Intubations, What Is A Gold Standard Method For Success?, Nathaniel Kitzmann

Theses and Graduate Projects

The objective of this thesis is to analyze existing literature and guidelines for difficult intubations and provide clinical recommendations. This paper is a retrospective analysis of human trials focusing on preparation, medication, and tools in the field of emergency airway management. Techniques will be described and discussed. A large portion of intubations are described as difficult and have the potential to fail. Articles retrieved from databases PubMed, Medline, and PLOS ONE and the search engine Google Scholar were reviewed. Websites for the institutions of the American Society of Anesthesiologists and Difficult Airway Society were used in guidance. Currently, many guidelines …

Mercury Concentrations In Store‐Bought Shrimp, Angelle Mccormick, Matthew D. Robertson, Rebecka Brasso, Stephen R. Midway

Faculty Publications

No abstract provided.

Neurological Symptoms Due To Coronavirus Disease 2019, Farage Ftiha, Moshe Shalom, Henry Jradeh

Publications and Research

In this review, we focus on summarizing everything that is known about the neurological effects of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). It has been shown that Coronavirus Disease 2019 (Covid-19) may result in neuromuscular disorders or damage to nerves outside of the brain and spinal cord, which may lead to weakness, numbness, and pain. Published literature has stated that SARS-COV-1 may infect the central nervous system and due to its similarities to SARS-COV-2, we suspect that SARS-COV-2 has the same potential. We conclude that Covid-19 has neurological manifestations. Further research should be done in this field to understand …

Ss-Amyloid Redirects Norepinephrine Signaling To Activate The Pathogenic Gsk3ss/Tau Cascade, Mary Ashley Canevaro

Browse All News

No abstract provided.

A Qualitative Study Of The Preparedness Of Novice Teachers To Teach Effectively In A Blended Learning Environment, Rachelle R. Lafave

Dissertations

Proponents of the effective use of blended learning argue that without technologyenhanced instruction, students graduate from high school missing the digital skills they need to be successful competitors in the labor market (Dickinson, 2018). Yet, authors of supporting work have established technology-enhanced instruction can have a negative effect on student achievement (Newman & Dickinson, 2017). Examined in this qualitative study was the preparedness of novice teachers to provide effective instruction in a blended learning environment, as researchers have found teacher self-efficacy is the number one predictor of instructional quality (Belanger, 2018; Conant, 2016; Künsting, Neuber, & Lipowsky, 2016). Self-efficacy is, …

Virus Infection Is Controlled By Hematopoietic And Stromal Cell Sensing Of Murine Cytomegalovirus Through Sting, Sytse J. Piersma, Jennifer Poursine-Laurent, Liping Yang, Glen N. Barber, Bijal A. Parikh, Wayne M. Yokoyama

Open Access Publications

Recognition of DNA viruses, such as cytomegaloviruses (CMVs), through pattern-recognition receptor (PRR) pathways involving MyD88 or STING constitute a first-line defense against infections mainly through production of type I interferon (IFN-I). However, the role of these pathways in different tissues is incompletely understood, an issue particularly relevant to the CMVs which have broad tissue tropisms. Herein, we contrasted anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV). Bone marrow chimeras revealed STING-mediated MCMV control in hematological cells, similar to MyD88. However, unlike MyD88, STING also contributed to viral control in non-hematological, stromal …

Graduate Commencement, Georgia (2020), Philadelphia College Of Osteopathic Medicine

Commencements

Georgia Campus Commencement program, Class of 2020. Degrees include Doctorate in Pharmacy, Master of Science in Biomedical Sciences, and Master of Science in Health Sciences - Physician Assistant Studies.

Lectures On Mathematical Computing With Python, Jay Gopalakrishnan

PDXOpen: Open Educational Resources

This open resource is a collection of class activities for use in undergraduate courses aimed at teaching mathematical computing, and computational thinking in general, using the python programming language. It was developed for a second-year course (MTH 271) revamped for a new undergraduate program in data science at Portland State University. The activities are designed to guide students' use of python modules effectively for scientific computation, data analysis, and visualization.

