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Containing The Blemmye: Anxiety Towards Congenital Difference In The Old English Wonders Of The East, Jessica L. Carrell

Master's Theses

This thesis aims to illuminate early medieval anxieties about sex, procreation, and congenital physical difference by applying a lens of critical disability theory to the Old English Wonders of the East, primarily as it survives in the eleventh-century manuscript, London, British Library, Cotton MS Tiberius B.v. This thesis focuses on the textual and illustrative representation of one Wonder, the Blemmye—an approximately eight-foot-tall, eight-foot-wide androgynous humanoid, whose eyes and mouth are in their chest and who does not possess a head—as a historic embodiment of what disability meant in relation to the early medieval English worldview. This thesis considers the …

Finding Identity Through Survival: The Impact Of The Hurricanes In Zora Neale Hurston’S Their Eyes Were Watching God And Jesmyn Ward’S Salvage The Bones, Crystal F. Giles

Master's Theses

This paper attempts to convey the importance of the hurricane symbol in Zora Neale Hurston’s Their Eyes Were Watching God and Jesmyn Ward’s Salvage the Bones. In both novels, the authors use the imagery of setting combined with the characterization of poor women of color in order to emphasize both the effects of environmental disaster on vulnerable communities and also the inherent power of their protagonists to overcome systemic racism combined with natural disaster. The climax of Zora Neale Hurston’s novel revolves around the deadly 1928 Okeechobee Hurricane in Florida, and the rising action of Jesmyn Ward’s novel peaks …

Lipid Quantification And Cryopreservation Of In Vitro Produced Jersey Cattle Embryos, Katherine A. Rhodes-Long

Master's Theses

Cryopreservation of in vivo derived Jersey bovine embryos have resulted in a 10% lower pregnancy rate compared to other dairy breeds. Poor embryo survival after cryopreservation has been partially attributed to the high lipid content of Jersey embryos. In vitro-produced (IVP) bovine embryos have darker cytoplasm than their in vivo-derived counterparts because of higher lipid accumulation. High lipid accumulation is associated with impaired embryo quality. Forskolin is an adenylate cyclase activator that regulates cAMP levels in cells and has been shown to induce lipolysis in IVP embryos. L-carnitine is required for transport of fatty acids from the intermembrane space of …

Exploring The Impact Of Musical Mnemonic Strategies On Student Achievement And Engagement In Inclusive Science Classes, Zinna Eaton

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Students with disabilities often struggle with comprehending material and performing at grade level, and teachers often find new ways to help their students comprehend the curriculum. A common challenge for special education teachers is incorporating different learning styles and various instructional strategies to better assist their students. One teaching strategy and resource that many teachers incorporate is the use of music in their instruction. This research project examines how incorporating music teaching strategies into daily instruction impacts the level of engagement and the academic achievement level of sixth-grade students with and without mild/moderate disabilities within inclusive science classrooms. The study …

Normal Ethanol Sensitivity And Rapid Tolerance Require The G Protein Receptor Kinase 2 In Ellipsoid Body Neurons In Drosophila, Yuan Yuan Kang, Yusuke Wachi, Elizabeth Engdorf, Emiliano Fumagalli, Youyou Wang, Jennifer Myers, Shebna Massey, Antony Greiss, Shiyu Xu, Gregg Roman

Faculty and Student Publications

© 2020 The Authors. Alcoholism: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcoholism Background: G protein signaling pathways are key neuromodulatory mechanisms for behaviors and neurological functions that affect the impact of ethanol (EtOH) on locomotion, arousal, and synaptic plasticity. Here, we report a novel role for the Drosophila G protein–coupled receptor kinase 2 (GPRK2) as a member of the GRK4/5/6 subfamily in modulating EtOH-induced behaviors. Methods: We studied the requirement of Drosophila Gprk2 for naïve sensitivity to EtOH sedation and ability of the fly to develop rapid tolerance after a single …

Molecular Approaches For Analyzing Organismal And Environmental Interactions, Stephanie Fern Hudon