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Whole Exome Sequencing In Patients With Williams-Beuren Syndrome Followed By Disease Modeling In Mice Points To Four Novel Pathways That May Modify Stenosis Risk, Phoebe C R Parrish, Delong Liu, Russell H Knutsen, Charles J Billington, Robert P Mecham, Yi-Ping Fu, Beth A Kozel

2020-Current year OA Pubs

Supravalvular aortic stenosis (SVAS) is a narrowing of the aorta caused by elastin (ELN) haploinsufficiency. SVAS severity varies among patients with Williams-Beuren syndrome (WBS), a rare disorder that removes one copy of ELN and 25-27 other genes. Twenty percent of children with WBS require one or more invasive and often risky procedures to correct the defect while 30% have no appreciable stenosis, despite sharing the same basic genetic lesion. There is no known medical therapy. Consequently, identifying genes that modify SVAS offers the potential for novel modifier-based therapeutics. To improve statistical power in our rare-disease cohort (N = 104 exomes), …

Estimating A Fair Value For Standing Forage, Jay Parsons, Daren Redfearn, Mary E. Drewnoski

Cornhusker Economics

Several things need to be considered when deciding what value to place on standing forage. Forage prices reflect current inventories, demand, expected current season production and associated yield risk, and quality characteristics. Standing forage can be harvested in a number of different ways which need to be considered when pricing it. Below, we provide a few general thoughts and questions concerning harvesting method and comparable feed value to consider when pricing standing forage. We follow with a few examples illustrating pricing calculations for forage mechanically harvested as hay, haylage, and silage. We close with pricing considerations for forage harvested by …

Metadata Of Six Nceas Data Sets In Elith Et Al. 2020, J. Elith, C.H. Graham, R. Valavi, M. Abegg, C. Bruce, A. Ford, A. Guisan, R.J. Hijmans, F. Huettmann, L.G. Lohmann, B.A. Loiselle, C. Moritz, J.Mcc. Overton, A.T. Peterson, S. Phillips, K. Richardson, S. Williams, S.K. Wiser, T. Wohlgemuth, N.E. Zimmermann

Faculty

The publication by Elith et al. 2020 publishes data from Elith et al. 2006 and consists of six data set; metadata descriptions provided here. Data are found in OSF and as an R package; details provided in Elith et al. 2020 and/or with authors.

Spatial And Temporal Patterns Of Bat Activity In A Southeast Nebraska Agricultural Landscape, Christopher Fill

School of Natural Resources: Dissertations, Theses, and Student Research

Intensive agriculture is associated with biodiversity loss and species decline. Yet wild species, such as bats, may provide critical ecosystem services to agriculture, even in transformed landscapes. In the United States, bats have been estimated to save the agricultural industry billions of dollars per year. However, white-nose syndrome and habitat loss have led to the decline of many bat species in North America, including the federally threatened northern long-eared bat, Myotis septentrionalis.

To better evaluate the effectiveness of these pest-controlling services, and to increase understanding of bat foraging behavior in these extreme landscapes, I deployed 11 grids of 24 detectors, …

Making Meaning In The Classroom: Developing An Oer For Equitable Teaching, Brenton Jackson

Instructional Psychology and Technology Graduate Student Projects

The cultural aspects of teacher-child interactions are emerging as key factors in K-6 learning, especially as the diversity of US classroom increases year to year. While there is growing evidence that culturally-connected classroom interactions can enrich development and improve classroom experience, finding accessible ways to teach, measure and improve those cultural aspects of teaching has been challenging, especially because of cost and access barriers.

The purpose of this project was to turn an existing cultural teaching observation protocol (the Classroom Assessment of Sociocultural Interactions, or CASI) into an instructional experience that would be accessible to all teachers. A team of …

Computational And Pharmacological Evaluation Of Carveol For Antidiabetic Potential, Muhammad Shabir Ahmed, Arif Ullah Khan, Lina Tariq Al Kury, Fawad Ali Shah

All Works

© Copyright © 2020 Ahmed, Khan, Kury and Shah. Background: Carveol is a natural drug product present in the essential oils of orange peel, dill, and caraway seeds. The seed oil of Carum Carvi has been reported to be antioxidant, anti-inflammatory, anti-hyperlipidemic, antidiabetic, and hepatoprotective. Methods: The antidiabetic potential of carveol was investigated by employing in-vitro, in-vivo, and in-silico approaches. Moreover, alpha-amylase inhibitory assay and an alloxan-induced diabetes model were used for in-vitro and in-vivo analysis, respectively. Results: Carveol showed its maximum energy values (≥ -7 Kcal/mol) against sodium-glucose co-transporter, aldose reductase, and sucrose-isomaltase intestinal, whereas it exhibited intermediate energy …

Synthesizing Expressive Behaviors For Humanoid Robots, Mathias Irwan Sunardi

Dissertations and Theses

Humanoid robots are expected to be able to communicate with expressive gestures at the same level of proficiency as humans. However, creating expressive gestures for humanoid robots is difficult and time consuming due to the high number of degrees of freedom (DOF) and the iterations needed to get the desired expressiveness.

Current robot motion editing software has varying levels of sophistication of motion editing tools ranging from basic ones that are text-only, to ones that provide graphical user interfaces (GUIs) which incorporate advanced features, such as curve editors and inverse kinematics. These tools enable users to create simple motions; but …

Piecing Together The Puzzle Of Pictorial Representation: How Jigsaw Puzzles Index Metacognitive Development, Mj Doherty, M Wimmer, C Golleck, E Robinson, C Stone

School of Psychology

Jigsaw puzzles are ubiquitous developmental toys in Western societies, used here to examine the development of metarepresentation. For jigsaw puzzles this entails understanding that individual pieces, when assembled, produce a picture. In Experiment 1, 3- to 5-year-olds (N = 117) completed jigsaw puzzles that were normal, had no picture, or comprised noninterlocking rectangular pieces. Pictorial puzzle completion was associated with mental and graphical metarepresentational task performance. Guide pictures of completed pictorial puzzles were not useful. In Experiment 2, 3- to 4-year-olds (N = 52) completed a simplified task, to choose the correct final piece. Guide-use associated with age and specifically …

Energy Stores And Life-History Transitions In Red-Sided Garter Snakes (Thamnophis Sirtalis Parietalis), Rachel Catharine Wilson

Dissertations and Theses

All organisms must prioritize investment in either reproductive or self-maintenance activities. Despite this established paradigm, our understanding of how organisms choose to prioritize certain behaviors and physiologies over others remains limited. It is likely that an organism's energy status not only influences variation in reproductive effort, but also transitions to and from reproductive activities. My dissertation aims to investigate how energy metrics (body condition index, adipocyte follicle size, and liver glycogen) relate to reproduction and associated life-history stages in red-sided garter snakes (Thamnophis sirtalis parietalis). Chapter two examines if energy metrics differ with migratory status and sex in …

Environmental Surveillance As A Tool For Identifying High-Risk Settings For Typhoid Transmission, Jason R. Andrews, Alexander T. Yu, Senjuti Saha, Jivan Shakya, Kristen Aiemjoy, Lily Horng, Farah Qamar, Denise Garret, Stephen Baker, Samir Saha, Stephen P. Luby

Department of Paediatrics and Child Health

Enteric fever remains a major cause of morbidity in developing countries with poor sanitation conditions that enable fecal contamination of water distribution systems. Historical evidence has shown that contamination of water systems used for household consumption or agriculture are key transmission routes for Salmonella Typhi and Salmonella Paratyphi A. The World Health Organization now recommends that typhoid conjugate vaccines (TCV) be used in settings with high typhoid incidence; consequently, governments face a challenge regarding how to prioritize typhoid against other emerging diseases. A key issue is the lack of typhoid burden data in many low- and middle-income countries where TCV …