Boise State University Theses and Dissertations

Our planet is undergoing rapid change due to the expanding human population and climate change, which leads to extreme weather events and habitat loss. It is more important than ever to develop methods which can monitor the impact we are having on the biodiversity of our planet. To influence policy changes in wildlife and resource management practices we need to provide measurable evidence of how we are affecting animal health and fitness and the ecosystems needed for their survival. We also need to pool our resources and work in interdisciplinary teams to find common threads which can help preserve biodiversity …

Lc-Ms Based Stability-Indicating Method For Studying The Degradation Of Lonidamine Under Physical And Chemical Stress Conditions, Ankit K. Rochani, Margaret A. Wheatley, Brian Oeffinger, John R. Eisenbrey, Gagan Kaushal

College of Pharmacy Faculty Papers

Background and purpose: Lonidamine is a hexokinase II inhibitor, works as an anticancer molecule, and is extensively explored in clinical trials. Limited information prevails about the stability-indicating methods which could determine the forced degradation of lonidamine under stressed conditions. Hence, we report the use of a rapid, sensitive, reproducible, and highly accurate liquid chromatography and mass spectrometry method to analyze lonidamine degradation. Experimental approach: The Xbridge BEH shield reverse phase C18 column (2.5 μm, 4.6 × 75 mm) using isocratic 50:50 water: acetonitrile with 0.1% formic acid can detect lonidamine with help of mass spectrometer in tandem with an ultraviolet …

Assessment Of The Growth In Social Groups For Sustainable Agriculture And Land Management, Pretty Jules, Simon Attwood, Richard Bawden, Henk Van Den Berg, Zareen P. Bharucha, Jacob I. Ricks

Research Collection School of Social Sciences

For agriculture and land management to improve natural capital over whole landscapes, social cooperation has long been required. The political economy of the later twentieth and early twenty-first centuries prioritized unfettered individual action over the collective, and many rural institutions were harmed or destroyed. Since then, a wide range of social movements, networks and federations have emerged to support transitions towards sustainability and equity. Here, we focus on social capital manifested as intentionally formed collaborative groups within specific geographic territories. These groups focus on: (1) integrated pest management; (2) forests; (3) land; (4) water; (5) pastures; (6) support services; (7) …

Polymyxins And Bacterial Membranes: A Review Of Antibacterial Activity And Mechanisms Of Resistance, Carole Ayoub Moubareck

All Works

© 2020 by the author. Licensee MDPI, Basel, Switzerland. Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the rising global prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria have both rejuvenated clinical interest in these polypeptide antibiotics. Parallel to the revival of their use, investigations into the mechanisms of action and resistance to polymyxins have intensified. With an initial known effect on biological membranes, research has uncovered the detailed molecular and chemical interactions that polymyxins have with Gram-negative outer …

The Application Of A Simple Tissue-Disruption Method To Dna Extraction For Species Identification, Jordana R. Fox

Student Theses

The TissueLyser II was used to disrupt animal bones and plant tissue without dry ice or liquid nitrogen for species identification. Bone fragments of fresh swine (Sus scrofa) ribs were used. A 521bp fragment of the cyt b locus was analyzed, and the BLASTn results confirmed that the origin of all the samples was swine (E-value = 0.0). Bone fragments of bovine, chicken, duck, fish, sheep, and swine were also used to test the procedure. An approximately 600bp fragment of the COI locus was analyzed, and the BLASTn results confirmed the origin of all the samples (E-value = …

Archaeology Or Crime Scene? Teeth Micro And Macro Structure Analysis As Dating Variable, Jessica A. Vincenty

Student Theses

Simple methods to aid in the determination of forensic or archaeologic relevancy of skeletonized remains have been researched since the 1950s. With advances in microscopic imaging techniques and machine learning computer data analysis methods the relevancy of decontextualized, comingled remains has room for improvement. This thesis is a study done to pioneer a new approach to analyzing dental skeletal remains to determine forensic relevancy.