The Experience Of Female Caregivers In The Kingdom Of Saudi Arabia, Nouf Albugami

Dissertations and Theses

In the Kingdom of Saudi Arabia ("KSA"), a minimal amount of research concerning the availability and level of social support specifically targeting the female caregiver has been conducted. Moreover, the extent to which social support has helped alleviate both the physical and psychological stress of caregiving has been studied very little, if at all. In light of this limited amount of research, the goals of this study are to investigate the following two questions: (1) What is the experience of female caregivers with chronically ill children in KSA, and (2) What is the nature and availability of social support among …

A Preliminary Investigation Of The Impact Of Forest Management Practices On Microhabitat Abiotic Variables In The Southern Appalachian Mountains, Jasmine Williamson, Allison Bailey, Jacob Lougee, David Patterson, Jessica Patterson

Georgia Journal of Science

Existing research has demonstrated that forest management practices (e.g., clear-cutting, planting) can dramatically impact animal communities. This is particularly the case with amphibian populations due to their sensitivity to microhabitat alterations. However, few studies have investigated the manner by which forest management practices impact the abiotic variables most relevant to healthy amphibian populations. In this study we investigated how spatially localized forest management practices (i.e., at the scale of hundreds of meters) alter the microhabitat variables that have been shown important to amphibian population distributions. We assessed the relationship between forest composition and microhabitat abiotic variables across three localities with …

Molar Protraction Through Downward Extension Of Maxillary Sinus In Patient With Central Diastema Caused By Small Lateral Incisors, Hsien-Fang Hung, Ming-Chu Huang, Ming-Jeaun Su

Taiwanese Journal of Orthodontics

A 32-year-old male patient presented with upper central diastema resulting from upper bilateral smallsized lateral incisors. The patient also had a deep bite of dental origin. A relatively simple mechanotherapy with pre-adjusted edgewise appliances was applied. A favorable and stable result of the ideal overbite and overjet after the correction of central diastema. Besides the above primary complaints, the prolonged retained roots of upper left first molar caused difficulty for proper space closure since the maxillary sinus wall was downward extended. The lower sinus floor may impede the orthodontic movement, but was very likely to be overlooked. The upper left …

The Shape Of Metabolism: Mitochondrial Dynamics, Remodeling, And Bioenergetic Reprogramming In Disease, Carl Decker

KGI Theses and Dissertations

Mitochondria are dynamic, double-membrane bound hubs of bioenergetics, cell signaling, and redox balance that exist as an oscillating network of fused superstructures and smaller, single organelles. Importantly, their position at the junction of catabolic and anabolic metabolism connects these morphological fluctuations to larger cellular metabolic programs, which in turn have implicated mitochondrial dynamics in a number of disease states and a varied set of cell phenomena. For example, differentiation of memory t-cells is dependent on mitochondrial network morphology, and in particular on remodeling dynamics that yield fused mitochondrial assemblies favoring oxidative phosphorylation-driven metabolism. In contrast, many cancers have been shown …

Role Of Lncrna Morrbid In Ptpn11(Shp2)E76k-Driven Juvenile Myelomonocytic Leukemia., Zhigang Cai, Chi Zhang, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Reuben Kapur

Faculty Research 2020

Mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, contribute to ∼35% of cases of juvenile myelomonocytic leukemia (JMML). A common clinical picture in children with JMML is that it presents as a constitutive hyperinflammatory syndrome, partially reminiscent of chronic myelomonocytic leukemia in adults. Thus, a component of JMML is associated with a hyperinflammatory state and abundant innate immune cells such as neutrophils and monocytes. Recently, we showed that the evolutionarily conserved mouse lncRNA Morrbid is specifically expressed in myeloid cells and uniquely represses the expression of the proapoptotic gene Bim to regulate the lifespan of myeloid cells. However, …

Under Discussion: Free Speech, Cancel Culture, And Compassion, Rachel Robinson-Greene

Languages, Philosophy, and Communication Studies Faculty Publications

In July, 2020, Harper’s Magazine published a letter signed by 153 prominent authors and thinkers. Signatories included figures such as Noam Chomsky, Gloria Steinem, and J.K. Rowling. Their main contention was that an “illiberal left” has emerged in recent political discourse — a left that allows no room for divergent points of view and that deals with “wrongdoers” swiftly and mercilessly.

Regulation Of Bmp4/Dpp Retrotranslocation And Signaling By Deglycosylation., Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F. Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M. Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad

Faculty Research 2020

During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N-glycanase 1 (NGLY1) is proposed to remove N-glycans from misfolded N-glycoproteins after their retrotranslocation from the ER to the cytosol. We previously reported that NGLY1 regulates Drosophila BMP signaling in a tissue-specific manner (Galeone et al., 2017). Here, we establish the Drosophila Dpp and its mouse ortholog BMP4 as biologically relevant targets of NGLY1 and find, unexpectedly, that NGLY1-mediated deglycosylation of misfolded BMP4 is required for its retrotranslocation. Accumulation of misfolded BMP4 in the ER results in ER stress and prompts the ER recruitment of NGLY1. The ER-associated NGLY1 …

Computational Identification Of Gene Networks As A Biomarker Of Neuroblastoma Risk, Lidan Sun, Libo Jiang, Christa N Grant, Hong-Gang Wang, Claudia Gragnoli, Zhenqiu Liu, Rongling Wu

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

Neuroblastoma is a common cancer in children, affected by a number of genes that interact with each other through intricate but coordinated networks. Traditional approaches can only reconstruct a single regulatory network that is topologically not informative enough to explain the complexity of neuroblastoma risk. We implemented and modified an advanced model for recovering informative, omnidirectional, dynamic, and personalized networks (idopNetworks) from static gene expression data for neuroblastoma risk. We analyzed 3439 immune genes of neuroblastoma for 217 high-risk patients and 30 low-risk patients by which to reconstruct large patient-specific idopNetworks. By converting these networks into risk-specific representations, we found …

"Not 'Just' A Barista": The Story Of Portland's College-Educated Baristas, Ned William Tilbrook

Dissertations and Theses

This paper examines graduate jobs/skills mismatch in craft occupations, through semi-structured interviews with college-educated baristas working in local and craft coffee shops in Portland, Oregon. This paper asks why college educated people work in such a role as it represents an interesting example of job/skills mismatch. Findings suggest that some see it as a good stop-gap on the way to something else, while others hope to use the skills they learned in studying for their degree to forge a career in the coffee industry. A desire to use these degree-relevant skills is prevalent throughout the sample, however many are still …

Influence Of Local Ph Environment And Zn(Ii) On The Structure Of The Antimicrobial Peptide Clavanin A And Its Dynamics With Different Membrane Models In Md Simulations, Searle Aichelle Duay

Doctoral Dissertations

In the latest report from the Centers for Disease Control and Prevention (CDC) on antimicrobial resistance, this problem remains to be an urgent global threat, infecting about three million people and killing about 36,000 people in the United States annually. Antimicrobial peptides (AMPs) offer a number of advantages over small molecule antibiotics, such as their structural flexibility in response to different local environments, allowing for having environment-responsive modes of action. In this dissertation, we will focus on Clavanin A (ClavA), an AMP that was identified and can be extracted from the tunicate Styela clava. Experimentally, it was shown that …

Microcracks And Metabolism Within Articular Cartilage During Mechanical Load, Stephany Santos

Doctoral Dissertations

Physical pain limits the quality of life for more than 20% of the adult population around the world. Joint injury and acute trauma account for a significant portion of this pain. The most common joint injuries include ankle sprains, ACL tears in the knee, Patellofemoral syndrome (injury resulting from the repetitive movement of the patella against the femur), and Tennis Elbow (Epicondylitis). There is strong evidence that suggest these injuries trigger a cascade of events that lead to post-traumatic osteoarthritis (PTOA). PTOA is a multifactorial disease that affects all aspects of joints, including ligaments, tendons, bones, menisci, and most prominently, …