Archaeological dental samples collected from the ancient city of Ur in modern day southern Iraq in addition to modern dental extractions were processed for scanning electron microscopy imaging. Archaeological and modern samples displayed different surface and …

Directed Evolution Of Macrocyclic Peptides For Inhibition Of Autophagy, Joshua Gray

Dissertations and Theses (Open Access)

In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from poor pharmacokinetics and high toxicity at therapeutic dosages. This has prompted intense interest in the development of targeted autophagy inhibitors to re-sensitize disease to treatment with minimal impact on normal tissue. We utilized Scanning Unnatural Protease Resistant (SUPR) mRNA display to develop macrocyclic peptides targeting the autophagy protein LC3. The resulting peptides bound LC3A and LC3B—two essential components of …

Investigating The Role Of Quaking In Antigen Uptake And Cross-Presentation By Dendritic Cells, Yating Li

Dissertations and Theses (Open Access)

Dendritic cells (DCs) are considered the most potent antigen presenting cells (APC) due to their superior capability of cross-presenting exogenous antigens to CD8⁺ T cell for strong adaptive immune responses. They internalize foreign antigens by phagocytosis, endocytosis or macropinocytosis, which are then processed in endosomal compartments and loaded onto MHC Class I molecules. However, the molecular mechanisms regulating exogenous antigen uptake and cross-presentation by DCs are not fully understood.

In this study, we discovered that an RNA-binding protein, Quaking (QKI) plays a pivotal role in antigen uptake by DCs. Our previous studies in neural stem cells and microglia have …

Active Magnetic Radiation Shielding For Long-Duration Human Spaceflight, Kristine Ferrone

Dissertations and Theses (Open Access)

Exploration of interplanetary space presents dramatic hazards to human survival.

Space radiation hazards outside the protection of the Earth’s magnetosphere can

produce both acute and chronic health risks and thus become limiting factors for

NASA’s planned mission to Mars by the 2030s. Radiation exposure on a Mars mission

is delivered primarily by high energy ions from galactic cosmic rays and moderate

energy protons from solar particle events. The chronic radiation dose due to galactic

cosmic rays on a typical Mars mission is on the order of 1 Sv, and additional acute

radiation dose from solar flares can reach over 4 …

Targeting Unique Domains Of Lsd1 Regulates Pediatric Glioma Innate Immunity And Nk Cell Metabolism, Cavan Bailey

Dissertations and Theses (Open Access)

Regulation of chromatin accessibility is a key mechanism of cellular identity, allowing different tissues to develop using the same DNA template. Cancers will often hijack these epigenetic pathways, reactivating developmental genes to drive growth and deactivating tumor suppressor and immune recognition genes. Chromatin-modifying proteins deposit and remove chemical moieties from histone tails to aid in governing gene expression, and these proteins have become a new therapeutic target in cancer. Traditional chemotherapeutics aim to damage DNA, dysregulate cell division, or block hormonal growth signals, but epigenetic therapy can target vulnerabilities specific to cancer cells and broadly change gene expression patterns that …

Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2b Signaling, Jeanne Manalo

Dissertations and Theses (Open Access)

Over 538 million people in the world have been diagnosed with hearing loss (HL). Current treatments for the most common type of HL, sensorineural HL, are limited to hearing aids and cochlear implants with no FDA-drugs available. The hearing process demands an abundance of ATP and HL is often attributed to a disruption in this metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has found a HL phenotype in …

Methods To Investigate Hyperthermia Induced By Tumor Treating Fields, Ruchi Singh

Dissertations and Theses (Open Access)

Tumor Treating Fields (TTFields) are an antineoplastic treatment delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. TTF’s is a non-invasive application of low-intensity (1-3 V/cm), intermediate-frequency (100-500 kHz) alternating electric fields. The predominant mechanism by which TTFields are thought to kill tumor cells is the disruption of mitosis through the depolymerization of microtubules and interruption of the spindle structure leading to mitotic catastrophe and the formation of non-viable daughter cells. Tumor Treating fields do not stimulate nerves and muscle because of their high frequency, and do …

Putative Roles Of Cd200 In The Leukemogenesis And Immune Evasion Of Leukemia Stem Cells, Shelley Herbrich

Dissertations and Theses (Open Access)

Acute myeloid leukemia (AML) stem cells (LSC) are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed disease. While stem cell transplant serves as proof-of-principle that AML LSCs can be eliminated by the immune system, the translation of existing immunotherapies to AML have been met with limited success. Consequently, understanding and exploiting the unique immune mechanisms of AML LSCs is critical. To identify novel immunotherapeutic targets, we sourced multiple large, publicly available datasets and identified CD200 as a potential stem-cell specific immune checkpoint in AML. We hypothesized that CD200 was a stem-cell specific mechanism of …

Histological And Functional Characterization Of Cervical Spinal Cord Injury After Graded Contusion, Chrystine Gallegos

Dissertations and Theses (Open Access)

Most spinal cord injuries (SCIs) are cervical contusions and result in deficits for both locomotion and reaching and grasping functions. Previous studies have characterized histological and functional deficits in locomotion using primarily thoracic contusions, but most patients have cervical injuries. Damage to descending long spinal tracts (dLSTs) is one well-established cause of functional loss after SCI and has been explored in laceration and transection models, but these are not clinically relevant. In this study, I will explore the histological and functional deficits after graded cervical hemicontusion SCI and examine the potential contribution of different histological deficits to forelimb function after …

Student Code Of Conduct, Saint Mary's College Of California

Student Handbook

No abstract provided.

Analysis Of Environmental Law Scholarship 2018-2019, Michael P. Vandenbergh, Courtney A. Tibbetts, Linda K. Breggin, Elizabeth A. Holden

Vanderbilt Law School Faculty Publications

The purpose of this article is to highlight the results of the ELPAR article selection process and to report on the environmental legal scholarship for the 2018-2019 academic year, including the number of environmental law articles published in general law reviews versus environmental law journals, and the topics covered in the articles. We also present the top 20 articles that met ELPAR's criteria of persuasiveness, impact, feasibility, and creativity, from which five articles were selected to republish in shortened form, some of them with commentaries from leading practitioners and policymakers. Thus, the goal of this article is to provide an …

Diagnosis, Rupture Risk Evaluation And Therapeutic Intervention Of Abdominal Aortic Aneurysms Using Targeted Nanoparticles, Xiaoying Wang

All Dissertations

Abdominal aortic aneurysm (AAA) disease causes dilation of the aorta that can lead to aortic rupture and death if not treated early. It is the 14th leading cause of death in the U.S. and is cited as the 10th leading cause of death in men over age 55, affecting thousands of patients and their families. To date, AAA patients have minimal access to safe and efficient imaging modalities for diagnosis as well as pharmacotherapies. AAA is usually detected and monitored with ultrasonography or contrast-enhanced computed tomography (C.T.), which doesn’t provide biomechanical information of the AAAs that are essential for predicting …

Development Of Solid Sampling Modalities For The Liquid-Sampling Atmospheric Pressure Glow Discharge Microplasma, Htoo Paing

All Dissertations

Fast pretreatment of samples, low resource consumption, and high analytical throughput makes direct solid sampling techniques an attractive choice for a wide range of applications. Currently there are a plethora of analytical techniques capable of solid sampling. However, no commercial technique is available that is capable of taking advantage of the key concepts of solid samplings. General disadvantages amongst the current solid sampling instrumentation are high cost of operation, limited analyte choice, and reduced analytical performance. In that regard, it is important to develop a source that has low operation cost as well as the capability to analyze a diversity …

Detecting Periods Of Eating In Everyday Life By Tracking Wrist Motion — What Is A Meal?, Surya Sharma

All Dissertations

Eating is one of the most basic activities observed in sentient animals, a behavior so natural that humans often eating without giving the activity a second thought. Unfortunately, this often leads to consuming more calories than expended, which can cause weight gain - a leading cause of diseases and death. This proposal describes research in methods to automatically detect periods of eating by tracking wrist motion so that calorie consumption can be tracked. We first briefly discuss how obesity is caused due to an imbalance in calorie intake and expenditure. Calorie consumption and expenditure can be tracked manually using tools …

Uav-Assisted Water Quality Monitoring, Cengiz Koparan

All Dissertations

Water quality assessment for the management of water resources requires the collection of water samples for physical, chemical, and biological analysis. It is essential to reduce the cost of water quality monitoring by minimizing the number of grab samples and to reduce the sampling time by rapidly accessing the sampling points. Adaptive, remote, and smart water sampling systems can provide more effective water quality monitoring programs. An adaptive water sampling system with an unmanned aerial vehicle integrated with sensor nodes was developed and tested in this research. Individual phases of this research were; in-situ water quality measurements with a UAV-integrated …

Metagenomic, Viral And Host Genetic Analyses Of Congenital Tremor In Pigs, Kylee Marie Sutton

School of Biological Sciences: Dissertations, Theses, and Student Research

The Pestivirus genus contains several viral species having a major impact on the livestock species. While there were only four major pestiviral species for a time, recent metagenomic sequencing approaches identified additional species, such as atypical porcine pestivirus (APPV). Congenital tremor was first identified almost a hundred years ago and since still has an impact on swine health. There are two main types of congenital tremor, type A and B, with type A congenital tremor further subcategorized based on causative agent. Until recently, type A-II congenital tremor did not have a known cause. Recent viral sequencing of affected samples, including …

From Simple To Sophisticated: The Organization Of Terrorist Groups, Michael K. Logan

Student Work

This dissertation draws on gang organization research and organizational theory to assess the underlying dimensions of organization in terrorist groups. Using the Leadership for the Extreme and Dangerous for Innovative Results (LEADIR) dataset, findings suggest that organization is a multidimensional construct in terrorist groups, including the structuring of activities dimension and the concentration of authority dimension. In relation to violence, terrorist groups high on the structuring of activities dimension were significantly more lethal in general and more lethal when attacking hard targets, whereas terrorist groups high on the concentration of authority dimension attacked hard targets at a significantly higher rate. …

Population Status, Threats, And Conservation Of Preuss's Red Colobus (Piliocolobus Preussi) And Other Diurnal Primates In The Ndokbou Forest, Littoral Region, Cameroon, Ruth Bowers-Sword

Masters Theses, 2020-current

The Ebo-Makombe-Ndokbou forest block in southwest Cameroon lies within the Gulf of Guinea biodiversity hotspot, characterized by extremely high levels of species richness and endemism, including those of primates. These forests may contain one of the last populations of the Critically Endangered Preuss’s red colobus monkey (Piliocolobus preussi; PRC), which is found only in southeastern Nigeria and western Cameroon. Gun hunting for bushmeat and habitat loss and degradation from logging and agriculture are the main threats to PRC. The conservation status of PRC and other primates in the Ndokbou forest are largely unknown, with most regional research efforts occurring in …

The Current: Orientation Issue - Volume 31 Issue 1, Nova Southeastern University

Student Newspapers

Orientation issue for 2020

Employed Mothers’ Satisfaction With The Breastfeeding Provisions In The Patient Protection And Affordable Care Act, Rebecca A. Penders

Graduate Doctoral Dissertations

Objective: Guided by the Conceptual Model for Nursing and Health Policy (CMNHP), the purpose of this study was to determine the extent to which employed mothers perceived satisfaction in their breastfeeding experiences after enactment of the Patient Protection and Affordable Care Act (PPACA) breastfeeding provisions. Methods: The participants (N=507) were employed mothers who returned to work after the birth of their infants and reported hourly pay. Convenience sampling was used to recruit women via La Leche USA Facebook account (LLL USA). Participants completed the Penders Breastfeeding Survey in Research Electronic Data Capture (REDCap). The survey consisted of 39-items; including five …